BREAST CANCER

This small study is testing whether a 3-month lifestyle program can help breast cancer survivors who are overweight or obese. The program involves three modified fasting days per week and aims to increase physical activity. Researchers want to see if this approach is safe, feasib…

This study is testing the safety and effectiveness of a two-drug combination for people with advanced or metastatic breast cancer that is no longer responding to standard hormone therapies. The two medicines, vepdegestrant and PF-07220060, are taken as pills at home. The goal is …

This study is testing whether eating a special, low-calorie diet before and during chemotherapy can help reduce side effects and make the treatment work better. It involves 130 people with breast cancer or prostate cancer who are receiving specific chemotherapy drugs. Participant…

This study is testing whether a shorter, 4-week course of radiation is as safe and effective as the standard 6-week treatment for breast cancer patients whose cancer has spread to their lymph nodes. The trial involves 108 women who have already had breast cancer surgery. Research…

This study is testing whether adding specific fasting routines to standard chemotherapy helps breast cancer patients. Researchers want to see if fasting can reduce side effects, improve the body's immune response to cancer, and enhance patients' quality of life during treatment. …

This study tested whether adding a new drug called abemaciclib to standard hormone therapies helps postmenopausal women with advanced breast cancer live longer without their cancer getting worse. It involved 463 women whose cancer had returned or spread and was fueled by hormones…

This early-phase study is testing a personalized vaccine for people with HER2-positive breast cancer. The vaccine is made from the patient's own immune cells and is designed to teach the body's immune system to attack the cancer. Researchers are giving the vaccine alongside stand…

This study aims to see if proton beam radiation causes less heart damage than traditional photon radiation for people with left-sided breast cancer. Researchers will randomly assign 60 participants to receive either proton or photon radiation and use heart MRI scans to measure sc…

This study is testing whether proton radiation focused only on the area where a breast tumor was removed can effectively control cancer while reducing side effects. The treatment targets 150 patients with early-stage breast cancer who have had surgery but need radiation. Research…

This study is testing whether an investigational drug called QBS72S can shrink tumors that have spread to the brain from breast or lung cancer. It involves 21 adults with advanced cancer that has spread to the central nervous system. Researchers will measure how well the drug wor…

This early-stage trial is testing whether adding an experimental drug called ipatasertib to standard hormone therapies can help control metastatic breast cancer that has stopped responding to previous treatments. The study will enroll 77 postmenopausal women to determine if the c…

This study is testing a hormone therapy drug called letrozole given before surgery to post-menopausal women with early-stage, estrogen-positive breast cancer. Researchers want to understand how some cancer cells survive this treatment and stay hidden in the body, which can lead t…

This study aims to see if a more personalized approach improves treatment for early-stage, hormone-positive breast cancer. It will test if adding a targeted drug called a CDK4/6 inhibitor to standard hormone therapy works better for patients identified as having a higher risk of …

This study is testing an existing drug, trastuzumab deruxtecan, in people with advanced HER2-positive breast cancer that has progressed after prior treatments. It specifically aims to see how well the drug works in two groups: those with and without cancer that has spread to the …

This study is testing a new approach to personalizing breast cancer treatment. It aims to see if doctors and patients are willing to adjust the amount of chemotherapy given after surgery, based on how well the cancer responded to treatment before surgery. The study involves 100 a…

This study is testing a drug called T-DM1 to see if it can help prevent a specific type of breast cancer (HER2-positive) from returning after surgery in patients aged 60 and older. The drug is designed to target cancer cells directly, which may lead to fewer side effects compared…

This study is for people with advanced triple-negative breast cancer, a hard-to-treat type. It tests if adding an immunotherapy drug (atezolizumab) to standard first-line chemotherapy helps control the cancer better and for longer. Researchers also want to learn which patients ar…

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This early-stage study is testing the safety and initial effectiveness of combining two drugs, olaparib and vorinostat, for adults with advanced breast cancer that has returned after treatment or spread. The goal is to find the safest dose and see if blocking two cancer cell repa…

This study is testing whether combining a targeted radiation procedure (stereotactic radiosurgery) with an immunotherapy drug (atezolizumab) works better than either treatment alone for triple-negative breast cancer that has spread to the brain. The goal is to see if the radiatio…

This large study is testing whether adding radiation to a specific set of lymph nodes inside the chest wall helps prevent breast cancer from coming back in high-risk patients. It involves 2,400 people who have already had surgery and chemotherapy. Researchers will compare two rad…

This study is testing a drug called Trastuzumab-Deruxtecan (T-DXd) for people with a specific type of advanced breast cancer (HER2-low) that has spread to the brain. The main goal is to see how well the drug shrinks these brain tumors. It will also track side effects and how the …

This study is testing a personalized approach to chemotherapy for HER2-positive breast cancer. It aims to see if doctors can safely give fewer chemotherapy cycles to patients who show a strong, early response to treatment on an MRI scan. The goal is to reduce side effects while s…

This study is testing whether women with a specific, very low-risk type of early breast cancer (DCIS) can safely skip whole-breast radiation after breast-conserving surgery. It aims to identify patients who are unlikely to have the cancer return, allowing them to avoid the side e…

This large study is testing whether adding an extra, focused dose of radiation to the tumor site helps prevent cancer from returning in women with a very early form of breast cancer called DCIS. All participants had surgery to remove the cancer followed by standard whole-breast r…

This large international study is testing whether adding a medication called palbociclib to standard hormone therapy is better at preventing breast cancer from coming back after initial treatment. It involved nearly 5,800 people with early-stage, hormone-sensitive breast cancer w…

This is an early safety study testing a new type of vaccine for people with a common form of breast cancer (estrogen receptor-positive). The vaccine uses small pieces of protein (peptides) from the cancer to try to teach the body's immune system to recognize and fight the disease…

This study is testing whether adding a drug called lenvatinib to standard hormone therapy (letrozole) can better shrink breast tumors before surgery. It involves post-menopausal women with newly diagnosed, hormone receptor-positive breast cancer. The research first aims to find a…

This study is testing a new treatment approach for early-stage HER2-positive breast cancer. It combines an experimental drug called pyrotinib with standard chemotherapy drugs, all given before surgery. The goal is to see if this combination can more effectively shrink or eliminat…

This study is testing if adding a highly focused, high-dose radiation treatment (called stereotactic body radiation therapy or SBRT) to standard first-line drugs can better control breast cancer that has recently spread to a few other body parts. It involves 154 patients whose ca…

This study is testing whether adding a drug called palbociclib to standard hormone therapy can better shrink tumors before surgery in people with early-stage, hormone-positive breast cancer. It involves 51 participants and aims to see if this combination improves treatment respon…

This study tested whether a new drug called DS-8201a works better than the current standard treatment (T-DM1) for advanced HER2-positive breast cancer that has worsened despite previous therapies. It involved 524 adults whose cancer had spread and could not be surgically removed.…

This study is testing whether a personalized survivorship care plan, along with counseling sessions, can help breast cancer survivors manage their health and improve their quality of life after active treatment ends. It compares this approach to just receiving the care plan bookl…

This early-stage study is testing the safety and dosing of an experimental pill called inavolisib. It is for people with advanced breast cancer or other solid tumors that have a specific genetic change called a PIK3CA mutation. The study will give the pill alone or in combination…

This study tested whether regular phone calls from an exercise coach could help people who recently finished treatment for early-stage breast or colorectal cancer become more physically active. Research suggests staying active after cancer may lower the chance of the cancer comin…

This study is testing whether giving hormone therapy pills for 6 months before breast cancer surgery helps surgeons remove all the cancer in one operation. It involves postmenopausal women with early-stage, hormone-sensitive breast cancer who haven't spread to lymph nodes. The go…

This study is testing a new combination of three drugs given before surgery for early-stage, hormone-sensitive breast cancer. The goal is to see if adding an immunotherapy drug (avelumab) to standard hormone-blocking treatments helps shrink tumors more effectively. Researchers wi…

This study is testing whether a 16-week exercise program can reduce harmful inflammation in body fat for overweight breast cancer survivors who have finished treatment. Researchers want to see if lowering this inflammation might help decrease the risk of the cancer returning. The…

This is the first human study of an experimental oral drug called AC699 for people with advanced ER+/HER2- breast cancer that has progressed after standard treatments. The main goals are to find a safe dose, understand how the body processes the drug, and look for early signs tha…

