New drug duo aims to wipe out breast cancer before surgery

NCT ID NCT07102381

Recruiting now Disease control Sponsor: Jazz Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding zanidatamab to standard chemotherapy can completely eliminate cancer in people with early-stage HER2-positive breast cancer before they have surgery. About 125 participants with stage II or III disease will receive the combination, and doctors will check tissue removed during surgery for any remaining cancer. The goal is to see if this approach is safe and more effective than chemo alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER2-POSITIVE BREAST CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Accellacare of McFarland
RECRUITING

Ames, Iowa, 50010, United States
Astera Cancer Care (Formerly Regional Cancer Care Associates)
RECRUITING

East Brunswick, New Jersey, 08816, United States
Cancer Partners of Nebraska
RECRUITING

Lincoln, Nebraska, 68516, United States
Hematology Oncology Associates of Central New York
RECRUITING

Camillus, New York, 13031, United States
Hosp Beata María Ana de Jesús
RECRUITING

Madrid, 28007, Spain
Hospital Clínico San Cecilio
RECRUITING

Granada, Andalusia, 18007, Spain
LSU Health Sciences Center
RECRUITING

Shreveport, Louisiana, 71103, United States
Maryland Oncology Hematology
RECRUITING

Laurel, Maryland, 20707, United States
Medical Oncology Hematology Associates
RECRUITING

Newark, New Jersey, 19713, United States
Nebraska Cancer Specialists
RECRUITING

Omaha, Nebraska, 68124, United States
New England Cancer Specialists
RECRUITING

Scarborough, Maine, 04074, United States
Northwest Cancer Specialists
RECRUITING

Vancouver, Washington, 98648, United States
Northwest Medical Specialties
RECRUITING

Puyallup, Washington, 98373, United States
Oncology Institute
RECRUITING

Long Beach, California, 90805, United States
Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Sarah Cannon Research Institute (Nashville)
RECRUITING

Nashville, Tennessee, 37203, United States
Shenandoah Oncology
RECRUITING

Winchester, Virginia, 22601, United States
Texas Oncology DFW
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology Gulf Coast
RECRUITING

Houston, Texas, 77024, United States
The Oncology Institute
RECRUITING

Lakeland, Florida, 33812, United States
The University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53706, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Álvaro Cunqueiro Hospital
RECRUITING

Vigo, Galicia, 36312, Spain