BREAST CANCER

This study is testing whether placing tiny radioactive seed markers in breast tumors before chemotherapy can help patients achieve better treatment results. Women with early-stage breast cancer will be randomly assigned to either receive these seed markers or receive standard tre…

This study aims to find the best method to guide surgeons when removing small, non-palpable breast tumors. It will compare three different guidance techniques: a special ultrasound-guided clip, a magnetic seed, and the traditional wire method. The goal is to see which method help…

This is a very early study to find the safest dose of a new drug called 177Lu-INN805 for people with advanced solid tumors that haven't responded to standard treatments. It will enroll about 10 patients with cancers like head & neck, lung, breast, or sarcoma to test how the body …

This early-stage study is testing the safety of combining a targeted cancer drug (Trastuzumab Deruxtecan) with precise radiation therapy for people with HER2-positive breast cancer that has spread to the brain. The goal is to see if this combination can better control the cancer …

This study is testing which of two drug combinations works better to shrink tumors before surgery in people with HER2-positive breast cancer. About 188 participants will receive either the standard three-drug combination plus a new drug called QL1706, or the standard combination …

This study is testing whether a personalized follow-up plan works better than the standard one-size-fits-all approach for breast cancer survivors. It will enroll 2,300 women who have had breast-conserving surgery and are at higher risk of the cancer coming back. The goal is to se…

This study is testing whether adding two new immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy helps shrink tumors before surgery in people with a specific type of breast cancer (HR+/HER2-). The goal is to see if this combination can completely eliminate…

This study compares two shorter radiation schedules for breast cancer patients who have had surgery. Researchers want to see if a 2-week radiation schedule works as well as the standard 3-week schedule at preventing cancer from returning. The study will also track side effects to…

This study is testing a community weight loss program that has been specially adapted for women who have completed treatment for breast cancer. About 25 participants will attend virtual group sessions for six months, then join in-person community groups, while researchers track t…

This study is testing whether a drug called leucogen can prevent a serious side effect of breast cancer treatment. Researchers want to see if leucogen reduces severe drops in white blood cells (neutropenia) in early-stage breast cancer patients taking ribociclib with hormone ther…

This study is testing a combination of four existing drugs given before surgery to shrink tumors in people with triple-positive breast cancer. The goal is to see if this four-drug approach is effective and safe when used as initial treatment. Researchers will measure how well the…

This study is testing whether adding a course of radiation therapy to standard chemotherapy before surgery is safe and more effective for shrinking tumors in patients with locally advanced breast cancer. It focuses on two specific, harder-to-treat types of breast cancer where sta…

This trial is testing whether combining two existing drugs—ribociclib and anastrozole—works better together for people with advanced or returning breast cancer. The study will involve 86 Japanese patients whose cancer is hormone-sensitive but HER2-negative. Researchers will first…

This study is testing whether adding an immunotherapy drug called eftilagimod alpha (Efti) to standard chemotherapy given before surgery can help eliminate more cancer in patients with early-stage, hormone-positive, HER2-negative breast cancer. The main goal is to see if this com…

This study is testing whether a traditional Chinese herbal medicine called Huaier granules can help lower elevated tumor marker levels in people who have had surgery for early-stage breast cancer. It will involve 232 participants who have no signs of cancer returning but have hig…

This small pilot study will test whether a nurse-led lifestyle support program is practical and acceptable for breast cancer survivors who also have heart conditions. The 4-week program, supported by a general practitioner, focuses on healthy habits like physical activity, diet c…

This study is testing a new approach for treating a common type of breast cancer before surgery. Patients first get a two-week course of two targeted drugs. Doctors then check a tumor marker (Ki67) to decide if they should continue with the drug combo or switch to standard chemot…

This study aims to find out which of two drug combinations works better to shrink or eliminate tumors before surgery in people with early-stage HER2-positive breast cancer. It will compare a three-drug regimen (THP) to a four-drug regimen (TCHP). The main goal is to see which tre…

This large study aims to determine if some breast cancer patients can safely skip radiation to the chest wall and lymph nodes after surgery. It will compare cancer recurrence and survival rates between patients who receive this radiation and those who do not. The goal is to reduc…

This early-stage study is testing whether a 'fecal microbiota transplant' (FMT)—transferring gut bacteria from a healthy donor—is safe and feasible when given alongside standard pre-surgery chemotherapy and immunotherapy for triple-negative breast cancer. Researchers want to see …

