Can a vaginal ring or moisturizer ease dryness for breast cancer survivors?
NCT ID NCT01984138
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at two treatments for vaginal dryness in women with estrogen receptor-positive breast cancer who are taking aromatase inhibitors. One group uses a vaginal estrogen ring that releases a low dose of estrogen over 90 days, while the other uses a non-hormonal vaginal moisturizer called Replens. The goal is to see which option better improves symptoms like dryness and itching, and whether it affects hormone therapy compliance. The trial enrolled 33 postmenopausal women and tracked their symptoms over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- estradiol vaginal ring (ESTRING) and Replens vaginal moisturizer
- What this could lead to
- If it works, this could offer a safe way to ease vaginal dryness and improve quality of life for breast cancer survivors on hormone therapy.
- What could go wrong
- This is a small, early-phase study with only 33 participants, so results may not apply to everyone. Vaginal estrogen might raise estrogen levels slightly, which could be a concern for hormone-sensitive cancers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ATROPHIC VAGINITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Houston Methodist Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a radioactive tracer pinpoint Cancer's first stop?
- Can a personalized exercise program boost recovery in cancer survivors?
- Smartwatch could spot nerve damage before it starts
- Could ionized gas help fight breast cancer after surgery?
- Radiation may let breast cancer patients keep their nipple
- Can a smart digital program restore sleep for cancer survivors?