New pill combo aims to wipe out breast tumors before surgery
NCT ID NCT04290793
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the targeted drug pyrotinib to standard chemotherapy and trastuzumab can completely eliminate HER2-positive breast tumors before surgery. About 113 women with early-stage HER2+ breast cancer will receive the combination, then have surgery to check for any remaining cancer. The goal is to see if this approach improves the chance of a complete response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pyrotinib (a targeted cancer pill) combined with chemotherapy drugs (epirubicin, cyclophosphamide, docetaxel) and trastuzumab (a targeted antibody)
- What this could lead to
- If successful, this combination could become a new standard neoadjuvant treatment to shrink or eliminate HER2-positive breast tumors before surgery, potentially reducing recurrence risk.
- What could go wrong
- This is a single-arm phase 2/3 trial with no comparison group, so results are preliminary. Side effects from the drug combination may be significant, and the regimen may not outperform existing therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
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