This study is testing if time-restricted eating (limiting daily food intake to a specific window) can help protect brain function and reduce heart disease risk in older women who have survived breast cancer. Researchers will compare this eating pattern against general healthy eat…

This study is testing whether a new drug called SHR-A1811 works better and is safer than the current standard treatment for people with advanced HER2-positive breast cancer whose cancer stopped responding to their first targeted therapy. About 100 adults with this specific type o…

This study is testing whether combining two drugs, entinostat and oral paclitaxel, can help control advanced breast cancer that is hormone receptor-positive and HER2-negative. It is for people who have already tried 2-4 other treatments, including specific hormone therapy and che…

This study is testing if a special, low-calorie 'fasting-mimicking' diet can make standard chemotherapy and immunotherapy work better for people with a hard-to-treat type of breast cancer. It will involve about 80 women with early or locally advanced triple-negative breast cancer…

This study is testing if a supervised exercise program can help protect the heart in women who have survived breast cancer. Many life-saving cancer treatments can damage the heart over time. Researchers will compare a 16-week exercise program to standard health advice to see if e…

This study is testing if adding a pill called fluzoparib to standard care helps prevent breast cancer from returning in women who have already had surgery. It is for women with early-stage breast cancer who have specific inherited gene mutations. The goal is to see if taking the …

This study is testing a new two-in-one immunotherapy drug called QL1706, given with chemotherapy before surgery for early triple-negative breast cancer. The goal is to shrink tumors and see if some patients can safely skip a type of chemotherapy that can harm the heart long-term.…

This study is testing whether getting regular brain MRI scans every 6 months helps detect cancer spread to the brain earlier in people with stage 4 breast cancer who don't have symptoms. Researchers want to see if finding cancer spread sooner leads to better treatment options and…

This study aims to understand why a powerful breast cancer drug, abemaciclib, causes severe diarrhea and low white blood cell counts in many patients. Researchers will measure drug levels in the blood of 235 patients to see if these side effects are linked to how much of the drug…

This study is testing a combination of targeted drugs given before surgery to treat a specific type of breast cancer that is both hormone-sensitive and HER2-positive. The goal is to see if this approach can effectively control the cancer while reducing the need for traditional ch…

This study is testing if time-restricted eating—consuming all daily food within an 8-hour window—is practical and helpful for women starting chemotherapy for breast cancer. Researchers will compare three different eating schedules to a control group over 24 weeks to see if this a…

This study is testing whether freezing small breast tumors with liquid nitrogen can completely destroy cancer cells in postmenopausal women. Researchers will treat 140 women with this freezing technique, then perform standard surgery to check if any cancer cells remain. The goal …

This study is testing if adding a new drug called inavolisib to standard pre-surgery treatments works better for people with a specific type of early-stage, HER2-positive breast cancer that has a PIK3CA gene mutation. About 164 participants will be randomly assigned to receive th…

This study is testing whether combining two drugs, camizestrant and ribociclib, can better control advanced hormone-positive breast cancer. It will involve about 150 adults whose cancer has progressed despite at least 5 years of prior hormone-blocking therapy. The main goal is to…

This study is testing if a new drug called SHR-A1811, given alone or with hormone therapy, is better and safer than standard chemotherapy when used before surgery for early-stage breast cancer. It will involve 120 women with a specific type of breast cancer (HR-positive, HER2-low…

This early study aims to check if it is safe and tolerable to give a targeted cancer drug (a CDK4/6 inhibitor) at the same time as standard radiation therapy after surgery. It will involve 30 women with a specific high-risk type of breast cancer (HR+/HER2-). Researchers will clos…

This study is testing a new program called ONLOOP that reminds adult survivors of childhood cancer in Ontario to get important health screenings. Many survivors are at higher risk for heart problems, breast cancer, or colon cancer due to their past cancer treatments, but often mi…

This study is for women with a specific, hard-to-treat type of advanced breast cancer that has grown despite standard hormone and CDK4/6 inhibitor therapy. It will test if adding a drug called famitinib to another drug (SHR-A1811) works better and is safe compared to using SHR-A1…

This study is for people with a common type of early breast cancer (HR+/HER2-) who have had surgery. It aims to see if a gentler, targeted drug combination (ribociclib plus hormone therapy) works as well as starting with chemotherapy for patients whose blood tests show no signs o…

This study compares two approaches for removing surgical drain tubes after breast cancer surgery. Researchers want to see if removing drains earlier is as safe as the standard timing and if it leads to better cosmetic results and higher patient satisfaction. The trial will involv…

