New hope for breast cancer patients who already had radiation: One-Time surgery radiation may spare mastectomy

NCT ID NCT05289466

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small study tested giving a single dose of radiation directly to the tumor site during breast-conserving surgery in women with early-stage breast cancer who had already received chest radiation. The goal was to see if this approach could provide good cosmetic results and few complications, offering an alternative to mastectomy. Only 5 women were enrolled before the study was stopped early, so the findings are very limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Intraoperative radiotherapy (IORT)
What this could lead to
If it works, this approach could offer a breast-conserving option for patients who previously had radiation, potentially avoiding mastectomy while maintaining good cosmetic results.
What could go wrong
This was a very small, terminated study with only 5 participants, so results are limited. The combination of prior radiation and additional IORT may increase risks of complications or poor wound healing.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Providence Saint John's Hospital

    Santa Monica, California, 90404, United States

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Other studies related to the condition(s) this trial covers.