This study is testing a new drug, MEN1611, given alone and with a chemotherapy called eribulin, for people with advanced breast cancer that has specific genetic changes. The goal is to see if these treatments can help control the cancer and are safe. It is for patients whose canc…

This is a first-in-human study to find a safe dose and see how the body processes a new oral drug called ATV-1601. It is being tested in adults with advanced solid tumors, including certain breast cancers, that have a specific genetic change called an AKT1 E17K mutation. The main…

This study is testing whether adding different immune-boosting drugs before standard chemotherapy and immunotherapy can improve treatment for triple negative breast cancer. The trial involves 12 participants with early-stage breast cancer who will receive treatment before surgery…

This study aims to find out which of two standard chemotherapy regimens is more effective and safer for patients after breast cancer surgery. It involves 1,560 women with specific types of breast cancer that has spread to lymph nodes. Researchers are comparing two different drug …

This study is testing if adding an immunotherapy drug called nivolumab to standard chemotherapy (carboplatin) works better for controlling advanced triple-negative breast cancer that has spread. It involved 78 patients whose cancer had not been treated for its spread. The main go…

This study is testing if adding an oral drug called pyrotinib to standard chemotherapy before surgery is more effective for a specific type of breast cancer. It involves 140 women with stage II-III, hormone-positive, HER2-negative breast cancer that has high levels of a protein c…

This study is testing whether adding heat treatment right after breast cancer tumor removal can help prevent the cancer from coming back. Researchers are applying radiofrequency energy to the surgical area immediately after tumor removal in women over 50 with early-stage breast c…

This study is testing whether a simple smartphone app that sends text message reminders can help people with breast cancer remember to take their medication, palbociclib (Ibrance), on the correct schedule. It involves 45 adults who are starting this medication for the first time.…

This study is testing whether adding the experimental drug capivasertib to standard fulvestrant treatment helps control advanced breast cancer that has worsened after hormone therapy. It involves about 258 Chinese patients with specific genetic changes in their tumors. The main g…

This study is testing whether just three radiation sessions can effectively treat early-stage breast cancer, instead of the usual weeks of treatment. It's designed for women over 50 with low-risk cancer who've had breast-conserving surgery. The goal is to see if this faster appro…

This early-stage study is testing a new drug called SRG-514. It is applied directly to the surgical site right after a breast tumor is removed, aiming to help control the cancer. The main goal is to find a safe and effective dose by testing it in a small group of patients. Resear…

This large study tested if a shorter, more intense 3-week radiation course is as effective and safe as the standard 5-6 week course for women with early-stage breast cancer after lumpectomy. It aimed to see if the shorter schedule provides the same cancer control with similar sid…

This study is testing whether a community program called Potlako+ can help people with possible cancer symptoms get diagnosed and treated faster. The program involves educating communities about cancer warning signs and providing patient navigators to guide people through the hea…

This study aims to improve health and quality of life for Black breast and prostate cancer survivors in Washington, D.C. by addressing social and economic barriers. It will test whether connecting survivors with community health workers and providing anti-racism training for clin…

This study is testing whether a newer targeted drug, either alone or in sequence with standard chemotherapy, works better than current standard chemotherapy when given before surgery for high-risk, early-stage HER2-positive breast cancer. It aims to see if more patients can achie…

This study tested whether a higher dose (500 mg) of the hormone therapy drug fulvestrant works better than the standard dose (250 mg) for postmenopausal women with advanced breast cancer that has continued to grow after previous hormone treatment. It involved 736 women and direct…

This study is testing a new drug called azenosertib, combined with two existing cancer drugs, for people with advanced triple-negative breast cancer that has spread. The main goals are to find a safe dose and see if the combination makes tumors shrink. About 78 participants will …

This study is observing patients in Brazil who are already receiving a breast cancer treatment called Zedora (a biosimilar version of trastuzumab) after surgery. The goal is to see how well it works and how safe it is in everyday medical practice, outside of a controlled clinical…

This study is testing a new approach for treating early-stage breast cancer. It gives a short, focused course of radiation to the tumor area *before* surgery, instead of after. The goal is to see if this method is safe and effective, and if using an MRI scan for planning helps ta…

This study is testing if a newer, MRI-guided radiation therapy system is as good as the current standard CT-guided system for treating early-stage breast cancer. It will compare how often the cancer comes back and the side effects, like skin problems and cosmetic changes, between…

This study is testing a new oral drug, CFI-402257, given alongside a standard weekly chemotherapy (paclitaxel) for people with advanced HER2-negative breast cancer. The first part aims to find the safest dose of the new drug combination. The second part will see if adding this ne…

This study is testing whether adding a new drug called ipatasertib to standard fulvestrant therapy can better control advanced breast cancer that has started growing again after initial treatment. It involves about 250 postmenopausal women whose cancer is hormone-sensitive and HE…

This study aims to find the best strategy to protect heart function in breast cancer patients receiving trastuzumab treatment, which can sometimes weaken the heart. Researchers are testing whether to give the heart-protecting drug carvedilol preventively before treatment starts, …

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a standard hormone-blocking drug (fulvestrant) can better control advanced breast cancer that has spread. It enrolled 47 adults whose cancer is fueled by hormones but not by the HER2 protein, and who ha…

This study is testing whether adding a new, experimental drug called onvansertib to a standard chemotherapy (paclitaxel) is safe and effective for people with triple-negative breast cancer that has spread. The first part finds the safest dose, and the second part checks if the co…

This study is testing whether some patients with early-stage, HER2-positive breast cancer can safely avoid chemotherapy before surgery. Researchers are using a specific biomarker test to select 63 participants whose cancer is highly dependent on the HER2 protein. These patients w…

This international trial is testing if a more intense, personalized chemotherapy regimen can improve survival and prevent cancer from returning in people with a specific, high-risk type of breast cancer. It compares the standard treatment to a stronger one, which includes a stem …

This study is testing whether a new immunotherapy drug called tobemstomig, when combined with standard chemotherapy, works better than the current standard treatment for advanced triple-negative breast cancer. It involves 83 people with a specific type of this aggressive cancer t…

This study compares two different drug combinations given before surgery to shrink tumors in people with stage II-III HER2-positive breast cancer. About 174 participants were randomly assigned to receive either a newer drug combination (margetuximab) or the standard combination (…

This study is testing whether a newer type of radiation called proton therapy can reduce long-term side effects for women with stage II or III breast cancer who need radiation after surgery. The goal is to see if this method lowers the risk of future heart problems and second can…

This early-stage study is testing whether combining two existing cancer drugs (abemaciclib and pembrolizumab) is safe and might help control advanced lung cancer or hormone-positive breast cancer. It will enroll about 100 people with these specific cancer types who meet strict he…

This study is testing whether some patients with triple-negative or HER2-positive breast cancer can safely skip a lymph node biopsy after successful chemotherapy. Researchers want to see if omitting this surgery reduces complications like arm swelling and pain without increasing …

This early-stage study is testing a new drug called ST101 in patients with advanced solid tumors that cannot be surgically removed and have spread. The trial aims to find a safe and effective dose for cancers including glioblastoma, melanoma, breast cancer, and prostate cancer in…

This study is testing a drug called entrectinib for people with advanced solid tumors that have specific genetic changes (NTRK, ROS1, or ALK gene rearrangements). It's a 'basket trial,' meaning it groups patients by their tumor's genetic type rather than where the cancer started …

This study is testing whether combining two new drugs can help control advanced triple-negative breast cancer. The trial involves 15 women whose cancer has spread or cannot be removed by surgery. Researchers want to see if the drug combination can shrink tumors and slow cancer gr…

This study is testing a focused, high-dose radiation treatment called SBRT for patients with advanced breast cancer who cannot have surgery. It involves 24 patients receiving four radiation sessions over about two weeks. The main goals are to see how safe the treatment is, how we…

This study is testing a shorter, more targeted form of radiation therapy for women with very early-stage breast cancer. Instead of radiating the entire breast for 5-7 weeks, doctors are giving radiation only to the area where the tumor was removed, over just 2 weeks. The main goa…

This study tested whether a shorter, 3-day radiation schedule is as safe and effective as the standard 5-day schedule for early-stage breast cancer. It involved 284 postmenopausal women who had small tumors removed with surgery. The goal was to see if reducing treatment days coul…

