BREAST CANCER

This early-stage study tests whether a DNA vaccine that targets a protein called mammaglobin-A (found on many breast cancer cells) is safe for people with ER+, HER2- breast cancer. The vaccine is given alongside standard hormone therapy or chemotherapy before surgery. The study i…

This early-phase study tests a vaccine made from estrogen receptor peptides, combined with immune boosters, in 8 people with ER-positive breast cancer who have completed standard therapy. The goal is to see if the vaccine is safe and can trigger an immune response against cancer …

This study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 women with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune system to help pre…

This study is for women with a low-risk type of breast cancer that has spread to nearby lymph nodes or is T3N0. It compares standard care (which includes radiation to the lymph node area) against skipping that extra radiation. The goal is to see if avoiding regional radiation wor…

This phase 2 trial investigates whether adding the targeted drug palbociclib to standard endocrine therapy (letrozole or tamoxifen) improves tumor shrinkage before surgery in people with hormone receptor positive, HER2 negative breast cancer. The study includes both invasive lobu…

This Phase 3 study tests whether a new drug, inavolisib, combined with fulvestrant works better than the current standard alpelisib plus fulvestrant for people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). The trial enrolled …

This early-stage trial tests a new drug called remzistotug, alone or with other cancer drugs, in 152 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the right dose. It is not yet known if the drug will sh…

This study tests whether taking enzalutamide for one year after standard treatment is practical for people with early-stage triple negative breast cancer that has androgen receptors. About 50 participants will take the drug and report on their quality of life. The main goal is to…

This early-stage trial tests a new approach for people with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to hormone therapy. It combines a radioactive drug (lutetium NeoB) that targets cancer cells with a standard chemotherapy pill (capecitabi…

This early-phase trial is testing a new combination of drugs for people with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to hormone therapy. The experimental treatment includes a radioactive drug (lutetium NeoB) that targets cancer cells, plu…

This study compares two modern, wire-free methods for locating non-palpable breast lesions before surgery: radioguided occult lesion localization (ROLL) using a radioactive tracer, and magnetic seed localization. The goal is to see which technique more reliably achieves clear sur…

This study tests an experimental drug, imlunestrant, in people with advanced or metastatic breast cancer that is estrogen-receptor positive (ER+), as well as certain other cancers like endometrial cancer. The drug is given alone or combined with other anticancer therapies. The ma…

This study tests whether losartan, a drug already used for high blood pressure, can reduce scarring (fibrosis) caused by radiation therapy in breast cancer patients. 43 women who had breast surgery and need radiation will receive either losartan or a placebo. Researchers will mea…

This study is testing whether women over 55 with a specific low-risk type of breast cancer (luminal A) can avoid radiation after lumpectomy. Instead, they take hormone-blocking pills for 5 years. Researchers are tracking 500 women for 10 years to see how many have the cancer come…

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors that have not responded to standard treatments. The drug targets a protein (CDK2) that helps cancer cells grow. The trial will check safety, find the right dose, and see if the drug shrin…

This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. About 32 adults with this aggressive cancer…

This phase 2 trial investigates whether a program of regular walking and a plant-based diet can lower aromatase levels in overweight postmenopausal women with hormone receptor-positive breast cancer who are already taking an aromatase inhibitor. Participants are randomly assigned…

This Phase 3 trial tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), can help prevent breast cancer from returning in people with triple-negative breast cancer who still have cancer cells after initial treatment and surger…

This study tests a shorter course of radiation (hypofractionated) to the breast and nearby lymph nodes in 137 women with node-positive breast cancer. The goal is to see if this approach reduces arm swelling (lymphedema) and other side effects while still preventing cancer from co…

This study tests whether adding the experimental drug inavolisib to two standard treatments (palbociclib and fulvestrant) can slow cancer growth in people with a specific genetic mutation (PIK3CA) in hormone receptor-positive, HER2-negative advanced breast cancer. About 325 parti…

This phase 3 study tests whether adding alpelisib (a targeted pill) to fulvestrant (a hormone-blocking shot) can slow cancer growth in men and postmenopausal women with HR-positive, HER2-negative advanced breast cancer that has a PIK3CA mutation. Participants must have already tr…

This early-stage trial is testing whether focused ultrasound (sound waves aimed at tumors) combined with a low dose of the chemotherapy drug gemcitabine can boost the immune system's ability to fight early breast cancer. About 32 participants will receive either ultrasound, low-d…

This study tested whether adding the drug palbociclib for two years to standard hormone therapy (taken for at least five years) helps prevent breast cancer from coming back in people with early-stage HR+/HER2- breast cancer. About 5,800 participants with stage II or III cancer to…

This study looks at whether patients with early-stage HER2-positive breast cancer who have a complete response to initial chemotherapy and HER2-targeted therapy can safely receive only 6 months of further HER2 treatment instead of the standard 12 months. The goal is to reduce hea…

This phase 2 trial tests a new immunotherapy drug called tobemstomig combined with chemotherapy (nab-paclitaxel) against the standard combination of pembrolizumab plus chemotherapy. It includes 83 people with previously untreated, PD-L1-positive, advanced triple-negative breast c…

This study offers continued treatment with the drug olaparib to people with ovarian or breast cancer who have already seen benefits from it in a previous study. The goal is to keep providing the drug safely while monitoring for any serious side effects. About 185 participants wil…

This early-phase study tests a new drug called inavolisib in people with advanced solid tumors or breast cancer that have a specific PIK3CA gene mutation. The study aims to find a safe dose and see how well the drug works alone or with other cancer treatments. About 200 participa…

This study tests a combination of two experimental drugs (LEE011 and BYL719) plus a standard hormone therapy (letrozole) in about 255 women with advanced ER+ breast cancer. The goal is to find safe doses and see if the triple combination can better control the cancer. Participant…

This study tests a drug called elacestrant combined with other medicines in people with a common type of advanced breast cancer (ER+/HER2-). The goal is to find safe doses and see if these combinations can slow down cancer growth. About 435 adults with metastatic breast cancer wi…

This study tested whether a higher dose (500 mg) of the drug fulvestrant works better than the standard dose (250 mg) in postmenopausal women with a certain type of advanced breast cancer that had worsened after previous hormone therapy. The trial involved 736 participants and me…

This phase 2 trial is testing whether adding local treatments like surgery or high-dose radiation to standard chemotherapy or hormone therapy can help breast cancer patients whose disease has spread to 1–3 bones. The goal is to see if this combination keeps the cancer from progre…

This early-phase trial tests whether a DNA vaccine made from a rat HER2 gene can safely stimulate the immune system in people with advanced or high-risk HER2-positive breast cancer. Thirteen participants receive multiple injections of the vaccine at different doses. The main goal…

This phase 3 trial is testing whether the drug trastuzumab deruxtecan (T-DXd), alone or with other chemotherapy drugs, works better than standard treatment before surgery in people with high-risk HER2-positive early breast cancer. About 927 participants will receive one of three …

This study follows 400 women for 10 years to see how safe and effective Mentor MemoryGel Ultra High Profile breast implants are for breast reconstruction after mastectomy or for revision surgery. Researchers track problems like repeat surgeries, infection, and capsular contractur…

This phase 2 trial is testing the drug taletrectinib in people with a rare, advanced form of breast cancer called invasive lobular carcinoma that has a specific gene change (CDH1 mutation). The study aims to see if the drug can shrink tumors or slow the cancer's growth. The trial…

This early-stage trial is testing whether amivantamab, a drug that targets specific proteins on cancer cells, can be given as a shot under the skin instead of through an IV. About 158 adults with advanced solid tumors (like lung or head and neck cancers) will receive different do…

This early-stage trial is testing a new drug called IDE161, alone or with the immunotherapy pembrolizumab, in adults with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The main goals are to check safety, find the right dose, and get a first look at wheth…

This phase III trial tests whether personalized therapy can improve survival for people with high-risk BRCA1-like breast cancer. Participants receive either standard chemotherapy or a more intense regimen with stem cell rescue. The study aims to find a better way to treat this ag…

This early-phase study tests a new oral drug, ATV-1601, in people with advanced solid tumors or certain breast cancers that have a specific AKT1 E17K mutation. The main goals are to check safety, find the right dose, and see how the drug moves through the body. About 134 adults w…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This study tests two drugs, olaparib and pembrolizumab, given before standard surgery for people with triple-negative or hormone receptor-positive HER2-negative breast cancer who have specific gene mutations. The goal is to see if the combination can shrink tumors enough to impro…

This study looks at whether using ultrasound before surgery can help identify women with early-stage HR+/HER2- breast cancer who have only a few affected lymph nodes. If so, they may be able to have a less invasive sentinel lymph node biopsy instead of a more extensive axillary l…

This study tests the drug letrozole in postmenopausal women with early-stage ER+ breast cancer. Participants take letrozole for 4 to 24 weeks before surgery to see how the tumor changes and to check if they take the medication as prescribed. The goal is to improve treatment for t…

This phase 2 study tests the drug entrectinib in over 500 people with advanced solid tumors that have specific gene changes (NTRK, ROS1, or ALK fusions). The goal is to see if the drug can shrink tumors and control the disease. Participants have various cancer types, including lu…

This early-stage trial tests a new drug, ALTA2618, in about 110 adults whose advanced solid tumors (like breast or endometrial cancer) have a specific genetic change called AKT1 E17K. The main goals are to check the drug's safety and find the right dose. Participants must have tr…

This study tests whether closely monitoring arm swelling after breast cancer surgery and treating it early with a compression sleeve can prevent long-term lymphedema. 250 women who had many lymph nodes removed will be randomly assigned to either the monitoring program or usual ca…

This phase 2 trial is testing a higher dose (500 mg) of the hormone therapy fulvestrant (Faslodex) as a first treatment for postmenopausal women with hormone receptor positive metastatic breast cancer. The study aims to see if this higher dose improves clinical benefit rates comp…

This study is testing a program called WeCan-Rural for breast cancer survivors living in rural, underserved areas. The program includes 12 weekly video sessions to help manage symptoms like pain and fatigue, and build healthy habits around eating, exercise, and weight. The goal i…

This study tests a new drug (PF-07220060) plus letrozole against standard treatments for people with HR-positive, HER2-negative advanced or metastatic breast cancer who haven't had prior therapy for advanced disease. About 1,035 adults will be randomly assigned to either the new …

This phase 2 trial tests whether giving sacituzumab govitecan and pembrolizumab before surgery can help control early-stage triple-negative breast cancer that didn't respond to initial chemotherapy and immunotherapy. The study enrolls 27 adults with specific tumor types. The main…

This study tests a drug called T-DM1 in older adults (age 60+) with HER2-positive breast cancer after surgery. The goal is to see if it can prevent the cancer from coming back. About 111 participants received the drug, and researchers are tracking how long they stay cancer-free.

This study tests whether a web application can help breast cancer patients take their hormone therapy as prescribed. About 438 patients starting hormone therapy will either use the app or receive standard care. The goal is to see if the app improves medication adherence and quali…

This study tests two drugs, niraparib and dostarlimab, given before surgery to people with BRCA- or PALB2-mutated breast cancer. The goal is to see if this combination boosts the immune system's attack on the tumor and leads to a complete response (no cancer left at surgery). Abo…

This phase 2 study tests the drug olaparib in 329 people with advanced solid tumors that have certain DNA repair mutations (HRRm) or deficiencies (HRD). Participants have already tried standard treatments without success. The main goal is to see if olaparib can shrink tumors, wit…

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can completely eliminate tumors in people with localized triple-negative breast cancer. About 51 women with early-stage, untreated disease will receive the combination, then…

This early-stage trial tests a new drug called YL202 in about 80 people with advanced lung or breast cancer that has not responded to standard treatments. The drug is given by IV every three weeks. The main goal is to check safety and find the right dose, not yet to prove it work…

This early-stage trial is testing a new drug called GDC-9545 (giredestrant), alone or combined with other medications, in people with advanced ER-positive breast cancer that has spread. The main goals are to check safety, find the best dose, and see if it shrinks tumors. About 18…

This phase 3 trial tests a new drug called Dato-DXd against standard chemotherapy for people with advanced triple-negative breast cancer who cannot receive immunotherapy. About 644 participants will be randomly assigned to receive either Dato-DXd or one of several chemotherapy dr…

This early-stage trial tests a new oral drug called ceralasertib, given alone or with other cancer treatments like chemotherapy or targeted drugs, in 354 adults with advanced solid tumors that no longer respond to standard care. The main goal is to check safety and find the best …

This study tests a new drug called SKB264 in people with advanced solid tumors that have not responded to standard therapies. The drug is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells. The trial includes over 1,400 participants with various …

This study tests whether extra care from a team of heart doctors, dietitians, exercise therapists, pharmacists, and physiotherapists can reduce side effects in breast cancer patients receiving chemotherapy. About 80 participants will be randomly assigned to either the team interv…

This study tests the drug trastuzumab deruxtecan in about 500 people with advanced HER2-positive breast cancer, some of whom also have brain metastases. The goal is to see how well the drug shrinks tumors and how long it keeps the cancer from growing. Participants receive the dru…

This study looks at whether women with early breast cancer (tumors smaller than 5 cm) and no signs of cancer in the lymph nodes can safely avoid axillary surgery. About 800 women will be randomly assigned to either have a sentinel lymph node biopsy or no surgery at all. The goal …

This early-stage trial tests a personalized treatment for people with metastatic solid cancers that have KRAS mutations. Doctors take a patient's own white blood cells, genetically modify them to recognize and attack KRAS-mutated cancer cells, and return them to the patient along…

This study tests a drug called trastuzumab-deruxtecan (T-DXd) in 28 people with HER2-low breast cancer that has spread to the brain. The goal is to see if the drug can shrink brain tumors. Participants receive the drug intravenously, and doctors monitor tumor response using brain…

This study tests giving radiation therapy before surgery to women aged 50+ with early-stage, hormone-positive breast cancer. The goal is to find the safest radiation dose and see how the tumor responds. Only 15 participants are enrolled, making this a very early-stage trial.

