Can vitamin d tweak breast cancer genes? weight may matter

NCT ID NCT01472445

Terminated Disease control Sponsor: Melinda Telli Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking vitamin D could change certain genes in breast cancer tumors, and if a woman's weight affected those changes. Researchers gave 41 women with breast cancer either a low or high dose of vitamin D before surgery. The goal was to see if vitamin D could reverse negative effects linked to obesity, but the study was stopped early, so the findings are not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D (cholecalciferol)
What this could lead to: If successful, this could point toward a way to use vitamin D to influence breast cancer growth, especially in women with different body weights.
What could go wrong: This was a small, early-phase study that was terminated early, so results are limited. Vitamin D is not a proven breast cancer treatment, and high doses may have side effects.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Stanford University Cancer Institute

Stanford, California, 94305, United States

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