Could a pill combo replace chemo for some breast cancers?
NCT ID NCT02712723
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding ribociclib to letrozole before surgery helps more women with ER-positive, HER2-negative early breast cancer achieve a low-risk score (PEPI 0) compared to letrozole alone. About 121 postmenopausal women with stage II or III breast cancer will take the drugs for 24 weeks before surgery. The goal is to see if this combo can improve outcomes and potentially spare patients from needing chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ribociclib (a targeted drug) combined with letrozole (a hormone therapy)
What this could lead to
If it works, this combination could help more women with early breast cancer avoid chemotherapy and still have a good outcome.
What could go wrong
This is a small, early-phase trial, so results may not apply to all patients. The drug combination can cause side effects like low blood cell counts or liver issues.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cancer Research Collaboration
Santa Ana, California, 92705, United States
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
Kansas City, Missouri, 64154, United States
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University of Kansas Cancer Center - Overland Park
Overland Park, Kansas, 66210, United States
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University of Kansas Cancer Center - South
Kansas City, Missouri, 64131, United States
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University of Kansas Cancer Center - West
Kansas City, Kansas, 66112, United States
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University of Kansas Cancer Center - Westwood
Westwood, Kansas, 66205, United States
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University of Miami Sylvester Comprehensive Cancer Center
Deerfield Beach, Florida, 33442, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53705, United States