This early-stage study tests a new drug called A166 in 120 adults with advanced HER2-positive solid tumors that have spread or cannot be removed by surgery. The main goal is to check safety and find the right dose, while also seeing if the drug shrinks tumors. Participants must h…

This phase 3 trial compares a standard 3-week radiation course to an experimental 2-week course for women with early-stage breast cancer. About 400 participants who had lumpectomy will receive whole breast radiation plus an extra boost to the tumor site. The study checks if the s…

This study looks at whether women with aggressive breast cancers (triple-negative or HER2-positive) who have a complete response to chemotherapy can safely avoid sentinel lymph node biopsy. The trial will enroll 350 patients across Europe, all of whom will have breast-conserving …

This study tests a modified radiation schedule for women aged 50 and older with early-stage, low-risk breast cancer. Instead of the standard every-other-day treatment over 10 days, participants receive five daily radiation sessions with a slightly lower dose each day. The goal is…

This Phase 3 trial is testing an experimental drug called Dato-DXd against standard chemotherapy in 732 people with advanced HR-positive, HER2-negative breast cancer. Participants have already tried one or two prior chemotherapies. The study aims to see if Dato-DXd can slow cance…

This study tests whether a single, focused radiation treatment works as well as five treatments for people with low-risk stage 0 or I breast cancer after a lumpectomy. About 134 participants will be randomly assigned to receive either one or five doses of radiation to the tumor a…

This study tests two oral medications, vepdegestrant and samuraciclib, taken daily at home by adults with advanced or metastatic ER+ breast cancer that no longer responds to standard treatments. The goal is to see if the combination is safe and can shrink or control the cancer. P…

This pilot study tests two oral drugs, anastrozole and palbociclib, in postmenopausal women with a common type of metastatic breast cancer (HR+/HER2-). The drugs are given either as the first treatment or as maintenance after chemotherapy. The main goal is to see if the combinati…

This phase 3 trial compares giving hormone therapy (aromatase inhibitors) at the same time as chemotherapy versus after chemotherapy in 1000 postmenopausal women with early breast cancer. The goal is to see which timing better prevents the cancer from coming back over 15 years. P…

This study tests whether the drug olaparib can help prevent breast cancer from returning in people with inherited BRCA1 or BRCA2 mutations who have already completed surgery and chemotherapy. About 1,800 participants with high-risk, HER2-negative breast cancer will receive either…

This study tests a new drug called PF-07104091 in people with advanced small cell lung cancer, ovarian cancer, or certain breast cancers that have not responded to prior treatments. The goal is to find the safest dose and see if the drug shrinks tumors, either alone or with other…

This early-stage trial tests two drugs, alpelisib and sacituzumab govitecan, together in people with advanced HER2-negative breast cancer that has spread or come back. The main goal is to find the safest dose and check for side effects. About 18 adults are taking part in this stu…

This study compares two approaches for women with early-stage invasive breast cancer undergoing breast-conserving surgery: no axillary surgery versus sentinel lymph node biopsy. The goal is to see if avoiding axillary surgery leads to the same cancer outcomes while reducing compl…

This study tested different chemotherapy combinations and schedules for women with breast cancer that had spread to lymph nodes. The goal was to see if adding a drug called fluorouracil or giving chemo every 2 weeks (with a support drug to boost immune recovery) worked better tha…

This phase 2 trial tests whether the number of immune cells in and around a triple-negative breast cancer tumor can help doctors personalize chemotherapy and immunotherapy. About 139 women with early-stage triple-negative breast cancer will receive standard chemotherapy drugs plu…

This study tested a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 30 people with a rare, advanced form of HER2-negative breast cancer that has many genetic mutations (hypermutated). The goal was to see if this drug pair could shrink or control the cancer. P…

This study looks at a new material called SC Derm, used in breast reconstruction after mastectomy for breast cancer. It compares how well this material works and its safety against other similar products. About 120 women aged 20 to 69 who are having a mastectomy and immediate imp…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether a 3-month program of dance classes three times a week plus a personalized nutrition plan can improve health in 40 obese breast cancer survivors. Researchers will measure changes in weight, body fat, fitness, gut bacteria, and quality of life. Participants…

This phase 2 trial tests whether adding an immunotherapy drug called IRX 2 to standard pembrolizumab (Keytruda) and chemotherapy can improve outcomes for people with triple-negative breast cancer. The study involves 12 participants who receive the combination before surgery. The …

This phase 3 study tests whether adding the targeted drug abemaciclib to standard hormone therapy helps prevent breast cancer from returning in people with high-risk, early-stage, hormone receptor-positive, HER2-negative breast cancer that has spread to lymph nodes. Over 5,600 pa…

This early-stage trial tests a treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The cells are given directly into the brain's fluid spaces to try to kill tumor cells. The main goals are to find the safest dose an…

This phase 2 trial tests whether adding the immunotherapy drug durvalumab to two standard targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in people with HER2-enriched breast cancer. The study involves 51 participants and measures how many have no or…

This study is testing a shorter, more intense radiation schedule (hypofractionation) for women with breast cancer who have had surgery. The goal is to see if this approach is safe and effective at preventing cancer from coming back while reducing side effects like arm swelling. F…

This early-stage study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alo…

This study tests whether giving the immunotherapy drug pembrolizumab (Keytruda) along with a small dose of radiation to the tumor before standard treatment (surgery, chemotherapy, or radiation) is safe and helps the immune system fight breast cancer. About 66 people with operable…

This early-phase study tests a new oral drug called MOMA-313, alone or with another drug (olaparib), in people with advanced solid tumors that have certain DNA repair flaws. The main goals are to check safety and find the right dose. About 220 adults with cancers like prostate, p…

This study tests whether giving two targeted drugs, T-DM1 and pertuzumab, before surgery can completely eliminate early-stage HER2-positive breast cancer. About 164 participants with stage II or III disease will receive the drugs for 18 weeks, then undergo surgery. The main goal …

This Phase III trial tests whether adding the experimental drug TQB3616 to standard hormone therapy can help prevent breast cancer from returning in women with HR-positive, HER2-negative breast cancer after surgery. About 1,946 women will receive either TQB3616 or a placebo, plus…

This study aimed to test the safety and effectiveness of combining the drug ribociclib with hormone therapy and radiation for women aged 70 and older with a certain type of breast cancer. The goal was to control the disease without surgery. However, the study was withdrawn before…

This Phase 2 study tests a drug called zelenectide pevedotin in 66 people with advanced breast cancer that has a specific gene change (NECTIN4 amplification). The study includes two groups: one with hormone receptor-positive/HER2-negative cancer and one with triple-negative breas…

This study tests whether a special fluorescent dye and imaging system can help surgeons see and remove all cancer during breast-conserving surgery. The goal is to reduce the chance that cancer cells are left behind, which often requires a second operation. About 175 women with br…

This study tests a different dosing schedule of the chemotherapy drug capecitabine combined with the targeted therapy neratinib in people with advanced HER2-positive breast cancer. The goal is to find the safest dose that still works. About 34 adults with stage IV breast cancer t…

This phase 3 trial tests whether adding the experimental drug ipatasertib to standard hormone therapy (fulvestrant) can slow the growth of advanced ER-positive, HER2-negative breast cancer. The study enrolls 250 postmenopausal women whose cancer worsened after initial treatment w…

This study tests a combination of three drugs (nivolumab, bicalutamide, and ipilimumab) in 30 people with advanced HER2-negative breast cancer that has spread. The goal is to see if this chemo-free approach can control the disease for at least 24 weeks. Participants must have mea…

This early-phase study tests a new immune-boosting drug (DPX-Survivac) combined with hormone therapy, with or without low-dose radiation or chemotherapy, in women with hormone receptor-positive, HER2-negative breast cancer. The main goal is to check safety before standard surgery…

This phase 2 study tests a new drug (TQB3616) combined with hormone therapy for people with a common type of breast cancer (HR-positive, HER2-negative) that has returned or spread and no longer responds to a standard class of drugs called CDK4/6 inhibitors. The trial enrolls 33 a…

This early-phase trial tests a two-step treatment for advanced breast cancer that cannot be cured with surgery or radiation. First, patients receive a drug called talazoparib alone, then both talazoparib and avelumab together. The main goal is to check safety and side effects, wh…

This study looks at whether high-dose vitamin D and a home exercise program (walking and strength training) can help prevent bone loss in women being treated for breast cancer. About 191 postmenopausal women with early-stage breast cancer will take either vitamin D or a placebo, …

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can eliminate all signs of cancer in people with early-stage triple-negative breast cancer before they have surgery. About 31 participants with small tumors (1 to 2.5 cm) that haven't sp…

This small study is testing whether hyperbaric oxygen therapy (HBOT) can help control the growth of breast cancer that has spread to the lungs. Ten women with advanced breast cancer and lung metastases will receive standard cancer treatment plus HBOT sessions. The goal is to see …

This phase 3 trial tests whether adding afuresertib (a targeted drug) to fulvestrant (a standard hormone therapy) can help control advanced HR+/HER2- breast cancer that has stopped responding to other treatments. The study includes 256 adults with specific genetic changes (PIK3CA…

This large Phase 3 trial tests whether a new combination of drugs (datopotamab deruxtecan plus durvalumab) given before and after surgery works better than the current standard treatment for people with untreated triple-negative or hormone receptor-low/HER2-negative breast cancer…

This Phase 2 trial is testing whether a combination of two targeted drugs (trastuzumab and pertuzumab) given as a single shot under the skin, along with standard hormone therapy, can prevent cancer from returning after surgery in people with early-stage, hormone receptor-positive…

This study looks at a way to help women under 40 with breast cancer keep their ability to have children after chemotherapy. Before starting chemo, participants receive hormone injections and tamoxifen to stimulate their ovaries, then eggs or embryos are frozen. The goal is to see…

This phase 2 trial is testing whether combining immunotherapy drugs (pembrolizumab, ipilimumab, nivolumab) with a freezing technique called cryoablation before standard surgery can improve outcomes for women with triple-negative breast cancer. The study enrolls 51 women who have …

This study tests a new drug called CFI-402257 combined with the standard chemotherapy paclitaxel in people with advanced HER2-negative breast cancer that cannot be cured. The goal is to see if the combination works better than paclitaxel alone at slowing tumor growth. About 37 wo…

This phase 3 trial is testing a combination of two drugs—capivasertib (a pill that targets cancer cell growth) and fulvestrant (an injection that blocks estrogen)—in 258 Chinese patients with advanced HR+/HER2- breast cancer that has worsened after hormone therapy. The study focu…

This study looks at whether women with triple-negative or HER2-positive breast cancer who have a complete response to chemotherapy can safely skip sentinel lymph node biopsy. The trial will compare standard surgery plus biopsy versus surgery alone, measuring how often cancer retu…

This study is testing whether shorter, more focused radiation treatments after lumpectomy are as safe and effective as the standard six-and-a-half-week course. About 121 women with early-stage breast cancer are receiving one of several accelerated radiation methods, including a s…

This study looks at whether ovarian stimulation and egg or embryo freezing is safe and doable for young women (ages 18–38) with early breast cancer who are about to start chemotherapy. The goal is to help preserve their fertility. Researchers will track how many eggs are collecte…

This study tests whether a highly focused type of radiation called stereotactic body radiation therapy (SBRT) can delay cancer progression in women with metastatic breast cancer who are starting their first treatment. About 154 participants will receive either standard therapy al…

This phase 2 trial is testing whether adding the targeted drug dalpiciclib to standard hormone therapy (letrozole) before surgery can improve outcomes for women with HR+/HER2- early-stage breast cancer. The study enrolls 100 women aged 18-70 whose tumors have a high genetic risk …

This phase II trial tests a single, high-dose radiation treatment given before surgery for early-stage breast cancer. The goal is to see if this approach leads to good or excellent cosmetic results and reduces the need for multiple radiation sessions. About 110 women with small, …

This study tests whether combining hormone therapy, a targeted drug (palbociclib), and an immunotherapy (avelumab) can shrink early-stage, hormone-positive breast tumors before surgery. About 33 women with stage II-III breast cancer will receive the treatment for about 4 months, …

This early-stage trial tests the safety of combining two drugs, olaparib and vorinostat, in people with advanced breast cancer that has returned or spread. About 28 participants will receive the combination to find the best dose and check for side effects. The goal is to see if t…

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors or slow the disease. About 75 adults with advanced cancer are taking part. …

This phase 2 trial tests whether adding ribociclib to letrozole before surgery helps more women with ER-positive, HER2-negative early breast cancer achieve a low-risk score (PEPI 0) compared to letrozole alone. About 121 postmenopausal women with stage II or III breast cancer wil…

This early-phase study planned to test whether injecting the seasonal flu vaccine directly into breast tumors could help the immune system attack the cancer. It was designed for women with triple-negative or HER2+ breast cancer who were already scheduled for chemotherapy before s…

