BREAST CANCER

This phase III trial tests whether a personalized, high-dose chemotherapy followed by stem cell rescue can improve cure rates for people with high-risk, BRCA1-like breast cancer. The study includes 174 participants with stage III, HER2-negative tumors. The goal is to see if this …

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 adults with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone the…

This early-phase study tests a peptide vaccine designed to help the immune system recognize and fight estrogen receptor-positive (ER+) breast cancer cells. Eight participants who have completed standard treatments receive the vaccine alongside immune-boosting agents. The main goa…

This early-phase study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 people with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune syste…

This study is for women with early-stage triple-negative breast cancer who still have tumor after initial chemotherapy. Researchers are testing a combination of a freezing treatment (cryoablation) and an immunotherapy drug given before surgery. The goal is to see if this approach…

This study tests a drug called T-DM1 in older adults (age 60+) with HER2-positive breast cancer after surgery. The goal is to see if it can prevent the cancer from coming back. About 111 participants received the drug, and researchers are tracking how long they stay cancer-free. …

This study looks at whether women with HER2-positive breast cancer who have a complete response to pre-surgery chemotherapy and antibody drugs can safely avoid more chemotherapy after surgery. Instead, they would receive only two antibody drugs (trastuzumab and pertuzumab) after …

This study tests whether adding a single dose of radiation to the immunotherapy drug pembrolizumab before surgery can shrink tumors in people with early-stage breast cancer. About 27 participants will receive the combination, and doctors will measure tumor shrinkage and immune ce…

This study tests whether giving hormone therapy for 6 months before surgery can help remove all cancer in one piece, reducing the need for a full mastectomy. It includes 8 postmenopausal women with early-stage, low-risk, ER-positive breast cancer. The main goal is to see if the t…

This study tests whether adding the experimental drug onvansertib to standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread to other parts of the body. About 50 adults with advanced disease are participating. The goa…

This study tests whether adding the drug pyrotinib to standard chemotherapy before surgery can improve outcomes for women with stage II or III hormone receptor-positive, HER2-negative breast cancer that also has high levels of the HER4 protein. About 140 participants will receive…

This study tests whether a combination of two targeted drugs (trastuzumab and pertuzumab) plus hormone therapy can prevent breast cancer from returning after surgery. It includes about 393 people with early-stage, hormone receptor-positive, HER2-positive breast cancer that has no…

This study tests two drugs, CFI-400945 and durvalumab, in 15 women with advanced triple negative breast cancer that cannot be cured. The goal is to see if the combination can shrink tumors or control the disease. Participants must have already tried standard treatments.

This study looks at whether women with early-stage HER2-positive breast cancer who have a complete response to initial chemotherapy and targeted therapy can safely receive only 6 months of additional targeted therapy instead of the standard 12 months. The goal is to reduce side e…

This study looks at whether aerobic exercise can lower ctDNA levels in the blood, which may help prevent cancer from returning. About 33 people who have been treated for high-risk breast, prostate, or colorectal cancer will try different amounts of weekly exercise to find the saf…

This study tested whether giving a mix of hormone therapy, a targeted drug (palbociclib), and an immunotherapy (avelumab) before surgery could shrink early-stage estrogen receptor-positive breast tumors. About 33 adults with stage II-III breast cancer took part. The goal was to s…

This study looks at whether a 16-week exercise program can lower inflammation in fat tissue for women who have finished treatment for early-stage breast cancer. About 100 participants will take part. The goal is to see if movement can improve long-term health and reduce the risk …

This study tests a drug called QBS72S in 21 adults with advanced breast or lung cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors and help people live longer without the cancer getting worse. Participants must be 18 or older and in fairly…

This study tests whether the drug olaparib can help prevent breast cancer from returning in people with inherited BRCA1 or BRCA2 mutations who have already completed surgery and chemotherapy. About 1,800 participants with high-risk, HER2-negative breast cancer will receive either…

This study tests whether adding an extra immunotherapy drug at the start of standard treatment can help the immune system better attack triple negative breast cancer before surgery. About 12 adults with untreated, locally advanced TNBC will receive either standard chemo plus pemb…

This study looks at 1,000 postmenopausal women with early breast cancer to find out whether giving chemotherapy and hormone therapy at the same time or one after the other works better. The goal is to see which approach helps keep cancer from coming back over 15 years. Participan…

This study tests an experimental drug called TQB3616 combined with standard hormone therapy to see if it can stop breast cancer from returning in people with HR-positive, HER2-negative breast cancer. About 1,946 women who have had surgery to remove their cancer will take either T…

This study tests a different dosing schedule of the chemotherapy drug capecitabine combined with the targeted drug neratinib in people with advanced HER2-positive breast cancer. The goal is to find a dose that is safer and still works. About 34 adults with stage IV breast cancer …

This study looks at whether women with triple-negative or HER2-positive breast cancer who have a complete response to chemotherapy can safely skip sentinel lymph node biopsy (SLNB). SLNB can cause side effects like arm swelling and pain. The trial will track if skipping it leads …

This study tests two experimental treatments (Dato-DXd alone or with durvalumab) against standard options in people with triple-negative breast cancer who still have cancer cells in the breast or lymph nodes after surgery and chemotherapy. About 1,174 participants will be randoml…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (carboplatin and paclitaxel) can completely eliminate tumors in people with stage I triple-negative breast cancer before surgery. About 31 participants with small, lymph-node-negative tu…

This study tests a combination of two drugs, capivasertib and fulvestrant, in Chinese patients with advanced or metastatic HR+/HER2- breast cancer that has returned or worsened after hormone therapy. About 258 participants will receive the treatment to see if it delays the need f…

This study tests a new oral drug, ARV-471, combined with ribociclib in people with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. About 20 adults will take both pills daily at home. Researchers will check safety and whether tumors shrink. Th…

This study tests whether combining two immunotherapy drugs, nivolumab and ipilimumab, can shrink tumors in people with a rare, hard-to-treat form of advanced breast cancer that has many genetic mutations. The study enrolled 30 adults with HER2-negative breast cancer that has spre…

This early-phase study tests a new drug called A166 in about 120 adults with advanced HER2-positive solid tumors that have stopped responding to standard treatments. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Partici…

This study tests a new drug called GDC-9545, alone or with other medicines, in people with advanced or spreading ER-positive/HER2-negative breast cancer. The goal is to find safe doses and see if the drug shrinks tumors. About 181 participants will take part in this early-phase t…

This study looked at whether adding the drug vorinostat to standard chemotherapy before surgery helps shrink tumors more in women with HER2-negative breast cancer. About 68 women took part, receiving either chemo alone or chemo plus vorinostat. The goal was to see if the combinat…

This study looks at whether adding surgery or radiation to standard chemotherapy or hormone therapy can keep breast cancer from progressing longer in patients whose cancer has spread to 1-3 spots in the bones. About 35 participants are being treated at M.D. Anderson Cancer Center…

This study tests whether adding a new drug called inavolisib to two standard treatments (palbociclib and fulvestrant) can help people with a certain type of advanced breast cancer live longer without their disease getting worse. The cancer must have a specific gene change (PIK3CA…

This study looks at whether women with aggressive breast cancers (triple-negative or HER2-positive) who have a complete response to chemotherapy can safely avoid sentinel lymph node biopsy. The trial enrolls 350 patients across Europe and will track cancer recurrence in the armpi…

This study tests a combination of three drugs (atezolizumab, trastuzumab, and vinorelbine) in people with advanced HER2-positive breast cancer that has stopped responding to standard treatments. The goal is to see if this mix can shrink tumors. About 55 participants will receive …

This early-phase study tests a new oral drug called inavolisib (GDC-0077) in people with advanced solid tumors or breast cancer that have a specific genetic change (PIK3CA mutation). The drug is given alone or combined with standard hormone therapies or targeted treatments. The m…

This study tests a drug called Trastuzumab-Deruxtecan (T-DXd) in 28 people with HER2-low breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors and control the cancer. Participants receive the drug intravenously, and doctors monitor tum…

This study tested two different chemotherapy regimens given before surgery to shrink tumors in people with stage II or III breast cancer. One group received a standard three-drug combo (TAC), while the other received two different combos in sequence (ACAC), with some also getting…

This study tested whether a higher dose (500 mg) of the drug fulvestrant works better than the standard dose (250 mg) in postmenopausal women with a certain type of advanced breast cancer that had worsened after previous hormone therapy. The trial involved 736 participants and me…

This study tests a new drug, DS-8201a, against standard treatments for people with a specific type of advanced breast cancer called HER2-low. The cancer has spread and cannot be removed by surgery. The goal is to see if the new drug can slow down the cancer better than current op…

This study tests whether giving two targeted drugs (T-DM1 and pertuzumab) before surgery can completely eliminate cancer in women with early-stage HER2-positive breast cancer. About 164 participants with stage II or III disease will receive the combination, then have surgery to c…

This study offers continued treatment with the cancer drug palbociclib to people who have already benefited from it in earlier Pfizer studies. It includes 35 adults with breast or head/neck cancer. The main goal is to monitor safety and track any serious side effects over time.

