Could a pill combo replace chemo for some breast cancers?
NCT ID NCT02712723
First seen Mar 13, 2026 · Last updated May 08, 2026 · Updated 7 times
Summary
This study tests whether adding ribociclib to the hormone therapy letrozole for 24 weeks before surgery can improve outcomes for postmenopausal women with ER-positive, HER2-negative early breast cancer. The goal is to help more women achieve a low-risk score (PEPI 0) at surgery, potentially allowing them to skip chemotherapy. About 121 women with stage II or III breast cancer are participating.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cancer Research Collaboration
Santa Ana, California, 92705, United States
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
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University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
Kansas City, Missouri, 64154, United States
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University of Kansas Cancer Center - Overland Park
Overland Park, Kansas, 66210, United States
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University of Kansas Cancer Center - South
Kansas City, Missouri, 64131, United States
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University of Kansas Cancer Center - West
Kansas City, Kansas, 66112, United States
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University of Kansas Cancer Center - Westwood
Westwood, Kansas, 66205, United States
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University of Miami Sylvester Comprehensive Cancer Center
Deerfield Beach, Florida, 33442, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53705, United States
Conditions
Explore the condition pages connected to this study.