This study aims to find better personalized treatment plans for patients with a specific type of breast cancer (HR+/HER2+) before they have surgery. Researchers will test different drug combinations based on how patients initially respond to treatment, with the goal of shrinking …

This large study is testing if a new treatment approach can work as well as chemotherapy for a specific group of early breast cancer patients. It will compare a targeted pill (dalpiciclib) plus hormone therapy directly against standard chemotherapy. The goal is to see if patients…

This study aims to observe how effective and safe the drug pyrotinib is for treating advanced HER2-positive breast cancer in a real-world setting. It will enroll 500 patients who are starting this treatment for the first time, following their progress as they receive care from th…

This study is testing a new combination of three drugs for advanced triple-negative breast cancer that has progressed after initial treatment. It will enroll 12 patients to see if adding an anti-fibrosis drug (pirfenidone) to an immunotherapy (camrelizumab) and chemotherapy can h…

This study is testing whether the drug sacituzumab govitecan can slow cancer progression when used as the first treatment for advanced triple-negative breast cancer. Researchers will enroll 24 adults who haven't received prior treatment for their advanced cancer and give them the…

This study is testing if some patients with a common type of early breast cancer can avoid chemotherapy before surgery. Instead, they would receive a targeted pill (abemaciclib) plus hormone therapy. The goal is to see if this gentler approach works as well for shrinking tumors, …

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This early-stage study is testing whether adding an experimental drug called HRS-6209 to standard hormone therapies (fulvestrant or letrozole) is safe and might help control advanced breast cancer. It will involve about 15 patients whose cancer has specific hormone receptor patte…

This study is testing if a drug called abemaciclib can prevent breast cancer from returning in people who have already had surgery and standard treatment. Researchers will use a special blood test to detect tiny traces of cancer early, and if found, participants will take the dru…

This early-stage study is testing a new type of cell therapy called HTR2 T cells for people with advanced HER2-positive breast cancer that has spread and stopped responding to standard treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to bett…

This study is for people with breast cancer that has spread to lymph nodes in the armpit, which is visible on an ultrasound before surgery. It will test if a less extensive surgery, which removes only the first few key lymph nodes, is just as effective for survival as the standar…

This study is testing whether a combination of two newer drugs, serplulimab and SHR-A1811, can effectively shrink tumors in patients with early-stage triple-negative breast cancer before they have surgery. The goal is to see if this non-chemotherapy approach can completely elimin…

This study is testing a questionnaire designed to help breast cancer patients on specific medications decide when they truly need to visit the hospital for a check-up. It aims to improve patients' quality of life by reducing unnecessary hospital trips while ensuring they get care…

This study compares two newer targeted drugs for HER2-positive breast cancer when given before surgery. It aims to see which drug helps more patients achieve a complete disappearance of cancer in the breast and lymph nodes after treatment. The trial will also track side effects a…

This study is looking at whether hormone therapy combined with ovarian suppression can work as well as chemotherapy for young women with certain types of breast cancer. Researchers will follow 4,000 women aged 50 or younger who have already had breast cancer surgery. They'll use …

This study aims to see if performing a broad genetic test on tumors early in treatment, rather than later, helps find more personalized treatment options for people with advanced pancreatic, liver, or triple-negative breast cancer. It will compare two approaches: one group gets t…

This study is creating and testing a patient navigation program to help young adults who have survived cancer. The program aims to guide survivors to get the recommended primary care and cancer check-ups they need. Researchers will first adapt an existing program for young surviv…

This early-stage study is testing a new personalized therapy for people with advanced breast or prostate cancer that has spread and stopped responding to standard treatments. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer, and then infu…

This study aims to find better treatments for advanced breast cancer by matching therapies to specific tumor characteristics. It will enroll 700 patients whose cancer has progressed after initial treatment. Doctors will analyze tumor markers and assign standard treatments accordi…

This study is testing whether a drug called axelopran can help control advanced cancers of the lung, breast, pancreas, and prostate in patients who are taking opioid pain medication. Researchers want to see if the drug can slow tumor growth, improve bowel function, and reduce inf…

This study is testing whether some breast cancer patients who respond exceptionally well to chemotherapy might be able to avoid surgery. It will enroll 84 people with HER2-positive or triple-negative breast cancer. Patients who show a complete response to chemo will be monitored …

