One-and-Done radiation before lumpectomy? new trial tests feasibility

NCT ID NCT04234386

Recruiting now Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a single, focused dose of radiation delivered by the GammaPod machine before lumpectomy surgery for early-stage breast cancer. The goal is to find a safe and effective dose that minimizes side effects and improves cosmetic outcomes. About 50 women with invasive ductal carcinoma will participate, receiving radiation at one of four dose levels before their tumor is removed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GammaPod radiation
What this could lead to: If successful, this could offer a shorter, more comfortable radiation treatment before surgery for early-stage breast cancer.
What could go wrong: This is an early-phase dose-finding study with only 50 participants, so results may not apply to all patients. Risks include infection or poor wound healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive ductal breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Baltimore Washington Medical Center
RECRUITING

Glen Burnie, Maryland, 21061, United States
Central Maryland Oncology Center
RECRUITING

Columbia, Maryland, 21044, United States
UMMC
RECRUITING

Baltimore, Maryland, 21201, United States
Upper Chesapeake Health
RECRUITING

Bel Air, Maryland, 21014, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.