Brain metastases breakthrough? scientists probe how a powerful drug crosses into the brain

NCT ID NCT07653893

Recruiting now Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at breast cancer that has spread to the brain. Researchers want to understand how much of the drug trastuzumab deruxtecan gets into the fluid around the brain and spinal cord, and whether that amount relates to how well the drug shrinks brain tumors. About 60 adults with this type of cancer will take part, providing samples and scans to help answer these questions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: trastuzumab deruxtecan
What this could lead to: If successful, this could help doctors understand how well this drug reaches brain metastases, potentially improving treatment strategies for breast cancer that has spread to the brain.
What could go wrong: This is a small, early-phase observational study, so results may not apply to all patients. The drug's effectiveness in the brain is still being explored, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER CENTRAL NERVOUS SYSTEM (CNS) METASTASES

Contacts and locations

Locations

Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China

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