This study is testing if a blood pressure medication called telmisartan can protect the heart from damage caused by a powerful chemotherapy drug (doxorubicin) used to treat breast cancer. It will involve 36 women with breast cancer who are about to start this specific chemotherap…

This study aims to understand why patients with early-stage, high-risk breast cancer stop taking their powerful new combination medications too soon. Researchers will follow 81 patients who are prescribed a standard hormone therapy pill plus a newer drug (like abemaciclib or ribo…

This study compares two types of diabetes medications to see if they can protect the heart from damage caused by a common breast cancer chemotherapy drug. Researchers will follow 150 Egyptian women with breast cancer who are receiving doxorubicin chemotherapy. Participants will t…

This study is testing if a drug called romiplostim N01 can help breast cancer patients recover their platelet counts after chemotherapy. Low platelets (thrombocytopenia) are a common side effect that can delay cancer treatment. The study will see if weekly injections of the drug …

This study is exploring whether a weekly medication called tirzepatide is a practical option for helping postmenopausal women who have survived hormone receptor-positive breast cancer and are living with obesity. Researchers want to see if participants can stick with the 6-month …

This study is testing whether combining two hormone therapy drugs (elacestrant and exemestane) can better control advanced breast cancer that has worsened after initial treatment. It will enroll 26 patients whose cancer is still driven by hormones, as confirmed by a special PET s…

This study is testing whether a combination of two drugs, Lucanisatuzumab and Tagolisumab, can help control advanced breast cancer that has grown despite standard hormone-blocking therapy. It will enroll about 35 patients whose cancer tests positive for a specific marker (PD-L1).…

This trial is for people with a specific type of early breast cancer (ER+/HER2-) that is at a high risk of coming back. It will test if starting treatment with a new drug called elacestrant, with or without another standard drug, for 5 years is better at keeping the cancer away t…

This study is testing whether a drug called trilaciclib can protect a patient's bone marrow and blood cells during chemotherapy for advanced triple-negative breast cancer. The goal is to reduce severe side effects like infections and fatigue, which often force doctors to delay or…

This study is testing whether a concentrated grape extract can help protect the heart from damage caused by certain breast cancer chemotherapy drugs. It will involve 120 women at high risk for this side effect, who will take either the grape supplement or a placebo pill for three…

This study is for people with a type of breast cancer (HER2-negative) that did not shrink enough after two rounds of standard chemotherapy. Researchers want to see if adding an immunotherapy drug (toripalimab) and a very precise, high-dose radiation treatment can help eliminate m…

This study is testing whether combining two drugs, elacestrant and trastuzumab deruxtecan, can help control advanced breast cancer that has grown despite prior hormone-based therapies. It will involve about 65 people with specific types of breast cancer (HR+/HER2-low or ultralow)…

This study aims to find the best dose of radiation to combine with standard chemotherapy and immunotherapy before surgery for an aggressive type of breast cancer that has spread to lymph nodes. It will enroll 32 patients who will be randomly assigned to receive either a low or hi…

This study is testing whether adding the drug ribociclib to standard hormone therapy helps prevent breast cancer from coming back in high-risk patients. It's for women whose cancer didn't completely disappear after initial chemotherapy. Researchers will compare the two-drug combi…

This large trial is testing two main ideas for treating aggressive, early-stage triple-negative breast cancer. First, it asks if patients who respond very well to initial chemo can safely skip more of it and go straight to surgery. Second, for patients who don't respond as well, …

This study is testing an investigational drug called SHR-A1811 for women with advanced HER2-positive breast cancer that has spread to the brain. It aims to see if the drug is safe and effective at controlling the cancer in the brain and spinal fluid. The trial will include two gr…

This large study is testing if a combination of newer, targeted drugs can effectively control a specific type of early-stage breast cancer, potentially allowing patients to avoid traditional chemotherapy. It will compare the new drug regimen against the standard approach of chemo…

This study is testing a new lab test that analyzes DNA from nipple fluid to tell if a woman's bloody nipple discharge is caused by cancer or a harmless condition. Currently, many women with this symptom undergo surgery for diagnosis, but most turn out to have benign (non-cancerou…

This study is testing a simple scoring system to help breast cancer survivors check themselves for nerve damage caused by chemotherapy. The goal is to find the best score that accurately tells the difference between having significant nerve problems and having none. Researchers w…

This study is testing a new device called the Histolog Scanner. It is used during breast cancer surgery to check if all the cancer has been removed from the edges of the tissue. The goal is to see if using this scanner during the operation can help surgeons get clear margins the …

