Promising combo for brain metastases? trial ends early
NCT ID NCT04791384
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested two oral drugs, abemaciclib and elacestrant, in women with a type of breast cancer (HR+/HER2-) that had spread to the brain. The goal was to see if the combination was safe and could shrink brain tumors. However, the study was stopped early after enrolling only 5 people, so we have very little information about how well it works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- abemaciclib (Verzenio) and elacestrant
- What this could lead to
- If successful, this combination could offer a new oral treatment option for breast cancer that has spread to the brain, potentially controlling the disease and improving outcomes.
- What could go wrong
- The trial was terminated early with only 5 participants, so results are very limited. It is unclear if the combination is safe or effective, and it may not work for others.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cancer Care Northwest
Spokane Valley, Washington, 99216, United States
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Duke Cancer Center
Durham, North Carolina, 27710, United States
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, 33140, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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