One and done? single radiation dose before breast cancer surgery tested
NCT ID NCT04040569
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-phase trial is testing whether a single, high dose of radiation given before surgery can safely treat early-stage breast cancer. Researchers are enrolling 45 women with small tumors (3 cm or less) to find the highest dose that does not cause severe side effects. If successful, this approach could shorten treatment from weeks to just one session.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (single-fraction pre-operative partial breast irradiation)
- What this could lead to
- If successful, this could lead to a shorter, more convenient radiation treatment before surgery for early-stage breast cancer, potentially reducing side effects and improving cosmetic outcomes.
- What could go wrong
- This is a very early (Phase I) trial with only 45 participants, so it is primarily testing safety and dosing. The approach may not prove effective or may cause unexpected side effects, and results may not apply to all breast cancer patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390, United States
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