This study aims to collect ultrasound images to help develop artificial intelligence (AI) software that can automatically find breast biopsy markers. The software is designed to assist doctors during routine ultrasound exams by highlighting where markers are located. The study in…

This study is testing a new approach to help women with dense breast tissue. It uses a computer model to analyze mammogram images and calculate a personal breast cancer risk score. Women with a high score will be offered an MRI scan to see if this extra test finds cancers that a …

This study is testing a new, wearable ultrasound patch to see if it can accurately detect breast lumps or other abnormalities. Researchers will compare the patch's images to those from a standard handheld ultrasound machine. About 50 women undergoing breast health checks will wea…

This early-stage study is testing a new, specialized camera designed specifically for breast imaging. Researchers want to see if it can produce clearer pictures of breast cancer and allow for lower radiation doses during scans. The study will enroll 20 participants with confirmed…

This study aims to see if routine mammograms and ultrasounds can predict the molecular subtype of a patient's breast cancer, which currently requires an invasive biopsy. Researchers will analyze imaging features from 122 women with confirmed breast cancer and compare them to biop…

This study aims to develop an artificial intelligence (AI) tool that analyzes standard breast MRI scans to predict a cancer's specific type, particularly its HER2 status. The goal is to provide this information non-invasively, potentially reducing the need for some pre-surgery bi…

This study is testing a new AI tool called Ataraxis that analyzes breast cancer biopsy images and patient information to predict how well chemotherapy will work before surgery. It aims to see if this tool can be easily used in real hospitals and if its predictions match what actu…

This study is testing a new AI-powered blood test to see how accurately it can determine the stage of breast cancer, specifically whether it has spread to lymph nodes. Researchers will collect blood samples from 269 people with breast cancer, some having surgery directly and othe…

This study is testing a new type of medical scan to see if it can better detect when a specific form of breast cancer (called lobular carcinoma) has spread to other parts of the body. Researchers will compare this new scan to the standard scan currently used. The goal is to find …

This study is testing whether nurses with brief training can use AI-supported portable ultrasound devices to help screen for breast cancer in community settings. After an initial breast exam, women with possible concerns or symptoms will get this quick ultrasound scan. The goal i…

This study is testing a new type of mammography machine. The goal is to see if it can take high-quality breast images using a lower dose of radiation than current machines, and possibly with less breast compression. It will involve about 52 women who have had mammograms before.

This study aims to see if a newer DNA sequencing machine (MGI) works as well as the current standard machine (Illumina) for genetic tests that look for changes linked to certain cancers. Researchers will compare results from the same patient samples run on both machines. The goal…

This study is testing a new type of PET scan (called FAPI) to see if it can find more cancer spread in patients with metastatic lobular breast cancer than the standard FDG PET scan. Fifteen patients will receive both scans within two weeks so doctors can compare the results. The …

This study is testing whether a drug called hetrombopag can prevent or reduce severe drops in platelet counts (thrombocytopenia) caused by certain breast cancer treatments known as ADC drugs. It will enroll 72 breast cancer patients who are either starting ADC treatment or who pr…

This study aims to see if women at higher risk for breast cancer will attend extra screening appointments. It focuses on two groups: women with very dense breast tissue and women who previously had a false alarm on a mammogram. The main goal is to measure how many women actually …

This study is testing whether a new surgical technique can prevent arm swelling (lymphedema) after breast cancer surgery. During standard lymph node removal, surgeons will rotate a small flap of tissue from the chest wall into the armpit to help support fluid drainage. The study …

This study is testing if wearing a tight surgical glove on one hand during chemotherapy can prevent or reduce nerve damage, a common and painful side effect. It will involve 44 adults with breast cancer who are receiving a specific type of chemo. The goal is to see if this simple…

This study is testing whether the drug rosuvastatin can protect the heart from damage caused by a common type of breast cancer chemotherapy. 400 women starting this chemotherapy will take either rosuvastatin or a placebo pill daily for one year. The main goal is to see if the dru…

This study is testing whether a smartphone app that scans food labels can help people at high genetic risk for cancers like breast, colon, or pancreatic cancer eat fewer ultra-processed foods. Over 12 weeks, researchers will compare diet improvements between people who just get s…

This study is testing whether two types of breathing exercises can help patients feel better after breast cancer surgery. Researchers will compare pranayama (alternate nostril breathing) and pursed-lip breathing against standard care to see if they reduce pain and anxiety. The go…