This study tests whether a shorter course of radiation (1 to 5 days) after breast cancer surgery works as well as the standard 6.5-week treatment. It includes women aged 40 and older with small tumors who choose lumpectomy. The goal is to see if the shorter approach is safe, keep…

This study looks at whether intermittent fasting or water-only fasting can improve how well chemotherapy works for breast cancer patients. 60 women will be split into four groups: chemo alone, or chemo plus one of three fasting plans. Researchers will check tumor markers, immune …

This study looks at whether adding a targeted drug (CDK4/6 inhibitor) to standard hormone therapy before surgery can improve outcomes for women with a specific type of early-stage breast cancer (HR+/HER2-). Researchers will use a genetic test and early changes in a cell growth ma…

This early-stage trial tests the safety of combining two drugs, olaparib and vorinostat, for people with breast cancer that has returned or spread. The study includes 28 adults with certain types of advanced breast cancer. The goal is to find the best dose and see if the combinat…

This study tests a combination of three drugs (nivolumab, bicalutamide, and ipilimumab) to see if they can control metastatic HER2-negative breast cancer without needing chemotherapy. The approach aims to boost the immune system and block certain hormone signals. About 30 adults …

This study tests a new drug combination (inavolisib plus fulvestrant) against an existing one (alpelisib plus fulvestrant) in people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation) that has worsened after prior treatment. About …

This study looks at different combinations and schedules of chemotherapy drugs for women with breast cancer that has spread to lymph nodes. The goal is to see if adding a drug called fluorouracil or giving treatment every 2 weeks (with a support drug to help the immune system rec…

This early-phase study tests the safety and effectiveness of combining two drugs, abemaciclib and pembrolizumab, in 100 people with advanced non-small cell lung cancer or a certain type of breast cancer (HR+/HER2-). The goal is to see if the combination can shrink tumors or slow …

This study tested whether adding the drug abemaciclib to standard hormone therapy helps prevent breast cancer from coming back in people with a high-risk, early-stage type called HR+/HER2-. Over 5,600 participants took either the combination or hormone therapy alone. The goal was…

This study tests whether adding an immunotherapy drug (durvalumab) to two standard HER2-targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in women with a specific, aggressive type of breast cancer called HER2-enriched. About 51 women with early-stage,…

This study compares two chemotherapy regimens for women with non-triple negative breast cancer after surgery. About 1,560 participants will receive either a standard four-drug sequence or a two-drug combination. The goal is to see which approach better prevents cancer from return…

This study tests a new drug called CFI-402257 combined with a standard chemotherapy (paclitaxel) in people with advanced HER2-negative breast cancer that cannot be cured. The goal is to find the safest dose and see if the combination shrinks tumors better than chemo alone. About …

This study compares a robotic surgical system (da Vinci SP) to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. About 204 participants will be randomly assigned to one of the two procedures to see which is safer and more effective. T…

This early-stage trial tests two drugs, alpelisib and sacituzumab govitecan, together in people with advanced HER2-negative breast cancer that has spread or come back. The main goal is to find the safest dose and see how the body handles the drugs. 18 adults are taking part in th…

This study aimed to test a new way to treat small breast cancers by freezing them (cryoablation) along with special biopsy methods guided by mammography. It was designed for women aged 60 or older with tumors 1 cm or smaller. However, the study was withdrawn before any participan…

This study looks at whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin) helps people with triple-negative breast cancer that has spread. About 78 participants will receive either carboplatin alone or carboplatin plus nivolumab. The goal is to se…

This early-phase trial tests a new drug called SRG-514, which is applied directly to the tumor site during breast-conserving surgery for breast cancer. The main goal is to find the safest dose and check for side effects in 24 adults. The drug is meant to help control the disease …

This study tests a new medicine called vepdegestrant combined with palbociclib for people with advanced ER+/HER2- breast cancer that cannot be cured by surgery. It compares this new combo to the standard treatment of letrozole plus palbociclib. Participants take pills by mouth on…

This study looks at whether people with HER2-positive metastatic breast cancer who have had an excellent response to treatment (cancer controlled for 3+ years) can safely stop their anti-HER2 therapy. Researchers will monitor how long it takes for the cancer to progress in those …

This study tests a new treatment for people with triple-negative or hormone receptor-low breast cancer that hasn't been treated yet. About 1,900 adults will get either the experimental drugs (datopotamab deruxtecan plus durvalumab) or the current standard treatment (pembrolizumab…

This study tests a combination of two drugs (anastrozole and palbociclib) in postmenopausal women with a specific type of advanced breast cancer (HR-positive, HER2-negative). The goal is to see if this combination is safe and effective as a first treatment or as ongoing therapy a…

This study follows 170 women with early-stage HER2-positive breast cancer who received the biosimilar drug Zedora after surgery. Researchers want to see how well it prevents the cancer from coming back and how safe it is in everyday medical practice. The goal is to gather real-wo…

This study tests whether a precise, high-dose form of radiation called stereotactic body radiation therapy (SBRT) can delay cancer progression in women with metastatic breast cancer who are starting their first treatment. About 154 participants will receive either standard therap…

This early-phase study tests a new oral drug, MOMA-313, alone or with another drug (olaparib) in people with advanced solid tumors that have a specific DNA repair problem (HR deficiency). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. …

This study tests a new drug called PF-07104091 in people with advanced small cell lung, ovarian, or breast cancers that have not responded to prior treatments. The goal is to find the safest dose and see if the drug can shrink tumors when used alone or with other cancer medicines…

This study tests an experimental drug called AZD5305, a PARP inhibitor, in people with advanced solid tumors (e.g., ovarian, breast, prostate, lung cancer). The goal is to see if the drug is safe and can shrink tumors when given alone or with other anti-cancer medicines. About 70…

This study tests a new drug (MEN1611) combined with chemotherapy (eribulin) in people with advanced breast cancer that has specific genetic changes (PIK3CA/PTEN). The goal is to see if the combination can shrink tumors or stop them from growing. The trial includes 14 adults whose…

This early-stage trial tests a two-step treatment for people with advanced breast cancer that cannot be cured by surgery or radiation. First, participants receive a drug called talazoparib alone, then both talazoparib and avelumab together. The main goal is to check safety and si…

This study tests whether giving two drugs—sacituzumab govitecan and pembrolizumab—before surgery can help control early-stage triple-negative breast cancer that didn't respond well to initial chemotherapy. About 27 adults with this aggressive cancer type will receive the combinat…

This study tests a new drug called azenosertib combined with two standard cancer drugs (carboplatin and pembrolizumab) in people with metastatic triple-negative breast cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 78 adults with a…

This study tests a precise type of radiation called proton therapy given after surgery for stage II/III breast cancer. The goal is to see if it can effectively treat cancer while reducing damage to the heart and other organs. About 220 women will receive this treatment and be fol…

This study tests whether adding the immunotherapy drug atezolizumab to the targeted therapy trastuzumab emtansine (T-DM1) can prevent breast cancer from returning in people with HER2-positive breast cancer who still have cancer cells after initial treatment and surgery. About 1,1…

This study tests whether a new drug called HS627 works as well as the approved drug pertuzumab when both are given with trastuzumab and chemotherapy before surgery for early or locally advanced HER2-positive breast cancer. About 408 participants will receive either HS627 or pertu…

This study tests a new oral drug, vepdegestrant (ARV-471), combined with abemaciclib in people with advanced or metastatic ER+ breast cancer that has stopped responding to previous treatments. About 37 adults will take both pills at home daily to see if the combination is safe an…

This study looks at whether a polyester mesh with a special coating can lower the risk of implant-related complications, like the implant moving out of place, after breast reconstruction surgery. It involves 100 women with breast cancer who are getting a single-stage reconstructi…

This study tested whether adding the drug abemaciclib to standard hormone therapy (anastrozole or letrozole) helps postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-). About 493 women took part, receiving either abemaciclib or a placebo alongside their…

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find th…

This study looks at whether women aged 65 and older with early-stage, estrogen-positive breast cancer can safely skip a sentinel node biopsy (a procedure to check if cancer has spread to lymph nodes) during their lumpectomy. The goal is to see if omitting this step leads to simil…

This study tests a new drug (MK-7119) combined with two standard chemotherapy drugs (trastuzumab and capecitabine) in people with advanced HER2+ breast cancer that has not responded to previous treatments. The main goal is to see if the combination can shrink tumors. About 66 par…

This study looks at whether giving extra radiation to the internal mammary lymph nodes after mastectomy can help prevent breast cancer from coming back. It involves 2,400 high-risk patients who have had surgery. The goal is to see if this additional treatment improves how long pa…

This phase 3 study tests a new drug, DS-8201a, against an existing treatment, T-DM1, in people with advanced HER2-positive breast cancer that has spread or cannot be removed. About 524 adults who have already tried trastuzumab and taxane will take part. The goal is to see which d…

This study looks at whether a less invasive surgery (sentinel lymph node biopsy) can replace a more extensive one (axillary lymph node dissection) in certain early-stage breast cancer patients. The researchers aim to see how often they can safely avoid the bigger surgery by using…

This study looks at whether giving an extra dose of radiation (16Gy) to the tumor area after standard whole-breast radiation (50Gy) helps prevent breast cancer from coming back in women with a very early form called ductal carcinoma in situ (DCIS). About 2004 women who had breast…

This study compares two types of radiation therapy—proton and photon—for people with non-metastatic breast cancer. The goal is to see if proton therapy reduces heart problems later in life while still controlling the cancer. Over 1,200 patients who had surgery for breast cancer t…

This study tested whether adding the drug abemaciclib to standard hormone therapy helps postmenopausal women with a certain type of advanced breast cancer (HR+, HER2-) live longer without their cancer growing. About 463 women took part. The main goal was to see if the combination…

This study tests a shorter radiation treatment for women with early-stage breast cancer. Instead of 5-7 weeks of whole-breast radiation, participants get partial breast radiation for just 2 weeks. The goal is to see if this shorter approach is safe, has fewer side effects, and ke…

This early-stage trial tests a new drug, OP-1250, combined with the approved drug palbociclib in people with advanced or metastatic HR-positive, HER2-negative breast cancer. The main goals are to find the safest dose and check for side effects. About 60 adults whose cancer has sp…

This study is for people with HR+, HER2- breast cancer who finished a previous study on TOL2506. It aims to check the long-term safety of TOL2506 when taken with tamoxifen or an aromatase inhibitor for up to 4 years. About 250 premenopausal women and men will take part. The main …