This study tests a new oral drug, ARV-471, combined with ribociclib in adults with advanced or metastatic ER+ breast cancer that has stopped responding to previous treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants …

This study tests a new drug (MEN1611) combined with chemotherapy (eribulin) for people with advanced breast cancer that has specific genetic changes (PIK3CA/PTEN). The goal is to see if the combination can shrink tumors or stop them from growing. About 14 participants will receiv…

This phase 1/2 trial tests a vaccine made from two viruses designed to target and kill cancer cells that have a specific protein called MAGE-A3. The viruses are given to 56 people with advanced solid tumours that have not responded to other treatments. The goal is to see if the v…

This early-phase trial tests whether adding a single, focused dose of radiation before surgery can make the immunotherapy drug pembrolizumab work better in people with early-stage breast cancer. About 27 participants will receive both treatments, then have surgery to see if the t…

This study tests whether a shorter, higher-dose radiation schedule (hypofractionation with a concurrent boost) works as well as the standard longer schedule for women with early-stage breast cancer after lumpectomy. Over 2,300 women participated. The goal is to see if the shorter…

This study looked at whether adding a drug called vorinostat to standard chemotherapy (carboplatin and nab-paclitaxel) before surgery helps shrink tumors more in women with HER2-negative breast cancer. About 68 women took part. The goal was to see if the combination leads to no c…

This study looks at women with early-stage breast cancer who need both radiation and chemotherapy after surgery. It compares giving these treatments at the same time versus one after the other, to see if the combined approach has similar side effects and outcomes. About 81 women …

This Phase 3 trial is testing whether adding the immunotherapy drug atezolizumab to the targeted therapy trastuzumab emtansine (Kadcyla) can prevent breast cancer from returning in people with high-risk HER2-positive breast cancer. About 1,188 participants who still had cancer af…

This early-stage study tests a new drug called E7389 liposomal formulation in people with advanced solid tumors that have not responded to standard treatments. The main goal is to find the safest dose and check for side effects. The study also looks at how the drug works in speci…

This study tests two oral drugs, vepdegestrant and PF-07220060, in people with advanced or metastatic ER+/HER2- breast cancer that has stopped responding to prior treatments. The goal is to see if the combination is safe and can shrink tumors. Participants take the pills at home …

This study tests whether a surgical technique called immediate lymphatic reconstruction can prevent lymphedema (arm swelling) in breast cancer patients who need lymph node removal. About 180 women will be randomly assigned to receive either standard lymph node removal alone or wi…

This study tests whether adding intermittent or water-only fasting to standard chemotherapy can improve outcomes for breast cancer patients. Sixty women will be split into four groups: chemo alone, chemo plus intermittent fasting, chemo plus intermittent fasting with a ketogenic …

This study aimed to test a new way to treat very small breast cancers by freezing them (cryoablation) during a biopsy. It was designed for women aged 60 and older with tumors 1 cm or smaller. However, the study was withdrawn before any participants were enrolled, so no results ar…

This phase II trial is testing a less intense chemotherapy regimen for people with early-stage HER2-positive breast cancer. The experimental treatment combines paclitaxel with two targeted drugs (trastuzumab and pertuzumab), skipping the harsher anthracycline drugs. Researchers w…

This early-phase study tests a combination of two drugs, olaparib and sapacitabine, in people with breast cancer that has spread and who have a BRCA gene mutation. The main goals are to find the safest dose and see if the combination shrinks tumors. About 10 participants are enro…

This study compares a robotic surgical system (da Vinci SP) to traditional open surgery for nipple-sparing mastectomy in women with early-stage breast cancer. The trial involves 204 participants and will measure safety, cancer recurrence, and patient satisfaction. The goal is to …

This study looks at whether people with HER2-positive metastatic breast cancer who have had their cancer controlled for at least three years can safely stop their anti-HER2 therapy. About 82 participants will either stop or continue treatment to see if the cancer stays away for a…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study tests giving a short course of focused radiation before breast cancer surgery, using MRI for precise planning. The goal is to treat a smaller area of the breast and possibly reduce side effects. About 39 women with early-stage breast cancer will receive five radiation …

This phase 2 trial is testing whether combining an experimental pill (CFI-400945) with an immunotherapy drug (durvalumab) can shrink tumors in 15 women with advanced triple negative breast cancer that has spread or cannot be removed. The study measures how many participants see t…

This study tests an experimental drug called AZD5305, a PARP inhibitor, either alone or combined with other cancer drugs in people with advanced solid tumors (like ovarian, breast, pancreatic, and lung cancers). The goal is to see if the treatment is safe and can shrink tumors. A…

This study tests whether certain women with early-stage HER2-positive breast cancer can be treated with a targeted drug combination (PHESGO™) without chemotherapy. Researchers use specific markers to select patients whose tumors are highly dependent on the HER2 pathway. The goal …

This study tests whether adding the experimental drug onvansertib to standard chemotherapy (paclitaxel) can safely shrink tumors in people with triple-negative breast cancer that has spread. About 50 adults with advanced or metastatic disease will receive the combination. The goa…

This study tests a new oral drug, vepdegestrant, combined with abemaciclib in people with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. About 37 adults will take both pills daily at home, with clinic visits every 4 weeks, to see if the comb…

This early-phase trial is testing a new type of cell therapy called P-MUC1C-ALLO1 for people with advanced solid tumors (like breast, ovarian, lung, or pancreatic cancer) that have not responded to other treatments. The therapy uses donor immune cells engineered to recognize and …

This Phase 3 trial tests a new experimental drug, vepdegestrant, combined with palbociclib against the standard treatment (letrozole plus palbociclib) for people with advanced ER+/HER2- breast cancer that has not been treated before. The study aims to see if the new combination w…

This study tests an experimental drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The trial includes cancers like glioblastoma, melanoma, breast, and prostate cancer. It aims to find a safe dose and see if the drug can shrin…

This Phase 3 trial is testing a new drug called gedatolisib combined with fulvestrant, with or without palbociclib, in about 700 people with advanced HR+/HER2- breast cancer that has worsened after prior treatment. The goal is to see if this combination can slow cancer growth bet…

This phase 3 trial tested whether adding the drug everolimus to standard hormone therapy helps prevent breast cancer from returning in nearly 2,000 patients with high-risk, hormone receptor-positive, HER2-negative breast cancer. Participants received either hormone therapy plus e…

This study looks at women with a very early form of breast cancer called ductal carcinoma in situ (DCIS). After surgery to remove the cancer, all women get radiation to the whole breast. Half also get an extra, stronger dose of radiation right where the cancer was. The goal is to…

This phase 3 trial tests whether adding the drug abemaciclib to standard hormone therapies (anastrozole, letrozole, or fulvestrant) can help slow cancer growth in postmenopausal women with a common type of advanced breast cancer (HR+, HER2-). About 463 women participated, and the…

This study tests a precise type of radiation called proton therapy for people with early-stage breast cancer. The goal is to see if it can control the cancer and reduce side effects compared to standard radiation. About 150 adults aged 40 and older who had a lumpectomy are taking…

This study tests whether giving stereotactic body radiotherapy (SBRT) to growing metastatic tumors can delay overall cancer progression. About 107 adults with triple-negative breast cancer or non-small cell lung cancer that has started to grow in a few spots will receive SBRT or …

This study tests whether a supervised exercise program (a mix of high-intensity cycling and strength training) done three times a week during chemotherapy can help shrink breast tumors and improve how much chemo patients can tolerate. About 100 women with breast cancer will be ra…

This phase 3 trial tests whether adding abemaciclib to standard hormone therapy (anastrozole or letrozole) can slow cancer growth in postmenopausal women with HR+ HER2- breast cancer that has spread or returned. About 493 women participated, receiving either the drug combination …

This Phase 2 trial tests an experimental drug called CFI-400945 in 51 people with advanced or metastatic breast cancer that has already been treated with chemotherapy. The goal is to see if the drug can shrink tumors or slow the disease. Participants take the drug in 28-day cycle…

This early-phase study tests whether combining two drugs, abemaciclib and pembrolizumab, is safe and effective for people with advanced non-small cell lung cancer or a certain type of breast cancer. About 100 participants with stage IV disease will receive the combination. The go…

This study looks at whether women aged 50 and older with a very low-risk type of early breast cancer (called DCIS) can avoid radiation therapy after having breast-conserving surgery. The goal is to see if the cancer stays away without radiation, reducing unnecessary treatment and…

This study compares two types of radiation therapy for women with early-stage breast cancer after lumpectomy. One group receives standard CT-guided radiation, while the other receives a newer MRI-guided approach. The goal is to see if MRI-guided radiation works just as well at pr…

This Phase 2 trial is testing a combination of two drugs—docetaxel (chemotherapy) and trastuzumab (a targeted therapy)—in 53 Nigerian women with HER2-positive breast cancer. The goal is to see how many women have no cancer left after treatment (called a complete response). The st…

This early-phase trial tests a combination of two drugs—valemetostat and trastuzumab deruxtecan—in 17 people with metastatic breast cancer that has low, ultra-low, or no HER2 protein. The goal is to find a safe dose and see if the combo can shrink tumors. It's a small, first-in-h…

This study is testing a new surgical technique for breast reconstruction after mastectomy in women with early-stage breast cancer. The approach combines endoscopic nipple-sparing mastectomy with immediate fat grafting, all done through a small incision in the armpit. Researchers …

This study tests a one-week radiation therapy for breast cancer patients who need treatment to the chest or breast and nearby lymph nodes. About 197 participants will receive this shorter radiation course and be followed for 5 years to check for side effects, cancer return, and q…

This study looks at the long-term safety of a drug called TOL2506, which suppresses ovarian function, in people with hormone receptor-positive (HR+) breast cancer. It includes premenopausal women and men who already completed a previous study. Participants will take TOL2506 along…

This phase 3 study tests a 3-month injection (TOL2506) to temporarily stop ovarian function in premenopausal women with HR+, HER2-negative breast cancer. The goal is to see if it works well with hormone therapy (tamoxifen or aromatase inhibitors) to control the cancer. About 250 …

This study looks at whether giving extra radiation to lymph nodes behind the breastbone can help prevent breast cancer from returning in high-risk patients. About 2,400 people who had a mastectomy and had cancer in their lymph nodes will take part. The goal is to see if this extr…

This phase 2 trial tests whether adding tucatinib to standard drugs trastuzumab and capecitabine can shrink tumors in people with advanced HER2+ breast cancer who have already tried several treatments. About 66 participants will receive the three-drug combination. The main goal i…

This study tests whether giving 6 months of hormone therapy before surgery helps remove all cancer cells in women with early-stage, estrogen-positive breast cancer. It involves 8 postmenopausal women with low-risk, node-negative tumors. The goal is to see if this approach leads t…

This study tests whether adding the drug pyrotinib to standard chemotherapy before surgery can improve outcomes for women with stage II to III hormone receptor-positive, HER2-negative breast cancer that also has high levels of the HER4 protein. About 140 participants will receive…

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy and trastuzumab can completely eliminate HER2-positive breast tumors before surgery. About 113 women with early-stage HER2+ breast cancer will receive the combination, then have surgery to check …

This phase II trial tests whether combining the immunotherapy drug pembrolizumab (Keytruda) with the hormone therapy fulvestrant (Faslodex) can help control advanced or metastatic breast cancer that is hormone receptor positive and HER2 negative. The study includes 47 adults and …

This study follows 170 women with early-stage HER2+ breast cancer who are receiving the biosimilar drug Zedora after surgery. Researchers want to see how well it prevents the cancer from coming back and how safe it is in real-world settings, where patients may have other health i…

This study aimed to see if the drug capivasertib could clear cancer DNA from the blood of women with ER-positive breast cancer who had finished initial treatment. The goal was to prevent the cancer from coming back or spreading. However, the study was withdrawn before any partici…

This Phase 2 trial is testing whether adding the drug ribociclib (Kisqali) to standard hormone therapy can improve outcomes for people with early-stage ER-positive breast cancer. The study involves 120 participants and focuses on clearing cancer DNA from the blood. The goal is to…

This study tests a drug called QBS72S in 21 adults with breast or lung cancer that has spread to the brain. The drug is given once a month through an IV. The main goal is to see if it shrinks brain tumors. The trial is active but not recruiting new participants.