This study will test whether a traditional Chinese herbal formula can help prevent and treat the painful skin burns that often occur during radiation therapy for breast cancer. Sixty patients will be randomly assigned to receive either the herbal formula or a placebo, in addition…

This study is testing whether a traditional Chinese medicine hand and foot bath can help reduce nerve pain and numbness caused by a common breast cancer chemotherapy drug. Researchers will compare the herbal soak to a standard vitamin B12 supplement in 78 participants. The main g…

This study is testing whether breathing muscle training can prevent weakness and breathing problems in adults newly diagnosed with breast cancer who are planning surgery. Researchers will compare breathing exercises to guided imagery relaxation techniques to see which helps more.…

This study is testing whether acupuncture can safely help reduce feelings of anxiety and depression in people who have been treated for breast cancer. It will involve 360 female participants who have mild to moderate anxiety or depression. Researchers will measure changes in ment…

This study aims to find the best way to prevent long-lasting pain after breast cancer surgery. Researchers will compare two different pain prevention methods in 120 women undergoing breast cancer surgery. They will track participants' pain levels for six months after surgery to s…

This study is testing if starting a personalized exercise program right when hormone therapy begins can prevent or reduce the severe joint and muscle pain it often causes. It will involve 182 postmenopausal women with early-stage breast cancer. Half will start the exercise progra…

This study aims to find the best way to manage pain after breast cancer surgery. It will compare two different types of ultrasound-guided nerve blocks given to 70 patients. The goal is to see which method provides better pain relief, reduces the need for strong painkillers like o…

This study is testing whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help relieve nerve pain and improve daily life for breast cancer patients who developed this side effect after a specific chemotherapy drug. The trial will enroll 160 wome…

This study is testing a new support program designed for mothers who have breast cancer and are worried about parenting their children. The program offers counseling and guidance to help manage these specific concerns. Researchers will enroll 20 participants to see if the program…

This study is testing if desloratadine, a common and safe allergy medication, can prevent or reduce nerve pain and damage (peripheral neuropathy) caused by taxane chemotherapy in people with breast cancer. About 116 participants will be randomly assigned to receive either the dru…

This study is testing if giving a low dose of the drug esketamine during surgery can help reduce anxiety and depression in breast cancer patients who already have mild to severe depression. It will involve 142 women undergoing breast cancer surgery. Researchers will compare those…

This study is testing whether a smartphone app that uses artificial intelligence (AI) can help women with breast cancer better manage their chemotherapy. The app, available in Arabic, provides personalized reminders for medications, advice for handling side effects, and alerts th…

This pilot study aims to see if offering focused upper body massage after radiation treatments can help breast cancer patients. It will test if the massages reduce muscle and joint pain, improve arm and shoulder mobility, and enhance overall quality of life during treatment. The …

This study aims to see if giving atropine, a common medication, can prevent severe diarrhea in people with advanced breast cancer who are being treated with the drug sacituzumab govitecan. It will enroll about 30 adults with specific types of advanced breast cancer that has progr…

This study is creating and testing a mobile app called SerenApp to help women who have finished breast cancer treatment. The app is designed with input from patients and doctors to provide psychological support and resources. Researchers want to see if using the app for 8 weeks c…

This study is testing a new digital tool designed to help women recently diagnosed with breast cancer make more informed decisions about their surgery. It compares the tool to standard doctor consultations to see if it helps patients feel less conflicted and regretful about their…

This study is testing if giving a low, continuous dose of a drug called esketamine (related to ketamine) during breast cancer surgery can help reduce the anxiety and depression many patients feel around their operation. It will involve about 218 patients and will measure their em…

This study aims to see if taking creatine, a supplement often used by athletes, can help prevent or reduce the memory and thinking problems known as 'chemo brain' that many breast cancer patients experience during chemotherapy. Researchers will compare creatine to a placebo in 22…

This study aims to find out if a newer, less invasive endoscopic surgery helps women regain feeling in their breast skin better than the standard surgery after a nipple-sparing mastectomy and implant reconstruction for early-stage breast cancer. Researchers will randomly assign 1…

This study is testing whether hyaluronic acid facial injections can safely improve skin quality and quality of life for young women who have finished breast cancer treatment. Many cancer treatments cause early menopause and skin aging, which can affect self-esteem. Researchers wa…

This study aims to see if stopping certain premedication drugs can improve quality of life for people with non-metastatic breast cancer receiving weekly chemotherapy. It will compare two groups: one that stops the premeds after two safe doses and one that continues them as usual.…

