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Can a simple antibiotic or wound VAC prevent complications after repeat breast surgery?

NCT ID NCT05823467

Terminated Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study looks at women who have had breast surgery and radiation before and need another breast surgery. Because radiation increases the risk of wound complications, the researchers want to see if giving a week of antibiotics or using a wound VAC (a special dressing) helps prevent these problems compared to no extra treatment. About 105 women will be randomly assigned to one of three groups to find out which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Trimethoprim/Sulfamethoxazole (antibiotic) and ciNPT dressing (wound VAC)
What this could lead to
If it works, this could show that a simple antibiotic or wound VAC reduces wound complications after repeat breast surgery in women who had radiation.
What could go wrong
This is a small, early-phase trial with only 105 participants, so results may not apply to everyone. Antibiotics can cause side effects like allergic reactions or diarrhea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • Meadowlark Health Centre

    Edmonton, Alberta, T5R 5W9, Canada

  • St Thomas Surgical Clinic

    St. Albert, Alberta, T8N 7J6, Canada

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