This phase II trial is testing whether giving the drug palbociclib (Ibrance) together with hormone therapy (letrozole, plus goserelin for premenopausal women) before surgery can shrink early-stage hormone receptor-positive, HER2-negative breast tumors. The study enrolls 51 patien…

This study tests a two-drug combination (tucatinib and trastuzumab) in people with advanced solid tumors that have HER2 alterations. The goal is to see if the treatment can shrink or control tumors. About 217 participants with various cancers (like lung, uterine, or bile duct) wi…

This trial compares two surgical flap techniques—Grisotti flap and reverse mirror Grisotti flap—for women with early-stage breast cancer in the central part of the breast. The study includes 106 women aged 25-70 with tumors up to 5 cm near the nipple. The main goal is to see whic…

This study tests a high-dose, precise radiation therapy called SBRT for people with breast cancer who cannot undergo surgery. Fifteen participants will receive five radiation treatments and be followed for five years to check for side effects and tumor response. The goal is to se…

This study offers continued access to the cancer drug ruxolitinib (sometimes combined with other therapies) for people with pancreatic, colorectal, breast, or lung cancer who were already benefiting and stable in a prior Incyte-sponsored trial. Only 10 participants are enrolled, …

This phase 3 trial compares two chemotherapy regimens for women with non-triple negative breast cancer after surgery. One group gets epirubicin plus cyclophosphamide followed by docetaxel (EC-T), the other gets paclitaxel plus carboplatin (PCb). The study includes 1560 participan…

This early-stage trial tests a new drug called OP-1250 combined with an approved targeted therapy, palbociclib, in 60 adults with advanced or metastatic HR-positive, HER2-negative breast cancer. The goal is to find the safest dose and see if the combination can slow tumor growth.…

This pilot study looks at whether a 12-week exercise program can change certain markers in breast tissue and blood of premenopausal women with dense breasts. Dense breast tissue is a known risk factor for breast cancer. The study involves 60 physically inactive women who will do …

This study provides continued access to the cancer drug palbociclib (IBRANCE) for up to 35 patients with breast or head and neck cancer who have already benefited from it in earlier Pfizer trials. Participants will keep taking their current treatment combination, which may includ…

This phase 3 trial tests whether a new drug called HS627 (a biosimilar) works as well as pertuzumab when given with trastuzumab and docetaxel before surgery for HER2-positive breast cancer. About 408 people with early-stage or locally advanced breast cancer took part. The main go…

This phase 2 trial tests whether a newer drug, margetuximab, combined with chemotherapy, works better than the standard trastuzumab combination for HER2-positive breast cancer before surgery. The study includes 174 people with stage II or III disease who have a specific genetic v…

This study looks at the safety of the drug TALZENNA in people with a specific type of breast cancer (BRCA mutation-positive, HER2-negative) that cannot be surgically removed or has come back after previous chemotherapy. Only 3 participants who have not used TALZENNA before will r…

This early-stage trial is testing a combination of two drugs—trastuzumab deruxtecan (a targeted chemotherapy) and pembrolizumab (an immunotherapy)—in about 115 adults with advanced breast or non-small cell lung cancer that has a specific marker called HER2. The study has two part…

This study tests a new drug called BT8009, alone or with another drug (pembrolizumab), in people with advanced solid tumors like bladder, breast, lung, or ovarian cancer. The drug targets a protein called Nectin-4 found on some cancer cells. The trial aims to find safe doses and …

This study tests whether applying radiofrequency ablation (a heat treatment) to the area where a breast tumor was removed can kill any leftover cancer cells and reduce the need for a second surgery. It involves 104 women aged 50 and older with early-stage breast cancer. The goal …

This study tests a technique called axillary reverse mapping during breast cancer surgery. Doctors inject a radioactive tracer and blue dye to map the arm's lymph drainage, hoping to avoid damaging those vessels and reduce the risk of lymphedema (arm swelling). The study involves…

This study compares two types of radiation therapy—proton and photon—for people with non-metastatic breast cancer. The goal is to see if proton therapy reduces heart problems and improves quality of life while still controlling the cancer. About 1,200 participants who had surgery…

This study tests whether a very low-carb (ketogenic) diet, a low-carb diet, or the diabetes drug canagliflozin can prevent high blood sugar and possibly make standard cancer therapy more effective. It involves 15 people with advanced, hormone-receptor-positive breast cancer that …

This phase 3 trial tests whether the experimental drug DS-8201a (trastuzumab deruxtecan) works better than the current standard T-DM1 for people with HER2-positive breast cancer that cannot be removed by surgery or has spread to other parts of the body. About 524 adults who have …

This study tests a new drug, DS-8201a, against standard treatments for people with a specific type of advanced breast cancer called HER2-low. The cancer has spread to other parts of the body and cannot be removed by surgery. About 557 adults whose cancer has already been treated …

This study tests a treatment using a patient's own immune cells (T cells) that are genetically modified to recognize and attack a protein called mesothelin found on cancer cells. The treatment is given through a tube in the chest to people with malignant pleural disease, includin…

This study tests a combination of three drugs—cisplatin, romidepsin, and nivolumab—in people with advanced triple-negative breast cancer or BRCA-related breast cancer that has spread. The goal is to see if the combination can shrink tumors and control the disease. About 51 partic…

This study tests a shorter radiation treatment (partial breast irradiation) for women with early-stage breast cancer or a pre-cancer called DCIS. Instead of treating the whole breast for 5-7 weeks, radiation is given only to the area where the tumor was removed, for just 2 weeks.…

This early-stage trial tests an experimental oral drug called AC699 in 100 adults with a common type of advanced breast cancer (ER+/HER2-). The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug can shrink tumors. Par…

This study tests a precise, 5-session radiation treatment called stereotactic partial breast irradiation (S-PBI) using a special device (GammaPod) for women with early-stage breast cancer. The goal is to see if this approach keeps the breast looking good (cosmesis) while controll…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin) helps people with metastatic triple-negative breast cancer live longer without their disease getting worse. About 78 participants with advanced cancer that has spread will rece…

This early-stage trial is testing whether adding an experimental drug called Ipatasertib to standard hormone therapy can help control metastatic hormone receptor positive breast cancer. The study involves 77 women whose cancer has spread and is no longer responding to usual treat…

This phase 2 trial tested two different chemotherapy regimens, with or without the targeted drug trastuzumab, given before surgery to patients with stage II or III breast cancer. The goal was to see which combination better eliminated cancer cells in the breast and lymph nodes. A…

This early-stage trial is testing a new drug called GNC-035, a tetra-specific antibody designed to attack breast cancer cells in multiple ways. It involves 36 adults with locally advanced or metastatic breast cancer whose disease has worsened after standard treatments. The main g…

This study tests a drug called pacritinib in people with advanced solid tumors (like breast cancer) that have a specific genetic change called 1q21.3 amplification. The goal is to see if the drug can shrink tumors or slow their growth. About 74 adults whose cancer has not respond…

This study tests a combination of two drugs, lenvatinib and letrozole, given before surgery to postmenopausal women with a common type of breast cancer (hormone receptor positive). The goal is to see if the drugs can shrink the tumor enough to improve surgical outcomes. About 40 …

This early-phase study tests a new drug called BL-M02D1 in people with advanced triple negative breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors.…

This study tests an oral chemotherapy drug called Lonsurf in people with metastatic breast cancer that has spread. The trial includes two groups: those who have had a certain type of chemo before and those who haven't. Researchers want to see if Lonsurf can stop the cancer from g…

This pilot study is testing whether women with HER2-positive breast cancer who respond well to initial chemotherapy can safely receive less treatment after surgery. About 100 participants will receive a combination of drugs (paclitaxel, trastuzumab, and pertuzumab) before surgery…

This study looks at whether a 16-week exercise program can lower inflammation in fat tissue for women who have completed breast cancer treatment. About 100 participants will do supervised aerobic and resistance training or home-based stretching. The goal is to see if exercise can…

This study tests whether a polyester mesh coated with fluoropolymer can reduce complications after breast reconstruction in women with breast cancer. One hundred women will receive either standard reconstruction or reconstruction with the coated mesh. The main goal is to see if t…

This phase 2 trial is testing whether doctors can safely reduce the amount of chemotherapy given to people with HER2-positive breast cancer by using imaging scans to guide treatment. The study involves 462 participants with stage II or III disease who receive a combination of dru…

This early-phase trial is testing whether a single, high dose of radiation given before surgery can safely treat early-stage breast cancer. Researchers are enrolling 45 women with small tumors (3 cm or less) to find the highest dose that does not cause severe side effects. If suc…

This phase 3 trial tests whether adding the drug capecitabine to standard chemotherapy improves outcomes for people with early triple-negative breast cancer. The study involves 325 participants and aims to see if the combination leads to a higher rate of complete tumor disappeara…

This phase 2 trial is testing a combination of three drugs—atezolizumab, trastuzumab, and vinorelbine—in people with HER2-positive advanced or metastatic breast cancer that has already been treated with trastuzumab and other anti-HER2 therapies. The study focuses on patients whos…

This study tests a high-precision radiation technique called SBRT for people with advanced breast cancer who cannot have surgery. Twenty-four participants will receive four radiation doses over two weeks. Researchers will track side effects and quality of life to see if this appr…

This study is testing a precise type of radiation called proton therapy for women with stage II or III breast cancer who need radiation to the whole breast or chest wall and lymph nodes. The goal is to see if this approach causes fewer side effects, especially to the heart, compa…

This study is testing a new mammography device to see if it can safely produce clear images for breast cancer screening and diagnosis. About 7,500 women aged 35 and older who need a mammogram or breast biopsy will get an extra scan with the new device. The goal is to check image …

This phase 2 trial tests whether a new radioactive tracer called [18F]FluorThanatrace can improve PET/CT scans in 36 people with breast cancer. The tracer is designed to highlight an enzyme linked to cancer growth. Participants will receive the tracer before their standard surger…

This study tests a new MRI technique called virtual MR elastography (vMRE) that uses standard scans to measure breast tissue stiffness, which can help tell benign from malignant lesions. Researchers will compare vMRE to the traditional MRE method in 238 women with suspicious brea…

This study is testing whether a special MRI that does not require a contrast dye injection can accurately detect breast cancer or other breast diseases. Over 1,000 women at risk or with suspected breast issues will receive the new MRI alongside standard care. The goal is to see i…

This study is testing a short (under 5 minutes) MRI technique called DWI that does not require an injection of contrast dye. The goal is to see if it can find breast cancers that mammograms miss in women with dense breasts. About 269 women with dense breasts will participate. If …

This study compares breast ultrasound with two types of breast MRI (abbreviated and full protocol) for detecting new breast cancers in women who have dense breasts and a personal history of breast cancer. About 1,756 women will be randomly assigned to one of the screening methods…

This study is testing an artificial intelligence (AI) tool that analyzes digitized images of tumor tissue from 2,200 women with ER-positive, HER2-negative early breast cancer. The AI aims to predict the risk of cancer spreading to distant parts of the body. Researchers will compa…

This pilot study tests a new type of breast scan called DBT-TOBI, which combines 3D mammography with light-based imaging. Researchers want to see if it can predict how well breast cancer responds to chemotherapy early in treatment. The study involves 30 women with HER2+ or triple…

This study tests a low-cost, portable ultrasound device (POCUS) combined with artificial intelligence to detect breast cancer in women with suspicious symptoms. The goal is to see if this approach works as well as standard imaging, especially in places where expensive equipment i…

This study looks at 400 women recently diagnosed with breast cancer to compare four imaging techniques: MRI, digital mammogram, ultrasound, and PET scan. The goal is to see which method, or combination, best determines how far the cancer has spread before surgery. The results cou…

This study tests whether contrast-enhanced mammography (CEM) finds breast cancer more accurately than standard mammography in women who have already had breast cancer. About 1,647 women ages 30-85 will get both types of mammograms to compare detection rates and false alarms. The …

This study is testing whether a simple blood test can help rule out breast cancer in women who had a suspicious mammogram. About 75% of women called back for extra testing turn out to be fine, but they still go through stressful and unnecessary procedures. The goal is to use bloo…

This pilot study is testing the world's first total-body PET/CT scanner (EXPLORER) to see if it can improve cancer imaging. Researchers will scan 9 people with prostate cancer, breast cancer, or neuroendocrine tumors using FDA-approved radiotracers. The goal is to measure how wel…

This pilot study tests a smart bra that measures skin temperature to find breast abnormalities, including cancer. About 70 women with or without breast cancer will wear the device to see how well it detects tumors. If it works, it could offer a simple, portable screening option.

This study looks at a special ultrasound technique to check lymph nodes during surgery in breast cancer patients who have already had chemotherapy. The goal is to see if this method can accurately tell whether cancer remains in the lymph nodes, helping doctors decide exactly whic…

This study tests whether a quick, low-cost breast MRI (about 10 minutes) finds cancer better than standard 3D mammography in women with dense breast tissue. Over 1,500 women without symptoms took part. The goal is to see which method catches more invasive cancers early, potential…

This study tests whether a new imaging technique called multispectral optoacoustic tomography (MSOT) can visualize breast cancer and melanoma tumors. Twelve participants will have MSOT scans before their standard biopsy or treatment. The goal is to see if MSOT can detect tumors a…

This study tests a new, 15-minute MRI scan that measures the types of fat in breast tissue. Researchers want to see if women with breast cancer have more saturated fat in their breasts than women with benign lumps. About 190 postmenopausal women will get the extra scan during the…

This study compares a new cone beam breast CT scan to standard digital mammography for breast cancer screening. About 1,024 women aged 30 or older (40+ for screening) will get both scans within 4 weeks. Researchers want to see if the new scan gives a similar or lower radiation do…

This study explores whether routine brain MRIs and spinal taps can detect early signs of breast cancer spreading to the brain in people with HER2-positive breast cancer. Researchers will enroll 9 participants to see if these tests are feasible and well-tolerated. The goal is to c…

This early-stage study tests a new radioactive tracer called [18F]ISO-1 in PET scans for people with breast cancer. The tracer targets sigma-2 receptors, which are linked to how fast cancer cells multiply. Researchers want to see if the scan can measure tumor growth rates and hel…

This study tests whether a fluorescent dye called indocyanine green (ICG) can replace the current radioactive tracer (technetium) for finding sentinel lymph nodes in breast cancer patients. About 493 women with early-stage breast cancer will take part. Surgeons will first use the…

This study tests a new handheld scanner (LymphaTech) to see if it can accurately measure arm swelling in 100 breast cancer survivors. The goal is to find a faster, easier way to screen for lymphedema, a common side effect of treatment. Researchers will compare the scanner's resul…