This early-stage trial is testing whether adding an experimental oral drug called AZD6244 to standard chemotherapy is safe for people with advanced cancers like breast, lung, colon, and kidney cancer. The study will find the highest dose patients can tolerate and track how the bo…

This study is testing whether adding the oral chemotherapy drug capecitabine to standard carboplatin-based chemotherapy improves outcomes for patients with early triple negative breast cancer before surgery. The main goal is to see if this combination helps more patients achieve …

This early-stage study is testing the safety and effectiveness of combining two drugs, olaparib and sapacitabine, for people with advanced breast cancer linked to a BRCA gene mutation. The main goals are to find the safest dose and see if the combination can shrink tumors. It is …

This study is testing if adding a drug called vorinostat to standard chemotherapy helps shrink breast tumors more effectively before surgery. It involves 68 women with operable, HER2-negative breast cancer who are randomly assigned to receive the standard chemo drugs or the stand…

This study is testing whether giving two drugs, pembrolizumab and olaparib, before surgery can shrink certain types of breast cancer in people with specific genetic mutations. The goal is to see if this combination can reduce the tumor enough to improve surgical outcomes. The tri…

This study compares an experimental drug called DS-8201a against standard treatments for advanced breast cancer that has low levels of a protein called HER2. It involves 557 people whose cancer has spread or cannot be removed by surgery and who have already tried other treatments…

This study aimed to test a new approach for treating small breast cancers in women aged 60 and older. Doctors planned to remove the tumor with a biopsy, then immediately freeze the area to kill any remaining cancer cells. The goal was to see if this combined procedure was safe, e…

This is the first human study of an experimental antibody called GNC-035 for people with advanced breast cancer that has spread or returned after standard treatments. The main goal is to find a safe dose by testing it in 36 patients and watching for side effects. Researchers will…

This study is for people with breast or prostate cancer that has spread to the bones and who have been taking bone-strengthening drugs for over two years. It aims to find out if it is safe and effective to either continue these drugs or reduce/stop them. The main goal is to see i…

This study is testing whether a three-part treatment is safe and can help control advanced triple-negative breast cancer that has spread and hasn't responded well to standard immunotherapy. The treatment combines two drugs—one that helps the immune system fight cancer and another…

This study aimed to see if adding aspirin to an immunotherapy drug (avelumab) could improve the body's immune attack against triple-negative breast cancer, a difficult-to-treat type. It planned to enroll 42 patients who would receive the drug, with half also taking aspirin for ab…

This study is testing if a new drug called HS627 works as well as the standard drug pertuzumab when combined with other treatments before surgery for early or locally advanced HER2-positive breast cancer. The goal is to shrink or eliminate the tumor before the operation. About 40…

This study compares two approaches to breast reconstruction after mastectomy for breast cancer. Researchers want to see if using a special surgical mesh called Acellular Dermal Matrix (ADM) leads to fewer complications than reconstruction without it. The trial involves 353 women …

This study is testing whether specific diets or a diabetes medication can prevent dangerous high blood sugar in people receiving a standard two-drug treatment for advanced breast cancer. Researchers want to see if controlling blood sugar helps the cancer therapy work better. The …

This study explores whether freezing eggs or embryos before chemotherapy is safe and feasible for young women with early breast cancer. It aims to preserve their future fertility options while managing cancer treatment. Researchers will track egg quality, pregnancy rates, and can…

This study is testing if adding local treatments like surgery and radiation to standard drug therapy helps control breast cancer that has spread to the bones for a longer time. It involves patients whose cancer has spread to only 1-3 bone sites. The goal is to see if aggressively…

This study allows patients with breast or head/neck cancer who benefited from palbociclib in previous Pfizer trials to continue receiving the medication. The main goal is to monitor the long-term safety of the treatment in these patients. Participants will be followed to track an…

This study tests whether a combination of three drugs (pembrolizumab, carboplatin, and paclitaxel) given before surgery can completely eliminate cancer in patients with early-stage triple-negative breast cancer. The trial involves 30 participants who haven't had previous cancer t…

This study is testing if starting with a lower dose of the cancer drug abemaciclib and slowly increasing it is easier for patients to tolerate than the standard full dose. It involves 90 people with early-stage, high-risk, hormone-positive breast cancer who have already had surge…

This study is testing a new, faster way to give radiation to women with early-stage breast cancer. Instead of multiple weeks of treatment, it gives one strong dose of radiation before surgery. The main goal is to see if this single dose leads to good cosmetic results while still …

This early-stage study is testing a new combination of two drugs, valemetostat and trastuzumab deruxtecan, for people with advanced breast cancer that has low or no HER2 protein. The main goals are to find a safe and effective dose and to see if the treatment can shrink tumors. I…

This study is testing the safety and effectiveness of two oral drugs, vepdegestrant and samuraciclib, taken together for advanced breast cancer that has spread and is no longer responding to standard treatments. It aims to see if this combination can help control the cancer. The …

This study tested whether adding a new drug called abemaciclib to standard hormone therapy works better for controlling advanced breast cancer. It involved nearly 500 postmenopausal women whose cancer had returned or spread and who had not yet received treatment for this advanced…

This study follows patients with hormone-sensitive breast cancer who completed a previous 48-week trial. It aims to collect safety information on a drug that suppresses ovarian function, given alongside standard hormone therapy, for up to four additional years. The main goal is t…

This study is testing if a new, gentler schedule for starting hormone therapy pills can help breast cancer patients stick with their treatment. It will compare the standard daily dose to a schedule where patients take the pill every other day for the first month before switching …

This study is testing the safety and feasibility of using two drugs, anastrozole and palbociclib, together to control advanced breast cancer that has spread. It is for postmenopausal women whose cancer is hormone-sensitive and HER2-negative. The trial has two groups: one testing …

This study is testing whether adding an immunotherapy drug (atezolizumab) to standard breast cancer treatment helps prevent the cancer from coming back in high-risk patients. It involves about 1,200 people with HER2-positive breast cancer who still had cancer cells after their in…

This study is testing a new oral drug called AZD5305 to see if it is safe and can help control advanced cancers. It is being tested alone and in combination with other cancer medicines in over 700 patients with various hard-to-treat solid tumors. The main goals are to find the ri…

This study is investigating whether a high-intensity exercise program during chemotherapy helps breast cancer patients respond better to treatment and feel better overall. It will compare 55 patients doing supervised workouts to those maintaining their usual activity level. Resea…

This study is testing whether women aged 70 and older with a specific, lower-risk type of early-stage breast cancer can safely skip hormone-blocking pills after their initial surgery and radiation. The goal is to see if avoiding these medications, which can have significant side …

This study aims to track side effects and quality of life in breast cancer patients receiving standard radiotherapy after surgery. It will follow 500 patients for two years after treatment to record their experiences. The goal is to better understand how this common treatment aff…

This study is testing two new experimental drugs (LEE011 and BYL719) combined with the standard hormone therapy letrozole for women with advanced ER+ breast cancer. The main goals are to find the safest and most effective doses and to see how well the combinations work to control…

This is a first-in-human study testing a new type of cancer treatment called P-MUC1C-ALLO1 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body tolerates this 'off-the-shelf' CAR-T …

This study is monitoring the safety of the drug Talzenna in a small group of patients with advanced breast cancer that has returned or cannot be surgically removed. The patients have a specific genetic profile and have received prior chemotherapy. The main goal is to track any si…

This early-stage study is testing a single, powerful dose of radiation given before surgery to women with early-stage breast cancer. The goal is to find the highest dose that is safe and effective at destroying the tumor. Researchers will carefully monitor patients for side effec…

This study is testing an experimental drug called BB-1701 for people with advanced breast cancer that has spread or cannot be removed by surgery. The trial aims to find the safest and most effective dose and see how well the drug shrinks tumors in patients who have already receiv…

This large study is testing whether some women with early-stage breast cancer can safely skip a common surgical procedure called a sentinel lymph node biopsy. The procedure can cause lasting side effects like arm swelling and pain. Researchers are comparing survival and recurrenc…

This study is testing whether focused radiation treatment can safely control breast cancer in patients who cannot have surgery. It involves 15 patients who will receive five radiation sessions and be followed for five years. The goal is to see if this approach can shrink or elimi…

This study is testing whether a combination of two immunotherapy drugs, nivolumab and ipilimumab, can help control advanced breast cancer that has spread and has a high number of genetic mutations. The trial is enrolling 30 people with a specific type of breast cancer (HER2-negat…

