New drug combo aims to control advanced breast cancer
NCT ID NCT05573555
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new oral drug, ARV-471, combined with ribociclib in adults with advanced or metastatic ER+ breast cancer that has stopped responding to previous treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants take both pills daily at home and visit the clinic every 4 weeks.
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.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BC Cancer Vancouver
Vancouver, British Columbia, V5Z 1H7, Canada
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BC Cancer Vancouver
Vancouver, British Columbia, V5Z 4E6, Canada
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Barnes Jewish Hospital Department of Laboratories
St Louis, Missouri, 63110, United States
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Barnes Jewish Hospital Lab- South County
St Louis, Missouri, 63129, United States
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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CIUSSS- saguenay-Lac-Saint-Jean
Chicoutimi, Quebec, G7H 5H6, Canada
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts, 02459, United States
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Lombardy, 20900, Italy
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Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, 28041, Spain
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Hospital Universitario Virgen Del Rocio
Seville, 41013, Spain
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Moffitt Cancer Center - International Plaza
Tampa, Florida, 33607, United States
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Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center
Tampa, Florida, 33612, United States
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Moffitt McKinley Hospital
Tampa, Florida, 33612, United States
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Siteman Cancer Center
St Louis, Missouri, 63108, United States
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Siteman Cancer Center - North County
Florissant, Missouri, 63031, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - WUPI
Shiloh, Illinois, 62269, United States
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Siteman Cancer Center - West County
Creve Coeur, Missouri, 63141, United States
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Stanford Women's Cancer Center
Palo Alto, California, 94304, United States
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Sunnybrook Research Institute
Toronto, Ontario, M4N 3M5, Canada
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The Ottawa Hospital - General Campus
Ottawa, Ontario, K1H 8L6, Canada
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UCSF Medical Center at Mission Bay
San Francisco, California, 94158, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, 63110, United States