BREAST CANCER

This trial tests a 12-week program called EmpowerHer that combines home-based exercise via a mobile app with weekly in-person group sessions. It aims to improve health-related quality of life, reduce fatigue, anxiety, and depression, and increase physical fitness in breast cancer…

This study compares a new experimental drug, BL-M07D1, to an approved therapy (DS-8201) in people with a common form of advanced breast cancer (HR-positive, HER2-low). The goal is to see if the new drug can delay cancer growth or improve survival. About 120 women aged 18 to 75 wi…

This study tests whether high-dose radiation can control tumors in people with locally advanced or recurrent metastatic breast cancer that has not responded to systemic therapy. Participants receive radical-dose radiotherapy, and those with large tumors (5 cm or more) may get a s…

This phase 3 trial is testing a drug called trastuzumab rezetecan, alone or combined with bevacizumab, in 140 women with advanced triple-negative breast cancer that has a specific immune-suppressed pattern. The goal is to see if the combination can delay cancer growth better than…

This study is testing whether some people with early-stage breast cancer can safely skip surgery after chemotherapy and instead use only radiation. It includes 84 adults with HER2-positive or triple-negative breast cancer who have responded well to initial chemo. The goal is to s…

The SASHA trial is testing whether a single, high-dose radiation treatment delivered directly to the tumor site over one day is safe and effective for women with early-stage breast cancer. The study will enroll 134 women aged 40-85 who have already had a lumpectomy. Researchers w…

This study tests a risk-based approach to radiation after breast-conserving surgery for early breast cancer. Depending on individual risk, patients receive either whole-breast or partial-breast radiation in fewer, larger doses (hypofractionation). The goal is to maintain cancer c…

This phase 2 study tests whether the drug hetrombopag can prevent dangerously low platelet counts caused by chemotherapy in breast cancer patients at high risk. About 126 participants will be split into three groups: one getting no preventive drug, one taking hetrombopag continuo…

This phase 3 trial compares an experimental drug called BL-B01D1 to standard chemotherapy in people with a common type of breast cancer (HR+/HER2-) that has stopped responding to hormone therapy and cannot be removed by surgery. The study aims to see if BL-B01D1 can delay cancer …

This study tests whether adding an immune-boosting drug called eftilagimod alpha to standard chemotherapy before surgery can completely eliminate tumors in people with early-stage hormone receptor-positive, HER2-negative breast cancer. About 50 participants will receive the drug …

This study looks at whether people with advanced breast cancer that has spread to lymph nodes can safely have a less extensive armpit surgery after chemotherapy. Instead of removing many lymph nodes, doctors will remove only a few and then give radiation. The goal is to see if th…

This study compares two methods of breast reconstruction in women who had a mastectomy and radiation for breast cancer: autologous fat transfer (AFT) and DIEP flap surgery. About 280 participants will be randomly assigned to one of the two procedures. The main goal is to see if A…

This study will compare a newer, less invasive endoscopic breast reconstruction method (direct-to-implant) with traditional flap surgery (using tissue from the abdomen) in 588 women who had a mastectomy at least one year ago. The goal is to see if the endoscopic approach leads to…

This phase II trial is testing a three-drug combination given before surgery for people with intermediate-to-high risk HR-positive, HER2-low breast cancer. Participants first take dalpiciclib (a pill) plus an aromatase inhibitor (another pill) for about 4 months, followed by infu…

This phase 3 trial tests whether a combination of sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda) works better than standard chemotherapy before surgery for stage II-III triple-negative breast cancer. About 765 participants will be enrolled. The study aims to improv…

This study looks at whether a structured support program can help people with early-stage, hormone-positive breast cancer stick to their ribociclib medication (taken with an aromatase inhibitor). About 90 participants will be split into two groups: one gets standard care, the oth…

This early-stage trial tests a new drug called ONC-783 in 20 people with advanced solid tumors, including colorectal, ovarian, pancreatic, or breast cancer. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal is to find a safe d…

This phase 2 trial is testing a combination of three drugs—inavolisib, ribociclib, and fulvestrant—in 160 Chinese women with a specific genetic mutation (PIK3CA) in hormone receptor-positive, HER2-negative advanced breast cancer that has stopped responding to endocrine therapy. T…

This study tests whether adding lovastatin, a common cholesterol-lowering drug, can help the cancer treatment trastuzumab deruxtecan work better in people with HER2-low or ultralow advanced breast cancer. About 60 participants will receive both drugs to see if more tumors shrink …

This study will test a device called LumiSystem that helps surgeons see if any cancer cells are left behind during breast cancer surgery. About 1500 women having a lumpectomy will be included. The goal is to see if using this imaging tool reduces the number of patients who need a…

This Phase 2 trial will enroll 100 young women (ages 18-45) with hormone receptor-positive breast cancer who are already on a 3-month GnRH injection for ovarian suppression. Half will switch to a monthly injection, while the other half stays on the 3-month schedule. The study aim…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy as prescribed. The program includes education, reminders, and behavioral support. Researchers will measure how well participants stick with their medication and how …

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether adding 4 cycles of the targeted drug trastuzumab rezetecan (T-DXh) can eliminate residual cancer in HER2-positive breast cancer patients who still have disease after standard chemotherapy. About 59 adults will receive the drug before surgery. The main goa…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests whether combining brain radiation with a targeted drug (dalpiciclib) and hormone therapy can help control breast cancer that has spread to the brain in people with HR-positive/HER2-negative disease. About 46 participants will receive the combination and be follow…

This study tests a new drug called AK138D1, given alone or with another drug (ivonescimab), in people with advanced breast cancer. The goal is to see if the treatment is safe and can shrink tumors. About 286 adults aged 18 to 75 will take part. This is an early-stage trial, so th…

This early-phase trial tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) plus a targeted drug called T-Dxd. The study aims to find the safest dose …

This study looks at how well a drug called inavolisib works in real-world settings for people with a certain type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). About 100 participants will take inavolisib along with hormone therapy, sometimes with…

This study tests a new combination of drugs (zanidatamab, tucatinib, and chemotherapy) in people with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. The goal is to find the safest dose and see if the treatment shrinks tumors. About 24 adults…

This study tests a new type of breast-conserving surgery that uses a small camera inserted through a hidden armpit incision to remove tumors, compared to the standard open approach. About 1,366 women with early-stage breast cancer will be randomly assigned to one of the two surge…

This phase 2 trial tests whether adding a targeted drug (axatilimab) and radiation to the immunotherapy pembrolizumab can help shrink tumors in people with metastatic triple-negative breast cancer who have already tried immunotherapy. About 34 participants will receive all three …

This study tests whether a special PET scan (HER2-PET) can help doctors personalize treatment for early-stage HER2-positive breast cancer. After two cycles of standard therapy, the scan results will determine if patients need stronger or milder treatment. The goal is to improve t…

This study tests a personalized approach for people with HER2-positive breast cancer. After two cycles of standard therapy, those whose tumors shrink less than 40% will switch to a new drug combination (SHR-A1811 plus pertuzumab) for four more cycles before surgery. The goal is t…

This study tests whether an artificial intelligence (AI) model can choose the best combination of targeted drugs for women with HER2-positive breast cancer before surgery. About 280 women with early or locally advanced breast cancer will be randomly assigned to either AI-guided t…