This study tests a highly targeted radiation treatment called stereotactic partial breast irradiation (S-PBI) for women with early-stage breast cancer. The treatment uses a special device called the GammaPod to deliver radiation in just 5 sessions, focusing on the tumor while spa…

This study looks at whether some women with HER2-positive early breast cancer can be treated with just the targeted drugs pertuzumab and trastuzumab (PHESGO™) without chemotherapy. Researchers use specific markers to pick patients whose tumors depend heavily on HER2. The goal is …

This study looks at the safety of the drug TALZENNA in people with a specific type of breast cancer (BRCA mutation-positive, HER2-negative) that cannot be removed by surgery or has returned after treatment. Participants must have had chemotherapy before and never taken TALZENNA. …

This study tests whether doctors can safely reduce the amount of chemotherapy given before surgery for HER2-positive breast cancer by using imaging scans to guide decisions. About 462 participants with stage II or III disease will receive a tailored treatment plan. The goal is to…

This study tests a drug called pacritinib in people with advanced solid tumors, including breast cancer, that have a specific genetic change called 1q21.3 amplification. The goal is to see if the drug can shrink tumors or slow their growth. About 74 participants will receive the …

This study offers continued treatment with ruxolitinib (alone or with other cancer therapy) to people with pancreatic, colorectal, breast, or lung cancer who were already benefiting from it in a previous Incyte-sponsored trial. Participants must have stable disease and be tolerat…

This study looks at giving radiation therapy before surgery for early-stage breast cancer. The goal is to find the safest radiation dose and see how the tumor responds. 15 women aged 50 or older with a specific type of breast cancer are taking part. This approach could help docto…

This study tested whether adding the drug everolimus to standard hormone therapy helps prevent breast cancer from returning in people with a high-risk type of breast cancer (hormone receptor-positive, HER2-negative). About 1,900 participants received either hormone therapy plus e…

This study tests whether a newer drug, Margetuximab, works better than the standard drug Trastuzumab when combined with chemotherapy and another targeted therapy before surgery for stage II-III HER2-positive breast cancer. About 174 participants will receive one of the two drug c…

This study looks at whether extra check-ups and early help from a team of specialists—like nurses, dietitians, and exercise therapists—can reduce heart problems in people being treated for breast cancer. About 80 adults receiving certain chemotherapy drugs will be randomly assign…

This early-stage study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alo…

This study tests a drug called ribociclib combined with standard hormone therapy for people with ER-positive breast cancer. The goal is to see if the combination can clear tumor DNA from the blood and help control the disease. About 120 postmenopausal women with early-stage breas…

This study tests a combination of two drugs, trastuzumab deruxtecan and pembrolizumab, in adults with advanced breast or non-small cell lung cancer that has spread. The goal is to find the safest dose and see how well the combo shrinks tumors. About 115 participants will receive …

This early-phase study tests a combination of two drugs, olaparib and sapacitabine, in people with breast cancer that has a BRCA gene mutation and has spread or cannot be removed by surgery. The main goals are to find the safest dose and see if the combination shrinks tumors. Abo…

This study tests a precise type of radiation called proton therapy for people with early-stage breast cancer. It is given only to the part of the breast where the tumor was removed, aiming to lower the chance of cancer coming back while reducing side effects. The trial includes 1…

This study tests whether giving two drugs, olaparib and pembrolizumab, before standard surgery can shrink tumors in people with triple-negative or hormone receptor-positive HER2-negative breast cancer who have specific gene mutations. About 23 participants will receive the combin…

This study tests whether giving two drugs (taxotere and trastuzumab) before surgery can eliminate all signs of invasive cancer in Nigerian women with HER2-positive breast cancer. About 53 women with stage II or III breast cancer who have not had prior chemotherapy will receive th…

This study tests whether adding afuresertib to the standard hormone therapy fulvestrant can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to usual treatments. About 256 adults whose cancer has specific genetic changes (PIK3CA/AK…

This study compares two surgical techniques (Grisotti flap and reverse mirror Grisotti flap) for women with early-stage breast cancer located in the central part of the breast. The goal is to see which method better preserves the new areola's blood supply and gives a more pleasin…

This early study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard cancer treatment can slow or shrink breast cancer that has spread to the lungs. Ten women aged 18-75 whose cancer progressed after at least one prior treat…

This study tests a high-dose, precise radiation treatment called SBRT for 15 breast cancer patients who cannot undergo surgery. The goal is to see if it safely controls the tumor and improves survival. Participants receive 5 radiation sessions and are followed for 5 years.

This study tests a new drug, Dato-DXd, against standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. About 644 participants will be randomly assigned to one of the two treatments. The goal is to see if Dato-DXd can slow can…

This study tests two new drugs (LEE011 and BYL719) combined with a standard hormone therapy (letrozole) in about 255 women with advanced ER+ breast cancer. The goal is to find safe doses and see if the combination can better control the disease. Participants have cancer that has …

This study tests a drug called trastuzumab deruxtecan (T-DXd) in about 500 people with advanced HER2-positive breast cancer that has spread or cannot be removed. Some participants have brain metastases, others do not. The goal is to see how well the drug shrinks tumors and how lo…

This study tests whether combining two drugs (atezolizumab and tivozanib) can help the immune system attack cancers that usually don't respond to immunotherapy, like certain prostate, pancreatic, and breast cancers. About 29 adults with advanced or metastatic disease who have alr…

This study looks at whether the number of immune cells in and around a triple-negative breast cancer tumor can predict how well the tumor shrinks with chemotherapy and immunotherapy given before surgery. About 139 women with early-stage triple-negative breast cancer will receive …

This study looks at whether using radiofrequency ablation (a heat treatment) on the area where a breast tumor was removed can lower the chance that cancer comes back or that more surgery is needed. About 104 women aged 50 and older with early-stage breast cancer will get this ext…

This study tests a high-precision radiation treatment called SBRT for people with advanced breast cancer who cannot have surgery. Twenty-four participants will receive 4 radiation sessions over 12-15 days. The goal is to see if this treatment is safe and helps control the disease…

This early-phase study tests a new drug called GNC-035 in 36 people with advanced or metastatic breast cancer that has not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can help control the cancer. The drug is a…

This study tested whether adding the drug palbociclib to standard hormone therapy for 2 years helps prevent breast cancer from coming back in people with early-stage HR+/HER2- breast cancer. About 5,800 participants were followed for at least 4 years. The goal was to see if the c…

This phase 3 trial tests whether adding a new drug called ipatasertib to standard therapy (fulvestrant) can slow the growth of advanced ER-positive, HER2-negative breast cancer. The study involves 250 women whose cancer progressed after initial treatment with CDK 4/6 inhibitors a…

This study tests if a shorter course of radiation (3 treatments over 5 days) is as safe and effective as the standard 5 treatments over 5 days for women with early-stage breast cancer. The trial involves 284 post-menopausal women who have had surgery to remove their tumor. The ma…

This early-phase trial tests a treatment for adults with certain advanced solid tumors (like colorectal, lung, or breast cancer) that have spread and stopped responding to standard therapy. The approach uses a person's own white blood cells, which are genetically modified in a la…

This early-stage trial tests the safety and effectiveness of combining the experimental drug Ipatasertib with hormone therapy (with or without another drug) in 77 women with metastatic hormone receptor-positive breast cancer. The goal is to see if this combination can control tum…

This study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…

This study looks at women with early-stage breast cancer who need radiation after surgery. It compares giving partial breast radiation at the same time as chemotherapy versus giving them at different times. The goal is to see if the combined approach has similar side effects and …

This study tests two oral drugs, vepdegestrant and samuraciclib, taken daily at home by adults with advanced or metastatic ER+ breast cancer that no longer responds to standard treatments. The goal is to see if the combination is safe and can shrink tumors. Participants continue …

This study looks at whether using a special material called acellular dermal matrix (ADM) during breast reconstruction after mastectomy leads to fewer complications. About 353 women having immediate two-stage reconstruction will be randomly assigned to get ADM or not. The main go…

This study tests a single, very high dose of radiation given to the tumor before surgery in women with early-stage breast cancer. The goal is to find the highest safe dose that can kill the tumor. About 45 women will take part, and researchers will watch for side effects and how …

This study looks at a way to help women under 40 with breast cancer keep their ability to have children after chemotherapy. Before starting chemo, participants receive hormone shots and tamoxifen to stimulate their ovaries, then eggs or embryos are frozen. The goal is to see if t…

This study tested a shorter course of radiation (hypofractionation) to the breast and nearby lymph nodes in 137 women with node-positive breast cancer. The goal was to see if this approach reduces long-term side effects like arm swelling (lymphedema) while still controlling cance…

This study tests a combination of two drugs, alpelisib and fulvestrant, in people with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a PIK3CA mutation and has stopped responding to previous treatments. The goal is to see if this combo can slow can…

This study offers continued access to the drug olaparib for people with ovarian or breast cancer who were already taking it in a previous study and are still benefiting. The goal is to keep providing the treatment while monitoring for serious side effects. About 185 participants …

This study tests an experimental drug, zelenectide pevedotin, in people with advanced breast cancer that has a specific genetic change called NECTIN4 amplification. The trial includes two groups: one with hormone receptor-positive/HER2-negative cancer and another with triple-nega…

This trial aims to improve treatment for high-risk breast cancer by personalizing drug combinations based on each patient's unique tumor genetics. Researchers will analyze tumor DNA from 200 participants before surgery to match them with specific therapies. The goal is to find be…

This study tests a less intense chemotherapy combination for people with early-stage HER2-positive breast cancer. The goal is to see if a milder regimen (paclitaxel, trastuzumab, and pertuzumab) can clear the cancer before surgery as effectively as the standard stronger regimen, …

