Breast cancer study tests best order for chemo and hormone pills

NCT ID NCT02918084

First seen May 16, 2026 · Last updated Jun 19, 2026 · Updated 7 times

Summary

This phase 3 trial compares giving hormone therapy (aromatase inhibitors) at the same time as chemotherapy versus after chemotherapy in 1000 postmenopausal women with early breast cancer. The goal is to see which timing better prevents the cancer from coming back over 15 years. Participants take the hormone pill daily for 5 years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O. S. Andrea - Università 'La Sapienza' - II Facoltà di Medicina e Chirurgia

    Roma, RM, 00189, Italy

  • A.O. San Giuseppe Moscati

    Avellino, AV, 83100, Italy

  • A.O.U. Careggi

    Florence, FI, 50134, Italy

  • A.O.U. Federico II

    Naples, 80131, Italy

  • A.O.U. Pisana - Ospedale Santa Chiara

    Pisa, PI, 56126, Italy

  • A.O.U. Policlinico 'Paolo Giaccone'

    Palermo, PA, 90129, Italy

  • A.O.U. Policlinico Modena

    Modena, MO, 41124, Italy

  • A.S.L. LT - Ospedale Santa Maria Goretti

    Latina, LT, 04100, Italy

  • ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico

    Milan, MI, 20121, Italy

  • ASST Lariana - Ospedale S. Anna

    Como, CO, 22100, Italy

  • ASST Melegnano e della Martesana - Ospedale Serbelloni

    Gorgonzola, MI, 20064, Italy

  • ASST Monza - Ospedale San Gerardo

    Monza, MB, 20052, Italy

  • ASST Ovest Milanese - Ospedale Nuovo di Legnano

    Legnano, MI, 20025, Italy

  • ASST Papa Giovanni XXIII - Ospedale Papa Giovanni XXIII

    Bergamo, BG, 24127, Italy

  • ASST Spedali Civili - P.O. Spedali Civili

    Brescia, BS, 25123, Italy

  • ASST della Valle Olona - Ospedale di Saronno

    Saronno, VA, 21047, Italy

  • AUSL di Frosinone - Ospedale Fabrizio Spaziani

    Frosinone, FR, 03100, Italy

  • AUSL di Frosinone - Ospedale SS. Trinità

    Sora, FR, 03039, Italy

  • Arcispedale S. Anna - A.O.U. di Ferrara

    Cona, FE, 44124, Italy

  • Azienda Ospedaliera 'A. Cardarelli' (AORN)

    Naples, 80131, Italy

  • Azienda Ospedaliera Bianchi - Melacrino - Morelli

    Reggio Calabria, RC, 89125, Italy

  • Azienda Ospedaliera Carlo Poma

    Mantua, MN, 46100, Italy

  • Azienda Ospedaliera G. Rummo

    Benevento, BN, 82100, Italy

  • Azienda Ospedaliera S. Carlo

    Potenza, PZ, 85100, Italy

  • Azienda Ospedaliera S. Croce e Carle

    Cuneo, CN, 12100, Italy

  • Azienda Ospedaliera San Camillo - Forlanini

    Roma, RM, 00149, Italy

  • Azienda Ospedaliera Treviglio-Caravaggio

    Treviglio, BG, 24047, Italy

  • Azienda Ospedaliera Universitaria di Parma

    Parma, PR, 43100, Italy

  • Azienda Ospedaliera n. 1 - Annunziata

    Sassari, SS, 07100, Italy

  • Azienda Sanitaria Regionale Molise - Ospedale F. Veneziale - Zona di Isernia

    Isernia, IS, 86170, Italy

  • Azienda U.S.L. N. 9 - Ospedale Misericordia

    Grosseto, GR, 58100, Italy

  • E.O. Ospedali Galliera

    Genova, GE, 16128, Italy

  • Fondazione S. Maugeri IRCCS

    Pavia, PV, 27100, Italy

  • Fondazione del Piemonte per l'Oncologia - IRCC di Candiolo

    Candiolo, TO, 10060, Italy

  • Humanitas Centro Catanese di Oncologia

    Catania, CT, 95126, Italy

  • IRCCS 'Casa Sollievo della Sofferenza'

    San Giovanni Rotondo, FG, 71013, Italy

  • IRCCS A.O. S.Maria Nuova

    Reggio Emilia, RE, 42123, Italy

  • IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

    Genoa, GE, 16132, Italy

  • IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.)

