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Could a simple hormone test spare thousands of women from chemo?

NCT ID NCT07671885

Recruiting now Disease control Sponsor: Tokyo Women's Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This phase 3 trial is testing whether premenopausal women with a common type of breast cancer (HR+/HER2-) can safely skip chemotherapy if their tumor responds well to hormone therapy before surgery. About 950 women will be randomly assigned to either standard surgery first or hormone therapy before surgery. Those whose tumors shrink enough on hormone therapy will receive only more hormone therapy after surgery, avoiding chemo. The goal is to see if this approach is just as effective at preventing cancer from coming back, while reducing the burden of chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
aromatase inhibitor and ovarian function suppression (hormone therapy), with or without chemotherapy
What this could lead to
If successful, this could allow many premenopausal women with intermediate-risk breast cancer to avoid chemotherapy and its side effects, relying only on hormone therapy.
What could go wrong
This is a large phase 3 trial, but it is still ongoing. The response-guided approach may not prove as effective as standard care, and some patients might still need chemotherapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • Aichi Cancer Center

    RECRUITING

    Nagoya, Japan

  • Akita University Hospita

    RECRUITING

    Akita, Japan

  • Chiba Cancer Center

    RECRUITING

    Chiba, Japan

  • Fukushima Medical University Hospital

    RECRUITING

    Fukushima, Japan

  • Gunma Prefectural Cancer Center

    RECRUITING

    Ōta-ku, Japan

  • Gunma University Hospital

    RECRUITING

    Maebashi, Japan

  • Hamamatsu University School of Medicine

    NOT_YET_RECRUITING

    Hamamatsu, Japan

  • Hiroshima City North Medical Center Asa Citizens Hospital

    RECRUITING

    Hiroshima, Japan

  • Hiroshima University Hospital

    RECRUITING

    Hiroshima, Japan

  • Hokkaido Cancer Center

    RECRUITING

    Sapporo, Japan

  • Ibaraki Prefectural Central Hospital

    RECRUITING

    Ibaraki, Japan

  • Institute of Science Tokyo Hospital

    RECRUITING

    Tokyo, Japan

  • Kanagawa Cancer Center

    RECRUITING

    Yokohama, Japan

  • Kansai Medical University Hospital

    RECRUITING

    Hirakata, Japan

  • Kindai University Hospital

    RECRUITING

    Sakai, Japan

  • Kitakyushu Municipal Medical Center

    RECRUITING

    Kitakyushu, Japan

  • Kitasato University Hospital

    RECRUITING

    Sagamihara, Japan

  • Mie University Hospital

    RECRUITING

    Tsu, Japan

  • NHO Nagoya Medical Center

    RECRUITING

    Nagoya, Japan

  • Nagoya City University

    RECRUITING

    Nagoya, Japan

  • Nagoya University Hospital

    RECRUITING

    Nagoya, Japan

  • National Cancer Center Hospital

    RECRUITING

    Tokyo, Japan

  • National Cancer Center Hospital East

    RECRUITING

    Kashiwa, Japan

  • National Center for Global Health and Medicine

    RECRUITING

    Tokyo, Japan

  • National Hospital Organization Fukuyama Medical Center

    RECRUITING

    Fukuyama, Japan

  • National Hospital Organization Kure Medical Center

    RECRUITING

    Kure, Japan

  • National Hospital Organization Kyushu Cancer Center

    RECRUITING

    Fukuoka, Japan

  • National Hospital Organization Nagasaki Medical Center

    RECRUITING

    Ōmura, Japan

  • National Hospital Organization Osaka National Hospital

    RECRUITING

    Osaka, Japan

  • National Hospital Organization Shikoku Cancer Center

    RECRUITING

    Matsuyama, Japan

  • National Hospital Organization Tokyo Medical Center

    RECRUITING

    Tokyo, Japan

  • Niigata Cancer Center Hospital

    RECRUITING

    Niigata, Japan

  • Osaka International Cancer Institute

    NOT_YET_RECRUITING

    Osaka, Japan

  • Saitama Cancer Center

    RECRUITING

    Saitama, Japan

  • Saitama Medical Center

    RECRUITING

    Kawagoe, Japan

  • Shizuoka Cancer Center

    RECRUITING

    Shizuoka, Japan

  • Shizuoka General Hospital

    RECRUITING

    Shizuoka, Japan

  • Showa Medical University Hospital

    RECRUITING

    Tokyo, Japan

  • Social medical corporation Hakuaikai Sagara Hospital

    RECRUITING

    Kagoshima, Japan

  • St.Luke's International Hospital

    RECRUITING

    Tokyo, Japan

  • The Cancer Institute Hospital of Japanese Foundation for Cancer Research

    RECRUITING

    Tokyo, Japan

  • Tohoku University Hospital

    RECRUITING

    Sendai, Japan

  • Tokai University Hospital

    RECRUITING

    Isehara, Japan

  • Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

    RECRUITING

    Tokyo, Japan

  • Tokyo Women's Medical University Hospital

    NOT_YET_RECRUITING

    Tokyo, Japan

  • Toranomon Hospital

    RECRUITING

    Tokyo, Japan

  • Tsukuba University Hospital

    RECRUITING

    Tsukuba, Japan

  • Yamaguchi University Hospital

    RECRUITING

    Ube, Japan

  • Yao Municipal Hospital

    RECRUITING

    Yao, Japan

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