This study tests whether a chemotherapy-free treatment using the targeted drug Dalpiciclib (a CDK4/6 inhibitor) plus hormone therapy works as well as standard chemotherapy for women with small, high-risk, hormone-receptor-positive breast cancer. About 2,288 participants will be r…

This phase 3 trial tests whether adjusting tamoxifen doses based on individual metabolism can reduce the number of breast cancer patients who stop treatment early due to side effects. About 1,100 premenopausal or perimenopausal women with hormone-sensitive breast cancer will rece…

This pilot study tests a device that uses short, high-frequency electrical pulses to shrink or destroy soft tissue tumors in people with metastatic breast cancer. The trial will enroll 20 adults with tumors near the skin that are at least 1 cm but no larger than 5 cm. The main go…

This study will follow 500 people with HER2-positive advanced breast cancer who are starting treatment with pyrotinib, a daily oral targeted therapy. Researchers want to see how well the drug controls the cancer and what side effects occur in everyday medical practice, not just i…

This phase 2 trial will test a combination of two drugs—serplulimab (an immunotherapy) and SHR-A1811 (a targeted chemotherapy)—given before surgery to women with early-stage triple-negative breast cancer. The main goal is to see how many patients have no cancer left at the time o…

This early-phase trial tests a new radioactive drug, 177Lu-INN805, in 10 people with advanced solid tumors (like head & neck, lung, breast, or sarcoma) that haven't responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers wi…

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants will receive a combination of hormone therapy and a targeted drug (abemaciclib) based on their tumor's gene test res…

This early-phase trial tests a new type of cell therapy for people with metastatic HER2-positive breast cancer that has worsened after standard treatment. Researchers take a patient's own immune cells (T cells), add new genes to help them recognize and attack cancer cells, and re…

This early-phase trial tests whether combining the targeted drug trastuzumab deruxtecan (T-DXd) with precise radiation (SRS) is safe for people with HER2-positive breast cancer that has spread to the brain. Up to 20 participants will receive the drug by IV every three weeks along…

This early-phase trial will test the safety and tolerability of combining a CDK4/6 inhibitor (abemaciclib) with radiation therapy after surgery in 30 women with HR+/HER2- high-risk breast cancer. The study aims to find the highest safe dose of the drug when used alongside radiati…

This phase 2 trial tests a combination of two drugs—entinostat and oral paclitaxel—in 50 people with HR-positive, HER2-negative advanced breast cancer who have already tried 2 to 4 prior treatments. The goal is to see if the combo can delay cancer growth. Participants take both d…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study looks at whether a combination of ribociclib (a targeted drug) and hormone therapy can be as effective as chemotherapy followed by the same combo for people with a common type of early breast cancer (HR+/HER2-). Only patients whose blood tests show no signs of cancer D…

This phase 2 trial tests whether a new drug, trastuzumab-rezetecan, works as well as the established drug T-DXd in shrinking HER2-positive breast tumors before surgery. About 68 women with early or locally advanced breast cancer will receive one of the two drugs for 8 cycles, the…

This study tests whether taking two drugs (imlunestrant and abemaciclib) before surgery can shrink tumors in people with a common type of breast cancer (ER+/HER2-). About 189 women aged 18-75 with early-stage breast cancer will join. The treatment is guided by a marker called Ki6…

This study compares a new drug, SHR-A1811, with a standard combination therapy (pyrotinib plus capecitabine) in 100 adults with advanced HER2-positive breast cancer that did not respond to the first-line treatment trastuzumab. The goal is to see which approach better delays cance…

This pilot study tests whether a daily grape polyphenol concentrate can reduce heart damage in women receiving certain chemotherapies for breast cancer. 120 women at high risk of heart problems will take either the supplement or a placebo for three months. Researchers will measur…

This phase 3 trial will test if women with intermediate-risk breast cancer can safely skip radiation to the lymph nodes after surgery. About 3,142 participants will be randomly assigned to receive either standard radiation to the breast or chest wall plus lymph nodes, or radiatio…

This study is for people with HER2-negative breast cancer whose tumors did not shrink after initial chemotherapy. Researchers are testing whether adding an immunotherapy drug (toripalimab) and targeted radiation before and after surgery can improve outcomes. About 110 participant…

This study tests whether adding famitinib to SHR-A1811 works better than SHR-A1811 alone for people with a certain type of advanced breast cancer (HR+/HER2-) that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will take part. The goal is to see if the combina…

This Phase 2 trial tests a new antibody drug (QL1706) combined with chemotherapy in 40 people with early triple-negative breast cancer. The treatment is tailored based on how the tumor responds after initial cycles, with the goal of avoiding certain heart-damaging drugs if possib…

This phase 2 trial tests whether adding the drug fluzoparib to standard treatment after surgery can help prevent breast cancer from coming back in women with certain inherited gene mutations (HRR). About 334 women with early breast cancer will be randomly assigned to receive eith…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study compares two shortened radiation therapy schedules for breast cancer patients after surgery: one lasting 2 weeks and another lasting 3 weeks. The goal is to see which schedule better controls the cancer and causes fewer skin side effects. About 70 women who have had br…

This study looks at 4,000 women aged 50 or younger with a common type of early breast cancer. Researchers want to see if hormone therapy plus ovarian function suppression works as well as chemotherapy for those with certain genetic test scores. The goal is to find out who can saf…

This Phase 2 trial tests a new drug called SHR-A1811, alone or with hormone therapy (letrozole), against standard chemotherapy in 120 women with early-stage HR-positive, HER2-low breast cancer. The goal is to see if these combinations can shrink tumors before surgery more effecti…

This phase 2 trial is testing the drug sacituzumab govitecan (Trodelvy) as a first treatment for people with advanced triple-negative breast cancer who haven't had prior therapy for advanced disease. Researchers want to see if the drug can shrink tumors or slow the cancer's growt…

This phase 2 trial tests a personalized approach for women with early-stage HR+/HER2+ breast cancer. After two cycles of standard therapy, patients who respond well continue the same treatment, while those who do not switch to a combination of targeted therapy and hormone-blockin…

This study is testing a combination of four drugs (trastuzumab, pertuzumab, palbociclib, and exemestane) given before surgery to 90 people with early-stage triple-positive breast cancer. The goal is to see if this treatment can completely eliminate cancer cells in the breast and …

This study tests whether monitoring tumor DNA in the blood (ctDNA) and treating with abemaciclib can prevent breast cancer from coming back. 30 people with HR+/HER2- breast cancer who have finished standard treatment will be followed. If ctDNA is detected, they will receive abema…

This phase II trial tests a combination of targeted drugs and hormone therapy given before surgery for a specific type of breast cancer (ER-positive, HER2-positive). The goal is to shrink tumors without using standard chemotherapy. The study will enroll 42 women and measure how m…

This early-stage trial tests whether fecal microbiota transplants (FMT) from healthy donors can safely be added to standard chemotherapy and immunotherapy for triple-negative breast cancer. About 125 patients will take part, first in an observation phase and then in a treatment p…

This phase 3 trial tests whether placing tiny radioactive seeds in breast tumors before chemotherapy can help eliminate cancer more completely. About 194 women with early or locally advanced breast cancer will either get standard chemo alone or chemo plus seed placement. The goal…

