New combo therapy for breast cancer shows promise in early trial

NCT ID NCT06139107

Recruiting now Disease control Sponsor: Mridula George, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study is testing whether giving radiation therapy together with two drugs (abemaciclib and letrozole) before surgery is safe and doable for people with a common type of early-stage breast cancer (HR+/HER2-). About 15 participants will receive this combination to see how well they tolerate it and to gather initial information on its effects. The goal is to find better ways to treat breast cancer before surgery, potentially improving outcomes.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
RWJBarnabas Health - Robert Wood Johnson University Hospital Somerset
RECRUITING

Somerville, New Jersey, 08873, United States
RWJBarnabas Health Clara Maas Medical Center
RECRUITING

Belleville, New Jersey, 07109, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.