Mesh Match-Up: which material works best for breast reconstruction?

NCT ID NCT05449691

Recruiting now Knowledge-focused Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether women and surgeons are comfortable with being randomly assigned to receive either a biological or synthetic mesh during immediate breast reconstruction after mastectomy. Sixty women will take part and be followed for six months. The results will help design a larger trial that could ultimately improve outcomes and quality of life for breast cancer patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: biological or synthetic mesh
What this could lead to: If successful, this could lead to a larger study that helps surgeons choose the best mesh for breast reconstruction, improving patient satisfaction and reducing complications.
What could go wrong: This is a small feasibility study with only 60 participants, so results may not apply to all patients. It is not designed to prove which mesh is better, only to see if a larger trial is possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Castle Hill Hospital
RECRUITING

Hull, United Kingdom
Nottingham City Hospital
RECRUITING

Nottingham, United Kingdom
University Hospitals of Derby and Burton NHS Foundation Trust
RECRUITING

Derby, DE22 3NE, United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, United Kingdom
Wycombe Hospital
RECRUITING

High Wycombe, United Kingdom

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