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few affected nodes is just as effective fo…

This study reviews 150 breast cancer patients who had a delayed breast reconstruction using a new endoscopic technique through a small armpit incision, at least 6 months after their mastectomy. The goal is to see if this method leads to better patient satisfaction and fewer compl…

This study looks at whether time-restricted eating (eating only during certain hours) can improve heart and brain health in 152 women aged 60-85 who finished chemotherapy for early-stage breast cancer at least a year ago. Participants will get counselling on when to eat and how t…

This phase 2 trial tests whether adding trilaciclib to the chemotherapy drug eribulin can protect bone marrow in people with advanced triple-negative breast cancer who have already tried at least two chemotherapies. The study will enroll 29 participants and measure how often seve…

This phase 2 trial tests whether adding an experimental immunotherapy (QL1706) to standard chemotherapy and targeted drugs can better eliminate HER2-positive breast cancer before surgery. About 188 people with early or locally advanced disease will be randomly assigned to receive…

This phase 2 trial tests whether adding the drug inavolisib to a standard pre-surgery regimen (pertuzumab, trastuzumab, and nab-paclitaxel) can improve outcomes for people with a specific genetic mutation (PIK3CA) in HER2-positive early breast cancer. About 164 participants will …

This study tests a drug called hetrombopag to see if it can prevent or reduce low platelet counts caused by antibody-drug conjugate (ADC) chemotherapy in breast cancer patients. The trial will include 72 adults aged 18-75. Researchers will measure how many patients develop severe…

This trial tests a program called ONLOOP that reminds adult survivors of childhood cancer to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors in Ontario will be randomly assigned to get the reminders …

This study tests whether a combination of targeted drugs and hormone therapy can replace chemotherapy for people with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread). About 1,500 participants will receive either the standard chemo p…

This study tests whether a 6-month supervised exercise program can improve blood flow to the brain and thinking skills in women who had breast cancer 5-10 years ago. Participants will be randomly assigned to either the exercise program or usual care. The goal is to see if exercis…

This phase II trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy before surgery can improve tumor response in 30 patients with HR+/HER2- breast cancer. The study uses a two-stage design to check if enough patients achieve a …

This study tests a drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain or the lining of the brain and spinal cord. The drug is given either through a vein or directly into the spinal fluid. The goal is to see if it is safe and can shrin…

This study tests whether adding radiation before surgery to standard chemotherapy can shrink tumors more effectively in people with locally advanced breast cancer. It includes 50 participants with Luminal or triple-negative subtypes who did not respond well to initial chemo. The …

This study tests whether Huaier granules, a traditional Chinese medicine, can help reduce elevated tumor markers (CEA, CA125, CA153) to normal levels in people with early-stage breast cancer. About 232 participants will take the granules daily for a year alongside standard care. …

This study tests a drug called romiplostim N01 in 68 breast cancer patients whose platelet counts dropped too low due to chemotherapy. The goal is to see if weekly injections can bring platelet levels back up within two weeks, so patients can safely continue their cancer treatmen…

This early-phase study will test a combination of three drugs—camrelizumab (an immunotherapy), pirfenidone (an anti-fibrotic drug), and standard chemotherapy—in 12 women with advanced triple-negative breast cancer that has already been treated with immunotherapy. The goal is to s…

This study tests a new drug called CVL006 combined with standard chemotherapy or other targeted drugs in people with advanced solid tumors that have not responded to previous treatments. The trial has two phases: first, to find the safest dose, and second, to see if the combinati…

This early-phase study tests a new imaging agent that targets a protein called TROP2, found on many cancer cells. About 40 adults with metastatic bladder, breast, or lung cancer will receive the agent to see where it goes in the body. The goal is to see if this tracer can help do…

This early-phase study will test two radioactive tracers designed to light up certain solid tumors on scans. Twenty adults with breast, head and neck, pancreatic cancer, or glioma will receive an injection of the tracers and then undergo PET/CT and SPECT/CT imaging. The goal is t…

This study tests whether a vacuum-assisted biopsy can accurately tell if breast cancer has been completely eliminated by chemotherapy, compared to the standard surgical removal. About 100 women with breast cancer who have finished chemotherapy will receive the biopsy, and results…

This study will test an artificial intelligence system that screens for breast, liver, kidney, and bladder cancers using standard CT scans taken for other reasons. Researchers plan to enroll 100,000 participants to see if the AI can catch tumors earlier and help doctors reduce mi…

This study tests whether a special ultrasound technique (super-resolution imaging) can predict if breast cancer will completely respond to chemotherapy after just one cycle. Researchers will enroll 150 women with invasive breast cancer scheduled for chemotherapy. The goal is to s…

This study looks at two ways to train non-radiologist doctors and nurses in rural Rwandan hospitals to perform breast ultrasound. The goal is to help women get diagnosed with breast cancer earlier, without having to travel to a big city hospital. About 1,792 women will take part,…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study looks at whether adding an MRI to the yearly mammogram can help find breast cancer earlier in women with dense breasts. Participants will have a mammogram and a risk score calculated from it. Those with a high risk score will be offered an MRI. The goal is to see if th…

This study tests a new type of PET/CT scan that uses a special tracer to see if HER2-positive breast cancer has been completely eliminated after chemotherapy and targeted therapy. The goal is to see if the scan can accurately predict which patients have no cancer left, potentiall…

This study tests a new radioactive tracer called 68Ga-MY for PET scans. It targets a protein (5T4) found on many cancer cells but rarely on healthy cells. About 20 people with lung or breast cancer will get both a standard FDG scan and a 68Ga-MY scan. Researchers will compare the…

This study tests whether a new software tool, Kenko Breast AI+, can help doctors read breast MRI scans more accurately to diagnose breast cancer. About 200 adult women who may have breast cancer or are being monitored for it will take part. Researchers will compare MRI readings d…

This study aims to see if a less invasive biopsy method, using ultrasound guidance, can accurately detect whether breast cancer has spread to nearby lymph nodes. Researchers will enroll 200 adults with newly diagnosed breast cancer. The goal is to find the best way to identify su…

This study compares a new type of PET scan (FAPI) to the standard PET scan (FDG) in 15 people with metastatic invasive lobular breast cancer. The goal is to see if the new scan finds more cancer spots. Each participant will get both scans within a few weeks, and doctors will comp…

This study tests a new type of PET/CT scan that targets a protein called FAP, which is found in many breast cancers. The goal is to see if this scan can find cancer spread more accurately than current scans, helping doctors plan better treatment. About 65 adults with newly diagno…

This study tests a new mammography machine that uses a special type of X-ray (monochromatic) to produce clear breast images with at least 20% less radiation than standard mammograms. Researchers will compare image quality and the ability to spot breast problems, especially in wom…

This study will test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can accurately measure the size of breast tumors in people with ductal carcinoma in situ (DCIS). Twelve participants will receive both a standard MRI and an FCI scan before surgery. The results…

This study tests a wearable ultrasound patch that sticks to the breast and is held in place by a sports bra. Researchers want to see if it can find breast lesions as well as a standard handheld ultrasound. About 50 women will try the patch during a quick 15-minute session. The go…

