Could adding vorinostat to chemo shrink breast tumors better before surgery?
NCT ID NCT00616967
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether adding a drug called vorinostat to standard chemotherapy (carboplatin and nab-paclitaxel) before surgery helps shrink tumors more in women with HER2-negative breast cancer. About 68 women took part. The goal was to see if the combination leads to no cancer left in the breast or lymph nodes at the time of surgery, potentially allowing for less tissue removal.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Anne Arundel Health System
Annapolis, Maryland, 21401, United States
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Indiana University Purdue University of Indianapolis
Indianapolis, Indiana, 46202, United States
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Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-2410, United States
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University of Alabama Comprehensive Cancer Center
Birmingham, Alabama, 35249, United States