BREAST CANCER

This study tests a new drug (QL1706) combined with chemotherapy before surgery in 40 people with early triple-negative breast cancer. The goal is to see if some patients can avoid a type of chemo called anthracyclines, which can harm the heart. After four cycles of treatment, tho…

This study compares two shortened radiation therapy schedules for breast cancer patients after surgery. One group receives radiation over 2 weeks (34 Gy in 10 sessions) and the other over 3 weeks (40.05 Gy in 15 sessions). The goal is to see which schedule better controls cancer …

This small pilot study will test a 4-week program where nurses and general practitioners support breast cancer survivors who also have heart disease. The program focuses on lifestyle changes like exercise, diet, and stress management to lower heart risks. The goal is to see if th…

This study tests whether adding an experimental drug (QL1706) to standard chemotherapy and targeted therapy works better than the usual approach for HER2-positive breast cancer. About 188 people with early or locally advanced breast cancer will receive treatment before surgery. T…

This study looks at whether tirzepatide, a once-weekly injection, is a practical and acceptable treatment for weight loss in 30 postmenopausal women who have had hormone receptor-positive breast cancer and are currently obese. Participants will take the medication for 6 months wi…

This study looks at whether women with a very early form of breast cancer called DCIS, who have a low-risk genetic score, can safely avoid radiation therapy after lumpectomy. About 5,270 women will be enrolled and followed to see if skipping radiation leads to a similar rate of c…

This study tests a new combination of drugs (iparomlimab and tuvonralimab with chemotherapy) given before surgery to 30 people with a common type of breast cancer called HR+/HER2-. The goal is to see if the treatment can eliminate all cancer cells in the breast and lymph nodes by…

This study tests whether giving a personalized dose of tamoxifen, based on how a person's body processes the drug, can reduce side effects and help more patients complete their treatment. About 1100 women with hormone-sensitive breast cancer will either receive the standard dose …

This study tests whether adding radiation and a drug called axatilimab to the immunotherapy pembrolizumab can help shrink tumors in people with metastatic triple-negative breast cancer (TNBC) who have already tried immunotherapy. About 34 adults with at least two measurable tumor…

This study looks at whether propranolol, a common heart medication, can prevent heart injury in breast cancer patients with high blood pressure or angina who are having surgery. About 100 women will be followed to see if those prescribed propranolol have fewer heart-related compl…

This study tests whether placing tiny radioactive seeds in breast tumors before chemotherapy can help the cancer disappear completely by the time of surgery. About 194 women with early or locally advanced breast cancer will be randomly assigned to get seeds or standard care. The …

This study tests whether adding a targeted drug (dalpiciclib) and hormone therapy to brain radiation can help control breast cancer that has spread to the brain. About 46 women with HR-positive, HER2-negative advanced breast cancer will receive the combination treatment. The goal…

This early-phase study tests whether immune cells (white blood cells) coated with a special antibody can safely attack HER2-positive metastatic breast and prostate cancers. About 23 adults with advanced cancer will receive weekly infusions for 5 weeks, then every other week. The …

This study looks at how well the drug pyrotinib works in people with advanced HER2-positive breast cancer. Researchers will track 500 patients to see how long the cancer stays under control and what side effects occur. The goal is to learn more about who benefits most from this t…

This study compares a 1-week ultra-hypofractionated radiation regimen (26 Gy in 5 sessions) to the standard 3-week moderate hypofractionated regimen (40 Gy in 15 sessions) for treating lymph nodes in breast cancer patients after surgery. The goal is to see if the shorter course i…

This early-phase study tests whether adding pirfenidone to standard immunotherapy (camrelizumab) and chemotherapy can shrink tumors in 12 people with advanced triple-negative breast cancer. Participants must have already tried first-line treatment. The goal is to see how many pat…

This study compares a new drug called SHR-A1811 with a standard combination therapy (pyrotinib plus capecitabine) in 100 people whose HER2-positive advanced breast cancer stopped responding to trastuzumab. The goal is to see which treatment works better at delaying cancer growth.…

This study tests a combination of two drugs, entinostat and oral paclitaxel, in people with a certain type of advanced breast cancer (HR+HER2-). The goal is to see if this treatment can slow down the cancer's growth. About 50 adults who have already tried 2 to 4 other treatments …

