New hope for Hard-to-Treat breast cancer: targeted pill plus hormone therapy shows promise

NCT ID NCT06635447

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing a combination of two drugs—capivasertib (a pill that targets cancer cell growth) and fulvestrant (an injection that blocks estrogen)—in 258 Chinese patients with advanced HR+/HER2- breast cancer that has worsened after hormone therapy. The study focuses on patients with specific genetic changes (PIK3CA/AKT1/PTEN) to see if the combo delays the need for further treatment. It is currently active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Capivasertib (a targeted cancer pill) plus fulvestrant (a hormone-blocking injection)

What this could lead to

If successful, this combination could offer a new treatment option for Chinese patients with a specific genetic subtype of advanced breast cancer that has stopped responding to hormone therapy.

What could go wrong

This is a single-arm, open-label study without a placebo group, so results may be less definitive. Side effects from the drug combination are possible, and the benefit may be limited to patients with certain genetic alterations.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Disease Progression hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

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Locations

Research Site

Baoding, 071000, China
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Beijing, 100021, China
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Beijing, 100071, China
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Beijing, 100730, China
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Beijing, CN-100730, China
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Bengbu, 233004, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chengdu, 610072, China
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Dalian, 116001, China
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Dalian, China
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Deyang, 618000, China
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Dongguan, 523009, China
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Foshan, 528000, China
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Fuzhou, 350001, China
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Fuzhou, 350011, China
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Guangzhou, 510060, China
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Guangzhou, 510120, China
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Guiyang, 550044, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Hangzhou, 310016, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230022, China
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Hefei, 230031, China
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Huizhou, 516001, China
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Jinan, 250012, China
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Jinhua, China
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Jining, 272029, China
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Kashgar, 844099, China
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Kunming, 650118, China
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Linhai, 317000, China
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Meizhou, 514031, China
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Nanchang, 330009, China
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Nanchong, 637000, China
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Nanjing, 210029, China
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Ningbo, 315099, China
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Ningbo, 315100, China
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Qingdao, 266042, China
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Shanghai, 200025, China
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Shanghai, 200080, China
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Shanghai, 201114, China
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Shanghai, 201210, China
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Shantou, 515063, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Shenzhen, 518020, China
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Shenzhen, 518036, China
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Shijiazhuang, 050020, China
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Sichuan, 610041, China
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Suining Shi, 629000, China
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Suzhou, 215004, China
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Taiyuan, 030000, China
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Tangshan, 063001, China
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Tianjin, 300060, China
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Ürümqi, 830000, China
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Ürümqi, 830054, China
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Wanzhou, 404000, China
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Weifang, 261000, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xi'an, 710000, China
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Xi'an, 710006, China
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Xi'an, 710061, China
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Xiamen, 361003, China
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Xuzhou, 221005, China
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Yinchuan, 750000, China
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Zhanjiang, 524004, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China