This study will test an AI-enhanced ultrasound system to see if it can detect breast biopsy markers placed during standard care. About 100 adult women scheduled for breast tumor removal will have a short ultrasound scan. The AI software will try to locate the marker, but results …

This trial tests whether using more sensitive imaging (like MRI or contrast mammograms) based on a woman's personal risk can detect breast cancer recurrences earlier than standard mammograms. It will involve 2,300 women who had breast-conserving surgery and are at higher risk of …

This study will test whether AI-enhanced 3D and 2D echocardiography (heart ultrasound) can detect chemotherapy-related heart damage as accurately as cardiac MRI. Researchers will compare these new imaging methods with standard ultrasound and MRI in 120 adults who have received po…

This study will check if standard mammogram and ultrasound images can accurately predict the molecular subtype of breast cancer. Researchers will compare imaging features to lab results from biopsies in 122 women with suspected or confirmed breast cancer. If imaging can reliably …

This pilot study will test a device called the Histolog Scanner in 20 women having breast-conserving surgery for breast cancer. The scanner uses special microscopy to check if all cancer has been removed while the patient is still in the operating room. The goal is to see if this…

This study tests a new type of PET scan using a tracer called 68Ga-FAPI-46 to find cancer that has spread in patients with lobular breast cancer. Standard scans often miss these metastases. The trial will enroll 45 adults whose standard PET scan was negative or unclear, and see i…

This study tests a new device called VTM that uses infrared light to look for early signs of breast cancer, possibly before a lump appears. Researchers will compare VTM scans with standard mammograms in 120 women with breast cancer. The goal is to see if VTM can find tumors and b…

This study is testing a new blood test called TuFEst that uses DNA fragments and deep learning to stage breast cancer and check if it has spread to lymph nodes. Researchers will enroll 269 breast cancer patients, including those having surgery and those receiving chemotherapy bef…

This study will check if two simple blood test ratios (AST/ALT and MPV/platelet count) are different in women with breast cancer compared to healthy women. Researchers will look at medical records of 110 women to see if these ratios can help diagnose breast cancer. The goal is to…

This study tests a new, gentle method to analyze DNA from nipple discharge to tell if it's cancer or a harmless condition. About 60 adults with bloody nipple discharge will provide a fluid sample before their planned surgery. Researchers will compare the test results with surgica…

This study will test whether artificial intelligence can analyze non-contrast breast MRI scans to detect cancer early, avoiding the need for contrast agents that can be costly and risky. Researchers plan to enroll 30,000 women aged 30-70 and compare AI readings to standard radiol…

This study will test a new type of PET/MRI scan that uses a radioactive tracer called 18F-FAPI to see if it can detect breast cancer more accurately than current methods. The researchers will enroll 60 women with breast cancer at various stages. The goal is to see how well this s…

This study compares a new DNA sequencing platform (MGI) against the current standard (Illumina) for diagnosing hereditary cancers like breast and ovarian cancer, Lynch syndrome, and intestinal polyposis. Researchers will analyze 248 patient samples using both platforms to see if …

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This pilot study tests whether a compression sleeve with a built-in sensor can prevent lymphedema in breast cancer survivors who already have mild arm swelling. About 40 women who had lymph node removal will wear the sleeve to see if it stops the swelling from getting worse. The …

This study tests a personalized program supported by a mobile app to prevent heart damage caused by breast cancer treatments. Researchers will enroll 102 women recently diagnosed with early-stage breast cancer who are at risk for heart side effects. The program uses artificial in…

This study compares three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—against no treatment for preventing phlebitis (vein inflammation) caused by chemotherapy. Researchers will enroll 190 adults with breast or colon cancer receiving specific chemo dru…

This study tests a simple idea: wearing tight surgical gloves during paclitaxel chemotherapy might prevent nerve damage in the hands. About 84 breast cancer patients will be randomly assigned to either wear the gloves during treatment or receive standard care. Researchers will th…

This study tests a new treatment called DA-020 to prevent hair loss in people with early-stage breast cancer receiving chemotherapy. About 60 participants will use DA-020 during their chemo sessions. The goal is to see if it can reduce hair loss and help hair grow back faster aft…

This study tests a procedure called regenerative peripheral nerve interface (RPNI) done during mastectomy with immediate reconstruction. The goal is to prevent chronic nerve pain that often follows breast cancer surgery. About 200 women will be randomly assigned to get either sta…

This study tests whether low doses of two hormone-blocking drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure side effects and quality of lif…

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests a gel called TAR-0520 to see if it can prevent hand-foot syndrome, a painful skin reaction caused by the chemotherapy drug capecitabine. About 25 people with breast or colorectal cancer will apply the gel to their hands twice daily for 12 weeks. Their feet will n…

This study tests whether two types of diabetes medications—SGLT2 inhibitors and DPP-4 inhibitors—can prevent heart damage caused by the chemotherapy drug doxorubicin in women with breast cancer. About 150 Egyptian women will be randomly assigned to receive one of the drugs or sta…

This study tests whether adding an ultrasound-guided nerve block (Pecs block) to a ketamine infusion can prevent chronic pain after breast cancer surgery. 120 women scheduled for mastectomy will be randomly assigned to receive either ketamine alone or ketamine plus the nerve bloc…

This study tests a surgical technique done at the same time as breast cancer lymph node removal to prevent arm lymphedema (chronic swelling). The procedure uses a small flap of tissue from the side of the chest to rebuild the armpit area and support fluid drainage. One hundred hi…

This study tests whether telmisartan, a blood pressure medication, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 36 newly diagnosed women and measure changes in heart function and injury markers. If effecti…

This study tests whether taking rosuvastatin, a cholesterol-lowering drug, can prevent heart damage caused by anthracycline chemotherapy in women with breast cancer. Four hundred participants will receive either rosuvastatin or a placebo daily for 12 months. The main goal is to s…

This study tests whether wearing a tight surgical glove on one hand during chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. 44 participants will wear a smaller glove on their dominant hand during each chemo session, while the other hand ser…

This study tests a device called ORASIS, which helps keep the surgical area clean during DIEP flap breast reconstruction. The device automatically removes fluid and smoke, so the surgeon can work without pausing. The trial will include 30 women who have had a mastectomy and are g…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study looks at whether doing special breathing exercises for at least two weeks before breast cancer surgery can keep the breathing muscles strong. About 40 adults recently diagnosed with breast cancer will either do breathing muscle training or guided imagery exercises at h…

This study compares three techniques—ultrasound, wire, and magnetic seed—to help surgeons remove non-palpable breast tumors more accurately during breast-conserving surgery. About 1,300 adult women with early-stage breast cancer will be randomly assigned to one of the three metho…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This study looks at whether adding the drug bupropion (Wellbutrin) to standard hormone therapy can help women with early-stage breast cancer who have lost interest in sex. About 100 women will be randomly assigned to receive either their usual hormone therapy alone or with buprop…

This study will test a structured early rehabilitation program for women who have had breast cancer surgery. The program includes education, gentle exercises starting the day after surgery, and home-based workouts with monitoring. Researchers want to see if it is safe and helps w…

