BREAST CANCER

This early-stage study tested a new drug called SAR443216 in people with advanced solid tumors that have a protein called HER2 and have stopped responding to other treatments. The main goals were to find a safe dose and see how the body processes the drug. Researchers also looked…

This early-stage trial tested a new combination of oral and injectable drugs for people with advanced HR-positive, HER2-negative breast cancer that had worsened after hormone therapy. The main goals were to find the safest and most effective dose of the new drug TQB3912 when give…

This study aimed to see if a new drug combination (amcenestrant plus palbociclib) could better control advanced breast cancer compared to the standard treatment (letrozole plus palbociclib). It involved over 1,000 adults with a specific type of breast cancer (ER+/HER2-) that had …

This study tested whether taking two oral medications, abemaciclib and elacestrant, together could help control breast cancer that had spread to the brain. It was designed for post-menopausal women with a specific type of breast cancer (HR+/HER2-) whose cancer had progressed in t…

This was an early safety study of a new oral drug called TAS2940 for people with advanced solid tumors that have specific genetic changes (EGFR or HER2). The main goals were to find a safe dose and see how the body processes the drug. The trial was terminated and enrolled 29 part…

This study tested a new oral drug called amcenestrant for postmenopausal women with advanced, estrogen receptor-positive breast cancer. The main goals were to find safe doses and see if the drug, given alone or with other cancer therapies, could help control the disease. The tria…

This study tested if a new drug called amcenestrant was better than the standard drug letrozole at slowing the growth of breast cancer cells before surgery. It involved 105 postmenopausal women with early-stage, hormone-sensitive breast cancer. Participants took one of the drugs …

This study aimed to find out if women over 50 with very small breast cancers could safely skip the routine removal of underarm lymph nodes during their initial surgery. Researchers compared the survival rates of women who had the lymph nodes removed versus those who did not. The …

This study aimed to compare three standard chemotherapy treatments for triple-negative breast cancer, an aggressive form that doesn't respond to hormone therapies. Researchers wanted to test a new consent approach while determining which chemotherapy regimen works best for patien…

This early-stage study tested a new oral cancer drug called NUV-868, both alone and combined with existing medications (olaparib or enzalutamide), in adults with advanced solid tumors. The trial aimed to find safe doses and see if these treatments could help control cancers that …

This study tested whether using special breast scans (mammogram and MRI) before surgery could help doctors better target a single dose of radiation given right after tumor removal. The goal was to see if this one-time treatment during the initial surgery could effectively control…

This early-stage study tested a new radioactive drug designed to target and destroy advanced solid tumors. It involved 78 patients with various cancers who had run out of standard treatment options. The main goals were to check the treatment's safety, find the right dose, and see…

This small, early-stage study tested whether using focused ultrasound on a tumor could help the immunotherapy drug pembrolizumab work better against metastatic breast cancer. The study aimed to see if the order of treatments mattered—giving the drug before or after the ultrasound…

This study tested whether combining an immunotherapy drug (pembrolizumab) with mifepristone could help control advanced breast cancers that lack the HER2 marker. It involved 24 patients with either triple-negative or hormone receptor-positive breast cancer that had spread or coul…

This study tested a new drug called TAK-500, designed to activate the immune system to fight cancer. It was given alone or combined with an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that had stopped responding to standard treatments. The mai…

This study tested whether adding a hormone-blocking drug (fulvestrant) to a targeted cancer drug (neratinib) worked better than the targeted drug alone for advanced breast cancer that had spread. It involved 21 women with specific types of breast cancer (HER2-positive and ER-posi…

This study tested whether the drug abemaciclib could help control advanced triple-negative breast cancer that had spread to other parts of the body. Researchers enrolled 27 patients whose cancer tested positive for a specific protein called Rb. The trial was terminated early, and…

This study tested whether adding an experimental drug called GDC-0084 to the standard treatment Herceptin could help control breast cancer that had spread to the brain. It involved 17 people with a specific type of breast cancer (HER2-positive) that had formed new or growing tumo…

This study aimed to see if a new drug called amcenestrant was better than the standard drug tamoxifen at keeping early-stage, hormone-sensitive breast cancer from coming back. It was for patients who had to stop their initial hormone therapy due to side effects. The trial was des…

This early-stage study aimed to find a safe dose for combining two drugs (infigratinib and tamoxifen) to treat advanced breast cancer with specific genetic changes. It enrolled only 4 participants before being terminated. The main goal was to identify side effects and determine i…

This study aimed to find out which of three common imaging scans—ultrasound, MRI, or PET-CT—most accurately measures the size of a breast cancer tumor after a patient completes chemotherapy. Doctors need this information to plan the best surgical approach. The researchers compare…