This study is testing a combination of three drugs—cisplatin, romidepsin, and nivolumab—for people with advanced triple-negative breast cancer or breast cancer linked to a BRCA gene mutation. The goal is to see if this combination is safe and can help control the cancer in patien…

This study is testing a new, highly focused radiation machine called the GammaPod for women with early-stage breast cancer. The goal is to see if delivering radiation in just 5 sessions can control the cancer while leading to better cosmetic outcomes than older radiation techniqu…

This study is testing if a supervised exercise program during chemotherapy before breast cancer surgery can help shrink tumors better and help patients tolerate treatment. About 102 women were randomly assigned to either follow the exercise program or receive usual care. Research…

This study is testing a new surgical technique for rebuilding the breast after cancer removal. It aims to see if using a small armpit incision and the patient's own fat tissue leads to better cosmetic results and quality of life. The study will enroll women with early-stage breas…

This study aims to find out which of two common radiation treatments is better for people with breast cancer that hasn't spread. About 1,200 participants were randomly assigned to receive either proton therapy or photon therapy. Researchers will follow them for at least 10 years …

This early-stage study is testing a new vaccine (PVX-410) alone and combined with an immunotherapy drug (durvalumab) for women who have already finished standard treatment for stage II or III triple-negative breast cancer. The main goals are to check if the treatments are safe an…

This study is testing whether a much shorter course of radiation, focused only on the area where the tumor was removed, is as safe and effective as the standard 6.5 weeks of whole-breast radiation. It is for women over 40 with early-stage breast cancer who had a lumpectomy. The g…

This study is testing whether adding the drug tucatinib to two standard breast cancer medications (trastuzumab and capecitabine) can help control advanced HER2-positive breast cancer that has worsened after previous treatments. It involves about 66 people with cancer that has spr…

This study is testing the safety and effectiveness of a new oral drug, ARV-471, when taken together with an existing cancer drug, abemaciclib. It is for adults with advanced or metastatic breast cancer that is hormone-sensitive but has stopped responding to previous treatments. T…

This study is testing an oral drug called Lonsurf in people whose breast cancer has spread and worsened despite other treatments. It aims to see if the drug can slow or stop the cancer's growth for a meaningful period. The trial will enroll 86 participants, including those who ha…

This large study tested whether adding a drug called everolimus to standard hormone therapy is better at preventing breast cancer from coming back. It involved nearly 2,000 patients with a high-risk type of breast cancer that is fueled by hormones. The goal was to see if the one-…

This study is testing whether giving a shorter course of radiation to just part of the breast at the same time as chemotherapy is as safe and works as well as giving the radiation and chemotherapy at separate times. It involves women with early-stage breast cancer who have had su…

This study is testing a new three-drug combination for people with advanced HER2-positive breast cancer that has stopped responding to standard treatments. It combines an immunotherapy drug (atezolizumab) with two established cancer drugs (trastuzumab and vinorelbine). The goal i…

This study is testing whether patients with early-stage HER2-positive breast cancer who respond very well to initial treatment can safely receive only 6 months of targeted therapy instead of the standard 12 months. Researchers want to see if the shorter treatment works as well wh…

This study is testing whether patients with advanced HER2-positive breast cancer can safely stop their targeted treatment after having their cancer under control for at least three years. The trial involves 82 participants who will either continue treatment or stop it, with resea…

This study is testing a new mixed reality system called VascuLens 2.0 to see if it helps surgeons perform a specific type of breast reconstruction surgery faster and with fewer complications. The system uses a special headset to project a 3D map of the patient's blood vessels dir…

This study is testing whether using a special coated mesh during breast reconstruction surgery can reduce complications. It involves 100 women with breast cancer who are having reconstruction with implants immediately after their mastectomy. Researchers will compare outcomes betw…

This study is testing a new oral drug called CFI-400945 for women with advanced breast cancer that has spread and stopped responding to standard chemotherapy. The drug works by blocking a specific protein that helps cancer cells grow and divide. The main goal is to see if the dru…

This study is testing whether some patients with early-stage, hormone-positive breast cancer that has spread to 1-2 lymph nodes can safely avoid a major surgery called axillary lymph node dissection (ALND). Researchers want to see if using a less invasive lymph node procedure dur…

This study is testing a new, potentially gentler combination of chemotherapy drugs given before surgery for early-stage HER2-positive breast cancer. It aims to see if this less toxic treatment works as well as the current standard by measuring if it completely removes the cancer.…

This early-stage study is testing a new drug called A166 in people with advanced HER2-positive cancers that have spread and cannot be removed by surgery. The main goals are to find a safe dose and see if the drug helps shrink tumors. It will include about 120 adults whose cancer …

This early-stage study is testing a new drug called LOXO-783, both alone and combined with other cancer treatments. It is for adults with advanced breast cancer or other solid tumors that have a specific genetic change called a PIK3CA H1047R mutation. The main goals are to find a…

This early-stage study is testing a new drug, OP-1250, combined with an existing cancer drug, palbociclib, for people with advanced or spreading breast cancer. The main goals are to find the safest dose of the combination and see how the body processes the drugs. Researchers will…

This study is testing whether women aged 65+ with early-stage, hormone-positive breast cancer can safely skip a procedure called sentinel lymph node biopsy during their tumor-removal surgery. The goal is to see if avoiding this extra surgery leads to acceptable cancer recurrence …

This study is testing the safety and effectiveness of a new oral drug, ARV-471, when taken together with an existing cancer drug called ribociclib. It is for adults with advanced or metastatic breast cancer that is hormone-sensitive but has stopped responding to previous treatmen…

This study is testing whether adding the drug alpelisib to standard fulvestrant treatment helps control advanced breast cancer better than fulvestrant alone. It is for men and postmenopausal women whose cancer has a specific genetic change (PIK3CA mutation) and has worsened after…

This study is testing whether a daily pill called olaparib can help prevent breast cancer from returning in patients who are at high risk. It is for people who have a specific inherited gene change (BRCA1/2) and have already finished their initial cancer treatments like surgery a…

This study is testing two special imaging tools to help surgeons see the edges of a breast tumor more clearly during surgery. The goal is to remove all the cancer in one operation, reducing the need for a second surgery and potentially improving cosmetic results. It involves 175 …

This study is testing how well a combination of two drugs (docetaxel and trastuzumab) works to shrink tumors before surgery in Nigerian women with a specific type of breast cancer called HER2-positive. The main goal is to see if the treatment can completely eliminate the cancer c…

This study is testing an experimental drug called Dato-DXd against standard chemotherapy for people with advanced HR-positive, HER2-negative breast cancer that has worsened after one or two prior rounds of chemotherapy. The main goals are to see if Dato-DXd helps patients live lo…

This study is testing whether a combination of two drugs, sacituzumab govitecan and pembrolizumab, can help control early-stage triple-negative breast cancer when given before surgery. It is for patients whose cancer did not shrink after their initial round of chemotherapy and im…

This study is for people with a specific type of advanced breast cancer that has a genetic change called PIK3CA and has continued to grow despite standard hormone-based therapy. It aims to see if a new drug combination (inavolisib + fulvestrant) works better and is safer than an …

This study is testing whether new drug combinations can help prevent triple-negative breast cancer from returning after surgery. It involves 1,174 patients who still had cancer cells present after initial chemotherapy and surgery. Participants will receive either the new drugs (d…

This study compares a new robotic surgery system to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. It aims to see if the robotic approach is as safe and effective while potentially improving cosmetic results and recovery. The trial…

This study is testing if adding a single, targeted dose of radiation to an immunotherapy drug (pembrolizumab) before surgery is safe and can help shrink breast tumors. It involves about 27 patients with early-stage, operable breast cancer. Researchers want to see if this combinat…

This study aimed to see if a drug called Capivasertib could help prevent breast cancer from coming back. It focused on women with a specific type of breast cancer who had finished their main treatment but had tiny traces of cancer DNA in their blood, which is an early warning sig…

This study is testing two different combinations of chemotherapy drugs, given before surgery, to see which is better at shrinking breast tumors. For some patients, a targeted drug called trastuzumab (Herceptin) is added to one of the combinations. The goal is to reduce the amount…

This is an early-stage study to test the safety and side effects of a new injectable drug called BL-M02D1 in adults with advanced triple-negative breast cancer or other solid tumors that have spread and have no standard treatment options. The main goals are to find the highest do…