This study looks at whether people with breast or prostate cancer that has spread to the bones can safely stop or reduce their bone-strengthening medication after taking it for at least two years. The goal is to see if this approach maintains quality of life and prevents bone com…

This phase 3 study tests a 3-month injection (TOL2506) to temporarily stop ovarian function in premenopausal women with HR+, HER2- breast cancer. The goal is to lower hormones that can fuel cancer growth. About 250 participants will receive the injection along with standard hormo…

This study tests whether adding the immunotherapy drug pembrolizumab to the hormone therapy fulvestrant can help control advanced breast cancer that is hormone receptor-positive and HER2-negative. About 47 adults with this type of breast cancer that has spread or cannot be remove…

This study tests whether adding the drug capecitabine to standard chemotherapy before surgery can completely eliminate early triple-negative breast cancer. About 325 adults with node-positive or larger tumors are participating. The main goal is to see if the combination leads to …

This study tests whether a fluorescent dye (Pegulicianine) and 3D breast imaging can help surgeons see and remove all cancer during a partial mastectomy, potentially reducing the need for a second operation. About 175 women with breast cancer will receive the dye before surgery, …

This study tests whether adding ribociclib to the hormone therapy letrozole for 24 weeks before surgery can improve outcomes for postmenopausal women with ER-positive, HER2-negative early breast cancer. The goal is to help more women achieve a low-risk score (PEPI 0) at surgery, …

This early-phase study tests the safety of adding an immune-targeting therapy (DPX-Survivac) to standard hormone therapy (letrozole) in women with a common type of breast cancer (HR+HER2-). Some participants also receive low-dose radiation or a chemotherapy drug (cyclophosphamide…

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer are randomly assigned to start carvedilol either before or after signs of heart…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard stereotactic radiation can better control brain metastases that are at higher risk of coming back after radiation alone. About 134 adults with cancers like melanoma, lung, breast, or colorectal cance…

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This study tests whether adding the drug pyrotinib to standard chemotherapy before surgery can completely eliminate HER2-positive early breast cancer in 113 women. Participants receive a combination of drugs, then surgery, and are followed for cancer recurrence. The goal is to se…

This study tests a drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking these faulty genes. About 534 adults with various cancers, including lung, breast, and br…

This study tests whether a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar caused by the cancer drug alpelisib. The goal is to see if controlling blood sugar helps the cancer treatment work better in people with adv…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This early-phase study tests an experimental cell therapy called P-MUC1C-ALLO1 in 180 adults with advanced solid tumors (e.g., breast, ovarian, lung, pancreatic cancers) that have not responded to standard treatments. The therapy uses donor immune cells engineered to attack cance…

This early-phase study tests a new drug called BL-M02D1 in people with advanced triple negative breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. …

This study tests whether giving a targeted drug (palbociclib) along with hormone therapy before surgery can shrink tumors in people with early-stage hormone receptor-positive, HER2-negative breast cancer. About 51 participants will receive the combination for several weeks before…

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of 20 women with ER-positive breast cancer who were already on hormone therapy. The goal was to prevent the cancer from coming back or spreading. However, the trial was withdrawn before any par…

This early-phase study tests a new drug, valemetostat, combined with the targeted therapy trastuzumab deruxtecan in people with advanced breast cancer that has low, ultra-low, or no HER2 protein. The main goal is to find a safe dose and see how well the combination shrinks tumors…

This study tests a combination of two drugs, lenvatinib and letrozole, given before surgery to postmenopausal women with a common type of breast cancer (hormone receptor positive). The goal is to see if the drugs can shrink the tumor enough to improve surgical outcomes. About 40 …

This phase 3 study compares a new drug called Dato-DXd with standard chemotherapy in people whose HR-positive, HER2-negative breast cancer has spread and is no longer responding to hormone therapy. About 732 participants who have already had 1-2 prior chemotherapies will be rando…

This study looks at whether women aged 50 and older with a very low-risk type of early breast cancer (called DCIS) can avoid radiation therapy after lumpectomy. The goal is to see if the cancer stays away without radiation, reducing unnecessary treatment and side effects. About 2…

This early-phase study tests a new drug, AC699, in about 100 people with a common type of advanced breast cancer (ER+/HER2-). The main goal is to find a safe dose and check for side effects. Researchers will also see if the drug can shrink tumors. Participants must have tried oth…

This study tests two oral drugs, vepdegestrant and PF-07220060, in people with advanced or metastatic ER+/HER2- breast cancer that has stopped responding to prior treatments. The goal is to see if the combination is safe and can shrink tumors. Participants take both pills at home…

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors and help patients live longer. About 75 adults with advanced disease are ta…

This study tested whether a shorter, higher-dose radiation schedule after breast cancer surgery works as well as the standard longer schedule. Over 2,300 women with early-stage breast cancer took part. The goal was to see if the faster approach could prevent the cancer from comin…

This study tests a treatment using a patient's own immune cells (T cells) that are modified in a lab to attack cancer cells with a protein called mesothelin. It is for people with malignant pleural disease, including mesothelioma and cancers that have spread to the chest lining. …

This study tests a new drug called tobemstomig combined with chemotherapy for people with a hard-to-treat breast cancer that has spread. About 83 participants will get either the new combo or a standard treatment. The goal is to see if the new combo helps keep cancer from growing…

This study tests a new way to rebuild a breast after cancer surgery. Doctors use a tiny cut under the arm to remove breast tissue and then add the patient's own fat in stages to shape a new breast. The goal is to see if this method leads to better satisfaction and quality of life…

This study tests a combination of three drugs (cisplatin, romidepsin, and nivolumab) in people with metastatic triple-negative breast cancer or breast cancer linked to BRCA gene mutations. The goal is to see if the combination can shrink tumors and control the disease. About 51 p…

This study tests an experimental drug called CFI-400945 in people with advanced or metastatic breast cancer that has not responded to standard chemotherapy. The goal is to see if the drug can shrink tumors or control the disease. About 51 participants will receive the drug, and r…

This study tests a drug called Lonsurf in people with metastatic breast cancer that has spread. The goal is to see if it can help control the cancer and delay its growth. About 86 adults with HER2-negative or HER2-positive tumors who have tried other treatments are taking part.

This study tests a new, shorter radiation treatment for breast cancer patients who also need radiation to nearby lymph nodes. Instead of the usual several weeks, the radiation is given in just one week. The goal is to see if this approach is safe and effective at controlling the …

This study tests a new drug combination (gedatolisib plus fulvestrant, with or without palbociclib) in 701 people with advanced HR+/HER2- breast cancer that worsened after initial treatment. The goal is to see if it delays cancer growth better than standard therapies. Participant…

This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. The trial enrolls 32 adults with advanced d…

This study tests giving a short course of focused radiation to the breast tumor before surgery, using MRI for precise planning. The goal is to treat a smaller area of breast tissue and possibly reduce side effects. About 39 women with early-stage breast cancer will receive radiat…

This study tests a drug called trastuzumab deruxtecan (T-DXd), given alone or with other treatments before surgery, in people with high-risk HER2-positive early breast cancer. The goal is to see if it can eliminate all signs of cancer by the time of surgery. About 927 adults with…

This study tests whether a single, high dose of radiation given before surgery can safely treat early-stage breast cancer while preserving breast appearance. About 110 women with small, early breast tumors will receive 21 Gray of radiation to the tumor area, then undergo standard…

This study is testing an experimental drug called BB-1701 for people with advanced breast cancer that has spread or cannot be removed by surgery. The trial has two parts: first to find the safest and most effective dose, and then to see how well that dose works at shrinking tumor…

This study is testing whether adding a new drug called TQB3616 to standard hormone therapy can help control advanced breast cancer that has stopped responding to commonly used CDK4/6 inhibitor medications. The trial involves 33 women whose cancer has returned or spread despite pr…

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This study tests advanced ultrasound signal processing to make breast images clearer, helping doctors spot microcalcifications, cysts, and tumors. Researchers will compare new methods with standard ultrasound and photoacoustic imaging. About 252 adult women with breast findings f…

This study tests a low-cost, portable ultrasound device (POCUS) combined with artificial intelligence to detect breast cancer. It aims to see if this approach works as well as standard methods, especially in places where expensive equipment and experts are scarce. About 600 women…

This study tests a new dye called LS301-IT that makes cancer cells glow during breast cancer surgery. About 100 women with early-stage breast cancer will receive the dye before their lumpectomy. The goal is to see if the dye helps surgeons remove all cancer while sparing healthy …

This study looks at whether a special MRI scan that does not use contrast dye can accurately find breast disease. About 1,030 women at risk or with suspected breast issues will be scanned. The goal is to see if this safer, dye-free method works as well as standard care.

