New pill cocktail aims to control Hard-to-Treat breast cancer

NCT ID NCT05548127

Ongoing Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new oral drug, vepdegestrant, combined with abemaciclib in people with advanced or metastatic ER+ breast cancer that no longer responds to prior treatments. About 37 adults will take both pills daily at home, with clinic visits every 4 weeks, to see if the combination is safe and can shrink tumors or slow disease progression. The goal is disease control, not a cure, as ongoing treatment is needed.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

BC Cancer Vancouver

Vancouver, British Columbia, V5Z 1H7, Canada
BC Cancer Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
CIUSSS- saguenay-Lac-Saint-Jean

Chicoutimi, Quebec, G7H 5H6, Canada
Clinica Universidad de Navarra

Madrid, Madrid, Comunidad de, 28027, Spain
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clínica Universidad de Navarra

Madrid, Madrid, Comunidad de, 28027, Spain
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore

Rome, Lazio, 00168, Italy
Hospital Universitari Dexeus

Barcelona, Catalunya [cataluña], 08028, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [barcelona], 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, Comunidad de, 28041, Spain
Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

Candiolo, Torino, 10060, Italy
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
Memorial Hospital

Shiloh, Illinois, 62269, United States
Moffitt Cancer Center - International Plaza

Tampa, Florida, 33607, United States
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center

Tampa, Florida, 33612, United States
Moffitt McKinley Hospital

Tampa, Florida, 33612, United States
Northwest Medical Specialties, PLLC

Bonney Lake, Washington, 98391, United States
Northwest Medical Specialties, PLLC

Federal Way, Washington, 98003, United States
Northwest Medical Specialties, PLLC

Gig Harbor, Washington, 98332, United States
Northwest Medical Specialties, PLLC

Puyallup, Washington, 98373, United States
Northwest Medical Specialties, PLLC

Tacoma, Washington, 98405, United States
Siteman Cancer Center

St Louis, Missouri, 63108, United States
Siteman Cancer Center - North County

Florissant, Missouri, 63031, United States
Siteman Cancer Center - Shiloh

Shiloh, Illinois, 62269, United States
Siteman Cancer Center - South County

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - WUPI

Shiloh, Illinois, 62269, United States
Siteman Cancer Center - West County

Creve Coeur, Missouri, 63141, United States
Stanford Women's Cancer Center

Palo Alto, California, 94304, United States
Sunnybrook Research Institute

Toronto, Ontario, M4N 3M5, Canada
The Ottawa Hospital - General Campus

Ottawa, Ontario, K1H 8L6, Canada
U.T. MD Anderson Cancer Center

Houston, Texas, 77030, United States
U.T. MD Anderson Cancer Center, Investigational Pharmacy Services - Unit 376

Houston, Texas, 77030, United States
UCSF Medical Center at Mission Bay

San Francisco, California, 94158, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Washington University School of Medicine - Siteman Cancer Center

St Louis, Missouri, 63110, United States

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