This study tests if a chemotherapy-free treatment using the drug Dalpiciclib (a CDK4/6 inhibitor) plus hormone therapy works as well as standard chemotherapy for women with a specific type of early breast cancer. Participants have small tumors (≤2 cm) that are hormone-receptor-po…

This study tests whether a grape polyphenol concentrate can help prevent heart damage in breast cancer patients receiving certain types of chemotherapy. About 120 women at high risk for heart problems will take either the grape supplement or a placebo for three months. Researcher…

This study tests a new drug, trastuzumab-rezetecan, against an approved one, T-DXd, in women with early or locally advanced HER2-positive breast cancer. About 68 participants will get one of the two drugs before surgery to see which leads to more tumor disappearance. The goal is …

This study looks at 4,000 women aged 50 or younger with a common type of breast cancer (HR+/HER2-). It compares two treatments: hormone therapy plus ovarian suppression versus chemotherapy. The goal is to see if hormone therapy works just as well as chemo for certain patients, he…

This early-phase trial tests a radioactive drug called 177Lu-INN805 in 10 people with advanced solid tumors (head & neck, thyroid, lung, breast, or sarcoma) who have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researche…

This study tests whether adding the drug inavolisib to standard targeted therapy and chemotherapy can eliminate more breast cancer before surgery in people with a specific genetic mutation (PIK3CA) and HER2-positive early breast cancer. About 164 participants will receive either …

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy pills as prescribed. The program includes education, reminders, and support. Researchers will check if it improves medication adherence and quality of life.

This study tests a new approach for women with a common type of early breast cancer (HR+/HER2-). Instead of standard chemotherapy before surgery, some participants may receive a combination of hormone therapy and a targeted drug (abemaciclib) based on a gene test result from thei…

This study tests whether giving two drugs—Serplulimab and trastuzumab rezetecan—before surgery can eliminate all signs of triple-negative breast cancer in 84 women. The goal is to see if this approach leads to a complete response (no cancer left in the breast or lymph nodes). Par…

This early-phase trial tests a new type of cell therapy called HTR2 T cells in people with metastatic breast cancer that has HER2 protein on its surface and has not responded to standard treatment. The therapy uses a patient's own immune cells, modified to better recognize and at…

This phase 3 trial tests whether adding famitinib to the drug SHR-A1811 helps people with a certain type of advanced breast cancer (HR+/HER2-) that no longer responds to CDK4/6 inhibitors. About 248 women aged 18-70 will be randomly assigned to receive either the combination or S…

This study explores whether women with early-stage breast cancer can keep their areola (the dark skin around the nipple) even if cancer is found in the nipple during surgery. About 40 women will have the nipple removed and a new one created right away, while the areola is saved. …

This study is for women with a specific type of early breast cancer (HR+/HER2+). The goal is to see if giving a personalized treatment plan before surgery can improve outcomes. Doctors will check how well the tumor responds to initial therapy and adjust the regimen accordingly, p…

This study tests whether adding fluzoparib (a daily pill for one year) to standard treatment can help prevent breast cancer from returning in women with early-stage disease who have inherited changes in HRR genes. About 334 women aged 18-75 will be randomly assigned to receive ei…

This study tests a combination of four drugs (trastuzumab, pertuzumab, palbociclib, and exemestane) given before surgery to people with early or locally advanced triple-positive breast cancer. The goal is to see if this treatment can eliminate all signs of cancer in the breast an…

This early-phase trial tests a new drug called AK138D1, given alone or with another drug (ivonescimab), in 286 people with advanced breast cancer. The main goals are to check safety and see if tumors shrink. Participants must be 18-75, in good enough health, and have at least one…

This study tests whether adding trilaciclib to the chemotherapy drug eribulin can protect the bone marrow in people with advanced triple-negative breast cancer who have already tried at least two other chemotherapies. The goal is to reduce serious side effects like low white bloo…

This early-stage study tests a new drug called IM-1617 in about 175 people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, finding the right dose, th…

This study looks at whether a combination of ribociclib and hormone therapy can work as well as chemotherapy followed by the same combination in people with a certain type of early breast cancer (HR+/HER2-). The study only includes patients whose blood tests show no signs of canc…

This study looks at over 1,000 people with HER2-positive breast cancer to see how their tumor's molecular makeup affects response to a standard pre-surgery drug combination (trastuzumab, pertuzumab, and chemotherapy). The goal is to find which subtypes respond best, helping docto…

