Can adding radiation to immunotherapy and chemotherapy boost breast cancer treatment?

NCT ID NCT07276880

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether adding low or high dose radiation to standard chemotherapy and the immunotherapy drug pembrolizumab can improve treatment for people with node-positive triple negative breast cancer. Thirty-two participants will be randomly assigned to receive either low or high dose radiation to the breast tumor before surgery. The main goal is to see which dose leads to a higher rate of complete cancer clearance in the lymph nodes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Pembrolizumab (immunotherapy drug) and radiation therapy
What this could lead to
If successful, this could help determine the best radiation dose to boost the immune system's response against triple negative breast cancer when combined with immunotherapy and chemotherapy.
What could go wrong
This is a small, early-phase trial with only 32 participants, so results may not apply to all patients. The added radiation could increase side effects, and it's unclear if it will improve outcomes over standard treatment.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

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