This study tests whether an artificial intelligence-powered digital education program can reduce the severity of radiodermatitis (skin irritation from radiation) and improve quality of life in women with breast cancer. 38 patients will be randomly assigned to either receive the A…

This study tests whether doing physiotherapy and using a mechanical stimulation device before breast reconstruction surgery can reduce shoulder pain and improve movement afterward. About 72 women scheduled for a specific type of breast reconstruction (using a back muscle flap) wi…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study tests whether a 16-week supervised exercise program can help breast cancer survivors improve their body's ability to switch between burning carbs and fats for energy. Researchers will enroll 44 women aged 18-70 who completed chemotherapy within the last 6 months and ar…

This pilot study tests a program called COPE (Creating Opportunities for Personal Empowerment) in 40 women with stage I-III breast cancer who are starting their first treatment. Participants will either receive the 7-week COPE sessions plus standard care, or standard care alone. …

This study compares two types of nerve blocks to see which one provides better pain relief after breast cancer surgery. About 70 women will receive either a newer block (SPSIP) or a standard block (SAP) before surgery. The goal is to reduce pain and the need for strong painkiller…

This study tests whether using a special heating device on the breast before mastectomy and reconstruction is practical and helpful. Forty adult patients will either use the device for one or three cycles, or receive no treatment. The main goal is to see if patients can follow th…

This study tests a small, wearable device that gently stimulates a nerve in the ear to reduce joint pain and stiffness caused by common breast cancer hormone pills (aromatase inhibitors). About 60 women with breast cancer who have joint pain will use either the active device or a…

This study tests whether 8 weekly acupuncture sessions can lower stress in breast cancer patients who finished primary treatment in the last 6 months. 112 participants will be randomly assigned to acupuncture or standard supportive care. The main goal is to see if acupuncture red…

This study will test whether a 16-week Pilates program can improve quality of life, reduce pain and fatigue, and boost emotional well-being in 50 women currently undergoing breast cancer treatment. Participants will do light-to-moderate Pilates exercises twice a week. The goal is…

This study tests whether a gentle electrical stimulation on the ear (called taVNS) can reduce joint and muscle pain caused by aromatase inhibitors, a common breast cancer treatment. 216 women with hormone-positive breast cancer will receive either real or sham stimulation daily f…

This study compares a new breast reconstruction method done in one surgery through a small armpit incision to the standard two-stage expander-to-implant approach. About 412 women who had a mastectomy at least a year ago will take part. The goal is to see which method has fewer co…

This study tests whether moderate aerobic exercise, done during breast cancer radiotherapy, can reduce inflammation and improve physical fitness and quality of life. Forty women with early-stage breast cancer will either do supervised exercise sessions or receive usual care. Rese…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests whether training doctors in shared decision-making and giving patients educational materials improves treatment conversations for HER2-negative metastatic breast cancer. 120 patients starting first-line therapy will be randomly assigned to receive the program or …

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that also removes lymph nodes. Sixty women aged 18-65 will receive one of the two blocks before surgery. Researchers will measure pain levels, opioid use, and side e…

This study tests whether a simple, video-guided mindfulness breathing program can improve quality of life and mental well-being in people with breast cancer. Fifty participants who have completed chemotherapy will either practice daily 5-minute breathing exercises for 6 weeks or …

This study tests whether a short psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can help chemotherapy work better in women with locally advanced breast cancer. Fifty-four participants will either receive standard chemotherapy alone or with Brief-…

This study tests whether a continuous nerve block using the numbing drug ropivacaine can reduce pain, inflammation, and opioid use in women undergoing mastectomy for breast cancer. Forty women will be randomly assigned to receive the nerve block or standard pain care. Researchers…

This study tests a decision aid called BCT Aid for women newly diagnosed with breast cancer. The tool helps patients understand their surgical options and what matters most to them. Researchers will compare women who use the aid to those who get usual care, looking at decision co…

This study tests whether foot reflexology, a gentle foot massage technique, can help reduce nausea and vomiting caused by chemotherapy in breast cancer patients. Fifty women receiving chemotherapy will be split into two groups: one gets standard care plus foot reflexology, the ot…

This study tests whether a personalized cognitive training program can reduce 'chemobrain' in breast cancer patients receiving chemotherapy. 75 women will be split into two groups: one gets the training plus a healthy lifestyle leaflet, the other gets only the leaflet. Researcher…

This study tests whether a low-level laser applied to specific points on the ear can improve sleep in women with breast cancer who have insomnia. Seventy participants will receive either real or sham laser acupuncture twice a week for five weeks. Sleep quality, fatigue, and mood …

This study develops and tests a support program for cancer survivors who worry about their cancer returning. 150 adults who finished treatment for breast, head and neck, colon-rectal, or prostate cancer will join. Depending on their level of fear, they will receive education, psy…

This study tests a new surgical approach for women with early breast cancer who need a nipple-sparing mastectomy. If cancer is found in the nipple during surgery, doctors will remove the nipple but try to save the pigmented skin around it (the areola) and rebuild a new nipple rig…

This study compares two types of radiation therapy—proton and photon—given after breast cancer surgery to see which causes fewer side effects. Researchers will track 750 women for one year, monitoring heart, lung, skin, and lymph node problems. The goal is to find a gentler treat…

This study looks at whether adding psychosocial support to standard chemotherapy helps breast cancer patients feel better and respond better to treatment. About 160 Palestinian women with early-stage breast cancer will take part. Half will get usual care, and half will also recei…

This study looks at whether a 6-week home program combining exercise and a limited eating window is practical and helpful for breast cancer survivors who are on hormone therapy and feel fatigued. Twenty participants will follow a plan to increase their steps, do resistance band e…

This study will test whether hyaluronic acid injections in the face can improve appearance and quality of life in women who have completed breast cancer treatment. The researchers plan to enroll 22 women aged 18 to 50 who became menopausal due to chemotherapy or hormone therapy. …

This study tests a special scanner that lets surgeons check, in real time during breast cancer surgery, whether all cancer has been removed. The goal is to reduce the need for a second operation. About 228 women with certain high-risk breast cancer types will take part. The scann…

This study compares two ways of giving a large-volume subcutaneous injection of targeted therapy (pertuzumab and trastuzumab) to 40 women with HER2-positive breast cancer. Each patient will receive one injection by a nurse using a stopwatch to mimic a steady speed, and another in…

This study tests whether Baduanjin, a gentle exercise, can improve arm and shoulder function in breast cancer survivors. About 76 women who have finished surgery and other treatments will practice this exercise and report how they feel. The goal is to see if it reduces disability…

This study tests if electroacupuncture or auricular acupressure (ear pressure) can reduce joint pain caused by hormone therapy in breast cancer survivors. 200 women will be split into three groups: electroacupuncture, ear acupressure, or a waitlist control. The goal is to see if …

This study tests whether a 10-week remote stress management program (R-CBSM) can reduce distress and slow aging in 192 breast cancer survivors aged 50+. Participants attend group video sessions on relaxation and coping skills. Researchers will measure changes in stress, immune ce…

This study tests whether a supervised exercise program, started two weeks before chemotherapy and continued for 16 weeks during treatment, can help adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemotherapy better. The goal is to see if participants can receive…