This pilot study aimed to see if contrast-enhanced ultrasound (CEUS) could predict how well triple-negative breast cancer patients respond to chemotherapy and immunotherapy. Researchers planned to measure tumor volume and blood flow changes with CEUS before and during treatment. …

This pilot study tests a special PET scan using a radioactive tracer called 64Cu-DOTA-trastuzumab in 18 women with advanced HER2-positive breast cancer. The goal is to see if this scan can better identify HER2-positive tumors compared to standard imaging. If it works, it may help…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. The goal is to see if this scan can detect tumors that standard methods might miss. About 20 adults with CEA-positive cancers (such as breast, colon,…

This study tests a new, faster breast MRI technique called GRASP. The goal is to see if it can accurately tell the difference between harmless and cancerous breast lumps by measuring how contrast dye moves into the tissue. About 264 women already scheduled for a standard breast M…

This early-stage study aimed to test a new radioactive imaging agent called [18F]GEH121224 for detecting HER2-positive breast cancer using PET scans. The plan was to enroll 12 women with advanced breast cancer to check safety, radiation exposure, and the best timing for scans. Ho…

This study tests advanced ultrasound signal processing to make breast images clearer. Researchers will compare new beamforming methods to standard ultrasound in 252 women with breast findings like cysts or microcalcifications. The goal is to better see important features and tell…

This study looks at whether a breast MRI-guided biopsy can accurately tell if a woman's breast cancer has completely disappeared after chemotherapy. Researchers will enroll 31 women whose tumors are no longer visible on MRI after treatment. If the biopsy correctly identifies a co…

This study looks at whether combining mammograms with breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the sc…

This study was designed to see if analyzing tiny particles called exosomes in spinal fluid could help doctors diagnose leptomeningeal metastasis—a serious complication where breast cancer spreads to the membranes around the brain and spinal cord. Researchers planned to collect sp…

This early-phase trial tests a radioactive tracer called [18F]FluorThanatrace to see if it can measure PARP-1, a protein linked to breast cancer, using PET scans. Up to 30 people with known or suspected breast cancer will get a scan before surgery or therapy. The goal is to see i…

This study looks at whether a special ECG and a blood test can find early signs of heart weakness in adult cancer survivors who had certain chemotherapy. Researchers will check how well these tests work compared to standard heart imaging. The goal is to gather information needed …

This phase 3 trial is comparing two types of mammograms—standard 2D digital mammography and newer 3D tomosynthesis—to see which is better at finding advanced breast cancers early. Over 108,000 women are taking part, and researchers will track cancer diagnoses over 4.5 years. The …

This study tests whether a special surgical technique called Axillary Reverse Mapping (ARM) can prevent lymphedema (arm swelling) in breast cancer patients who need lymph node removal. The ARM technique aims to preserve the arm's lymph drainage during surgery. 100 patients will b…

This study looks at whether taking omega-3 fatty acids (like fish oil) can lower the chance of breast cancer returning in women who have already been treated. Eighty women with a specific type of breast cancer will take either a low or high dose of omega-3s for 12 months. Researc…

This study tests whether wearing two layers of surgical gloves during paclitaxel chemotherapy can prevent nerve damage in the hands. About 104 breast cancer patients will be randomly assigned to wear the gloves or not. Researchers will compare changes in nerve pain and function b…

This study explores whether aerobic exercise, like walking, can lower levels of ctDNA (a marker of cancer in the blood) and help prevent breast, prostate, or colorectal cancer from coming back. Researchers will test different amounts of weekly exercise (90 to 375 minutes) in 33 p…

This phase IIB trial tests whether a low dose of tamoxifen (a hormone-blocking drug) can reduce breast cancer risk in people who received chest radiation therapy before age 40. The study involves 84 survivors and measures changes in breast density as a risk indicator. If successf…

This phase 3 trial tests a long-acting injection called PEG-G-CSF to prevent severe neutropenia (dangerously low white blood cell counts) after chemotherapy in 250 women with breast cancer. Participants receive either the test drug or the already-approved Neulasta. The goal is to…

This phase 2 trial tests whether a daily pill combining bazedoxifene and conjugated estrogens can reduce breast cancer risk in 120 women aged 45-64 who have menopausal hot flashes and are at increased risk for breast cancer. Participants take the drug for 6 months or join a waitl…

This study looks at whether a mobile health program that combines physical activity tracking with mindfulness lessons can help breast cancer survivors become more active and feel better. About 304 women who finished cancer treatment within the past 5 years will take part in a 24-…

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') in people who have had breast or gynecologic cancer. About 50 participants will wear either the active headband or a placebo version for 18 hour…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. About 192 people who finished cancer treatment in the last 5 years will take part. They will write and report how they feel, and researchers will track an…

This study tests if whole-body cryotherapy (brief exposure to extreme cold) can reduce joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. About 70 women will be randomly assigned to either a real or placebo cryotherapy session. Researchers will…

This study compares two types of nerve blocks (retrolaminar block vs. serratus anterior plane block) to see which provides better pain relief after radical mastectomy. About 90 women aged 25-65 undergoing breast cancer surgery will receive one of the blocks before general anesthe…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study tests an exercise program designed for Hispanic women who have had breast cancer. The goal is to find the best ways to help them become more physically active. Researchers will measure changes in exercise habits and look at certain health markers in the blood. The stud…

This study compares a new counseling approach called Acceptance and Commitment Therapy (ACT) with standard counseling to help people with head and neck, lung, breast, gastrointestinal, or genitourinary cancer stop smoking. About 51 adults who smoke at least one cigarette per day …

This study tests a mobile lifestyle program for women with breast cancer who have unhealthy habits. The program offers coaching on diet, exercise, stress management, mindfulness, and sleep. Researchers want to see if it's practical and helps improve quality of life. About 30 wome…

This study tests whether a 6-week online yoga program can improve quality of life, reduce joint pain, and lessen night sweats and hot flashes in women with breast cancer who are taking endocrine therapy. About 64 women will take part, with half doing yoga four days a week and the…

This study tests a mindfulness-based program (Nite2Day) for women with breast cancer who have trouble sleeping. Participants learn strategies to cope with insomnia, fatigue, stress, and pain during six remote sessions with a therapist. The goal is to see if the program is practic…

This study tests whether sexual counseling delivered via WhatsApp can help breast cancer survivors who have sexual problems after treatment. About 86 women who have had mastectomy and finished chemo/radiotherapy will receive counseling using the EX-PLISSIT model. The goal is to s…

This study tests the DISCO app, designed to help cancer patients talk with their doctors about treatment costs. About 254 adults newly diagnosed with breast, prostate, lung, or colorectal cancer will use the app to become more confident in asking cost-related questions. The goal …

This study looks at whether providing food assistance—like vouchers, grocery delivery, or a hospital food pantry—helps cancer patients finish their treatment. About 600 patients with breast cancer who struggle to afford food will be randomly assigned to one of three programs. Res…

This study tests whether eating a low-calorie diet before chemotherapy can reduce side effects like fatigue, nausea, and mouth sores, and also improve how well the treatment works. About 130 people with breast or prostate cancer will be randomly assigned to either follow the diet…

This study tested if a scalp cooling cap set to a colder temperature than usual can safely prevent hair loss in breast cancer patients receiving chemotherapy. 34 adults with stage I-III breast cancer took part. The goal was to see if the lower temperature is safe and tolerable.

This study tests whether a cream made with caffeine can help prevent skin hardening and other complications in breast cancer patients who need radiation after mastectomy with tissue expander reconstruction. About 60 participants will use either the caffeine cream or a placebo cre…

This pilot study tests whether a home-based virtual program of cardio and yoga (IM@Home) can help breast cancer patients undergoing radiation feel less fatigued and more active. Forty participants will wear a FitBit and attend online classes. The goal is to see if the program is …

This study looks at whether writing about your thoughts and feelings about breast cancer can improve quality of life. About 272 people recently diagnosed with breast cancer will be asked to write for 20 minutes once a week for four weeks. They will fill out questionnaires to meas…

This phase 2 trial tests whether injecting platelet-rich plasma (PRP) into the vulva and vagina can improve symptoms of genitourinary syndrome of menopause (GSM) in breast cancer survivors. GSM causes dryness, burning, and pain, often worsened by cancer treatments. The study enro…

This study looks at whether a 12-week dance program can reduce pain, fatigue, and improve quality of life in women being treated for breast cancer. Twenty-eight women will either take dance classes twice a week or continue their normal routine. Researchers will measure changes in…

This study looks at whether women aged 65 and older with early-stage, estrogen-positive breast cancer can safely have a lumpectomy without also removing and testing nearby lymph nodes (sentinel node biopsy). The goal is to see if skipping this extra step leads to cancer coming ba…

This study tests whether a 20-week program of exercise alone or exercise combined with cognitive training can improve thinking and memory in breast cancer survivors. 108 women who have finished primary treatment will be assigned to one of three groups: dual-task training, exercis…

This study tests whether a type of pain education that teaches the brain's role in pain, combined with motivational interviewing, can reduce chronic pain in breast cancer survivors. 156 women who have finished primary treatment and still have pain will be randomly assigned to thi…

This study compares a single dose of radiation given during breast cancer surgery (IORT) to standard whole breast radiation given over weeks. The goal is to see if IORT causes less fatigue in women with low-risk early breast cancer. About 100 women aged 50 and older with small, h…

This study compares two relaxation programs (including stretching and relaxation techniques) to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. About 700 women with early-stage breast cancer will participate, with so…

This study aims to develop and test a shortened version of Mindfulness-Based Cognitive Therapy (MBCT) to improve mood in older African American/Black women who have had breast cancer and now have mild to moderate depression. About 23 participants will attend group sessions and re…

This study tests whether a therapy program that combines in-person sessions with a smartphone app can help cancer patients feel more flexible in dealing with difficult thoughts and emotions. About 120 adults with breast, lung, or colorectal cancer will be randomly assigned to one…

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This pilot study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS), combined with cognitive training, is feasible and tolerable for breast cancer survivors who have memory or thinking problems after chemotherapy. The st…

This study tests an online self-help program called Together After Cancer for Latina breast cancer survivors and their intimate partners. The program includes brief coach calls and aims to improve the survivor's quality of life and the couple's relationship satisfaction. About 48…

This study tests whether a 12-week program of online chair-based exercise and health education, combined with a geriatric assessment, is feasible and helpful for adults aged 65+ with certain cancers and their support persons. The program is delivered remotely, and the study will …

This study looks at whether a special cooling cap, called the Amma system, can help women with early-stage breast cancer keep more of their hair during chemotherapy. Fifteen women will use the cap during each chemo session and answer questions about how satisfied they are. The go…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer who are receiving chemotherapy. Twenty-four participants will take part in weekly group music sessions and use personalized playlists at home, alternating periods…

This study develops and tests a mobile app to help breast cancer and rare cancer survivors manage their fear of the cancer coming back. About 252 participants will try one of three app versions to see which is most helpful and easy to use. The goal is to create a personalized too…

This study tests a portable scalp cooling system called Amma to see if it can prevent hair loss in women receiving chemotherapy for early-stage breast cancer. Forty women with stage I-III breast cancer will use the cooling cap during their chemo sessions. The goal is to see if mo…

This study tests whether acupuncture can improve thinking problems (like memory and focus) in breast cancer survivors. About 270 women who have finished cancer treatment will receive either real acupuncture, sham acupuncture, or standard care. Researchers will track their cogniti…

This study looks at whether a shorter, more intense course of radiation (accelerated radiation therapy) is safe and tolerable for women with breast cancer who have already had chemotherapy and surgery. About 88 participants will receive the accelerated radiation to the breast and…

This study looks at whether people with breast or prostate cancer that has spread to the bones can safely stop or reduce their bone-strengthening medication after taking it for at least two years. The goal is to see if this change improves their quality of life without increasing…

This study looks at two ways to give radiation to brain tumors in people who are also receiving immunotherapy for cancers like lung, breast, kidney, or melanoma. The standard approach gives one high dose of radiation, while the experimental approach gives smaller doses over sever…

This study tests whether romiplostim can prevent chemotherapy delays or dose reductions caused by low platelet counts in people with lung, ovarian, or breast cancer. About 145 adults will receive either romiplostim or a placebo alongside their chemotherapy. The goal is to help pa…

This study looks at whether starting hormone therapy every other day for one month, then switching to daily, helps women with early breast cancer take their medication as prescribed. About 240 participants will be randomly assigned to either the standard daily dose or the gradual…

This study tests whether a smartphone app that sends text reminders can help breast cancer patients take their medication (palbociclib) on time. 45 participants will either use a paper diary or receive text reminders over three treatment cycles. The goal is to see if the app is e…

This study tests whether a personalized care plan, based on a geriatric assessment, can reduce severe side effects in older adults (65+) starting chemotherapy for common cancers. Participants are randomly assigned to receive the assessment-driven plan plus usual care, or usual ca…

This study is testing whether listening to calming classical music twice a day can help women with breast cancer feel less anxious and depressed during surgery and chemotherapy. Researchers will also check if music affects certain substances in the blood linked to stress and nerv…

This study follows 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life over time. Researchers want to understand how well patients tolerate this treatment and how it affects t…

This study tests whether combining pain neuroscience education (teaching patients about how pain works) with a gradual, timed increase in physical activity can reduce chronic pain in breast cancer survivors. About 122 survivors who have finished cancer treatment will be randomly …

