Double hormone blockade may tackle Hard-to-Treat breast cancer
NCT ID NCT05618613
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This trial tests a combination of two drugs, elacestrant and onapristone, in people with a specific type of advanced or metastatic breast cancer that is fueled by the hormones estrogen and progesterone. The goal is to see if blocking both hormone signals at once is safe and can shrink tumors. The study is in early phases and involves a small number of participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of two hormone-blocking drugs: elacestrant and onapristone
- What this could lead to
- If successful, this combination could offer a new treatment option for people with a specific type of advanced breast cancer that has stopped responding to standard hormone therapies.
- What could go wrong
- This is an early-phase trial with a small number of participants, so the benefits and risks are not yet well understood. The combination may cause significant side effects or fail to shrink tumors.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cancer Treatment Centers of America - Midwestern Regional Center
Zion, Illinois, 60099, United States
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Cancer Treatment Centers of America - Western Regional Medical Center
Phoenix, Arizona, 85338, United States
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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