This early-stage study is testing the safety of combining two drugs, alpelisib and sacituzumab govitecan, for people with advanced HER2-negative breast cancer that has spread or returned. The main goal is to find the safest and most effective dose of this combination for use in f…

This study allows patients who were already taking the drug ruxolitinib in a previous cancer trial to continue receiving it, along with their other cancer treatments, if they are benefiting. It's for people with pancreatic, colorectal, breast, or lung cancer who are doing well on…

This study is testing a 3-month injection called TOL2506, which aims to temporarily shut down the ovaries in premenopausal women with a common type of breast cancer. The goal is to see if this injection, when combined with standard hormone-blocking pills, effectively lowers hormo…

This study is testing two different ways to provide follow-up care for people who have finished treatment for early-stage breast or colorectal cancer. It compares the usual cancer specialist care to a new model where a primary care doctor works right in the cancer clinic. The goa…

This study is testing whether adding a drug called ribociclib to standard hormone therapy can better prevent early-stage, hormone-sensitive breast cancer from returning. It is for patients who have completed initial surgery and have a specific marker of very low-level cancer in t…

This study is testing a new three-drug combination (gedatolisib, fulvestrant, and palbociclib) against standard treatments for people with advanced HR+/HER2- breast cancer. It is for patients whose cancer has continued to grow despite prior treatment with a common type of hormone…

This study is testing whether adding a drug called ribociclib to standard hormone therapy (letrozole) helps shrink breast tumors more effectively before surgery. The goal is to help more women achieve excellent outcomes without needing chemotherapy. Researchers are comparing the …

This early-stage study aimed to test whether injecting seasonal flu vaccine directly into breast cancer tumors is safe. The approach was being tested in women with triple-negative or HER2-positive breast cancer who were scheduled for chemotherapy. Researchers planned to give incr…

This study is testing whether a new targeted drug called datopotamab deruxtecan (Dato-DXd) works better and is safer than standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. It will involve about 644 participants who have…

This study allows ovarian and breast cancer patients who were benefiting from olaparib treatment in a previous clinical trial to continue receiving the medication. The program provides ongoing access to the drug for 185 patients who show continued clinical improvement. Participan…

This early-stage trial is testing the safety and appropriate dosing of an experimental drug called GDC-9545 for advanced breast cancer. The study involves 181 patients with estrogen receptor-positive breast cancer that has spread or returned. Researchers are testing GDC-9545 alon…

This study is testing a new combination of two cancer drugs, trastuzumab deruxtecan and pembrolizumab, for people with advanced breast or lung cancer. The first part aims to find a safe dose, and the second part will see how well the combination works to control the cancer. It is…

This study is testing whether switching breast cancer treatment earlier, based on a blood test that detects cancer DNA, helps control the disease longer than waiting for standard scans to show it's getting worse. It involves 24 people with advanced, hormone-positive breast cancer…

This study is testing a much shorter, one-week radiation schedule for breast cancer patients who need treatment to the breast area and nearby lymph nodes. It aims to see if this faster approach is as effective as standard, longer courses at controlling cancer while checking for s…

This trial is testing a new treatment for advanced cancers that have spread to the lining of the chest (pleura), including mesothelioma, lung cancer, and breast cancer. Doctors collect a patient's own immune cells (T cells), genetically modify them to recognize a cancer protein c…

This large, late-stage trial is comparing a new two-drug treatment to the current standard treatment for triple-negative breast cancer. It aims to see if the new combination is better at preventing the cancer from coming back after surgery. The study involves nearly 2,000 adults …

This early-stage trial is testing a new drug called ARV-471, both alone and combined with an existing cancer drug (palbociclib), for people with advanced breast cancer that has stopped responding to hormone therapy and chemotherapy. The study aims to find safe doses and see if th…

This study is testing whether a new drug called vepdegestrant, when combined with palbociclib, works better than the current standard treatment (letrozole plus palbociclib) for advanced breast cancer. It's for adults with a specific type of breast cancer (estrogen receptor positi…

This study is testing whether adding a new drug called inavolisib to two standard breast cancer medications works better than the standard medications alone. It is for people with a specific type of advanced breast cancer (HR+/HER2- with a PIK3CA mutation) that has worsened after…

This study compares two specific surgical techniques used during breast-conserving surgery for tumors located in the central part of the breast, near the nipple. It involves 106 female patients with early-stage breast cancer. The main goal is to see which technique—the standard G…

This study is testing if the drug pacritinib can help control the growth of advanced solid tumors that have a specific genetic feature called 1q21.3 amplification. It is enrolling up to 74 adults with cancers, mostly breast cancer, that have stopped responding to standard treatme…

This trial is testing whether personalized treatment plans work better than standard care for high-risk breast cancer. Doctors analyze each patient's tumor genetics to choose the most promising drug combination before surgery. The study involves 200 participants and aims to under…

This study is testing whether combining mammograms with MRI scans can help detect breast cancer earlier in women at high genetic or family risk. Researchers want to see if this two-part screening approach finds small cancers better than mammograms alone, especially in younger wom…

This study is testing a new type of MRI scan to help find breast cancer in women with dense breast tissue. Dense breasts can make cancers harder to see on a standard mammogram. The new scan is quick, doesn't use a contrast dye, and aims to be more accurate than ultrasound and saf…

This study aims to compare four advanced imaging techniques—MRI, digital mammography, ultrasound, and PET scans—to see which combination best maps out the extent of breast cancer before surgery. It involves 400 women recently diagnosed with breast cancer who are scheduled for sur…

This study is testing a special imaging scan to see if it can predict how well chemotherapy works for women with breast cancer before they have surgery. The scan is done before, during, and after chemotherapy to see if changes in the tumor can show early signs of treatment succes…

This study is testing a new program to help women in Ethiopia, South Africa, Nigeria, and Tanzania get diagnosed and treated for breast cancer faster. Healthcare providers will be trained to offer breast exams to women visiting clinics for any reason, and patient navigators will …

This study is testing whether a special MRI-guided biopsy can accurately tell when breast cancer has completely disappeared after chemotherapy. Researchers want to see if this biopsy method is reliable enough that, in the future, some women who show no cancer on their post-treatm…

This study is testing a special type of ultrasound called elastography to help surgeons make better decisions during breast cancer operations. It focuses on patients who had chemotherapy before surgery and aims to see if this scan can accurately tell if cancer remains in the lymp…

This study looks back at 1,064 women who had breast cancer surgery to compare four different methods surgeons use to locate small, non-palpable tumors during operations. The goal is to determine which technique most reliably helps surgeons remove all cancerous tissue in one proce…

This study is testing a new, non-radioactive dye method to find the first lymph nodes where breast cancer might spread. It compares a fluorescent green dye (ICG) to the current standard method that uses a radioactive tracer. The goal is to see if the new dye is just as effective …

This study is testing a new type of MRI scan designed to detect breast disease without needing an injected contrast dye. It aims to provide a better option for women with dense breast tissue, where standard mammograms can miss tumors. Over 1,000 women referred to a breast clinic …

This study aimed to see if analyzing tiny particles in spinal fluid could help doctors better detect when breast cancer spreads to the lining of the brain and spinal cord. It planned to enroll patients already suspected of having this serious complication. The goal was to compare…

This study aimed to test if a special type of ultrasound scan, called contrast-enhanced ultrasound (CEUS), could tell doctors earlier if a patient's triple-negative breast cancer was responding to a combination of chemotherapy and immunotherapy. The goal was to see if changes on …

This study is testing a new imaging method called MSOT to see if it can help doctors better visualize breast tumors and melanoma. Participants will have the MSOT scan right before their standard breast biopsy procedure. The goal is to see if this new technology can successfully c…

This study is testing a genomic test called Prosigna to see if it helps doctors and patients choose the best personalized treatment before breast cancer surgery. Researchers will give the test to 60 women with hormone-positive, HER2-negative breast cancer to see if the results ch…

This study is testing how well a lymph node biopsy procedure works for women with advanced breast cancer who have already received chemotherapy. Researchers want to see if this less invasive test can accurately detect any remaining cancer cells after treatment. The goal is to hel…

This early-stage study aimed to test a new radioactive tracer for PET scans, called [18F]GEH121224, to see if it could better detect and monitor HER2-positive breast cancer that has spread. The study planned to enroll 12 women with advanced breast cancer to check the safety of th…