This study looks at a breast reconstruction method that uses only a small part of a back muscle, aiming to reduce shoulder pain and stiffness. Researchers will compare this technique to standard implant reconstruction in about 190 women. The goal is to see which approach gives be…

This study looks at whether taking synbiotics (probiotics plus a prebiotic from agave) or prebiotics alone can help prevent memory and thinking problems (chemobrain) in people with breast cancer getting chemotherapy. About 80 participants will take a supplement or none daily for …

This study tests whether a personalized survivorship care plan, including a booklet and counseling sessions, can improve quality of life for breast cancer survivors. About 100 women in Southern California who have finished active treatment for early-stage breast cancer will take …

This study tests a mixed reality system called VascuLens 2.0 that projects 3D images of a patient's blood vessels onto their body during DIEP flap breast reconstruction surgery. The goal is to help surgeons make more accurate incisions, potentially reducing surgery time and compl…

This study tests whether listening to nature sounds (like birds or water) during a breast core biopsy can lower pain and anxiety. About 200 participants will be randomly assigned to either hear nature sounds or receive standard supportive conversation. The goal is to see if natur…

This study tests a fixed-dose combination of netupitant and palonosetron (NEPA) to prevent nausea and vomiting in breast cancer patients receiving chemotherapy with adriamycin and cyclophosphamide. The trial includes 55 women in Hong Kong and tracks how well the drug works during…

This study tests whether a 30-minute education session with a radiation therapist, before standard radiotherapy, can reduce anxiety and improve quality of life for breast cancer patients. About 109 participants will be randomly assigned to either the extra session or standard car…

This study tests whether giving breast cancer patients a 3D printed model of their breast helps them make better surgery decisions. Twenty women who need surgery will either get the 3D model or standard scans. Researchers will measure how conflicted patients feel about their choi…

This study tests whether talking to an exercise specialist over the phone can help breast and colorectal cancer survivors become more active. Many people become less active after cancer treatment, and this program aims to change that. The trial includes 120 participants who recen…

This study tests whether a special cooling mat can reduce hot flashes and night sweats in people taking hormone therapy for breast or prostate cancer. About 40 participants will use the mat for 8 weeks and track their symptoms. The goal is to see if this simple, non-drug approach…

This study tests an internet-based program called SHINE to help breast cancer survivors manage sexual concerns after treatment. About 340 women who finished primary cancer treatment at least 12 weeks ago will join. Participants get online education and tools, and the study checks…

This study compares two methods of prepectoral breast reconstruction after mastectomy for breast cancer: one using acellular dermal matrix (ADM) and one without. The goal is to see if using ADM leads to fewer major complications like infection or implant removal within 90 days. A…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This trial tests whether an AI-based management platform, called 'Zhiliao Doctor,' can reduce anxiety and depression in 300 breast cancer patients taking CDK4/6 inhibitors at home. Participants are randomly assigned to standard care, the AI platform, or personalized follow-up cal…

This study compares a shorter, higher-dose radiation schedule (hypofractionated) with the standard longer schedule for breast cancer patients who have had surgery. The goal is to see which approach causes less fatigue and better quality of life. About 132 adults with breast cance…

This study tests whether virtual reality (VR) games, combined with lifestyle changes like walking and better sleep, can improve arm function in women who had breast cancer surgery. Sixty female survivors aged 30-60 will be randomly assigned to VR therapy or conventional physical …

This study tests whether a 12-week program of Mediterranean diet counseling and strength training can improve physical fitness, body composition, and emotional well-being in women who have completed treatment for breast cancer. 120 survivors aged 30-65 will be randomly assigned t…

This study looks at two treatments for vaginal dryness in women with estrogen receptor-positive breast cancer who are taking aromatase inhibitors. One group uses a vaginal estrogen ring that releases a low dose of estrogen over 90 days, while the other uses a non-hormonal vaginal…

This study tests whether eating only within a 10-hour window each day can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty makes it harder to recover from stress and can lead to loss of independence. The trial will enroll 30 participa…

This study tests a mobile game called UMAY that helps breast cancer patients imagine their immune cells attacking cancer cells. 80 women with locally advanced breast cancer will play the game or a placebo game at home alongside their usual chemotherapy. Researchers will measure c…

This study looks at whether a 16-week home exercise program can help Black and Hispanic patients with breast, colorectal, or prostate cancer become more active during chemotherapy. Participants will do aerobic and resistance exercises either with virtual supervision or on their o…

This study tests a mobile cognitive-behavioral therapy program called MAAT to help breast cancer survivors who have memory and concentration problems after chemotherapy. About 220 survivors who finished chemo 1-5 years ago will either use MAAT or receive supportive therapy. The g…

This phase 2 trial is testing whether gradually increasing the dose of abemaciclib (a targeted cancer drug) can reduce side effects like diarrhea and help patients stick with treatment. It involves 90 people with early-stage, hormone receptor-positive, HER2-negative breast cancer…

This study tests a special cooling cap (Orbis Paxman system) to prevent hair loss in Chinese women with breast cancer undergoing chemotherapy. 25 participants will use the cap during chemo sessions. The goal is to see if it safely reduces hair loss and improves quality of life.

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was practical and well-liked, and whether it improved quality of life, physical activity, and mood. Participan…

This study looks at whether a program combining exercise and psychological support can help breast cancer patients manage negative emotions like anxiety and depression. About 200 patients who have finished initial cancer treatment will take part. The goal is to see if this approa…

This study tests if a shorter course of radiation (3 doses over 5 days) is as safe and works as well as the standard 5-dose schedule for women with early-stage breast cancer. About 284 post-menopausal women with small, low-risk tumors took part. The main goal is to see if the sho…

This study aimed to compare two ways of numbing the chest after a mastectomy: a targeted nerve block versus direct injection into the surgical area. It was planned for adults aged 18-80 undergoing unilateral mastectomy. However, the trial was withdrawn before enrolling any partic…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study tests whether a live, personalized exercise and meditation coaching program, delivered through a digital app, can improve the quality of life for cancer survivors. The trial involves 146 adults who have had breast, lung, prostate, colorectal, or other cancers. Particip…

This study tests a 3-month intermittent fasting weight loss program in 36 adults who have completed treatment for breast cancer and are overweight or obese. Participants follow a 4:3 fasting schedule (3 modified fast days per week) and aim for 150 minutes of physical activity wee…

This study tests a web-based portal (YES) for women aged 18–39 newly diagnosed with breast cancer. The portal helps track symptoms, offers self-management tips, and connects users with peers. Researchers want to see if it reduces issues like vaginal dryness and improves well-bein…

This study compares two types of nerve blocks (PECS II-PIFB vs. SAPB) to see which provides better pain relief for women undergoing modified radical mastectomy. Seventy women aged 18-65 will be enrolled, and the main goal is to measure how much extra pain medicine they need in th…

This study aimed to see if a tailored neck exercise program could improve motor control, reduce pain, and boost mood and quality of life in women who survived breast cancer for at least five years. The trial was withdrawn before any participants were enrolled, so no data was coll…

This pilot study tests whether curcumin, the active ingredient in turmeric, can reduce joint pain caused by aromatase inhibitors in breast cancer survivors. 42 postmenopausal women will receive either curcumin or a placebo for 3 months. Researchers will measure changes in pain an…

This study looks at whether Tai Chi, a gentle moving meditation, can improve chronic insomnia in breast cancer survivors. About 90 women who have completed cancer treatment and have had trouble sleeping for at least 6 months will practice Tai Chi. Researchers will measure sleep q…

This study looks at whether flibanserin, a drug for low sexual desire, can be safely taken by breast cancer survivors who are on tamoxifen or similar hormone therapies. About 43 women with a history of breast cancer and no current disease will take flibanserin for 24 weeks. The m…

This study tests whether temporarily freezing the nerves that supply the breast can reduce pain and the need for opioid painkillers after mastectomy. About 216 women having breast removal will receive either the freezing treatment or a sham procedure. The goal is to see if a sing…

This study looks at whether using a Fitbit activity tracker along with health coaching can help reduce persistent pain and improve well-being in young Hispanic women who had breast cancer surgery. The trial will enroll 25 women who have had surgery at least six months ago and sti…

This study tests whether neurofeedback training—a non-invasive therapy that uses brain wave monitoring—can help people with chemotherapy-induced peripheral neuropathy (nerve pain, numbness, or tingling) learn to change their own brain activity to feel less pain and improve qualit…

This study tests if the DigniCap scalp cooling system can prevent hair loss in Black women with early-stage breast cancer undergoing chemotherapy. About 30 participants will use the cooling cap during chemo sessions. The goal is to see if it helps keep hair, reducing the need for…

This study is testing whether a special compression bra, called Mobiderm Intimate, can safely reduce breast swelling (edema) that often happens after breast cancer surgery and radiation. Thirty women who had breast-conserving surgery will wear the bra day and night for three week…

This study tests a non-invasive brain stimulation technique called prolonged continuous theta burst stimulation (pcTBS) to relieve nerve pain caused by chemotherapy in breast cancer patients. Forty women will receive either pcTBS or standard repetitive transcranial magnetic stimu…

This study tests whether an interactive 3D tool, used during a standard surgical consultation, helps women feel more satisfied with the information they receive about breast reconstruction options. Researchers will also check if the tool improves satisfaction with their breasts a…

This study planned to test photobiomodulation (a type of light therapy) on nerve pain and sensation in one woman after mastectomy. The treatment used red and near-infrared light on the affected area for six weeks. However, the study was withdrawn before any participants enrolled,…

This study aimed to see if offering aesthetic care (like makeup and skincare) to women who had a mastectomy or lumpectomy for breast cancer could improve their body image and quality of life. It planned to compare women who received these sessions with those who did not. However,…

This study tests a 5-week computer-based memory training program for breast cancer survivors who have memory and attention problems after chemotherapy. Sixty women will be randomly assigned to either the full working memory training or a less challenging version. The goal is to s…

This study tests whether a 12-week online yoga program can reduce fatigue and inflammation in women who have had breast cancer surgery. 229 participants are randomly assigned to either the yoga group or standard care. The goal is to see if yoga helps with energy, stress, and dail…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study investigates whether early changes on a PET scan can predict which patients with HER2-positive breast cancer will have a complete response to a combination of trastuzumab and pertuzumab given before surgery. Participants receive the two drugs and undergo PET scans at t…

This study looks at how breast cancer treatment affects quality of life in women of different ages. Researchers are asking 650 women recently diagnosed with early-stage breast cancer to fill out questionnaires about their physical and emotional well-being. The goal is to understa…

This study follows over 64,000 adults who grew up on farms to see if early exposure to pesticides and other agricultural factors is linked to cancer. Participants fill out an online questionnaire and may provide biological samples. Researchers will track their health over many ye…

This study tests a special PET scan (FES) that tracks estrogen receptors in breast cancer tumors. Researchers want to see if changes in scan results before, during, and after hormone therapy can show how well the treatment is working. The study involves adults with estrogen recep…

This study collects blood, urine, and tumor tissue from 500 adults with breast, ovarian, or uterine cancer, plus some of their relatives. The goal is to create a repository of samples for future research on DNA changes that drive these cancers. Participants give samples during ro…

This study follows 810 young women aged 18-45 with early-stage breast cancer to understand how treatment affects their menstrual cycles and quality of life. Participants complete questionnaires every six months for up to 42 months. The goal is to identify factors that lead to ear…

This study looks back at 1,400 women who had breast-conserving surgery for non-palpable breast lesions. It compares two methods used to find the lesion during surgery: injecting a radioactive substance (ROLL) or placing a tiny magnetic seed. The goal is to see which technique lea…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tests new ways to help rural primary care clinics provide better follow-up care for cancer survivors. Researchers will give clinics telementoring, quality improvement coaching, and an obesity management toolkit. The goal is to see if these tools help clinics follow nat…

This study looks at how radiation therapy for breast cancer affects tumor DNA and immune cells in the blood. Researchers will track these markers in 217 patients to see if they can predict treatment response. The goal is to use this information to customize radiation plans in the…

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study checks the eye health of people with breast cancer using standard tests like vision charts, eye exams, and scans. The goal is to spot any vision changes or eye damage that might happen during cancer treatment. About 160 participants will be followed to understand how b…

This study tests five different reminder strategies to encourage women in Singapore who are overdue for mammograms to get screened. About 12,750 women aged 50-69 who have not had a mammogram in over two years will receive reminders by mail, with some getting a pre-scheduled appoi…

This study asks 12 clinicians in Florida who care for women with breast cancer about gaps in emotional and mental health support. They will join virtual focus groups and fill out a short survey. The goal is to use their insights to build an AI-powered digital platform called Mamm…

This study looks at how to best collect information about social and behavioral needs (like housing, food, or transportation) from women newly diagnosed with breast cancer. Researchers will compare different screening tools and methods (like chatbots or phone calls) to see which …

This study looks at how different breast cancer treatment decisions, like choosing between a lumpectomy or mastectomy, affect women's quality of life and emotional distress. Researchers followed 345 women with early-stage breast cancer and their partners to measure cancer-related…

This study collects white blood cells and tumor cells from cancer patients, and white blood cells from healthy volunteers, to help researchers grow anti-cancer cells in the lab. The goal is to create experimental cell therapies for future use. Up to 7,000 participants will provid…

This study analyzed stored tumor samples and medical records from nearly 1,900 Greek women who had surgery for early breast cancer. Researchers looked at genetic changes and protein markers in the tumors to see how they relate to breast cancer subtypes and long-term survival. The…

This study follows over 3,600 women who received MemoryShape or MemoryGel breast implants for augmentation or reconstruction. Researchers track complications like rupture, connective tissue disease, and cancer over 10 years. The goal is to gather real-world safety data, not to te…

This study looks at how age changes the way the body handles a breast cancer drug called nab-paclitaxel. Researchers are studying 40 people with metastatic breast cancer to see if older patients process the drug differently. The goal is to make chemotherapy safer and more effecti…

This study tests whether a computer algorithm called ENLIGHT can help find better drug matches for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer will have their tumor…

This study looks at attention and memory in breast cancer survivors compared to healthy women of the same age. Researchers use EEG to measure brain activity during memory tasks. The goal is to understand why some survivors have trouble focusing or remembering. Results may help de…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study tests whether an AI system can create safe and effective exercise plans for women recovering from breast cancer surgery. Researchers will compare the AI's plans to those made by doctors. The goal is to make rehabilitation more personalized and accessible.