This study is testing whether a specialized form of talk therapy, called Meaning-Centered Psychotherapy for Latinos (MCP-L), can better reduce anxiety and depression and improve quality of life for Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. It…

This study is testing whether a simple genetic test can help doctors choose the most effective anti-nausea medication for patients. It involves 200 Chinese women with early breast cancer who are about to start their first round of a specific chemotherapy. Half will get anti-nause…

This study is testing if a special pre-surgery program can help reduce shoulder pain and improve movement after breast reconstruction. The program combines physical therapy with a gentle tissue massage technique called mechanostimulation. Researchers will compare patients who rec…

This study aims to find out if a newer robotic surgery technique leads to better recovery and satisfaction compared to the standard surgery for women having a nipple-sparing mastectomy with implant reconstruction. It will follow 108 women for a year, measuring their well-being, b…

This study aims to see if giving the drug esketamine during surgery can help reduce anxiety and depression symptoms in breast cancer patients who also have severe depression. It will involve about 240 female patients undergoing breast cancer surgery. Researchers will compare thos…

This study will test two simple, drug-free methods to make hormone injections less painful and scary for people with breast cancer. Researchers will compare a plastic device called a ShotBlocker and a tapping technique against standard injections in 99 patients. The goal is to fi…

This study tests if a guided exercise program, tracked by a smartwatch, can help reduce the severe fatigue many people experience after finishing chemotherapy for cancer. It will involve 98 adults who have recently completed treatment for certain cancers. Researchers will compare…

This study aims to see if adding logotherapy—a type of talk therapy focused on finding meaning in life—to standard psychological support helps women newly diagnosed with breast cancer. It will compare anxiety, depression, stress, and quality of life between two groups of 66 parti…

This study will test if eight weeks of weekly acupuncture can help reduce stress and improve quality of life for breast cancer patients who have recently finished their main cancer treatments. It will compare 112 participants who receive acupuncture right away to a group that wai…

This study is testing a six-month online support program designed to help women undergoing treatment for breast cancer. The program provides daily guidance on exercise, stress reduction, healthy habits, and social support through videos and emails. Researchers want to see if this…

This study is testing whether using virtual reality (VR) during chemotherapy can help reduce pain and anxiety for breast cancer patients. It will involve 50 patients who are receiving chemo for the first time. Researchers will measure pain and anxiety levels before and after pati…

This study aims to see if a special fitness and nutrition program can help women newly diagnosed with breast cancer better handle their cancer treatments. It will test if supervised exercise and personalized diet advice, started before treatment and continued at home, can reduce …

This study examines whether a simple writing exercise can improve quality of life for people recently diagnosed with breast cancer. Participants will write about their cancer experience for 20 minutes each week for four weeks. Researchers will measure changes in well-being throug…

This study is testing a brief telehealth program designed to help older women with breast cancer in underserved areas better manage their pain. Participants will learn coping skills in one main session followed by five short check-in calls. The goal is to see if this approach red…

This study is testing a phone app called FOCUS that teaches coping skills to help people with advanced cancer manage common symptoms like fatigue, anxiety, depression, and sleep problems. It aims to make this support more accessible to patients living in rural areas who may have …

This study is looking back at a new surgical technique for breast reconstruction after cancer removal. It aims to see if this method, which uses an armpit incision and one implant surgery, leads to good cosmetic results, high patient satisfaction, and few complications. The resea…

This study aims to understand why women in the Hauts-de-France region experience longer delays in breast cancer care despite similar cancer rates. Researchers will track 500 women's journeys from first symptoms to treatment, measuring time between key steps like mammograms and bi…

This study aims to understand what types of bacteria live inside breast cancer tumors and how they differ across various breast cancer subtypes. Researchers will collect tumor tissue, normal tissue, urine, and stool samples from 240 women undergoing breast cancer surgery. The goa…

This study aims to understand how cancer and its treatments affect patients' enjoyment of food and eating. Researchers will survey 180 adults with various cancers to identify which factors most harm food-related quality of life. The goal is to create a model to predict which pati…

This study aims to see if taking a probiotic supplement changes the community of bacteria and fungi in the gut and breast tissue of people with breast cancer. Researchers will compare 100 participants, with half taking the probiotic and half taking a placebo, to measure changes i…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to understand if a standard blood test used to determine safe chemotherapy doses works correctly for patients who also have kidney problems. Researchers will measure a specific enzyme activity in the blood cells of about 740 patients with breast or digestive cance…