This study tested a special fluorescent dye (PD G 506 A) and camera system to help surgeons see leftover breast cancer cells in real-time during breast-conserving surgery. The goal was to help surgeons remove all the cancer in one operation, reducing the need for patients to have…

This study tested a new, shorter MRI scan designed to be a better and more affordable screening tool for breast cancer. It focused on women with dense breast tissue or a moderately increased risk, where standard mammograms can miss cancers. The goal was to see if this faster MRI …

This study tested a new type of ultrasound imaging called acoustic angiography. It was designed to see tiny blood vessels in breast and thyroid tumors more clearly, hoping to help doctors better tell if a growth is cancerous. The study included patients scheduled for biopsies and…

This study tested whether a special type of MRI scan could help doctors better tell if a suspicious breast lump is cancerous or benign. It involved 11 women who had suspicious findings on their mammograms or ultrasounds. The goal was to see if this scan could reduce the number of…

This study tested whether giving preventive radiation to the brain could stop cancer from spreading there in people with advanced HER2-positive breast cancer already receiving targeted drug therapy (trastuzumab). It aimed to see if this approach helped patients live longer withou…

This study tested whether a special surgical technique performed during lymph node removal could prevent lymphedema, a painful and chronic swelling of the arm. It involved 264 patients with breast cancer or melanoma who were having lymph nodes removed. Researchers compared standa…

This study tested whether a smartphone app could help people with HER2-positive breast cancer better manage side effects during chemotherapy. About 196 participants were randomly assigned to either use the app alongside their normal treatment or receive normal treatment alone. Th…

This study tested whether wearing a special chest bandage could help reduce the need for repeated needle drainage procedures in breast cancer patients who develop a painful fluid buildup (seroma) after a mastectomy. Half of the 60 participants wore the bandage in addition to rece…

This study tested whether applying a drug called tranexamic acid (TXA) directly to the surgical site could reduce common complications like bleeding and fluid buildup after breast reconstruction surgery following a mastectomy. Each participant acted as their own control, with the…

This study tested whether meeting with a psychologist early in treatment helps women with breast cancer return to their jobs. It compared this special support to standard care. The trial was stopped early and involved 128 working women who had finished surgery and chemotherapy.

This study tested whether the prescription sleep medication suvorexant could help breast cancer survivors who have trouble sleeping. A small group of survivors with significant insomnia were randomly assigned to receive either the drug or a placebo pill, along with basic sleep ad…

This study aimed to see if a mechanical stimulation device works better than standard massage to reduce pain and improve shoulder movement for breast cancer patients after mastectomy surgery. It planned to enroll 80 patients needing physical therapy and compare their pain levels,…

This small, terminated pilot study tested a special graft made from donated human tissue for reconstructing the nipple and areola after breast cancer surgery. The main goal was to see how safe it was and how long it took to heal. Researchers also wanted to measure patient satisfa…

This study tested if using a secure website for patients to regularly report their symptoms during chemotherapy could improve their quality of life. It compared this online system, which alerted nurses to worsening symptoms, against standard doctor's visits. The goal was to manag…

This early-stage study tested a cream called Dermaprazole, made from a common heartburn medicine, to see if it could safely prevent or reduce severe skin burns (radiation dermatitis) in breast cancer patients receiving radiation therapy after mastectomy. The main goals were to ch…

This study tested whether a special app on an Android phone could help cancer survivors become more physically active and improve their heart and blood vessel health. Participants were asked to use the app and wear a Fitbit for 3 months, with follow-up checks at 3 and 6 months. T…

This study aimed to understand why some breast cancer cells become resistant to chemotherapy. Researchers analyzed tumor and blood samples from 56 women before, during, and after standard chemotherapy treatment. The goal was to learn how certain aggressive 'cancer stem cells' eme…

This study aimed to understand how standard chemotherapy treatments for breast cancer affect the future fertility of young women. Researchers followed 135 women under age 38, measuring key hormones and ovarian markers before, during, and for two years after chemotherapy. The goal…

This study aimed to understand how a single dose of different chemotherapy combinations affects muscle health in people with breast cancer. Researchers compared three drug regimens by taking small muscle samples before and after treatment to measure changes. The goal was to learn…

This study created a registry to learn about the long-term health and wellbeing of young adults who survived cancer. It aimed to measure their levels of anxiety, depression, social support, and financial stress over time. Participants completed online surveys every 6-12 months to…

This study aimed to understand how and when certain breast cancer chemotherapy drugs cause heart damage. Researchers planned to closely monitor the hearts of patients receiving treatment, starting from the very beginning of their therapy. The goal was to gather detailed informati…

This study tested whether a short course of immunotherapy drugs, given just before standard surgery or chemotherapy, could boost the immune system's attack on early-stage breast cancer. Researchers measured changes in specific immune cells in tumor samples taken before and after …