Promising combo for rare breast cancer subtype hits early snag
NCT ID NCT04504331
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested a combination of two drugs—infigratinib (a targeted therapy) and tamoxifen (a hormone therapy)—in people with a specific type of advanced breast cancer (hormone receptor-positive, HER2-negative, with FGFR gene changes). The goal was to find a safe dose. However, the study was terminated early after enrolling only 4 participants, so we have very limited information about how well the combination works or its side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Infigratinib (a targeted drug) combined with tamoxifen (hormone therapy)
- What this could lead to
- If it worked, this combination might offer a new treatment option for people with a specific genetic subtype of advanced breast cancer.
- What could go wrong
- This was a very early (Phase 1) trial that was terminated after enrolling only 4 people, so we have very little data on safety or effectiveness. The results may not apply to a broader population.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Stanford University
Stanford, California, 94304, United States
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