This study looks at why some women with breast cancer in one breast later develop cancer in the other breast. Researchers are comparing women with cancer in both breasts to those with cancer in only one breast. They are studying how genes, past radiation treatment, and lifestyle …

This study examines whether medications given during mastectomy to keep blood pressure stable might affect the risk of breast cancer coming back. Researchers will review the records of 250 patients who had mastectomy over five years. They will look at which drugs were used and tr…

This study tests a new way of organizing care for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) plus at least one other serious health condition. The GERONTE program brings all their doctors and nurses together using a shared digital care plan. …

This study looks at how breast cancer treatment impacts women's jobs, finances, and daily life, especially comparing women from different ethnic groups. About 935 breast cancer survivors who were working before or during treatment will share their experiences. The goal is to unde…

This study uses a special ultrasound technique to monitor blood flow in the breast skin of women who have had a mastectomy and radiation therapy. Researchers want to see how fat grafting affects blood supply. Fifteen women who are already scheduled for breast reconstruction will …

This pilot study aimed to test a new breast-dedicated PET camera that can see details as small as 1 millimeter. Researchers planned to inject a radioactive tracer into people with breast cancer and see if the camera could produce clear images. However, the study was withdrawn bef…

This study looks at how three common breast cancer drugs (abemaciclib, ribociclib, or palbociclib) change body fat and muscle in 30 people with ER+/HER2- breast cancer that has spread. Participants get CT and DEXA scans before and after 24 weeks of treatment. The goal is to under…

This study involves 15 postmenopausal women with metastatic ER+ breast cancer. Researchers are testing a special PET scan that uses a radioactive tracer to see estrogen receptors on tumors. The goal is to find the best way to measure these receptors, which could help doctors know…

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study is testing whether people with cancer or diabetes can use a Fitbit and a continuous glucose monitor (CGM) to track their daily exercise and glucose levels. The goal is to see if it's practical and if people will stick with it. Thirty-five participants will wear both de…

This study looks at whether it is safe to have an MRI scan when you have breast tissue expanders in place. About 68 people with these expanders will be scanned, and researchers will check for any burning, heating, or pain. The goal is to see if MRI can be done safely in this grou…

The FATLAS study is looking at how body fat (adiposity) influences breast cancer at both the whole-body and cellular levels. Researchers will enroll 150 breast cancer patients with different body types (lean, overweight, obese) and collect blood, tumor tissue, and body measuremen…

This study looks at survival rates for people with cancers like melanoma, breast, colon, and lung cancer using data from Russian cancer registries. It includes 100,000 people of any age. The goal is to understand survival trends to help improve cancer care, not to test a new trea…

This study creates a long-term repository of blood, tissue, and health information from 810 people with breast cancer, benign breast disease, or no breast issues. The goal is to provide researchers with resources to better understand breast cancer. No treatment or experimental th…

This study reviews medical records from 300 cancer patients to see if the makeup of a tumor's surroundings (the tumor microenvironment) is linked to how well antibody-based therapies work. Researchers will analyze tissue samples and blood markers from patients with seven types of…

This study looks at 625 people in Russia with high-risk early-stage breast cancer that is HER2-negative. Researchers want to find out how many have BRCA1 or BRCA2 gene mutations and what treatments they receive in real-world practice. Participants provide blood and tumor samples …

This study looks at whether people with HER2-positive breast cancer can safely have fewer heart check-ups while on a specific type of treatment (trastuzumab without anthracyclines). About 190 participants will be followed to see if less monitoring leads to serious heart problems.…

This study looks at why women in the Hauts-de-France region of France may wait longer to start breast cancer treatment, even though they get cancer at similar rates as elsewhere. Researchers will track 500 women from their first symptom to their first treatment, breaking down del…

This study collects medical information and tumor samples from 200 men with breast cancer to better understand the disease. Researchers will analyze patient characteristics, treatments, and outcomes over time. The goal is to learn more about male breast cancer, which is rare and …

This study tests a new program to help breast cancer patients return to work after treatment. It includes 16 working-age women who have work difficulties. The program offers meetings and support from a team of specialists. The goal is to see if this approach is practical and help…

This study looks at whether giving doctors a patient's genetic information can help them personalize chemotherapy doses and reduce serious side effects. About 860 adults with certain cancers (like breast, stomach, or head and neck) will be randomly assigned to have their doctors …

This study tests a program to improve follow-up care for breast cancer survivors in primary care clinics. The program includes training, expert advice, and feedback for clinic staff. Researchers will see if it helps clinics provide more complete care for managing symptoms and lon…

This study looks at whether a physical exercise program can prevent heart damage in breast cancer patients receiving a type of chemotherapy called anthracycline. About 70 participants will be randomly assigned to exercise or usual care. Researchers will use heart scans and blood …

This study looks at whether artificial intelligence (AI) can help radiologists find breast cancer earlier when reading mammograms. Researchers will review past mammograms from 785 women, some with breast cancer and some without, to compare how well doctors detect cancer with and …

This study looks back at medical records of 1,950 breast cancer patients to build a tool that predicts whether lymph nodes are cancer-free after chemotherapy. The goal is to identify patients who could safely have a less invasive sentinel node biopsy instead of full lymph node re…

This study enrolls 4,000 people with breast, ovarian, or colorectal cancer to test a comprehensive genetic panel. The panel looks for inherited cancer risks and tumor mutations that may affect drug sensitivity. Researchers aim to validate these genetic findings to potentially gui…

This study tracks over 1,400 breast cancer and lymphoma patients to see how chemotherapy affects memory, attention, and thinking skills. Researchers test patients before, right after, and up to years after treatment. The goal is to learn who is most at risk for 'chemo brain' and …

This study examines how genetic variations (SNPs) in certain genes influence how well the drug raloxifene works and its side effects in 600 patients with lobular carcinoma in situ (LCIS), a high-risk breast condition. Participants take raloxifene daily, and researchers sequence t…

This study looks at whether combining breast MRI with blood and tissue samples can help find early signs of breast cancer in high-risk women. About 344 women will undergo standard screening MRI and donate leftover tissue and blood. The goal is to better understand how normal brea…

This study is watching nearly 3,000 people newly diagnosed with breast cancer in Latin America. It does not test a new treatment but instead collects information on how the cancer is diagnosed, what treatments are used, and how patients do over time. The goal is to better underst…

This study tests a new imaging tool called HyperSight that takes clearer, faster pictures during radiation therapy for cancers of the head/neck, breast, lungs, upper GI, or pelvis. The goal is to see if these images are good enough to help doctors plan treatment more precisely, p…

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength and heart health in 14 postmenopausal breast cancer patients who received anthracycline chemotherapy. Researchers will measure changes in heart function, muscle energy, and blood…

This study planned to give high doses of vitamin D to women with breast cancer before their surgery. Researchers wanted to see if the vitamin would change certain markers in the cancer cells. However, the study was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether using loco-regional anesthesia (numbing a specific area) during breast cancer surgery can help prevent chronic pain that often lasts months or years after the operation. About 30% of women experience this long-term pain. Researchers will follow 1,500 p…

This study planned to monitor tiny bits of tumor DNA in the blood of people with early breast cancer. Researchers wanted to see how these DNA levels change during treatment and follow-up. The study was withdrawn before any participants were enrolled, so no results are available.

This study tests whether sending text message reminders to patients and alerts to doctors can increase the number of women who get their recommended mammograms. About 8,490 women aged 40-74 who are overdue for screening will take part. The goal is to see if these simple 'nudges' …

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …

This study tests whether peer navigators—trained breast cancer survivors—can help African-American women recently finished with breast cancer treatment better understand and stick to their follow-up care plans. About 145 women will either receive standard educational materials or…

This study tests whether trained nurses can perform breast exams and guide women through the healthcare system to reduce delays in diagnosing and treating breast cancer. Researchers will enroll 8,000 women in Ethiopia, South Africa, Nigeria, and Tanzania. The goal is to see if th…

This study involves 2,200 women aged 50–67 to see if personalized mammography screening, based on genetic and lifestyle risk factors, is safe and acceptable. Half the women receive standard biennial mammograms, while the other half get a risk assessment and a tailored screening s…

This study aims to find out how common persistent pain is after mastectomy and breast reconstruction, and whether a nerve surgery called RPNI can help reduce that pain. Researchers will follow 274 women who had mastectomy and reconstruction at Memorial Sloan Kettering. The study …

This study looks at blood samples from 25 cancer patients receiving radiation therapy. Researchers want to find specific genes that show how each person's body responds to radiation. The goal is to better understand individual reactions and possibly personalize radiation treatmen…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study follows 238 breast cancer patients to see how chemotherapy impacts their physical function, overall health, and quality of life. Researchers compare older adults (65+) with younger patients to understand recovery patterns and identify who is at higher risk for serious …

This study looks at why some women develop hard scar tissue (capsular contracture) around breast implants after mastectomy for breast cancer. Researchers will follow 300 women who had immediate implant-based reconstruction and check their results six months later. The goal is to …

This study follows 132 young breast cancer patients who had chemotherapy, with or without a fertility preservation procedure (controlled ovarian hyperstimulation). Researchers track how many become pregnant and give birth over the long term. The goal is to understand how cancer t…

This study looks at whether it is practical to give women recovering from breast-conserving surgery or mastectomy with reconstruction immediate feedback from their recovery surveys. The tool, called BREAST-Q REACT, shows scores on physical well-being and arm function and offers t…

This study collects tumor tissue, blood, and saliva from 2500 people with various solid cancers to analyze their genetic makeup. The goal is to understand why some tumors become resistant to targeted therapies. Samples may also be grown in special mice to study how genetics affec…

This study watches how women with a certain type of advanced breast cancer are treated with the drug ribociclib in everyday medical practice in France. It does not give any new treatment but simply collects information on dosing, side effects, and how long the drug works. About 1…

This study follows women who are cancer-free three or more years after early breast cancer treatment. Researchers want to see if things like patient traits, cancer type, or treatment side effects affect long-term quality of life. Participants fill out short questionnaires about e…

This study is testing a new set of evaluations called the SAE (Sensory-Attention-Executive) Battery to see if it can help researchers learn how breast cancer treatment affects the brain. Researchers will compare results from the SAE Battery with traditional questionnaires in 187 …

This study tests whether a less invasive ultrasound-guided biopsy can accurately tell if breast cancer has been completely wiped out by chemotherapy, compared to the standard method of checking during surgery. About 43 women with aggressive breast cancer types (triple negative or…

This study tracks 20 women with breast cancer to see if radiotherapy causes muscle loss outside the treated area and how it relates to fatigue. Participants complete fatigue questionnaires and get CT scans at four time points: start, end, and 1 and 3 months after treatment. The g…

This study looks at whether a special type of breast scan, called molecular breast imaging, can help doctors predict how well chemotherapy is working in women with invasive breast cancer. About 96 women will get the scan before, during, and after treatment. The goal is to see if …

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study looks at whether adding a polygenic risk score (a blood test that estimates genetic risk) to standard risk tools helps high-risk women make decisions about breast cancer prevention. About 737 women aged 35-75 with elevated risk are involved. The goal is to see if the s…

This study asks breast cancer patients about their thoughts on screening for lymphedema, a common side effect where the arm becomes swollen and painful after treatment. Researchers use a device called a perometer to measure arm size before and after surgery. The goal is to see if…

This study looks at whether a sentinel lymph node biopsy (a less invasive procedure) can accurately find leftover cancer cells after chemotherapy in women with locally advanced breast cancer. Researchers will compare the biopsy results to the standard full lymph node removal. The…

This study looks back at 88 women who had two-stage breast reconstruction after mastectomy for breast cancer. It compares complication rates between nano- and microtextured tissue expanders and checks how prior radiotherapy affects outcomes. The goal is to find which expander typ…

This study tests a new PET/CT scan that uses a tracer called 18F-FluorThanatrace to measure PARP-1 activity in breast cancer tumors. About 50 adults with known or suspected breast cancer will get one or two scans. The goal is to see how well the scan detects cancer activity and c…

This study examines stored tumor tissue and blood samples from 22 women with early breast cancer to find genetic or chemical markers that might predict whether the cancer will spread to the brain. Researchers will compare women whose cancer did spread to the brain with those whos…

This study was designed to see how much information people with breast or prostate cancer can recall about their screening and diagnosis. Researchers planned to give participants access to their online medical records and then test if that helped them remember more accurately. Ho…

This study collects information from 100 adults with breast, lung, gastrointestinal cancer, or multiple myeloma. Participants fill out weekly online surveys about their symptoms and treatment experiences for at least 12 weeks. The goal is to learn how symptoms change over time an…

This study tests a new payment model for cancer care in Hawaii. Instead of paying for each service separately, doctors get a single payment for an episode of care, with bonuses for meeting quality goals. The study includes 7 oncologists and looks at how this affects care quality,…

This study is collecting tumor and blood samples from 268 women with early breast cancer before they receive standard chemotherapy. Researchers want to see if certain immune-related factors in the tumor and circulating tumor DNA can predict whether the cancer will completely disa…

This study looks at fertility, pregnancy, and contraception in women diagnosed with breast cancer between ages 18 and 50. Researchers will collect data from 22,000 patients to understand how cancer treatments affect their ability to have children and the health of their newborns.…

This study tests whether giving breast cancer treatment based on each tumor's unique genetic makeup works better than standard therapy. About 200 people with large or aggressive breast tumors will receive a personalized drug plan before surgery. Researchers will track how well th…

This study looks at whether women with small breast cancers (under 5 cm) and no signs of cancer in their lymph nodes on ultrasound can safely skip sentinel lymph node biopsy during breast-conserving surgery. About 1,734 women are being randomly assigned to either have the biopsy …

This study watches 25 people with breast or lung cancer who are getting immune checkpoint inhibitor therapy. Researchers use heart scans and blood tests to see if the treatment harms the heart's tiny blood vessels. No new drugs are given; the goal is to learn how to better protec…

This study follows 700 breast cancer patients to understand how chemotherapy affects the heart. Researchers use echocardiograms and blood tests to find early signs of heart damage. The goal is to better predict and prevent cardiotoxicity in cancer treatment.

