Glow-in-the-Dark drug could slash repeat breast cancer surgeries

NCT ID NCT04815083

Terminated Disease control Sponsor: SBI ALApharma Canada, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial tested a drug called PD G 506 A that makes cancer cells glow under a special camera during breast-conserving surgery. The goal was to help surgeons see and remove leftover cancer in real time, reducing the need for a second operation. The study enrolled 57 women with breast cancer scheduled for lumpectomy. The trial was terminated early, so the full benefits and risks are not yet clear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aminolevulinic acid hydrochloride (PD G 506 A)
What this could lead to: If successful, this could help surgeons remove all cancer in one operation, reducing the need for repeat surgeries and preserving more healthy breast tissue.
What could go wrong: The trial was terminated early with only 57 participants, so results are limited. The drug may not reliably highlight all cancer cells, and there is a risk of false positives or side effects from the imaging agent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST NEOPLASM FEMALE

Contacts and locations

Locations

Aurora St. Luke's Medical Centre

Milwaukee, Wisconsin, 53215, United States
BayCare Morton Plant Hospital

Clearwater, Florida, 33756, United States
BayCare St. Joseph's Hospital

Tampa, Florida, 33607, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Orlando Health, Inc.

Orlando, Florida, 32806, United States
Stamford Hospital

Stamford, Connecticut, 06902, United States
University of Miami Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States

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