New mapping technique aims to prevent arm swelling after breast cancer surgery

NCT ID NCT00572481

Ongoing Disease control Sponsor: University of Arkansas Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a technique called axillary reverse mapping during breast cancer surgery. Doctors inject a radioactive tracer and blue dye to map the arm's lymph drainage, hoping to avoid damaging those vessels and reduce the risk of lymphedema (arm swelling). The study involves 1,000 participants and will track swelling for one year after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Axillary reverse mapping procedure using technetium-99m sulfur colloid and blue dye
What this could lead to: If successful, this technique could reduce the risk of lymphedema after breast cancer surgery, improving long-term quality of life.
What could go wrong: This is a phase 2 study, so results are still preliminary. The technique may not significantly lower lymphedema risk, and there are standard surgical risks.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER OF THE BREAST

Contacts and locations

Locations

University of Arkansas For Medical Sciences

Little Rock, Arkansas, 72205, United States

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