Genetic clues may reveal why some breast cancers resist treatment
NCT ID NCT03439735
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study is investigating whether genetic changes in tumor tissue and blood can predict how well people with hormone receptor-positive metastatic breast cancer respond to a combination of endocrine therapy and palbociclib. Researchers will collect tumor samples and blood from participants over time to look for specific mutations, like ESR1, that may be linked to treatment resistance. The goal is to better understand why some cancers stop responding, which could help tailor future treatments for each person.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Endocrine therapy and palbociclib (a CDK4/6 inhibitor)
- What this could lead to
- If successful, this could help doctors personalize treatment for metastatic breast cancer, identifying who will benefit from endocrine therapy and palbociclib and who might need different options.
- What could go wrong
- This is a small, early-stage study focused on understanding resistance, not on proving a new treatment works. The genetic markers studied may not reliably predict response, and results may not apply to all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Johns Hopkins University
Baltimore, Maryland, 21287, United States
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