Could a simple hormone test spare thousands of women from chemo?
NCT ID NCT07671885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial is testing whether premenopausal women with a common type of breast cancer (HR+/HER2-) can safely skip chemotherapy if their tumor responds well to hormone therapy before surgery. About 950 women will be randomly assigned to either standard surgery first or hormone therapy before surgery. Those whose tumors shrink enough on hormone therapy will receive only more hormone therapy after surgery, avoiding chemo. The goal is to see if this approach is just as effective at preventing cancer from coming back, while reducing the burden of chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
aromatase inhibitor and ovarian function suppression (hormone therapy), with or without chemotherapy
What this could lead to
If successful, this could allow many premenopausal women with intermediate-risk breast cancer to avoid chemotherapy and its side effects, relying only on hormone therapy.
What could go wrong
This is a large phase 3 trial, but it is still ongoing. The response-guided approach may not prove as effective as standard care, and some patients might still need chemotherapy.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Cancer Center Hospital
RECRUITINGTokyo, Japan
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National Cancer Center Hospital East
RECRUITINGKashiwa, Japan