New hope for Hard-to-Treat breast cancer: targeted pill plus hormone therapy shows promise

NCT ID NCT06635447

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing a combination of two drugs—capivasertib (a pill that targets cancer cell growth) and fulvestrant (an injection that blocks estrogen)—in 258 Chinese patients with advanced HR+/HER2- breast cancer that has worsened after hormone therapy. The study focuses on patients with specific genetic changes (PIK3CA/AKT1/PTEN) to see if the combo delays the need for further treatment. It is currently active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Capivasertib (a targeted cancer pill) plus fulvestrant (a hormone-blocking injection)
What this could lead to: If successful, this combination could offer a new treatment option for Chinese patients with a specific genetic subtype of advanced breast cancer that has stopped responding to hormone therapy.
What could go wrong: This is a single-arm, open-label study without a placebo group, so results may be less definitive. Side effects from the drug combination are possible, and the benefit may be limited to patients with certain genetic alterations.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Disease Progression hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

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Baoding, 071000, China
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Beijing, 100021, China
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Beijing, 100071, China
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Beijing, 100730, China
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Beijing, CN-100730, China
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Bengbu, 233004, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 410011, China
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Changsha, 410013, China
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Chengdu, 610072, China
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Dalian, 116001, China
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Dalian, China
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Deyang, 618000, China
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Dongguan, 523009, China
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Foshan, 528000, China
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Fuzhou, 350001, China
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Fuzhou, 350011, China
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Guangzhou, 510060, China
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Guangzhou, 510120, China
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Guiyang, 550044, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Hangzhou, 310016, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230022, China
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Hefei, 230031, China
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Huizhou, 516001, China
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Jinan, 250012, China
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Jinhua, China
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Jining, 272029, China
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Kashgar, 844099, China
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Kunming, 650118, China
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Linhai, 317000, China
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Meizhou, 514031, China
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Nanchang, 330009, China
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Nanchong, 637000, China
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Nanjing, 210029, China
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Ningbo, 315099, China
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Ningbo, 315100, China
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Qingdao, 266042, China
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Shanghai, 200025, China
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Shanghai, 200080, China
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Shanghai, 201114, China
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Shanghai, 201210, China
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Shantou, 515063, China
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Shenyang, 110004, China
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Shenyang, 110042, China
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Shenzhen, 518020, China
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Shenzhen, 518036, China
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Shijiazhuang, 050020, China
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Sichuan, 610041, China
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Suining Shi, 629000, China
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Suzhou, 215004, China
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Taiyuan, 030000, China
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Tangshan, 063001, China
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Tianjin, 300060, China
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Ürümqi, 830000, China
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Ürümqi, 830054, China
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Wanzhou, 404000, China
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Weifang, 261000, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Xi'an, 710000, China
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Xi'an, 710006, China
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Xi'an, 710061, China
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Xiamen, 361003, China
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Xuzhou, 221005, China
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Yinchuan, 750000, China
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Zhanjiang, 524004, China
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Zhengzhou, 450000, China
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Zhengzhou, 450008, China
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Zhengzhou, 450052, China

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