This is a small, early-stage study to test a new type of imaging scan. The scan uses a special radioactive tracer that attaches to a protein (CEA) made by many cancers. The goal is to see if this new scan can find cancer spots that standard imaging tests might miss in patients wi…

This study is testing new ways to process ultrasound signals to create clearer pictures of the breast. Researchers want to see if these advanced techniques can help doctors better see important features like microcalcifications and tell the difference between fluid-filled cysts a…

This study is testing a new fluorescent dye called LS301-IT. It is given by IV before surgery to help surgeons see the edges of breast cancer tissue and nearby lymph nodes more clearly. The main goals are to check if the dye is safe and to see how well it helps guide surgery for …

This study tested a new type of PET scan to see if it could better show where and how much HER2-positive breast cancer has spread in the body. It involved 18 women whose cancer had spread beyond the original tumor site. The goal was to see if this special scan could help doctors …

This study is testing if a simple blood test can help improve breast cancer screening. It aims to see if the test can identify women who are very unlikely to have cancer after a suspicious mammogram result. If successful, this could reduce the need for many women to go through fu…

This study is testing a new wearable device—a smart bra—to see if it can detect breast abnormalities that might indicate cancer. It involves 70 women, some with diagnosed breast cancer and some without, to check how accurately the device identifies problems. The goal is to develo…

This study is testing if a needle biopsy can accurately tell when breast cancer has been completely eliminated by chemotherapy. If the biopsy shows no cancer, it might mean some patients could safely avoid surgery. Researchers are comparing the biopsy results to what is found dur…

This study is testing a new tool designed to measure arm circumference, which helps monitor for lymphedema (swelling) after breast cancer surgery. Researchers want to see if this device is more accurate, faster, and easier for both nurses and patients to use compared to a standar…

This study is testing a new imaging technology called HyperSight to see if it can take clearer pictures during radiation therapy. The goal is to help doctors more accurately target cancer cells while better protecting healthy tissue. About 40 adults with head and neck, breast, lu…

This study is testing if a special type of mammogram that uses a contrast dye is better at finding new or returning breast cancers in women who have already had the disease. It compares this new method to the standard mammogram to see if it finds more cancers without causing too …

This study looks back at past surgeries to compare two methods for finding small, hidden breast tumors that can't be felt by hand. It involves 1,400 women who had breast-conserving surgery. Researchers want to see if using a tiny magnetic seed is as good as or better than using a…

This study tested a new, much faster type of breast MRI scan to see if it can accurately tell the difference between cancerous and non-cancerous breast tissue. It involved 264 women who were already scheduled for a standard breast MRI as part of their care. The goal is to make br…

This study is testing a new device called the LymphaTech Scanner to see if it can effectively and quickly detect early signs of arm swelling (lymphedema) in people treated for breast cancer. Researchers will compare it to the current standard device (Perometer) by measuring arm v…

This study aims to see if a patient navigator can help women get timely follow-up tests after an abnormal mammogram, especially for groups most affected by COVID-19 delays. It will enroll about 196 women and randomly assign them to receive either usual care or support from a navi…

This study is testing a new 3D imaging technology called cone beam breast CT (KBCT) to see if it can detect breast cancer as well as or better than standard mammograms. Over 1,000 women aged 40 and older will receive both a mammogram and the new 3D scan within a few weeks of each…

This study is testing whether a low daily dose of the drug tamoxifen can help prevent breast cancer in women who had radiation therapy to their chest area earlier in life. It involved 84 women who were randomly assigned to take either the low-dose tamoxifen or a placebo pill for …

This study aims to find the best ways to get more women in Kenya screened for breast and cervical cancer. It will test different community support strategies, like education and help navigating the healthcare system, to see which ones work best. The goal is to help women catch ca…

This study tests a health education program designed for women who are leaving jail. The program aims to improve their knowledge and actions related to preventing cervical cancer, breast cancer, sexually transmitted diseases, and unintended pregnancy. Researchers are comparing th…

This study is testing simple reminder systems to help more women get recommended breast cancer screenings. It sends text message reminders to patients and alerts doctors in their computer system when a patient is overdue for a mammogram. The goal is to see if these low-cost nudge…

This study is testing whether a combination of two hormone medications (bazedoxifene and conjugated estrogens) can reduce markers of breast cancer risk in women who are at increased risk and experiencing menopausal hot flashes. About 120 women will be randomly assigned to take th…

This study is testing whether regular aerobic exercise can prevent cancer from returning in people who have already been treated. Researchers are working with 33 people who have had breast, prostate, or colorectal cancer to find the right amount of weekly exercise that safely low…

This study is testing whether it is safe and practical for breast cancer survivors to take a medication called flibanserin while they are on their standard hormone therapy (tamoxifen or similar drugs). The researchers want to see if flibanserin can help improve low sexual desire,…

This study is testing how well a single pill containing two drugs (netupitant and palonosetron) works to prevent nausea and vomiting caused by a specific type of chemotherapy for breast cancer. The trial involves 55 female patients in Hong Kong who are receiving their first round…

This study wanted to see if offering beauty treatments to breast cancer patients right after surgery could help them feel better about their bodies and improve their overall quality of life. It planned to compare two groups: one receiving the pampering care and one not. The trial…

This study is testing a new rehabilitation program that combines exercise and psychological therapy to help breast cancer patients who are struggling with anxiety or depression. It aims to see if this approach can reduce these negative emotions, improve mental resilience, and enh…

This study is testing whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer stay more active and protect their heart health while they undergo chemotherapy. About 135 participants are randomly assigned to try eith…

This study is testing whether adding a personalized 30-minute education session with a radiation therapist can help breast cancer patients feel less anxious and more prepared during their radiation treatment. It compares this extra support to the current standard care. The goal i…

This study aims to see if two different relaxation programs, involving stretching and breathing exercises, can help improve the physical and emotional well-being of women with breast cancer while they are receiving radiation therapy. About 700 participants are randomly assigned t…

This study aimed to test if an online patient navigation program could help women with breast cancer get supportive care services (like counseling or pain management) more easily than traditional in-person methods. It planned to compare the two approaches over four weeks by measu…

This study is testing a 16-week home exercise program designed specifically for Hispanic women who have survived breast cancer. Researchers want to find the best ways to encourage regular physical activity in this group. Participants are asked to exercise 3-5 times per week and a…

This study is testing whether a simple writing exercise can help breast cancer patients better manage the difficult side effects of their medication and stick to their treatment plan. 250 women taking aromatase inhibitors will write short essays monthly for six months—some about …

This study is testing whether a vaginal estrogen ring or a non-hormonal moisturizer cream works better to relieve vaginal dryness in breast cancer survivors taking anti-estrogen medication. It involves 33 postmenopausal women who have this common side effect. Researchers will tra…

This study is developing and testing a mobile app program to help breast and rare cancer survivors manage the fear of their cancer returning. Researchers are working with 252 survivors to create and refine different versions of the app, checking if they are easy to use and helpfu…

This study is testing whether virtual reality exercises work as well as standard physical therapy to help women recover arm function after breast cancer surgery. Researchers are comparing both approaches, with and without healthy lifestyle changes, in 60 breast cancer survivors. …

This study is testing a scalp cooling device to see if it can safely prevent or reduce hair loss in Chinese women undergoing chemotherapy for breast cancer. It involves 25 participants who will use the cooling cap during their treatment cycles. The main goal is to collect data on…

This study is testing if listening to nature sounds during a breast biopsy can help reduce patients' pain and anxiety. About 200 participants will be randomly assigned to either listen to nature sounds or receive standard supportive conversation during the procedure. Researchers …

This study is testing a web-based portal designed to help young women (ages 18-39) who have been diagnosed with breast cancer. The portal helps monitor common symptoms like vaginal dryness and fatigue, provides self-management information and resources, and offers a way to connec…

This small pilot study is testing whether curcumin, the active ingredient in turmeric, can reduce joint pain in breast cancer survivors. The pain is a common side effect of essential hormone-blocking medications. Forty-two participants will take either the curcumin supplement or …

This study is developing and testing a shorter version of mindfulness therapy specifically for older Black women who have survived breast cancer and are experiencing mild to moderate depression. The program involves 8 weekly one-hour online group sessions that combine mindfulness…