This study compares two types of radiation therapy—proton and photon—given after breast cancer surgery to see which causes fewer side effects. Researchers will follow 750 women for one year, tracking problems like arm swelling, low immune cells, and heart issues. The goal is to f…

This early-phase study tests a new drug called HRS-6209 combined with standard hormone therapies (fulvestrant or letrozole) in people with a specific type of advanced breast cancer (HR-positive, HER2-negative). The main goals are to check safety and how the drug moves through the…

This study tests a combination of two drugs, camizestrant and ribociclib, in 150 adults with advanced hormone receptor-positive (HR+) breast cancer. Participants must have had at least 5 years of prior hormone therapy. The goal is to see if the combination can delay cancer growth…

This study looks at how well the drug inavolisib works in everyday medical practice for people with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has a PIK3CA gene mutation. About 100 participants will receive inavolisib combined with hormone therapy,…

This study tracks about 500 postmenopausal women with a certain type of advanced breast cancer (ER+, HER2-, with an ESR1 mutation) who are taking the drug elacestrant. Researchers want to see how the drug affects quality of life, side effects, and how well it works in everyday me…

This study tests whether transferring healthy gut bacteria (via fecal transplant) can make standard chemotherapy and immunotherapy more effective for triple-negative breast cancer. About 125 patients will take part, first to see if collecting samples is possible, then to check sa…

This study tests a new combination of targeted drugs for people with a specific type of breast cancer (ER-positive, HER2-positive). The goal is to see if using these drugs before surgery can shrink or eliminate tumors without needing standard chemotherapy. The trial will enroll 4…

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found by ultrasound before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial will check if removing only the first few affected nodes (sen…

This study tests a new drug combination (imlunestrant plus abemaciclib) given before surgery to people with ER-positive, HER2-negative breast cancer. The treatment plan is adjusted based on a tumor marker called Ki67 measured after two weeks. The goal is to see if this approach s…

This early-phase study tests a new treatment for people with advanced breast cancer that has stopped responding to standard therapies. The treatment combines specially engineered immune cells (TRICK-NK) with a targeted drug (T-Dxd) to try to control the cancer. About 60 participa…

This study tests whether some people with early-stage breast cancer can safely avoid surgery after chemotherapy and radiation. Participants will be monitored with MRIs, mammograms, and blood tests to check if the cancer stays away. The goal is to see if a non-surgical approach wo…

This phase 3 study tests whether an artificial intelligence model can pick the most effective combination of anti-HER2 drugs for each patient before surgery. About 280 women with early or locally advanced HER2-positive breast cancer will be randomly assigned to either AI-guided t…

This early-phase study tests a targeted drug (trastuzumab deruxtecan) combined with precise radiation (stereotactic radiosurgery) in 20 people with HER2-positive breast cancer that has spread to the brain. The goal is to find the safest drug dose and see how well the combination …

This study tests a personalized approach for people with HER2-positive breast cancer. After two cycles of standard therapy, those whose tumors shrink less than 40% will switch to a new drug combo (SHR-A1811 plus pertuzumab) for four more cycles before surgery. The goal is to see …

This study is for people with HER2-negative breast cancer whose tumors did not respond to initial chemotherapy. It tests whether adding the immunotherapy drug toripalimab and targeted radiation to standard chemotherapy can improve outcomes before and after surgery. About 110 part…

This study tests whether the drug sacituzumab govitecan can slow down advanced triple-negative breast cancer when used as the very first treatment. About 24 adults who have not had prior therapy for their advanced cancer will receive the drug on days 1 and 8 of each 21-day cycle.…

This study tests an experimental drug called SHR-A1811 in 51 women with HER2-positive breast cancer that has spread to the brain. Some participants also have cancer in the lining of the brain and spinal cord. The goal is to see if the drug is safe and can shrink or control these …

This study looks at whether regular blood tests to find tiny bits of cancer DNA (ctDNA) can catch breast cancer returning early in people with HR+/HER2- breast cancer. If the test turns positive, participants will take a drug called abemaciclib to try to prevent the cancer from c…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This phase 2 trial tests a combination of two hormone therapies (elacestrant and exemestane) in 26 people with advanced HR+/HER2- breast cancer whose disease has progressed after initial treatment. The study uses a special PET scan to select participants whose tumors still have a…