This study will test a culturally tailored online peer-support program for Korean-speaking breast cancer survivors and patients. Over 12 weeks, mentors (survivors) and mentees (patients in treatment) will interact through a bilingual platform. Researchers will measure whether the…

This study is testing a smartphone-based system that gives personalized advice to breast cancer patients going through chemotherapy. The system uses a knowledge graph to combine medical guidelines and patient-reported symptoms. Thirty patients and their nurses will use the system…

This study tests a virtual group program called Breath-Body-Mind (BBM) that uses slow breathing and gentle movements to help young breast cancer survivors (ages 18-50) cope with psychological distress. Thirty participants will be randomly assigned to either the BBM program or a g…

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study aims to find the best combination of three support strategies—priority coaching, education, and guided goal-setting—to help people who finished early-stage breast cancer treatment return to work, social life, and daily activities. About 352 participants will try one of…

This study tests whether a specific set of shoulder and scapular exercises can reduce pain, improve range of motion, and lessen disability in women who have had a mastectomy. 33 women aged 30-65, 4-12 weeks post-surgery, will be randomly assigned to either the exercise program or…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study looks at whether breast cancer patients can safely stop taking allergy-preventing medications before weekly paclitaxel after two doses without a reaction. Researchers want to see if stopping these drugs improves quality of life, since they can cause side effects like i…

This pilot study tests a device called BLOOM43 that warms the breast skin the night before reconstructive surgery after mastectomy. The goal is to see if preconditioning reduces skin necrosis (tissue death) and improves healing. Sixty women undergoing immediate breast reconstruct…

This study compares a plyometric strength-endurance exercise program to conventional strength training in 51 women who are breast cancer survivors or currently undergoing treatment. Over 12 weeks, participants will attend supervised 60-minute sessions twice a week. Researchers wi…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study will test if a specific exercise program can improve forward head posture and shoulder movement in women who have had a mastectomy. Sixty women aged 45-65 with upper cross syndrome will participate. The program focuses on exercises to correct posture and increase range…

This study tests whether adding magnesium to standard nerve blocks can better control pain after breast removal surgery. Sixty women scheduled for a mastectomy will receive either the standard nerve block or one with added magnesium. The goal is to see if the magnesium helps redu…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study looks at whether adding magnesium sulfate to a standard nerve block can better control pain after a mastectomy. One hundred women having breast cancer surgery will be randomly assigned to receive the nerve block with or without magnesium. The main goal is to see if it …

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study compares two types of nerve blocks for pain after modified radical mastectomy. One block is placed under the chest muscle, the other above it, and a third combines both. The goal is to see which approach reduces opioid use and pain scores most effectively. Sixty women …

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…

This study tests whether hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study looks at whether laser acupuncture can help reduce carpal tunnel syndrome symptoms in breast cancer patients who take aromatase inhibitors. Fifty-four women aged 40-60 will be split into two groups: one gets laser acupuncture plus standard physical therapy, the other g…

This study tests a 6-month online program for women with newly diagnosed breast cancer. The program includes daily exercise, mindfulness, and support via email and optional group sessions. Researchers want to see if it reduces psychological distress and improves well-being compar…

This study tests whether giving a mild electrical stimulation to the nerves during mastectomy surgery can help restore sensation to the breast and nipple. Thirty women having both breasts removed and reconstructed will receive the stimulation on one breast only, and their sensati…

This study tests whether a traditional Chinese herbal formula called Qibei Jiedu can prevent or ease the painful skin rash (radiation dermatitis) that often occurs during breast cancer radiotherapy. Sixty women with early-stage breast cancer will receive either the herbal drink o…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This Phase 3 trial tests whether taking creatine supplements daily can prevent or reduce the memory and thinking problems that often come with chemotherapy. About 227 women with early-stage breast cancer will receive either creatine or a placebo, starting before chemo and continu…

This study will compare two surgical techniques for nipple-sparing mastectomy in 170 women with early breast cancer: the traditional open surgery and a newer endoscopic method using small hidden cuts. The main goal is to see which approach leads to better recovery of breast skin …

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study tests whether giving atropine before treatment can prevent diarrhea in people with advanced breast cancer receiving the drug sacituzumab govitecan. About 30 participants will receive atropine alongside their cancer therapy. The goal is to improve treatment tolerance an…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study looks at whether wellness coaching, delivered through a mobile app or in a group, can help women recently diagnosed with breast cancer adjust emotionally and feel better overall. About 124 women will take part, answering surveys before and after an 8-week program. The …

This study tests if a traditional Chinese medicine hand and foot bath can help control nerve pain and numbness caused by chemotherapy in breast cancer patients. About 78 adults will either receive the herbal bath or a standard vitamin treatment. The goal is to see which approach …

This study tests whether a special skin-like sheet (SureDerm) placed during breast-conserving surgery can improve how the breast looks and feels afterward. About 116 women with breast cancer will be randomly assigned to get the implant or standard surgery alone. Researchers will …

This study tests a 6-week support program for young and middle-aged women with breast cancer who are raising children. The program includes counseling and parenting guidance to help reduce anxiety about parenting. Researchers will enroll 20 participants to see if the program is a…

This study tests whether reconnecting nerves during breast reconstruction can improve sensation and quality of life. Twenty-eight women who had a mastectomy will be randomly assigned to receive either standard reconstruction or reconstruction with a nerve graft. Researchers will …

This study tests whether using a virtual reality headset for 30 minutes during chemotherapy can reduce pain and anxiety in breast cancer patients. Fifty participants will either receive standard care or standard care plus VR. Researchers will measure pain and anxiety levels using…

This study tests whether a single injection of liposome bupivacaine, a long-acting anesthetic, into the chest wall can reduce pain sensitivity and prevent chronic pain after radical mastectomy. 120 breast cancer patients will receive the nerve block during surgery, and their pain…

This study looks at two ways to improve sleep after breast cancer surgery: a nerve block injection or a mild ear stimulation device. About 136 women will be randomly assigned to one of the two treatments. Their sleep will be tracked with a wrist monitor and questionnaires for the…

This study tests whether a mobile app can help women with breast cancer better manage side effects from chemotherapy, like fatigue, nausea, and sleep problems. 74 patients will either use the app plus standard care or receive standard care alone. The app includes symptom tracking…

This study tests whether adding logotherapy—a type of counseling that helps people find meaning in their struggles—to standard support can reduce anxiety and depression in women newly diagnosed with breast cancer. Sixty-six women will be randomly assigned to receive either standa…

This study tests whether a combination of two anti-nausea drugs (NEPA plus megestrol acetate) works better than the standard regimen (NEPA plus dexamethasone) for preventing nausea and vomiting in breast cancer patients receiving T-DXd therapy. 120 participants will be randomly a…

This study tests two different ultrasound-guided nerve blocks to see which one provides better pain relief after breast cancer surgery. 70 adults aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to reduce the need for strong painkillers and impro…

This study compares removing drainage tubes earlier versus later after a specific type of nipple-sparing mastectomy with immediate breast implant reconstruction. About 379 women aged 18–70 with breast cancer or those having preventive mastectomy will take part. The goal is to see…

