New hope for breast cancer patients who already had radiation: One-Time surgery radiation may spare mastectomy
NCT ID NCT05289466
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small study tested giving a single dose of radiation directly to the tumor site during breast-conserving surgery in women with early-stage breast cancer who had already received chest radiation. The goal was to see if this approach could provide good cosmetic results and few complications, offering an alternative to mastectomy. Only 5 women were enrolled before the study was stopped early, so the findings are very limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intraoperative radiotherapy (IORT)
What this could lead to
If it works, this approach could offer a breast-conserving option for patients who previously had radiation, potentially avoiding mastectomy while maintaining good cosmetic results.
What could go wrong
This was a very small, terminated study with only 5 participants, so results are limited. The combination of prior radiation and additional IORT may increase risks of complications or poor wound healing.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Providence Saint John's Hospital
Santa Monica, California, 90404, United States