This study tests a short, non-contrast MRI technique called DWI to see if it can find breast cancers that mammograms miss in women with dense breasts. About 269 women will participate to find the best settings for the scan and how accurately it tells cancer from non-cancer. If su…

This study tests a new imaging technique called MSOT that uses light and sound to create pictures of tumors. About 12 adults with suspicious breast findings or melanoma will get an MSOT scan before their standard biopsy. The goal is to see if MSOT can find tumors and measure oxyg…

This study compares how well ultrasound and breast MRI find cancer in women with dense breasts who have had breast cancer before. About 1,756 women will get both types of scans to see which one detects more cancers. The goal is to find the best way to check for new cancers in thi…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps. About 264 women already scheduled for a standard breast MRI will also get this quick scan. If successful, it …

This study checks whether a breast MRI biopsy can correctly tell if a woman's breast cancer has completely disappeared after chemotherapy. About 31 women whose tumors are no longer visible on MRI will get a biopsy to see if it matches the final surgical results. If the biopsy is …

This study is testing a special smart bra that can detect breast abnormalities, potentially helping with breast cancer screening. About 70 women—some healthy and some already diagnosed with invasive breast cancer—will wear the device to see how well it finds tumors. The goal is t…

This study looks at whether a special type of mammogram using a contrast dye can find breast cancer more accurately than standard mammograms in women who have already had breast cancer. About 1,647 women will get both types of imaging to compare how many cancers are found and how…

This study compares a new 3D breast CT scan (CBBCT) with standard mammography for breast cancer screening. Over 1,000 women aged 30 or older (40+ for routine screening) will get both scans within 4 weeks. Researchers will measure radiation dose and how often each method leads to …

This study was designed to test a new radioactive tracer called [18F]GEH121224 for PET scans in people with advanced HER2-positive breast cancer. The goal was to see if it could safely and accurately detect cancer spread. The study was withdrawn before any participants were enrol…

This study looks at whether combining mammograms and breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the scr…

This study tests a new method to find sentinel lymph nodes (the first nodes cancer may spread to) in breast cancer patients. Instead of using a radioactive tracer, doctors use a fluorescent dye called indocyanine green that glows under a special camera. The goal is to see if this…

This study tests whether a handheld scanner called LymphaTech can accurately measure arm swelling (lymphedema) in 100 women treated for breast cancer. The scanner is compared to a standard device called a Perometer. The goal is to see if the new scanner is reliable and faster, wh…

This study tests a special PET scan that uses a radioactive tracer to find HER2-positive breast cancer tumors in women with advanced (stage IV) disease. The goal is to see if this scan can better identify which tumors have the HER2 protein, helping doctors plan more targeted trea…

This study tests whether a blood test can help avoid unnecessary follow-up exams for women who had a suspicious mammogram. About 1,200 women in Denmark will give blood samples to see if certain markers can rule out breast cancer. The goal is to make screening more accurate and re…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study looks at whether a special ultrasound technique can accurately detect remaining cancer in the lymph nodes of breast cancer patients after they've completed chemotherapy. About 97 women who had cancer spread to their lymph nodes before treatment will be tested during su…

This study aimed to test whether analyzing tiny particles in spinal fluid could help doctors detect when breast cancer has spread to the lining of the brain and spinal cord. Researchers planned to compare this new method against current diagnostic tests in breast cancer patients …

This study looks at whether taking omega-3 fatty acid supplements (like fish oil) can help prevent breast cancer from returning in women who have already been treated. Eighty women with a specific type of breast cancer (hormone receptor negative) will take either a low or high do…

This study tests whether a low dose of tamoxifen can reduce the risk of breast cancer in people who have had radiation therapy for other cancers. Tamoxifen works by blocking estrogen, which can fuel breast cancer growth. The trial involves 84 participants and compares tamoxifen t…

This study tests a surgical method called the ARM technique to prevent lymphedema (arm swelling) in 100 breast cancer patients who need lymph node removal. The goal is to see if this technique reduces swelling without harming cancer treatment outcomes. Participants are adults wit…

This study tests whether a combination of bazedoxifene and conjugated estrogens can lower breast cancer risk in women going through menopause who have hot flashes. About 120 women at higher risk for breast cancer will take the drug for 6 months or be placed on a waiting list. Res…

This study looks at whether adding a polygenic risk score (a measure of many small genetic factors) to standard risk tools helps women ages 35-75 at high risk for breast cancer decide on prevention steps, such as taking medication, having risk-reducing surgery, or getting extra i…

This study looks at better ways to help women in Kenya get screened for breast and cervical cancer. Many women are diagnosed late, so the goal is to find cancer early when treatment works best. About 5,400 women aged 30-55 will take part, and researchers will compare different st…

This study looks at 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life during and after treatment. Researchers want to understand how well patients tolerate this type of radi…

This study tests a 3-month intermittent fasting program (fasting 3 days a week) in 36 adults who have had breast cancer and are overweight or obese. The goal is to see if the program helps with weight loss, sticking to the diet, and increasing physical activity. Participants also…

This study tests whether slowly increasing the dose of the drug abemaciclib can cause fewer side effects than the standard dose in people with early-stage, hormone receptor-positive breast cancer. About 90 participants will take the drug along with standard hormone therapy. The g…

This study looks at whether a simple mobile app can help breast cancer survivors exercise more after finishing treatment. About 200 people will either use the app for 12 weeks or get standard exercise guidelines. The goal is to see if the app reduces fatigue, improves physical fu…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer undergoing chemotherapy. Twenty-four participants will take turns having weekly music therapy sessions and weeks without, acting as their own control. The goal is…

This study looks at whether taking daily supplements like probiotics and prebiotics can help prevent memory and thinking problems (often called chemobrain) in people with breast cancer who are getting chemotherapy before surgery. About 80 participants will take either a supplemen…

This study tests whether a smartphone app that sends text reminders can help people with breast cancer remember to take their medication, palbociclib, on schedule. About 45 participants will use the app, and researchers will check how often they take their pills correctly. The go…

This study compares two ways of giving radiation after breast cancer surgery to see which causes less fatigue and better quality of life. About 132 adults who had a mastectomy or lumpectomy will receive either standard or shorter-course radiation to the chest and lymph nodes. The…

This study tests a web portal (YES) designed for young women aged 18-39 with breast cancer (stages 0-4). It provides symptom tracking, supportive care info, and peer support. The goal is to see if using the portal reduces common symptoms like vaginal dryness and improves well-bei…

This study looks at whether a shorter, more intense course of radiation (called accelerated radiation) is safe for women with breast cancer who have already had chemotherapy and surgery. About 88 women with stage I to III breast cancer will receive this faster radiation to the br…

This study tests an online self-help program called Together After Cancer for breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 480 coupl…

This study tests a memory training program for breast cancer survivors who have memory problems after chemotherapy. About 60 women who finished chemo 1-10 years ago will use either a challenging or easier version of a computer program for 5 weeks. The goal is to see if the traini…

This study looks at whether talking to an exercise specialist over the phone can help breast and colorectal cancer survivors become more physically active after finishing chemotherapy. Many people become less active during cancer treatment and struggle to return to their previous…

This study tests whether injections of platelet-rich plasma (PRP) into the vulva and vagina can improve symptoms of genitourinary syndrome of menopause (GSM) in breast cancer survivors. GSM causes dryness, burning, and pain, especially after cancer treatments. The trial enrolled …

This study looks at whether women with early breast cancer (tumors smaller than 5 cm) and no signs of cancer in the lymph nodes can safely avoid axillary surgery. About 800 women will be randomly assigned to either have a sentinel lymph node biopsy or no surgery at all. The goal …

This study looks at whether a 12-week dance program can improve pain, fatigue, quality of life, balance, and mood in women being treated for breast cancer. About 28 women will either take dance classes twice a week or continue their usual routine. Researchers hope dancing helps r…

This study looks at whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer become more active while on chemotherapy. Participants will either do supervised or unsupervised aerobic and resistance exercises, or simpl…

This study compares different local treatments for vaginal dryness, irritation, and pain in 160 breast cancer patients who are on hormone therapy. The goal is to see which treatment works best to improve symptoms and quality of life over 12 weeks. Researchers will also check horm…

This study tests whether listening to nature sounds during a breast core needle biopsy can lower pain and anxiety compared to standard supportive conversation. About 200 patients will be randomly assigned to one of the two groups. Researchers will measure stress levels using ques…

This study tests whether the DigniCap scalp cooling system can prevent chemotherapy-induced hair loss in Black patients with early-stage breast cancer. About 30 participants will use the cooling cap during at least four cycles of chemo. The goal is to see if hair loss is mild eno…

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The goal is to see if the program is practical…

This study looks at whether a 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more in control during their radiation treatment. About 109 patients will be randomly assigned to either receive this extra session or standa…

This study looks at whether a 12-week program of online chair-based exercise and health education, combined with a full geriatric assessment, can help older adults (65+) with cancer and their support person. The goal is to see if the program is practical and acceptable, and if it…

This study is testing a mobile app designed to help breast cancer and rare cancer survivors cope with the fear that their cancer might return. About 252 survivors will try different versions of the app to see which one is most helpful and easy to use. The goal is to create a tool…

This study looks at whether curcumin, the ingredient in turmeric, can reduce joint pain in breast cancer survivors caused by aromatase inhibitor drugs. 42 postmenopausal women will take either curcumin or placebo capsules for 3 months. The goal is to see if curcumin improves pain…

This study looks at a breast reconstruction method that uses a smaller piece of back muscle to rebuild the breast after mastectomy. The goal is to see if this less invasive approach causes less shoulder pain and stiffness while still giving good cosmetic results. Researchers will…

This study tests a fixed-dose combination pill called NEPA (netupitant and palonosetron) to prevent nausea and vomiting in 55 women with early breast cancer receiving chemotherapy with adriamycin and cyclophosphamide in Hong Kong. The goal is to see how well the drug works during…

This study compares two relaxation programs (including stretching and relaxation techniques) to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. Up to 700 women with early-stage breast cancer will participate, with so…

This study looks at whether giving a single dose of radiation directly to the tumor site during breast-conserving surgery can reduce fatigue compared to the standard 3-6 weeks of whole breast radiation. It includes women aged 50 and older with low-risk, early-stage breast cancer.…

This study looks at whether supervised exercise (a mix of aerobic and strength training) during chemotherapy can help shrink breast tumors and improve how well patients tolerate treatment. About 100 women with breast cancer will participate. The goal is to see if exercise can be …

This study looks at whether an artificial intelligence (AI) program can improve anxiety and depression in 300 women with breast cancer who are taking CDK4/6 inhibitor pills at home. Participants will be assigned to one of three groups: an AI-based management model, a customized f…

This study tests a portable cooling cap (AMMA) worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. About 40 women receiving specific chemo drugs will use the cap. The goal is to see if the cap keeps hair loss mild (Grade 2 or less) and safe.