This study aimed to see if giving a single dose of methadone during breast reconstruction surgery could provide longer-lasting pain relief. The goal was to reduce the total amount of opioid painkillers patients need after their operation, which could lower the risk of side effect…

This study is testing whether an artificial intelligence (AI) management system can help reduce anxiety and depression in breast cancer patients who are taking CDK4/6 inhibitor pills at home. It will compare the AI system against standard follow-up care to see which is better at …

This study is testing whether listening to relaxing classical music can help women with breast cancer feel less anxious and depressed and improve their quality of life during surgery and chemotherapy. Researchers will also check if the music therapy changes certain markers in the…

This study is testing whether a 5-week computer training program can help breast cancer survivors who are having memory and attention problems after chemotherapy. Researchers want to see if using special memory-training software can improve these cognitive issues. The study will …

This study is testing whether daily supplements that support gut health (called prebiotics and synbiotics) can help reduce memory and thinking problems that sometimes occur during chemotherapy for breast cancer. Researchers will give supplements to about 80 patients for four mont…

This study is testing whether a special cooling cap can help prevent hair loss in Black patients receiving chemotherapy for breast cancer. It involves 30 participants who will use the cap during their treatment. The main goal is to see if the cap helps patients keep at least half…

This study is testing whether injections of platelet-rich plasma (PRP) into the vulva and vagina can improve uncomfortable menopause symptoms in breast cancer survivors. It involves 18 participants who have completed or are undergoing breast cancer treatment and are experiencing …

This study is comparing two different schedules of radiation therapy given after surgery for breast cancer. It aims to see if a shorter 3.5-week schedule causes less fatigue and fewer side effects than the standard 5.5-week schedule, while being just as effective. The trial invol…

This study is testing if whole-body cryotherapy (brief exposure to extreme cold) can reduce joint pain caused by hormone therapy in breast cancer patients. 70 participants with this pain will be randomly assigned to receive either a full 4.5-minute cold treatment or a shorter 1-m…

This study is testing whether a personalized mobile app with live coaching can improve quality of life for people who have had cancer. The 18-month program focuses on exercise, meditation, and diet advice. Researchers will compare the app's coaching to standard lifestyle resource…

This study is testing whether increasing daily movement can help reduce the chronic pain some women experience after breast cancer surgery. It focuses on young Hispanic women who have moderate pain lasting at least six months. Participants will use a Fitbit to track their steps a…

This study is testing whether a free mobile app can help breast cancer survivors exercise more after finishing their main treatments. Researchers are comparing 200 survivors who use the app for 12 weeks against a group that just gets standard exercise advice. The goal is to see i…

This study is testing whether adding an interactive 3D visualization tool to a standard surgical consultation helps breast cancer patients feel more satisfied with the information they receive about reconstruction options. Researchers want to see if women who use the 3D tool are …

This study is comparing two methods of breast reconstruction after mastectomy for breast cancer. It focuses on a newer technique that uses less back muscle, hoping to reduce shoulder pain and stiffness while still achieving a good cosmetic result. Researchers are tracking 200 pat…

This study is testing a smartphone app designed to help breast cancer survivors become more physically active and practice mindfulness. Over 300 participants will use a fitness tracker and app for 24 weeks, with some also getting support from a buddy, a coach, or mindfulness less…

This study aims to understand how regular exercise might change the biology of breast tumors. Researchers are comparing women with early-stage breast cancer who are either very active or mostly sedentary. They will analyze tumor tissue from surgery to look for differences in gene…

This study aims to understand the experiences of older adults (age 70+) with breast cancer to find ways to improve their care and health outcomes. Researchers are following a group of 253 patients to learn about the barriers they face, their treatment patterns, and how their phys…

This study aims to understand how often chronic pain develops after breast cancer surgery and what factors put patients at risk. Researchers will follow 220 patients for at least four months after their surgery to track pain levels and quality of life. The goal is to gather infor…

This study is testing whether a new type of PET scan can measure a specific protein (PARP-1) inside breast cancer tumors. About 30 people with suspected or confirmed breast cancer will get this special scan before their surgery or chemotherapy. Researchers will compare the scan r…

This study looked at patients with advanced breast cancer to understand if losing the estrogen receptor (ER) target during the disease is different from having triple-negative breast cancer from the beginning. Researchers compared survival and treatment response between these two…

This study aims to understand whether breast cancer patients lose muscle outside the radiation treatment area during radiotherapy, and if that muscle loss is connected to their fatigue. Researchers will follow 20 women with non-metastatic breast cancer, measuring their muscle via…

This study aims to understand how genetic testing affects stress and anxiety levels in people with or at high risk for breast cancer. Researchers will measure stress using questionnaires before testing and several times after patients receive their results. The goal is to gather …

This study aims to understand how chemotherapy affects memory, focus, and thinking skills in people with breast cancer or lymphoma. Researchers will follow over 1,400 patients and healthy volunteers, testing their cognitive function before, right after, and for years following tr…

This study aims to understand why and how certain breast cancer drugs can damage the heart over many years. Researchers will follow 200 women for up to 15 years, tracking their heart health with regular scans and surveys. The main goal is to learn how a person's background—includ…

This study is testing whether 3D printed models of the breast help breast cancer patients make better decisions about their surgery. Researchers are comparing patients who receive 3D printed models against those who receive traditional 2D imaging scans. The goal is to see if the …

This study aims to understand how early breast cancer treatment affects women's quality of life and daily function years after they finish therapy. Researchers are following 253 women who are cancer-free for at least three years, comparing those who received chemotherapy to those…

This study uses advanced brain MRI scans to understand how chemotherapy affects the brain in older women with breast cancer. Researchers will scan 49 women before and after chemotherapy to look for changes in brain structure and function. The goal is to find brain scan patterns t…

This study aims to understand how women feel physically and emotionally after treatment for certain pre-cancerous breast conditions. Researchers surveyed over 900 women who had been diagnosed with these conditions to learn about their pain levels and overall experience. The goal …

This study aims to understand how breast cancer treatments affect menstrual cycles and quality of life in young women. Researchers are following 810 women aged 45 and younger who have been recently diagnosed with breast cancer. The goal is to learn how often treatment causes earl…

This study follows young breast cancer survivors for 10 years to understand how chemotherapy affects their long-term fertility and ability to have children. Researchers are comparing outcomes between patients who underwent fertility preservation procedures and those who did not. …

This study is measuring how breast reconstruction surgery affects shoulder muscle strength and movement in breast cancer patients. Researchers are following 32 women who had a specific type of reconstruction using back muscle tissue, checking their strength and quality of life be…

This study follows 500 breast cancer survivors for years after their treatment ends to understand their long-term health and quality of life. Researchers collect feedback through questionnaires and samples to learn about complications, immune responses, and what makes recovery mo…

This study is testing whether a new payment model that encourages better care coordination improves health outcomes and reduces costs for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who receive chemotherapy through specific Hawaii prov…

This study aims to understand how a 10-week exercise program might change the types of bacteria living in the gut of breast cancer survivors. Researchers will carefully control participants' diets and measure if changes in gut bacteria are linked to improvements in fatigue and ot…

This study aims to learn if simple blood tests can help doctors personalize radiation treatment for breast cancer. Researchers are tracking tiny cancer DNA fragments and immune cells in the blood of 217 patients before, during, and after their radiation therapy. The goal is to se…

This study aims to find early warning signs that predict if breast cancer will spread to the brain and spinal cord. Researchers are analyzing old tumor tissue and blood samples from 22 women who were treated for early-stage breast cancer. The goal is to identify markers that coul…

This study aims to understand how different breast cancer surgery decisions affect patients' emotional well-being and satisfaction over time. Researchers are following 345 women with early-stage breast cancer, surveying them before surgery and at several points afterward. The goa…

This study aims to find biological markers that can predict which early breast cancer patients will respond well to chemotherapy given before surgery. Researchers will analyze tumor tissue and blood samples from 268 patients to look for immune system signals and cancer fragments …

This study aims to understand how a common type of cancer immunotherapy might affect the heart's smallest blood vessels. Researchers will follow 25 adults with breast or lung cancer who are starting this treatment. They will use heart scans and blood tests to monitor for changes …

This study aims to collect information on pregnancy, fertility preservation, and child health for women who had breast cancer before age 50. By reviewing the medical records of 22,000 women, researchers want to understand how cancer treatments affect family planning and pregnancy…

