Glow-in-the-Dark drug could slash repeat breast cancer surgeries
NCT ID NCT04815083
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 3 trial tested a drug called PD G 506 A that makes cancer cells glow under a special camera during breast-conserving surgery. The goal was to help surgeons see and remove leftover cancer in real time, reducing the need for a second operation. The study enrolled 57 women with breast cancer scheduled for lumpectomy. The trial was terminated early, so the full benefits and risks are not yet clear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aminolevulinic acid hydrochloride (PD G 506 A)
What this could lead to
If successful, this could help surgeons remove all cancer in one operation, reducing the need for repeat surgeries and preserving more healthy breast tissue.
What could go wrong
The trial was terminated early with only 57 participants, so results are limited. The drug may not reliably highlight all cancer cells, and there is a risk of false positives or side effects from the imaging agent.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aurora St. Luke's Medical Centre
Milwaukee, Wisconsin, 53215, United States
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BayCare Morton Plant Hospital
Clearwater, Florida, 33756, United States
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BayCare St. Joseph's Hospital
Tampa, Florida, 33607, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Orlando Health, Inc.
Orlando, Florida, 32806, United States
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Stamford Hospital
Stamford, Connecticut, 06902, United States
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University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States