This study aims to see if a special education program can help women perform breast self-exams more regularly, reduce their fear of breast cancer, and increase their overall knowledge. Researchers will compare a group of women who receive the training to a group who do not. The g…

This study aims to understand if having COVID-19 increases the chance or severity of radiation-induced lung inflammation (pneumonitis) in people treated for breast cancer. Researchers will look back at the medical records of about 200 patients who received radiation therapy at a …

This study is testing whether a simple finger-prick blood test can reliably replace standard blood draws from the arm for monitoring drug levels in breast cancer patients. Researchers will compare results from both methods in 90 patients taking common CDK4/6 inhibitor medications…

This study aims to learn more about the biology of HER2-positive breast cancer by observing patients receiving standard pre-surgery drug treatment. Researchers will collect tumor samples from about 1,000 participants to identify different molecular subtypes and see how they relat…

This study is testing a virtual reality (VR) education program designed to help breast cancer survivors learn about potential heart risks from their cancer treatments. The program teaches survivors about these risks and suggests healthy lifestyle changes, like physical activity, …

This study aims to find blood markers that might predict how well breast cancer patients respond to chemotherapy before surgery. Researchers will collect blood samples from 80 patients before and after their standard chemotherapy treatment. They'll look for tiny molecules in the …

This study aims to see if two simple ratios calculated from routine blood tests can help tell breast cancer patients apart from healthy people. Researchers will look back at medical records of 110 people, comparing those with newly diagnosed breast cancer to healthy controls. The…

This study aims to understand why strength training improves the health of people with various cancers. Researchers will enroll 150 patients with lung, breast, colon, blood, or lymph node cancers. Half will do supervised strength training twice a week for 12 weeks, while the othe…

This study is creating an international registry to track what happens when doctors skip lymph node surgery for certain early-stage breast cancer patients. It will follow about 827 patients whose scans show no cancer in their armpit lymph nodes to see if avoiding this surgery is …

This study aims to find out if exposure to common chemicals called endocrine disruptors is connected to breast cancer. Researchers will test tissue, urine, and hair samples from 42 women who are having surgery to remove a breast lesion. The goal is to measure the levels of these …

This study aims to understand how chemotherapy affects thinking skills, memory, and emotional well-being in women with breast cancer. Researchers will follow 100 newly diagnosed patients in Egypt, assessing them before starting treatment and again one year after finishing. The go…

This study aims to understand how well a blood test can detect tiny amounts of leftover cancer DNA after surgery. It will follow 840 patients with breast, lung, prostate, ovarian, or gastric cancer to see if this 'liquid biopsy' can predict if the cancer might come back. The stud…

This study aims to understand how often and to what extent chemotherapy for early-stage breast cancer changes a person's sense of taste. Researchers will follow 40 women receiving chemotherapy, using taste tests to measure changes in flavor perception. The study will also look at…

This study aims to understand how tiny traces of cancer DNA in the blood change during and after treatment for early-stage breast cancer. Researchers will follow 300 patients, taking blood samples at different points to see if these DNA signals can help predict if the cancer migh…

This early-stage study aims to understand how a potential new breast cancer drug, called HRS-8080, is absorbed, broken down, and removed from the body. Researchers will give a tiny, safe amount of a radioactive version of the drug to six healthy postmenopausal women to track its …

This study aims to understand how a common breast cancer drug, Verzenio, affects the bacteria living in patients' digestive systems (the gut microbiome). Researchers want to see if changes in these bacteria are connected to digestive side effects like diarrhea that patients often…

This study aims to find out if measuring a hormone in the blood (GDF-15) can help predict which breast cancer patients will experience severe nausea, vomiting, or weight loss from the drug T-DXd. Researchers will follow 150 patients with advanced breast cancer who are starting T-…

This study aims to find out if new types of PET/MRI scans can predict how well different breast cancer treatments will work for a patient. It will enroll 300 women with breast cancer who are about to start either pre-surgery (neoadjuvant) therapy or treatment for recurring cancer…

This study aims to understand why a common breast cancer drug, pyrotinib, causes severe diarrhea in many patients. Researchers will observe 60 patients, comparing the gut bacteria of those who get diarrhea with those who don't. The goal is to find bacterial patterns that might pr…

This is a small, early-stage study to learn if injecting one or two immune-stimulating drugs directly into a breast tumor a week before surgery is safe and feasible. The main goal is to see if this approach activates the patient's immune system against the cancer and does not del…