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Blood test could spot hidden breast cancer early and guide Life-Saving treatment

NCT ID NCT04567420

Ongoing Disease control Sponsor: Criterium, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study is for people with a high-risk type of breast cancer (ER+/HER2-) who have finished initial treatment but still face a chance of the cancer coming back. Researchers will use a simple blood test to look for tiny bits of tumor DNA. If found, participants will be randomly assigned to get either standard hormone therapy or a stronger drug combination (palbociclib plus fulvestrant) to try to stop the cancer from returning. The goal is to see if this personalized approach improves outcomes.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

  • Cancer Partners of Nebraska

    Lincoln, Nebraska, 68516, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Intermountain

    Golden, Colorado, 80401, United States

  • Louisiana State University Health Sciences Center- New Orleans

    New Orleans, Louisiana, 70112, United States

  • New Mexico Cancer Care Alliance

    Albuquerque, New Mexico, 87131, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • PRiSMs Group

    Laredo, Texas, 78041, United States

  • Stephenson Cancer Center

    Oklahoma City, Oklahoma, 73104, United States

  • Stony Brook University Cancer Center

    Stony Brook, New York, 11794, United States

  • Swedish Cancer Institute

    Seattle, Washington, 98104, United States

  • The Ohio State University Wexner Medical Center James Cancer Hospital

    Columbus, Ohio, 43210, United States

  • USC/Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • University of Arizona Cancer Center

    Tucson, Arizona, 85724, United States

  • University of Colorado Cancer Center

    Aurora, Colorado, 80045, United States

  • University of Wisconsin Clinical Science Center

    Madison, Wisconsin, 53792, United States

  • Virginia Cancer Institute

    Richmond, Virginia, 23229, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 30322, United States

  • Yale Cancer Center

    New Haven, Connecticut, 06510, United States

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