This study looks at whether special numbing techniques used during breast cancer surgery can help prevent chronic pain that often lasts for months or years after the operation. About 1,500 women having breast cancer surgery will be followed for a year to see if these techniques r…

This study tests an exercise program designed for Hispanic breast cancer survivors. Researchers want to find the best ways to help survivors become more active. The study includes 53 women who are at least 3 months past treatment. The goal is to improve exercise habits and overal…

This study aimed to see if offering beauty treatments (like skincare or makeup) to women right after breast cancer surgery could improve how they feel about their bodies and their overall quality of life. It planned to compare women who received these treatments with those who di…

This study tests a mindfulness-based program (Nite2Day) for women with breast cancer who have trouble sleeping. Participants learn strategies to cope with nighttime sleep problems and daytime symptoms like fatigue, stress, and pain during six remote sessions. The goal is to see i…

This study tests whether live exercise coaching plus a personalized digital app can improve quality of life for cancer survivors. About 146 adults with breast, lung, prostate, colorectal, or other cancers who had treatment in the last year will use the program for 18 months. Rese…

This study looks at whether using an interactive 3D tool during a surgical consultation helps women with breast cancer feel more satisfied with the information they receive about breast reconstruction options. About 88 women planning mastectomy will take part. Researchers will me…

This study looks at whether virtual reality exercises or standard physical therapy, with or without lifestyle changes, can help women who had breast cancer surgery move their arms better and feel less pain. About 60 women aged 30-60 will take part. The goal is to find better ways…

This study looks at whether a device called Amma can help women with early-stage breast cancer keep more of their hair during chemotherapy. About 15 women will use the device and report how satisfied they are with it. The goal is to see if offering this option in cancer clinics i…

This study tests whether acupuncture can improve memory, concentration, and sleep problems in 270 breast cancer survivors. Participants receive either real acupuncture, placebo acupuncture, or no acupuncture, and complete questionnaires over 26 weeks. The goal is to see if acupun…

This study looks at whether listening to music (receptive music therapy) can help women with breast cancer feel less anxious and depressed, and improve their quality of life. About 90 women will be randomly assigned to either a music group or a control group. Researchers will als…

This study tests whether eating a low-calorie diet before chemotherapy can reduce side effects like fatigue, nausea, and mouth sores, and also improve how well the treatment works. About 130 adults with breast or prostate cancer will follow either a controlled low-calorie diet or…

This study tests whether using a fitness tracker and health coaching to increase daily activity can reduce chronic pain in young Hispanic women who had breast cancer surgery. The trial includes 25 women who still have moderate to severe pain at least 6 months after surgery. Resea…

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on hormone therapies like tamoxifen. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The main go…

This study tests a shorter course of radiation to the lymph nodes in breast cancer patients. The goal is to see if it reduces long-term arm swelling while still preventing cancer from coming back. About 56 women will be followed for 3 years after treatment.

This study looks at whether a simple writing exercise—reflecting on personal values—can help breast cancer patients handle side effects from aromatase inhibitors and stick to their medication. About 250 women will write monthly essays for six months, either about their values or …

This study tests whether starting hormone therapy every other day for one month, then switching to daily, helps patients with early-stage breast cancer take their medication as prescribed. About 240 participants will be randomly assigned to standard daily dosing or the gradual sc…

This study tests a special cooling cap worn during chemotherapy to prevent hair loss in Chinese women with breast cancer. About 25 participants will use the cap while receiving standard chemo. The goal is to see if the cap is safe and effective at reducing hair loss.

This study tests a smartphone-based program that combines physical activity tracking with mindfulness lessons to help breast cancer survivors exercise more. About 304 women who finished primary treatment for early-stage breast cancer within the past 5 years will use the program f…

This study looks at two treatments—vaginal estrogen and a moisturizer called Replens—for vaginal dryness in breast cancer patients taking aromatase inhibitors. About 33 women with estrogen-receptor-positive breast cancer will be followed for 6 months to see which treatment works …

This study looks at whether a program combining exercise and psychological support can reduce anxiety and depression in breast cancer patients. About 200 women who have finished initial treatment for breast cancer and still feel anxious or depressed will take part. The goal is to…

This study tests a mixed reality system called VascuLens 2.0 to help surgeons during DIEP flap breast reconstruction. The system projects a 3D map of a patient's blood vessels onto their body, which may improve accuracy, shorten surgery time, and lower complication risks. About 6…

This study looks at whether whole-body cryotherapy (brief exposure to extreme cold) can reduce joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 70 women with breast cancer who have joint pain from their medication will be randomly assig…

This study compares personalized mammography screening based on individual risk factors (like genetics and lifestyle) to the standard every-two-years approach. About 2200 women aged 50-67 will be randomly assigned to either continue standard screening or receive a risk assessment…

This early-phase study tests a new PET imaging agent called 18F-FluorThanatrace (FTT) to measure a protein called PARP-1 in breast cancer tumors. About 30 adults with known or suspected breast cancer will receive an FTT PET/CT scan before surgery or treatment. Some may get a seco…

This study tests a new program to help breast cancer patients return to work after treatment. It involves 16 working-age women with breast cancer who have work difficulties. The program includes meetings with a team of experts to support their return to work. The goal is to see i…

This study follows 238 breast cancer patients to see how chemotherapy impacts their physical function, health, and quality of life over time. Researchers compare women aged 65 and older with those under 65, tracking changes from before treatment to six months after. The goal is t…

This study follows 220 women who had breast cancer surgery to learn how many develop long-term pain and why. Researchers will look at medical, emotional, and lifestyle factors to find ways to prevent this pain. The goal is to help doctors better prepare patients and reduce suffer…

This study tests whether using MRI to guide radiation therapy for breast cancer is as good as the standard CT-guided method. About 17 women aged 50 or older with early-stage breast cancer who had lumpectomy will receive either CT-based or MRI-based radiation. The main goal is to …

This study follows 500 people who had early-stage breast cancer (stage 0 to IIIC) to learn about their long-term health, quality of life, and any late side effects from treatment. Researchers will also study blood and tumor samples to understand how the immune system fights cance…

This study looks at how small genetic differences (SNPs) in certain genes affect how well the drug raloxifene works and its side effects in people with a type of early breast cancer called LCIS. Researchers will analyze DNA from 600 participants to find gene patterns linked to be…

This study looks at whether brain scans and spinal fluid tests can find early signs of brain cancer in people with HER2+ breast cancer. The goal is to catch and treat brain metastases before they cause symptoms. The study involves about 9 participants and is being done at Memoria…

This study collects white blood cells and tumor cells from up to 7,000 cancer patients and healthy volunteers. The cells are used in the lab to grow large numbers of immune cells that may be given back to patients in future experimental treatments. No direct treatment is provided…

This study looks at how regular exercise might change the biology of breast tumors and the surrounding normal tissue. Researchers will compare tumor samples from 42 women with early-stage breast cancer who exercise regularly versus those who do not. The goal is to understand thes…

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength and heart health in 14 postmenopausal women treated for early-stage breast cancer with a specific type of chemotherapy. Participants will undergo MRI scans and provide blood and …

This study looks at whether artificial intelligence (AI) can help radiologists find breast cancer earlier on mammograms. Researchers reviewed past mammograms from 785 women, comparing how well doctors detected cancer with and without AI support. The goal is to see if AI improves …

This study follows over 1,300 women aged 40 or younger who were just diagnosed with breast cancer. Researchers collect surveys, blood samples, and tumor tissue to learn about the disease, treatment side effects, and emotional challenges over at least 10 years. The goal is to bett…

This study collects blood, tissue, and saliva samples from 7,000 people with and without breast cancer. Researchers use these samples to learn more about what causes breast cancer and how to better prevent, find, and treat it. Participants provide samples once, and no direct trea…

This study looks at how the area around a tumor changes in HER2-positive breast cancer patients during chemotherapy before surgery. Researchers will take samples before, during, and after treatment to track these changes. The goal is to better understand how the tumor responds to…

This study collects tumor samples from over 3,000 adults with advanced cancers to look for specific genetic markers, called biomarkers. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants do not receive a new tre…

This study looks at whether a genomic test called Prosigna can help doctors and patients choose the best treatment before surgery for HR+/Her2- breast cancer. About 60 women with early-stage or locally advanced breast cancer will participate. The main goal is to see how often the…

This study looks at how screening for social needs (like food, housing, and transportation) and providing community health worker support can improve quality of life for Black breast and prostate cancer survivors in Washington, D.C. It also tests anti-racism training for healthca…

This study looks at data from 1,950 breast cancer patients to create a model that predicts whether cancer has been cleared from the lymph nodes after chemotherapy. The goal is to help doctors decide who can safely have a less invasive procedure instead of full lymph node removal.…

This study creates a bank of breast cancer tissue samples from 600 patients who previously took part in the TAILORx trial. Researchers will analyze the tissue to find biological markers that can predict if the cancer will come back or resist hormone therapy or chemotherapy. No ne…

This study looks at whether giving breast cancer patients a 3D printed model of their breast helps them feel more confident about their surgery choices. About 20 women will take part, with some getting the 3D model and others getting standard scans. The goal is to see if the mode…

This study looks at stored tumor tissue and blood samples from 22 women with early breast cancer to find clues that might predict if the cancer will later spread to the brain. Researchers are analyzing gene activity in the original tumor and measuring certain proteins in the bloo…

This study tests a special PET scan tracer called [18F]ISO-1 to see if it can detect sigma-2 receptors in breast cancer tumors. About 30 adults with known or suspected breast cancer will receive the tracer and undergo imaging. The goal is to see if the tracer's uptake matches tum…

This study looks at how well a cardiopulmonary exercise test (CPET) can measure oxygen use in women with HER2-positive breast cancer who have mild heart problems from their cancer treatment. The goal is to see if this test can help predict how their heart and lungs will handle co…

This study looks at how well young women with breast cancer can have children years after chemotherapy, comparing those who also had a procedure to freeze their eggs (controlled ovarian hyperstimulation) and those who did not. Researchers are following 132 patients who took part …

This study tests whether sending personalized text reminders to patients and doctors can increase the number of women who get recommended breast cancer screenings. About 8,490 women aged 40-74 who are overdue for a mammogram will take part. The goal is to see if simple nudges in …

This study aimed to find out if certain psychological and social factors make women more likely to develop long-term pain after breast cancer surgery. Researchers planned to follow women having a mastectomy or lumpectomy and measure their pain levels. However, the study was withd…

This study looks at how immune checkpoint inhibitors, a type of cancer drug, affect the tiny blood vessels in the heart. Researchers will use heart scans and blood tests to check for changes in 25 people with breast or lung cancer. The goal is to learn more about potential heart …

This study follows 700 breast cancer patients to understand how chemotherapy affects the heart. Researchers use blood tests and heart ultrasounds to find early signs of heart damage. The goal is to better predict and prevent heart problems caused by cancer therapy.