    Meldola, FC, 47014, Italy

  • Istituto Europeo di Oncologia (IRCCS)

    Milan, MI, 20141, Italy

  • Istituto Nazionale dei Tumori - Fondazione G.Pascale

    Naples, 80131, Italy

  • Istituto Oncologico Veneto - I.R.C.C.S.

    Padova, PD, 35128, Italy

  • Istituto Regina Elena per lo studio e la cura dei tumori

    Roma, RM, 00144, Italy

  • Istituto Tumori 'Giovanni Paolo II' - IRCCS Ospedale Oncologico

    Bari, BA, 70124, Italy

  • Ospedale 'Guglielmo da Saliceto'

    Piacenza, PC, 29121, Italy

  • Ospedale Belcolle - AUSL di Viterbo

    Viterbo, VT, 01100, Italy

  • Ospedale Civile 'Gaetano Bernabeo'

    Ortona, CH, 66026, Italy

  • Ospedale Civile 'San Massimo'

    Penne, PE, 65017, Italy

  • Ospedale Civile Renzetti

    Lanciano, CH, 66034, Italy

  • Ospedale Civile di Campobasso - A. Cardarelli

    Campobasso, CB, 86100, Italy

  • Ospedale Civile di Città di Castello - A.S.L. n. 1

    Città di Castello, PG, 06012, Italy

  • Ospedale Civile di Guastalla

    Guastalla, RE, 42016, Italy

  • Ospedale Clinicizzato 'S. Annunziata' - Università degli Studi 'G. d'Annunzio'

    Chieti, CH, 66100, Italy

  • Ospedale Fatebenefratelli 'Sacro Cuore di Gesù'

    Benevento, BN, 82100, Italy

  • Ospedale Fatebenefratelli San Giovanni Calibita - Isola Tiberina

    Roma, RM, 00186, Italy

  • Ospedale Felice Lotti - Azienda USL 5 di Pisa

    Pontedera, PI, 56025, Italy

  • Ospedale S. Anna - A.O.U. Città della Salute e della Scienza

    Torino, TO, 10126, Italy

  • Ospedale S. Anna - Città della salute

    Torino, TO, 10126, Italy

  • Ospedale S. Eugenio

    Roma, RM, 00144, Italy

  • Ospedale S. Maria della Misericordia

    Perugia, PG, 06132, Italy

  • Ospedale Sacro Cuore Don Calabria

    Negrar, VE, 37024, Italy

  • Ospedale San Luca

    Lucca, LU, 55100, Italy

  • Ospedale San Sebastiano

    Correggio, RE, 42015, Italy

  • Ospedale Santa Croce - A.O. Ospedali Riuniti Marche Nord

    Fano, PS, 61032, Italy

  • Ospedale Santo SpiritoH

    Casale Monferrato, AL, 15033, Italy

  • Ospedale Umberto I

    Lugo, RA, 48022, Italy

  • Ospedale Unico Versilia

    Lido di Camaiore, LU, 55041, Italy

  • Ospedale Vietri

    Larino, CB, 80035, Italy

  • Ospedale Vito Fazzi

    Lecce, LE, 73100, Italy

  • Ospedale di Macerata

    Province of Macerata, MC, 62100, Italy

  • Ospedale di Rete 'Engles Profili' - A.S.U.R. Area Vasta 2

    Fabriano, AN, 60044, Italy

  • Ospedale per gli Infermi

    Faenza, RA, 48018, Italy

  • Policlinico Umberto I

    Roma, PM, 00186, Italy

  • Presidio Ospedaliero 'Antonio Perrino'

    Brindisi, BR, 72100, Italy

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Anastrozole, Letrozole, or Exemestane (aromatase inhibitors) given alongside or after chemotherapy

What this could lead to

If it works, this could show the best way to combine chemotherapy and hormone therapy to reduce the chance of breast cancer returning.

What could go wrong

This is a large phase 3 trial, but results are not yet available. The benefit may be small, and side effects from combining treatments could be higher.

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.