Weight may influence breast cancer drug response, study suggests
NCT ID NCT02095184
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether body weight affects how breast cancer responds to aromatase inhibitors (AIs) like Anastrozole and Letrozole. Researchers gave standard doses of these drugs to 42 postmenopausal women with hormone-sensitive breast cancer before surgery. The goal was to see if overweight or obese women had a different anti-proliferative response compared to normal-weight women. The study was terminated early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Anastrozole (Arimidex) and Letrozole (Femara)
- What this could lead to
- If successful, this could help doctors personalize aromatase inhibitor doses based on a patient's body weight, potentially improving treatment effectiveness for overweight or obese women with breast cancer.
- What could go wrong
- This was a small, early-stage study that was terminated, so results are limited. It may not provide clear answers, and findings may not apply to all breast cancer patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Maryland Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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