This study looks at two new models of care for people who have finished treatment for early-stage breast or colorectal cancer. The goal is to see if these models help survivors get the recommended follow-up tests and preventive care they need. About 2,450 adults from Kaiser Perma…

This study looks at whether a blood test that tracks tumor DNA can help doctors switch treatments earlier in people with stage IV breast cancer. The goal is to see if acting on this early signal can keep the cancer under control longer than waiting for scans to show growth. About…

This study gathers information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants complete weekly online surveys about their symptoms and treatment experience for at least 12 weeks. The goal is to learn how symptoms change over time, not…

This study follows 403 women with early-stage breast cancer to see how chemotherapy affects their heart, ability to exercise, and fatigue levels. Researchers compare these women to people without cancer to understand the long-term side effects of treatment. The goal is to learn m…

This study looks at whether avoiding armpit surgery in early-stage breast cancer patients is as safe as the standard sentinel lymph node biopsy. Over 5,500 women having breast-conserving surgery are being followed to see if skipping armpit surgery leads to fewer side effects with…

This study develops and tests a new arm circumference measurement device for patients who may develop lymphedema after breast cancer surgery. 35 participants (patients and nurses) will compare the new tool against a traditional tape measure to see which is more accurate, faster, …

This study looks at whether women with small breast tumors (under 5 cm) and no signs of cancer in their lymph nodes can avoid sentinel lymph node biopsy during breast-conserving surgery. About 1,734 women are being randomly assigned to either have the biopsy or skip it. The goal …

This study aims to create a repository of biological samples—such as blood, urine, and tumor tissue—from 500 adults with breast, ovarian, or uterine cancer, plus some of their relatives. Researchers will use these samples to study DNA changes that drive cancer, which may guide fu…

This study was designed to see if adding aspirin to an immunotherapy drug called avelumab could help treat triple-negative breast cancer, a type that doesn't respond to hormone therapy. The plan was to give some patients avelumab alone and others avelumab plus aspirin for about 1…

This study looks at whether giving doctors information about a patient's genes can help them personalize chemotherapy doses and reduce severe side effects. About 860 adults with certain cancers (like breast, gastrointestinal, or head and neck) will be randomly assigned to have th…

This study tests a new imaging system called HyperSight that takes clearer, faster 3D scans during radiation therapy for cancer. The goal is to see if these scans are good enough to help doctors plan treatment more accurately. About 40 adults with head and neck, breast, lung, upp…

This study looks at how well the shoulder muscle works after breast reconstruction using a less invasive surgical technique. Researchers will measure muscle strength and function in 32 women before surgery and at 3, 6, and 12 months after. The goal is to see if the muscle returns…

This study looks at how radiation therapy changes tumor DNA and immune cells in the blood of breast cancer patients. Researchers hope to learn how to better tailor radiation treatments in the future. About 217 adults with breast cancer who are scheduled for radiation will partici…

This study aims to improve how total-body PET scans work for people with prostate cancer, breast cancer, or neuroendocrine tumors. Researchers will collect extra data from FDA-approved imaging agents during routine scans. Only 9 participants are needed, and the goal is to learn m…

This study looks at whether certain genes can predict how much chemotherapy damages the ovaries in young women with breast cancer. Researchers will follow 73 women aged 18-36 for five years after treatment, measuring hormone levels and egg counts. The goal is to better understand…

This study looks at whether a special type of breast scan called molecular breast imaging (MBI) can predict how well chemotherapy is working in women with invasive breast cancer that has spread to nearby tissue. About 96 women will get MBI scans before, during, and after chemothe…

This study looks at how the drug letrozole works in postmenopausal women with early-stage, hormone-sensitive breast cancer before they have surgery. About 178 participants will take letrozole for 4 to 24 weeks, and researchers will compare tumor samples taken before and after tre…

This study looks at ways to help people who have inherited gene changes that raise cancer risk. It tests if certain tools can help them follow doctor guidelines for managing their cancer risk and share their genetic results with family members. About 720 adults with these gene ch…

This study looks at immune-related factors in tumor tissue and blood samples from 268 women with early breast cancer. The goal is to see if these markers can predict which patients will have a complete response to chemotherapy before surgery. The findings could help doctors bette…

This study tests a new PET imaging agent called 18F-FluorThanatrace to measure PARP-1 activity in breast cancer tumors. About 50 adults with known or suspected breast cancer will receive an injection of the tracer and undergo one or two PET/CT scans. The goal is to see how well t…

This study looks at how exercise changes the gut microbiome in breast cancer survivors and whether those changes help reduce fatigue and other symptoms. About 126 women who have finished primary cancer treatment will take part. Researchers will measure gut bacteria from stool sam…

This study tests whether a new type of breast scan (DBT-TOBI) can predict how well chemotherapy works in women with certain breast cancers. About 30 participants will get scans before and during treatment to see if early changes in blood flow can tell doctors if the cancer will f…

This study tracks over 1,400 breast cancer and lymphoma patients to see how chemotherapy affects memory, attention, and thinking skills. Participants are tested before treatment, after treatment, and during follow-ups. The goal is to better understand who is most at risk for cogn…

This study looks at whether regular high-intensity interval training (HIIT) can improve how breast cancer patients respond to chemotherapy before surgery. Researchers will compare a group that exercises three times a week during treatment to a group that keeps their usual activit…

This early-stage study planned to give flu vaccine injections directly into breast tumors in women with triple-negative or HER2+ breast cancer. The goal was to see if this approach could safely trigger the body's immune system to attack the cancer. However, the study was withdraw…

This study looks at whether an artificial intelligence (AI) program can accurately predict if early-stage breast cancer will come back. Researchers will analyze stored tumor slides from 2,200 women who had ER-positive, HER2-negative breast cancer. The AI's predictions will be com…

This study looks at whether people aged 70 and older with a less aggressive type of breast cancer can safely avoid long-term hormone therapy. The goal is to see if skipping this treatment reduces side effects without increasing the risk of cancer coming back. About 100 participan…

This study looks at whether it is safe and possible for young women with early breast cancer to freeze their eggs or embryos before starting chemotherapy. The goal is to understand how well this method works to protect future fertility. About 140 women aged 18 to 38 will take par…

This study follows over 900 women who had a breast biopsy for certain non-cancerous conditions (like atypical hyperplasia or DCIS). Researchers want to learn about patients' long-term pain, emotional well-being, and quality of life after routine treatment. The goal is to better u…

This study involves 500 women in northern France diagnosed with invasive breast cancer in 2024. Researchers want to understand why some women wait longer between noticing a symptom and starting treatment. Participants fill out a one-time questionnaire about their feelings, behavi…

This study looks at how women with a certain type of advanced breast cancer (HR+/HER2-) are treated with the drug ribociclib in everyday medical practice across France. Researchers will collect information on dosing, treatment patterns, and how long the cancer stays under control…

This study looks at whether a patient navigator—a person who helps guide patients through the healthcare system—can improve timely follow-up after an abnormal breast imaging result. The study includes 196 people who had an abnormal screening mammogram and had not yet completed di…

This study follows women who are cancer-free at least three years after finishing early breast cancer treatment. Researchers want to learn how things like the type of cancer, treatments received, and side effects during treatment may affect quality of life and daily function year…

This study brings together healthcare experts to agree on the best ways to care for skin during breast cancer treatment. Skin problems are common side effects of therapies like chemotherapy and radiation. The goal is to create simple, clear guidelines that help patients avoid ski…

This study looks at 625 people in Russia with high-risk early breast cancer to find out how common BRCA1/2 gene mutations are and what treatments they receive. Participants are already diagnosed and treated, and researchers will collect data from medical records and genetic tests…

This observational study follows 2000 women aged 40 or younger with breast cancer to see how childbirth after diagnosis affects their survival and disease recurrence. It also checks the growth and health of their children. The goal is to provide clearer information for young pati…

This study looks at how different breast cancer treatment decisions affect women's quality of life and emotional distress. Researchers followed 345 women with newly diagnosed breast cancer to see how their choices influenced their well-being. The goal is to help future patients m…

This study looks back at 1,400 women who had breast-conserving surgery for non-palpable breast cancer. It compares two techniques used to locate the tumor during surgery: a radioactive injection (ROLL) and a tiny magnetic seed placed beforehand. The main goal is to see which meth…

This study gathers medical records and tumor samples from 200 men with breast cancer to better understand the disease. It has two parts: looking back at past cases (1990-2010) and tracking new cases for 30 months. The goal is to learn how the disease behaves and how it is treated…