This study compares two types of nipple-sparing mastectomy: one done with a robotic arm through a small side incision, and the standard open surgery. Researchers want to see if the robotic method improves women's satisfaction, body image, and recovery over 12 months. The trial wi…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests whether acupuncture can reduce anxiety and depression in women with breast cancer. Researchers will compare real electroacupuncture to a sham version in 360 participants. The goal is to see if this needle-based therapy improves emotional well-being without medica…

This study tests a simple home questionnaire for women with HR+HER2- advanced breast cancer who are taking CDK4/6 inhibitors and hormone therapy. The goal is to see if the questionnaire can accurately identify which patients truly need to come to the hospital for a check-up, pote…

This study tests whether a CO2 laser combined with a regenerative gel can relieve vaginal atrophy symptoms—like dryness, pain, and itching—in 180 breast cancer survivors who cannot use hormone therapy. Participants will be randomly assigned to receive the laser plus gel, laser al…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This study will test SerenApp, a smartphone app designed with input from patients and doctors to help breast cancer survivors cope with anxiety, depression, and stress. 90 women who have finished primary treatment will use the app for 8 weeks. Researchers will measure changes in …

This study collects spinal fluid, blood, saliva, and tumor samples from 139 adults with HER2-positive or triple-negative breast cancer that has spread to other organs but not yet to the brain. Researchers will analyze these samples for tumor DNA that might predict when the cancer…

This study looks at whether breast-conserving surgery (removing only the tumor, not the whole breast) is safe for women diagnosed with multifocal or multicentric breast cancer—meaning they have two or more tumors in one breast. Researchers will follow 100 adult women for at least…

This study tests whether an 8-week program using Instagram posts and podcast episodes can improve breast cancer awareness and screening habits in women aged 20 to 39. Participants follow a dedicated Instagram account and listen to podcast content designed to educate about symptom…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study follows 100 women whose breast cancer has come back after a mastectomy. Researchers will track their health for at least three years to understand what factors affect survival and how different standard treatments work. No experimental drugs are given; the goal is to l…

This study looks at whether tracking tumor DNA in the blood (ctDNA) can help doctors see how well breast cancer treatment is working before surgery. It will include 186 people with stage II-III HER2-positive or triple-negative breast cancer. Researchers will take blood samples at…

This study looks at how common stigma is for breast and cervical cancer patients, caregivers, and community health workers in Rwanda. It also tests a program called RISE that includes resilience training, support groups, and videos of cancer survivors to see if it can reduce stig…

This study looks at how financial stress from cancer treatment affects quality of life in breast cancer survivors, and whether personal strengths like resilience and posttraumatic growth can soften that blow. About 160 women will fill out surveys before, during, and after chemoth…

This study looks at whether changes in gut bacteria are linked to cancer-related weight and muscle loss (cachexia) in women with breast cancer who receive care at home. About 140 participants will provide blood, stool, and urine samples and answer questionnaires. Some will take a…

This study will enroll 56 women with breast cancer to see if two different regional anesthesia techniques (paravertebral block vs. erector spinae plane block) cause different immune responses during surgery. Participants will receive one of the two blocks along with general anest…

This study tests whether taking omega-3 supplements before surgery can change the types of fats found in breast tumors. About 35 adults with early-stage breast cancer will take the supplement for 4 to 28 weeks while also receiving standard cancer treatments. The goal is to see if…

This pilot study will test whether a 4-week Mediterranean diet program is practical and acceptable for women newly diagnosed with breast cancer before they have surgery. Twenty post-menopausal women with stage I-III breast cancer will receive all their meals and snacks. The main …

This study will map the location of small blood vessels in the chest wall using bony and soft tissue landmarks. The goal is to help surgeons perform partial breast reconstruction more precisely after breast cancer surgery. The study will involve 20 women undergoing elective breas…

This study aims to see if taking PET/CT scans later after injection of a special tracer (18F-Fluoroestradiol) can better detect breast cancer that has spread to the liver or abdomen. Researchers will use a new, more sensitive scanner that allows for later imaging, which may impro…

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

This study aims to use MRI and 3D images from 25 women who have had or will have a mastectomy (breast removal) to develop a computer model for a customizable breast implant called MyBREAST One. The goal is to create implants that are tailored to each person's body. This is an ear…

This study tests whether a culturally tailored program can help Black women keep their mammogram appointments. About 176 women aged 40 and older who are scheduled for a screening mammogram will take part. The goal is to find better ways to reduce racial disparities in breast canc…

This early-stage trial will test two different versions of the experimental drug HRS-6209 in 21 healthy Chinese adults. The goal is to see how the body absorbs the old and new capsule forms, and whether a high-fat meal affects absorption. No treatment benefit is expected for part…

This study aims to find the best score on a simple, self-administered questionnaire to identify mild nerve damage caused by chemotherapy in breast cancer survivors. About 28 women who have completed taxane-based chemotherapy and radiation will participate. The goal is to improve …

This study aims to understand why breast cancer in young women is often more aggressive. Researchers will look at how pregnancy and breastfeeding might influence the disease. They will collect information from 1,000 women aged 45 or younger (and a comparison group aged 55+) with …

This study will follow about 109 women in Gulf Cooperation Council (GCC) countries who have a certain type of advanced breast cancer (HR-positive, HER2-low or ultra-low) and are taking the drug trastuzumab deruxtecan after hormone therapy stopped working. Researchers want to see …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study looks at two ways to rebuild a breast after mastectomy for breast cancer: one-step with a permanent implant, or two-step using a temporary expander first. Researchers will compare complication rates in 276 women to see which method works better. The goal is to help doc…

This study will follow 2,200 young women (aged 40 or younger) who had breast cancer and carry a mutation in a breast cancer gene other than BRCA1/2. Researchers want to see if getting pregnant after diagnosis affects the cancer's return. The study does not test any drug or treatm…

This study checks if a new set of thinking and memory tests can better detect cognitive problems in breast cancer survivors who had chemotherapy. Researchers will compare results from 200 survivors and healthy volunteers to see if the tests are accurate. The goal is to improve di…

This study monitors 1,500 adults with breast cancer who receive LUMISIGHT during lumpectomy surgery. Researchers will track how often serious allergic reactions occur within 60 minutes of injection. No new drug is being tested; the goal is to better understand the safety of this …

This study looks at how gut bacteria affect diarrhea and other stomach issues in people with HR+/HER2- breast cancer taking the drug abemaciclib. In the first part, researchers will collect stool samples to track bacteria changes. In the second part, a small group will try eating…

This study will look at a specific genetic marker called PCGEM1 in blood and tissue samples from 90 newly diagnosed breast cancer patients. The goal is to learn more about how breast cancer develops and find possible targets for new treatments. No extra procedures are needed beyo…

This study surveys 240 breast cancer patients to understand how they use herbs and supplements alongside standard treatments like chemo or hormone therapy. Researchers want to see if ethnicity influences which products people take. The goal is to gather information, not to test a…

This study looks at women with a very early form of breast cancer called DCIS. It uses a special test to find those at low risk of the cancer coming back. The goal is to see if these low-risk women can skip radiation therapy after their lump-removal surgery without a meaningful i…

This study looks at whether a blood test can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, ovarian, or pancreatic cancer. Researchers will collect blood and tumor samples from 300 adults to analyze cancer cells and their DN…