This study looks at whether a gene test called Prosigna can help doctors choose the best treatment for women with a common type of breast cancer (HR+/HER2-) before surgery. About 60 women will have their treatment decisions recorded before and after the test results. The goal is …

This study looks at how patients feel physically and emotionally after having a breast biopsy for certain non-cancerous but atypical breast conditions. Over 900 participants from several hospitals answered surveys about pain and quality of life, on average nearly four years after…

This study follows over 1,300 women aged 40 or younger who were recently diagnosed with breast cancer. Researchers collect surveys, blood samples, and tumor tissue to learn about the disease, treatment side effects, and emotional challenges like fertility and menopause. The goal …

This study looks at how chemotherapy and other factors affect thinking and memory in older women who survived breast cancer. Researchers will compare these women to older women who never had cancer. They will also study how genetics and smoking history play a role. About 500 wome…

This study looks at how regular exercise might change the biology of breast tumors in women with early-stage breast cancer. Researchers will compare tumor and normal tissue samples from 42 women who exercise regularly versus those who don't. The goal is to understand if exercise …

This observational study follows 2000 women aged 40 or younger with breast cancer to see how having a baby after diagnosis affects their survival and disease return. It also checks the growth and health of their children. The goal is to gather information, not to test a new treat…

This study looks at how breast cancer itself may affect a woman's ability to have children later. Researchers are comparing egg quality and hormone responses in 100 women with breast cancer versus healthy egg donors. The goal is to understand why cancer can reduce the number and …

This study tests a program called the Sexual Health Empowerment (SHE) Project for women who are about to leave jail. The goal is to improve their understanding of cervical cancer, breast cancer, contraception, and sexually transmitted diseases. About 279 women will take part, and…

This study looks at how the tumor microenvironment changes during chemotherapy in 30 patients with HER2-positive breast cancer. Researchers will take samples before, during, and after treatment to see what happens at the cellular level. The goal is to better understand how chemot…

This study uses advanced brain scans to see how chemotherapy changes the brain in women aged 65 and older with early-stage breast cancer. Researchers will compare brain images and thinking tests taken before and after treatment. The goal is to better understand why some older pat…

This study looks at how screening for social needs (like food, housing, and transportation) and connecting Black breast and prostate cancer survivors with community health workers can improve their quality of life and well-being. Researchers are also testing anti-racism training …

This study looks at tumor and blood samples from 1,000 breast cancer patients who received immunotherapy. Researchers will analyze the samples using advanced techniques to build a model that predicts whether a patient will respond to treatment. No new drugs are tested; the goal i…

This study looks at whether a blood test that tracks tumor DNA (ctDNA) can help doctors switch treatments earlier in people with metastatic breast cancer. The goal is to see if acting on a molecular signal of progression, before symptoms or scans show it, can keep the cancer unde…

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study looks at tumor samples from over 3,000 people with advanced cancers to find specific biomarkers—unique features of each cancer. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants are adults with vario…

This study looks at 197 women with advanced breast cancer to compare survival between those whose tumors lost estrogen receptors (ER) and those with triple-negative disease. Researchers used a special PET scan to track receptor changes. The goal is to understand how these changes…

This study collects blood and saliva samples from people with cancer and their relatives to build a DNA bank. Researchers hope to better understand how cancer runs in families. About 992 participants are expected to join. The samples will be stored and analyzed later for genetic …

This study collects blood, tissue, and saliva samples from 7,000 people—both those with breast cancer and healthy volunteers. Researchers at Memorial Sloan Kettering will use these samples to study what causes breast cancer and find better ways to prevent, detect, and treat it. N…

This study tests a program called Potlako+ that combines community education, support for healthcare providers, and patient navigation to help people with cancer symptoms get diagnosed and treated faster. About 874 participants in Botswana will be split into two groups: one recei…

This study brings together 15 healthcare experts to agree on the best ways to care for skin during breast cancer treatment. Many cancer therapies cause skin problems like dryness, rashes, and irritation. The goal is to create simple, clear recommendations—such as using gentle cle…

This study follows 220 women who had breast cancer surgery to understand why some develop persistent pain afterward. Researchers will track pain, mood, and daily function for 4 months to identify risk factors. The goal is to help doctors counsel patients and take steps to reduce …

This study follows 32 women who had breast reconstruction using a minimally invasive technique after mastectomy for breast cancer. Researchers measure shoulder muscle strength and function before surgery and at several points up to one year after. The goal is to see how well the …

This study looks at whether having a patient navigator—a person who helps guide you through the healthcare system—can help women get timely follow-up care after an abnormal mammogram. The COVID-19 pandemic caused many delays in cancer diagnosis, especially for at-risk groups. Res…

This study looks at how normal breast tissue appears on MRI and mammogram to see if it can help predict breast cancer risk. Researchers are comparing images and health information from over 2,000 women, including those with and without breast cancer. The goal is to better underst…

This study collects and stores breast cancer tissue from 600 people who took part in the TAILORx trial. Researchers will analyze the samples to find biological markers that can predict if the cancer will come back or resist hormone therapy and chemotherapy. No new treatments are …

This study follows 253 breast cancer patients aged 70 and older over five years. Researchers collect data on treatments, side effects, and quality of life to understand what helps older adults stick with their care. The goal is to find ways to improve outcomes and tailor treatmen…

This study aimed to see if changing how cancer patients think about their illness could improve their quality of life and treatment outcomes. Researchers planned to follow newly diagnosed patients and give some a short mindset training. However, the study was withdrawn before any…

This study collects information from about 866 women to better understand breast cancer that occurs during pregnancy, breastfeeding, or within a year after giving birth, as well as in women who become pregnant after breast cancer treatment. Researchers will track details like tum…

This study looks at 100 breast cancer patients taking CDK4/6 inhibitor drugs. Researchers want to find genetic and blood markers that can predict who will have bad side effects or not get enough benefit from the medication. The goal is to help doctors choose safer and more effect…

This study looks at two new models of follow-up care for people who have finished treatment for early-stage breast or colorectal cancer. The goal is to see if these models help survivors get the recommended cancer surveillance and preventive care. About 2450 adults from Kaiser Pe…

This study brings together cancer experts to agree on standard definitions for key measurements used in cancer clinical trials, such as how long patients live without their cancer getting worse. Currently, different trials define these measurements in different ways, making it ha…

This trial was designed to test whether adding aspirin to the immunotherapy drug avelumab could help the immune system fight triple-negative breast cancer. Participants would have received either avelumab alone or with aspirin for about 18 days, with biopsies and blood tests to m…

This study follows 500 breast cancer survivors (stage 0-IIIC) who were treated at City of Hope. Researchers will collect feedback and samples over time to understand long-term health, quality of life, and how the immune system responds to cancer. The goal is to improve follow-up …

This study looks at whether a genetic test (BRCA1-like) can help doctors choose the best first chemotherapy for people with advanced triple-negative breast cancer. About 304 participants will receive either carboplatin-cyclophosphamide or paclitaxel, with or without the immunothe…

This study was designed to see if giving methadone during breast reconstruction surgery helps patients use fewer opioids for pain afterward. It planned to enroll women having autologous breast reconstruction after mastectomy. However, the trial was withdrawn before any participan…

This study looks at women with newly diagnosed breast cancer who take part in exercise or mind-body programs for 3-6 weeks before their surgery. Researchers want to see if these programs help reduce stress, anxiety, and improve mood and quality of life. They also check for change…

This study looks at how Palbociclib and other CDK4/6 inhibitors are actually used in patients with a common type of advanced breast cancer (HR+/HER2-). Researchers will analyze anonymous medical records from routine care to see how long patients stay on treatment and whether it d…

This study tests whether community education and support can increase the number of women in Kenya who get screened for breast and cervical cancer. Researchers will enroll 5,400 women aged 30-55 and track how many complete recommended screenings and follow-up care. The goal is to…

This study follows 73 young women with breast cancer to see if certain genes make them more likely to lose fertility after chemotherapy. Researchers measure ovarian reserve (egg supply) before and up to 5 years after treatment. The goal is to better predict who might face fertili…

This study looks at whether a set of online, game-like tests can reliably measure changes in thinking and memory in breast cancer survivors. About 441 women aged 40-65 will take these tests from home. The goal is to find a better way to detect and understand cognitive problems af…

This study compares two types of radiation therapy for left-sided breast cancer: proton beam therapy and conventional photon therapy. The goal is to see which one causes fewer changes to the heart, measured by MRI scans. About 60 adults with non-metastatic breast cancer will part…

This study is looking for ways to predict which older adults (age 65 and up) with early-stage breast cancer are more likely to have serious side effects from chemotherapy. Researchers will collect medical information and blood samples from 700 participants to build a model that c…

This study follows 200 women with breast cancer who are receiving doxorubicin and/or trastuzumab. Researchers want to learn how these drugs affect the heart over time and how factors like race, income, and access to healthcare play a role. Participants will have heart ultrasounds…

This study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…

This study looks at how chemotherapy for breast cancer affects the heart, exercise ability, and fatigue. Researchers will compare breast cancer patients to people without cancer using heart MRIs and walking tests. The goal is to better understand and predict heart-related side ef…

This study looks at how well women recover after mastectomy surgery. Some women receive a PECS nerve block with a long-lasting painkiller, while others do not. Researchers want to see if the block leads to better pain control and recovery quality 72 hours after surgery. About 800…

This study looks at how genetic testing affects stress and anxiety in women with breast cancer or at high risk. Researchers will survey 164 participants before and after genetic counseling to track changes in worry and health anxiety. The goal is to learn how to better support pa…

This study looks at how well a cardiopulmonary exercise test (CPET) can measure oxygen use in women with HER2-positive breast cancer who have mild heart problems from their cancer treatment. The goal is to see if this test can help predict how their heart and lungs will handle co…

This study was designed to see if an online program could help breast cancer patients get the support services they need faster than traditional in-person help. Participants would have been randomly assigned to either online or in-person navigation for 4 weeks. However, the study…

The IMPACT Study is testing two online tools—GeneSHARE and LivingLabReport—to help people with inherited cancer gene variants share their results with family members and follow cancer screening guidelines. The study involves 720 adults who have a genetic variant linked to cancers…

This study was designed to see if getting an IV in the arm that had breast cancer surgery increases the risk of lymphedema (arm swelling). Researchers planned to use a special dye called indocyanine green (ICG) and a camera system (SPY angiography) to watch how fluid moves throug…

This study looks at how aerobic exercise changes the gut microbiome in breast cancer survivors and whether those changes relate to less fatigue. About 126 women who have finished primary treatment will take part. Researchers will measure gut bacteria from stool samples and track …

This pilot study tests a new FDA-approved cone-beam CT imaging system (Halcyon 4.0) for planning radiation therapy. Researchers will compare its image quality and ease of use to standard CT scans in 27 adults with various cancers. The goal is to see if the new system can improve …

This pilot study tests a new assessment tool called IA3-CP for cancer patients aged 65 and older. The tool gathers information on aging-related issues, mental health, health behaviors, and social factors to help doctors provide better, more personalized care. 35 participants are …

This study looks at whether high-intensity interval training (HIIT) can improve how breast cancer patients respond to chemotherapy before surgery. Fifty-five patients will either follow a personalized HIIT program or maintain their usual activity level. Researchers will analyze t…

This study aimed to understand why some women develop chronic pain after breast cancer surgery. Researchers planned to track psychological and social factors in women undergoing mastectomy or lumpectomy. However, the study was withdrawn before it started, so no results are availa…

This study is testing a newly developed arm circumference measurement device for patients who may develop lymphedema after breast cancer surgery. Researchers want to see if the device is more accurate, faster, and easier to use than the traditional tape measure. The study involve…

This study looks back at over 1,000 women who had breast-conserving surgery for non-palpable breast lesions. It compares four techniques used to locate these hidden lesions: wire-guided localization, radioguided occult lesion localization, magnetic seeds, and carbon dye. The goal…