This study planned to test whether giving methadone during breast reconstruction surgery could reduce the need for other painkillers afterward. It was designed for women having breast reconstruction after mastectomy. However, the study was withdrawn before enrolling any participa…

This study looks at how genetic testing for breast cancer affects a person's stress and anxiety levels. Researchers will measure stress before and after testing in 164 women who either have breast cancer or are at high risk. The goal is to help doctors provide better support duri…

This study looks at how the drug Palbociclib is actually used in everyday medical practice for people with a specific type of advanced breast cancer (HR+/HER2-). Researchers will analyze anonymous medical records to see how long patients take the drug and how it affects their nee…

This study follows 200 women with breast cancer who are receiving chemotherapy drugs doxorubicin or trastuzumab. Researchers want to understand how these treatments affect the heart over time and how factors like race, income, and access to healthcare play a role. Participants wi…

This study looks at how breast cancer treatment affects quality of life in women of different ages. Researchers will ask 650 women who were recently diagnosed with early-stage breast cancer to fill out questionnaires about their health and well-being. The goal is to understand ag…

This study tests whether closely monitoring for early signs of lymphedema (arm swelling) after breast cancer surgery and treating it right away can prevent long-term swelling. About 250 women who had lymph nodes removed will be randomly assigned to either the monitoring program o…

This study uses a special MRI technique to measure the amount of saturated fat in breast tissue without needing a biopsy. Researchers will compare the fat composition in women with breast cancer versus those with non-cancerous breast changes. The goal is to learn whether breast f…

This study searches for brand-new gene changes that appear in a person with cancer but not in their parents. By comparing cancer patients, their healthy parents, and other family members, researchers hope to uncover genetic clues that raise cancer risk. The goal is to better iden…

This study looks at whether a new way of paying for cancer care can help doctors work together better and improve health outcomes for patients with breast, colon, or lung cancer. The study involves 7 participants and compares the new payment model to the usual way of paying for c…

This study looks at whether a short program of exercise or mind-body activities (like relaxation techniques) can help women with breast cancer feel less stressed and anxious while waiting for surgery. About 49 women will take part, and researchers will also check if these program…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse (TGD) adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal i…

This study looks at whether a survivorship care plan (a personalized health roadmap) can improve quality of life and reduce stress for breast cancer survivors. About 100 women in early survivorship (up to 18 months after treatment) will take part. The goal is to see if having a c…

This study was designed to learn how much information people can recall about their own cancer screening and diagnosis. Researchers planned to see if giving extra time or resources helps people remember more accurately. The study was withdrawn before enrolling any participants, s…

This study aimed to see if contrast-enhanced ultrasound (CEUS) could predict how well triple-negative breast cancer patients respond to chemotherapy and immunotherapy earlier than standard scans. No participants were enrolled, so the study was withdrawn. The goal was to find a fa…

This study follows 253 adults aged 70 and older with early-stage breast cancer to learn how to improve their care and health outcomes. Researchers will track treatment decisions, medication adherence, and barriers to care. The goal is to gather information, not to test a new trea…

This study aimed to see if an online program could help breast cancer patients access supportive care services more easily than traditional in-person guidance. It planned to enroll women with non-metastatic breast cancer and track their use of services, barriers, and satisfaction…

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with cancer symptoms or at risk will take part. Half the communities get the prog…

This study was designed to watch for changes in tumor DNA in the blood of people with early breast cancer during and after treatment. It aimed to learn how this DNA test might help monitor the disease. However, the study was withdrawn before enrolling any participants, so no info…

This study looks at DNA from over 21,000 cancer patients in New York to find inherited gene changes linked to several cancers, including breast, colon, and prostate. The goal is to gather information for future research, not to test a new treatment. Participants donate a blood sa…

This study aims to find genetic and blood markers that can predict which breast cancer patients will have severe side effects or poor response to a class of drugs called kinase inhibitors. Researchers will analyze DNA and blood samples from 100 women with breast cancer who are ta…

This study looks at whether exercise can prevent heart damage in breast cancer patients receiving a type of chemotherapy called anthracycline. About 70 women will be followed using heart scans and blood tests to see if exercise helps keep the heart healthy. The goal is to find ea…

This study looks at how to predict serious side effects from chemotherapy in older adults (65+) with early-stage breast cancer. Researchers will use clinical factors and blood tests to build a model that forecasts toxicity. The goal is to help doctors choose safer treatments for …

This study looks at whether it is safe to skip a more extensive armpit surgery (axillary lymph node dissection) in patients with HER2+ or triple-negative breast cancer who still have cancer in their lymph nodes after chemotherapy. Researchers will track 600 patients over 3 years …

This study aims to understand how breast cancer treatment may change brain functions like attention, memory, and emotional processing. Researchers will test a new set of evaluations called the SAE Battery in 187 women aged 40-75 with early-stage breast cancer. The goal is to see …

This study looks at whether using a physical activity screener, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors increase their physical activity and reduce sitting time. About 20 survivors aged 50 or older who finished primary cancer t…

This study follows 810 young women (ages 18-45) with early-stage breast cancer to understand how treatment affects their menstrual cycles and quality of life. Researchers track who stops having periods and why, looking at factors like age, smoking, and race. The goal is to gather…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong use medical services more wisely and feel more in control of their health. About 1,728 women will either receive the nurse coaching or general health advice. The goal is to see if …

This study examines what normal breast tissue looks like on MRI and mammogram to see if it affects a woman's risk of developing breast cancer. Researchers are comparing images and health information from over 2,100 women, including those with and without breast cancer. The goal i…

This study looks at how a 12-week exercise program affects certain markers in the breast tissue and blood of premenopausal women with dense breasts. Dense breast tissue is linked to a higher risk of breast cancer. The goal is to see if physical activity can change these markers, …

This study planned to give high doses of vitamin D to women with breast cancer before their surgery, to see if it changed certain markers in the cancer cells. The goal was to learn how vitamin D might affect the cancer, not to cure it. However, the study was withdrawn before any …

This study tests whether a campaign featuring real stories from cancer survivors can encourage more people in rural India to get screened for oral, breast, and cervical cancer. About 1,120 adults aged 30-59 who have never had cancer will be randomly assigned to hear either the su…

This study uses advanced brain scans to see how chemotherapy changes the brain in women aged 65 and older with early-stage breast cancer. Researchers will compare brain images and thinking tests before and after treatment. The goal is to better understand why some older patients …

This study looks at pregnancy and fertility in women who had breast cancer. Researchers will collect information from 22,000 patients aged 18 to 50 at diagnosis to see how many get pregnant, whether they used fertility preservation, and the health of their babies. The goal is to …

This study looks back at over 1,000 women who had breast-conserving surgery for early breast cancer that couldn't be felt. It compares four techniques used to locate the tumor during surgery: wire guidance, radioactive seed, magnetic seed, and carbon dye. The goal is to see which…

This study looks at how well sentinel lymph node biopsy finds leftover cancer cells after chemotherapy in women with locally advanced breast cancer. About 162 women who had chemotherapy and whose lymph nodes seemed cancer-free will get this biopsy. The goal is to see how often th…

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…

This study looks at four different breast imaging techniques—MRI, digital mammography, ultrasound, and PET scans—to see how well they work together to determine the size and spread of breast cancer. About 400 women recently diagnosed with breast cancer will be scanned before surg…

This study is testing a new genetic test (called Gersom panel) in 4,000 people with breast, ovarian, or colorectal cancer. The goal is to see if the test can accurately find inherited genetic risks and tumor mutations that might guide treatment choices. Participants provide blood…

This study looks at whether a less invasive ultrasound-guided biopsy can accurately tell if breast cancer has been completely eliminated after chemotherapy, compared to standard surgery. About 43 women with triple-negative or HER2-positive breast cancer will have both a biopsy an…

This study looked at two groups of people with advanced breast cancer: those whose tumors stopped responding to estrogen (ER loss) and those with triple-negative breast cancer. Researchers used a special PET scan to track these changes and compared how long each group lived witho…

This study is testing whether having healthcare providers offer breast exams and guide patients through the healthcare system can help women in Sub-Saharan Africa get diagnosed and start treatment for breast cancer faster. The study involves 8,000 women in Ethiopia, South Africa,…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …

This study looks at how much muscle loss and fatigue breast cancer patients experience during and after radiation therapy. Researchers want to see if muscle loss happens in areas not directly treated by radiation, and whether it's linked to how tired patients feel. Twenty women w…

This study looks at 304 people with advanced triple negative breast cancer, a hard-to-treat type. Researchers want to see if a genetic test can tell who will do better on one chemo (carboplatin-cyclophosphamide) versus another (paclitaxel), and whether adding the immunotherapy dr…

This study tests a new system that helps doctors better understand the needs of older adults with cancer. The system combines checks on aging, mental health, lifestyle, and social factors. About 35 patients aged 65 and older will try it during their first cancer visit. The goal i…

This study follows about 64,000 adults who grew up on farms to see if early exposure to pesticides and other farm-related factors is linked to cancer. Participants fill out a questionnaire and may provide blood or other samples. The goal is to understand how childhood agricultura…

This study tests a program to improve health knowledge for women about to leave jail. It focuses on cervical and breast cancer, STDs, and birth control. About 279 women will take part to see if the program helps them understand and prevent these health issues.

This study looks at whether trained peer navigators can help African-American women who finished breast cancer treatment stick to their follow-up care plans. About 145 women will be randomly assigned to get peer support or usual care. The goal is to see if this approach improves …

This study looks at how breast cancer is diagnosed and treated in Latin America. It will follow about 2,900 newly diagnosed patients to understand their cancer types, treatments, and outcomes. No new treatments are being tested—the goal is to gather information to improve future …

The purpose of this study is to test whether patients with breast cancer who are being treated with non-anthracycline trastuzumab therapy can safely be monitored for heart related side effects less often than usual.