This study looks at whether a color Doppler ultrasound feature called the 'twinkling artifact' can make breast tissue marker clips easier to see. These clips are placed to mark suspicious areas in the breast or lymph nodes. The study will review past images from about 86 women wi…

This study will use a special PET/CT scan after proton radiation therapy for breast cancer to see how accurate the proton beam is. The goal is to link any beam errors with side effects like lung inflammation or rib fractures. By understanding these errors, doctors hope to improve…

This study aims to see if a simple finger-prick blood test can accurately measure levels of certain breast cancer drugs (CDK4/6 inhibitors) compared to standard blood draws from a vein. About 90 breast cancer patients currently taking these drugs will provide both types of blood …

This study tests a simpler way to check for cancer spread after chemotherapy in women with node-positive breast cancer. Doctors will use a blue dye called methylene blue to find and remove a wider area of lymph nodes, instead of the standard method. The goal is to see if this app…

This study will take tumor samples from 40 women with locally advanced breast cancer and grow them in the lab as 3D 'mini tumors' called organoids. Researchers will test how these organoids respond to chemotherapy and compare the results to how the patients actually responded. Th…

This study aims to make a community weight loss program called TOPS more helpful for breast cancer survivors. Researchers will first gather feedback from survivors in focus groups, then use that feedback to tailor the program. The study will enroll 25 women who have finished prim…

This study looks at whether an artificial intelligence (AI) tool can safely and accurately help breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI tool and answer surveys. The goal is to see if the tool is helpful …

This study will enroll 235 women with hormone receptor-positive, HER2-negative breast cancer who are taking abemaciclib after surgery. Researchers want to see if higher levels of the drug in the blood are linked to severe diarrhea, a common side effect. By understanding this link…

This study looks at whether tiny particles called exosomes, released by breast cancer cells, contain genetic material (microRNA) that can predict how well chemotherapy will work before surgery. Researchers will collect tumor tissue and blood samples from 60 women with breast canc…

This observational study will follow 300 women aged 45-55 with hormone receptor-positive breast cancer to see if changes in a hormone called AMH can predict when they will reach menopause. Researchers will collect blood samples at seven time points and track menstrual patterns. T…

This study is testing a new web and mobile app called SHIELD, designed to support women with hormone receptor-positive breast cancer who are on long-term hormone therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women will particip…

This study looks at 150 breast cancer patients starting T-DXd, a drug that often causes nausea, vomiting, and weight loss. Researchers will measure blood levels of a hormone called GDF-15 before and during treatment to see if changes in GDF-15 are linked to these side effects. If…

This study will follow 81 people with early-stage, hormone-positive breast cancer who are at high risk of the cancer coming back. Researchers want to see how often patients take their prescribed CDK4/6 inhibitor pills (abemaciclib or ribociclib) alongside standard hormone therapy…

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study will compare two different tissue expanders used in breast reconstruction after mastectomy in 80 women. Some participants will also receive radiation therapy, which is not typically recommended with these devices. Researchers will evaluate aesthetic outcomes, patient s…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study looks at whether doing broad gene testing early, instead of later, helps find more effective treatments for people with advanced pancreatic, liver, or triple-negative breast cancer. About 360 adults with poor-prognosis cancers will be randomly assigned to early or stan…

This study tests whether special PET/MRI scans can predict how well breast cancer treatments work. 300 women will get scans before and after two cycles of therapy. The goal is to find which scan patterns match good or poor responses, helping doctors choose the right treatment for…

This study looks at whether chemicals called endocrine disruptors (found in plastics, food, and everyday items) are linked to breast cancer. Researchers will measure these chemicals in urine, hair, and breast fat from 42 women scheduled for breast lesion surgery. The goal is to u…

This study will track gut microbiome changes in 12 women with hormone receptor-positive breast cancer starting Verzenio (abemaciclib) therapy. Participants will take either a resistant potato starch supplement or a placebo, and provide stool samples and symptom questionnaires rem…

This study will use MRI scans and artificial intelligence to predict the type and aggressiveness of breast cancer without needing a biopsy. Researchers will analyze images from 400 patients to see if computer models can identify HER2 status and other key features. The goal is to …

This study will track 827 people with early breast cancer who had breast surgery but no armpit (axillary) surgery. The goal is to see if skipping armpit surgery is safe and how it affects quality of life. Researchers will monitor for cancer coming back in the armpit over three ye…

This study looks at whether women identified as having a higher risk of breast cancer will attend additional breast imaging appointments. About 3,000 women in Norway who either have very dense breasts or had a false-positive screening result will be invited for extra scans. The g…

This study looks at how chemotherapy for breast cancer affects the sense of arm position (proprioception). Researchers will compare three groups: breast cancer patients who had chemotherapy, those who had surgery only, and healthy volunteers. Using robotic tasks and video trackin…

This study will check if people with metastatic breast or colon cancer have antibodies that might also attack the heart. Researchers will collect blood samples and ECGs from 196 participants over 12 months. The goal is to see if these antibodies raise the risk of dangerous heart …

This study tests a structured education program to help women learn and practice breast self-exams. 76 women aged 20-69 will be randomly assigned to receive the program or not. Researchers will measure changes in self-exam behavior, breast cancer knowledge, awareness, and fear le…

This study looks at how often women with early-stage breast cancer experience taste changes during chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect nutrition and quality o…

This study looks at how a personalized strength training program affects people with different cancers, including lung, colon, breast, and blood cancers. 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers …

This study aims to see if MRI can measure breast tumor volume more accurately than the usual one-dimensional ruler method. About 59 women with suspicious or confirmed breast cancer will get an MRI before surgery, and the MRI-based tumor volume will be compared to the actual tumor…

This study looks at whether a blood test for circulating tumor DNA (ctDNA) can detect leftover cancer after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 participants will give blood samples before and after standard treatments. No new treat…

This study looks at why some breast cancer patients get diarrhea from the drug pyrotinib while others don't. Researchers will compare the gut bacteria of 60 patients who develop diarrhea with those who don't. They hope to find specific bacteria that protect against this side effe…

This study looks at bacteria living inside breast tumors and compares them to bacteria in the gut and urine of 240 women undergoing breast cancer surgery. Researchers want to see if these microbes differ across cancer subtypes and if they relate to tumor features. The goal is to …

This study looks at 80 women with breast cancer who had a port placed in the right side of their neck for chemotherapy. Researchers want to see if the side of the cancer (right or left breast) affects how long the port works without problems like infection or blood clots. The goa…

This study examines whether having COVID-19 increases the chance of lung inflammation (radiation pneumonitis) in breast cancer patients receiving radiation therapy. Researchers will review medical records of 200 patients to compare outcomes between those who had COVID-19 and thos…

This study will follow 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will use questionnaires and exams before treatment and one year later. The goal is to better understand these side effects in…

This study will enroll over 1,000 women with HER2-positive breast cancer to analyze the molecular characteristics and subtypes of their tumors. Participants will receive standard pre-surgery treatment with trastuzumab, pertuzumab, and chemotherapy. The goal is to identify which s…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…

This large study will follow over 6,700 adults with obesity-related cancers (like breast, colorectal, or lung cancer) to track changes in their body fat and muscle using advanced imaging. The goal is to see how these changes relate to survival, cancer recurrence, and quality of l…