This study aims to understand how chemotherapy for breast cancer affects heart function, exercise capacity, and fatigue. It follows about 400 women with early-stage breast cancer and compares them to women without cancer over two years. Researchers will use heart scans, walking t…

This study aims to collect and analyze information about how breast cancer is found, treated, and what the outcomes are for transgender and gender-diverse people. Researchers are looking at past medical records from 125 people to better understand the unique experiences and chall…

This study aims to understand how breast cancer treatment affects quality of life differently in women of various ages. Researchers will follow 650 women for 18 months after diagnosis, collecting information through questionnaires about their physical and emotional well-being. Th…

This study is testing a new type of PET scan that uses a special tracer to take pictures of breast cancer. The goal is to see if the scan can measure a specific protein activity inside tumors, which might help doctors understand the cancer better. Up to 50 adults with known or su…

This study aims to see if providing a personalized genetic risk score helps women at high risk for breast cancer make more informed decisions about taking preventive medication. It involves 737 women who will receive their genetic risk score during a standard consultation and the…

This study is testing whether a decision guide helps women aged 39-49 make more informed choices about mammogram screening. 700 participants will read the guide and complete surveys over one year to see how it affects their knowledge, conversations with doctors, and final screeni…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study is creating a collection of breast cancer tissue samples from 600 people who previously participated in a treatment trial. Researchers will analyze these samples to find biological markers that might predict if cancer returns or becomes resistant to treatment. The goal…

This study is testing whether regular brain scans and spinal fluid tests can detect the early spread of breast cancer to the brain in people with HER2-positive breast cancer. Researchers want to see if finding this spread early, before symptoms start, is possible and practical. T…

This study aims to understand why some young women treated for breast cancer experience more severe fertility loss after chemotherapy than others. Researchers will follow 73 young women to see if specific genetic markers, linked to the age of natural menopause, can predict who is…

This study aims to understand how the environment immediately surrounding a HER2-positive breast tumor changes when a patient receives chemotherapy before surgery. Researchers will observe 30 patients undergoing this standard treatment to see how the tumor's local area responds. …

This study aims to create a tool to help doctors predict which older adults with breast cancer are most at risk for severe side effects from chemotherapy. Researchers will study 700 patients aged 65 and older to identify health factors and blood markers linked to higher toxicity …

This study aims to improve how doctors use a special total-body PET scanner to see cancer more clearly. Researchers will test three different FDA-approved imaging agents in people with prostate cancer, breast cancer, or neuroendocrine tumors. The goal is to collect better data on…

This study aimed to understand how much information people can remember about their own cancer screening and diagnosis. Researchers wanted to see if giving people time or helping them access their online medical records would help them recall more accurate details. The study was …

This study aims to understand how a person's genes affect their response to the drug raloxifene, which is used to reduce breast cancer risk in people with a condition called LCIS. Researchers will analyze genetic data from 600 patients to see if specific gene variations predict h…

This study looked at whether exercise and mind-body programs in the weeks between breast cancer diagnosis and surgery could help women feel less stressed and improve their mood. Researchers also checked if these activities caused any changes in breast cancer cells or blood hormon…

This study is observing nearly 3,000 newly diagnosed breast cancer patients across Latin America to understand how the disease is treated and what outcomes patients experience. Researchers are collecting information about patient characteristics, treatment approaches, and surviva…

This study aims to understand how much oxygen women with HER2-positive breast cancer use during exercise when they have mild heart issues from their cancer treatment. Researchers want to see if this exercise test can predict how well participants' hearts and lungs will work if th…

This study is looking at how high and low doses of omega-3 fish oil supplements affect breast tissue in women who have had a certain type of breast cancer. Researchers are testing 80 survivors to find biological signs that omega-3s might help prevent cancer from coming back. The …

This study aims to understand the long-term fertility and family planning outcomes for young women diagnosed with breast cancer. Researchers will follow 2,000 patients aged 40 or younger to see if having children after diagnosis affects their cancer survival and to check the heal…

This study aims to better understand the experiences of young women diagnosed with breast cancer. It follows over 1,300 women aged 40 and under for at least 10 years after their diagnosis. Researchers collect surveys, blood samples, and tumor tissue to learn about the disease, tr…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study aims to understand how the appearance of normal breast tissue on MRI scans might relate to a woman's risk of developing breast cancer. Researchers are comparing MRI and mammogram images from over 2,000 women—some recently diagnosed with breast cancer and others at high…

This study aims to better understand the real-world symptoms and treatment experiences of adults with certain cancers. About 100 participants with breast, lung, gastrointestinal cancer, or multiple myeloma will complete weekly digital surveys about their symptoms for at least 12 …

This study aims to create a collection, or biobank, of biological samples from people with breast, ovarian, or uterine cancers, as well as from some of their close relatives. Researchers will collect samples like blood, urine, and leftover tumor tissue to store for future researc…

This study aims to develop a test to predict which breast cancer patients might experience severe side effects or poor response to a common class of drugs called CDK4/6 inhibitors. Researchers will analyze blood samples and genetic information from 100 female patients taking thes…

This study aimed to understand why some women develop long-term pain after breast cancer surgery while others don't. Researchers wanted to see if psychological traits or social factors could predict who might experience chronic pain. The study was withdrawn before it could be com…

This study aims to find early warning signs that predict heart damage in breast cancer patients receiving certain chemotherapy drugs. Researchers will follow 700 patients for up to 10 years, tracking blood markers and heart scans to identify who is most at risk. The goal is to he…

This study aims to understand whether exposure to farm environments during childhood increases the risk of developing cancer and other diseases in adulthood. Researchers are following over 64,000 adults who grew up on farms, collecting health information and biological samples ov…

This study is investigating whether the amount of saturated fat in a woman's breast tissue is linked to breast cancer. Researchers are using a new, non-invasive MRI technique to measure fat types in the breasts of 190 postmenopausal women. The goal is to see if this measurement c…

This study aims to help doctors choose the best future treatments for patients with advanced cancers. Researchers are analyzing stored tumor samples from over 3,000 patients to look for specific genetic markers. The goal is to create a personalized profile for each patient's canc…

This study brings together 15-25 medical experts to create practical skin care guidelines for breast cancer patients in the Middle East and North Africa. Cancer treatments often cause skin problems like dryness, rashes, and sensitivity to sunlight, which can affect patients' comf…

This study looks at how the breast cancer drug palbociclib is actually used in everyday medical practice and what results patients experience. Researchers will analyze anonymous medical records of adults with advanced hormone-positive breast cancer who started treatment between 2…

This study collects blood, saliva, and tissue samples from breast cancer patients and healthy volunteers to create a research bank. Researchers at Memorial Sloan Kettering will use these samples to study what causes breast cancer and find better ways to prevent, detect, and treat…

This study collects blood and tumor cells from cancer patients and blood from healthy volunteers. The cells are used in the lab to support research into future immune cell therapies for cancers like melanoma, breast cancer, and lung cancer. No treatment is given in this study; it…

This study is exploring how starting an exercise program might change markers in breast tissue and blood in women with dense breasts. Researchers want to understand the biological reasons why exercise might lower breast cancer risk. The study involves 60 inactive premenopausal wo…

This study observes how the already-approved cancer drug ribociclib, combined with hormone therapy, works for women with advanced breast cancer in real-world French clinics. Researchers will follow over 1,000 patients for several years to see how long the treatment controls the c…

This study aims to discover new types of inherited gene changes that might explain why some people develop cancer. Researchers are studying cancer patients along with their unaffected parents to look for gene differences that appear in the child but not the parents. The goal is t…

This study is testing whether a new imaging tracer called [18F]ISO-1 can help doctors see specific features inside breast cancer cells using PET/CT scans. Researchers will scan 30 adults with breast cancer to see if the imaging results match what's found in tissue samples. The go…

This study is testing different online tools to help people who have inherited a gene change that increases cancer risk. It aims to help them better share this important information with their family members and follow the recommended cancer screening and prevention guidelines. T…

This study is testing a new set of brain function tests called the SAE Battery to understand how breast cancer treatment affects thinking, attention, and emotion processing. Researchers are comparing 187 breast cancer patients with healthy women to see if treatment changes how th…

This study aims to understand how common BRCA gene mutations are in Russian patients with high-risk, early-stage breast cancer that is HER2-negative. It will observe 625 patients to see how these genetic factors relate to the treatments they receive and their long-term health out…