This study tests a new combination of two targeted drugs (zanidatamab and tucatinib) plus chemotherapy in people with HER2-positive advanced breast cancer that cannot be removed by surgery or has spread. The goal is to find the safest dose and see if the combo helps shrink tumors…

This study tests a program called ONLOOP that sends reminders to adult survivors of childhood cancer in Ontario to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors will be randomly assigned to receive…

This study tests whether adding an immune-boosting drug (eftilagimod alpha) to standard chemotherapy before surgery can eliminate more breast cancer in people with early-stage HR+/HER2- breast cancer. About 50 participants will receive the drug combination, and researchers will c…

This study tests whether a 16-week supervised exercise program can help repair heart damage caused by breast cancer treatments like chemotherapy. Researchers will enroll 44 women who finished cardiotoxic therapy 6 to 12 months ago. Half will do twice-weekly strength and aerobic s…

This study tests whether combining two drugs, Lucentis and tagolimumab, can help control advanced breast cancer in 35 people whose cancer has a specific marker (PD-L1 positive) and has stopped responding to standard hormone therapy and CDK4/6 inhibitors. Participants will receive…

This study looks at whether women with intermediate-risk breast cancer can avoid radiation therapy to the lymph nodes after surgery without harming their chances of staying cancer-free. About 3,100 women will be randomly assigned to receive radiation or not, and researchers will …

This study tests a new drug called SHR-A1811, given alone or with hormone therapy (letrozole), before surgery for early-stage breast cancer that is hormone-receptor-positive and HER2-low. About 120 women will be randomly assigned to one of three groups: the new drug plus hormone …

This study tests whether Huaier granules, a traditional Chinese medicine, can help reduce tumor marker levels (CEA, CA125, CA153) in people with early-stage breast cancer. About 232 participants will be randomly assigned to receive Huaier granules or not. The goal is to see if th…

This study tests whether women with a specific type of early-stage breast cancer (HR-positive, HER2-positive, no lymph node spread) can safely skip chemotherapy. Instead, they would receive a combination of hormone therapy, a CDK4/6 inhibitor, and anti-HER2 drugs. The trial will …

This study tests whether adding radiotherapy to chemotherapy before surgery can help shrink tumors and improve outcomes for people with locally advanced breast cancer. About 50 participants with Luminal or triple-negative breast cancer that didn't shrink enough after initial chem…

This early-phase trial tests whether giving an immune-boosting drug (Mitazalimab) alone or with another drug (Nivolumab) directly into the tumor before surgery is safe and helps the immune system fight breast cancer. About 32 adults with early-stage or recurrent breast cancer tha…

This study tests a personalized approach for people with stage II or III triple-negative breast cancer. Participants first receive 12 weeks of standard chemo plus the immunotherapy pembrolizumab. Those whose tumors shrink well stop treatment early; others are randomly assigned to…

This early-stage study tests whether adding a targeted drug (CDK4/6 inhibitor) to standard radiation after surgery is safe and tolerable for women with a common type of high-risk breast cancer (HR+/HER2-). About 30 participants will receive the combination, and researchers will m…

This study tests whether the drug hetrombopag can prevent or reduce low platelet counts caused by a type of breast cancer treatment called ADC drugs. It involves 72 breast cancer patients who are about to start or have already had low platelets from these drugs. The goal is to se…

This study aims to find the best method to guide surgeons during breast-conserving surgery for tumors that cannot be felt. It will compare three different guidance techniques—ultrasound, a magnetic seed, and the standard wire method—in over 1,300 patients. The goal is to see whic…

This study tests a new type of PET scan (68Ga-FAPI) to see if it can find cancer spread in people with lobular breast cancer when the standard scan is negative or unclear. About 45 adults whose standard scan didn't show clear spread will get the new scan. If it finds hidden tumor…

This study tests a new mammography machine that uses at least 20% less radiation than standard machines while still producing clear images. About 52 women aged 40 and older who have had a mammogram before will participate. The goal is to see if the new machine can detect breast c…

This study tests a new, gentle way to analyze nipple fluid to find out if bloody discharge is caused by cancer or a harmless condition. About 60 adults scheduled for breast surgery will provide a small fluid sample before their operation. Researchers will check the DNA for cancer…

This study will see if artificial intelligence (AI) can help find breast cancer by looking at non-contrast chest CT scans that women already get for other reasons. Researchers will compare the AI's accuracy to mammograms and breast MRIs in 5,000 women. If successful, this could a…

This study looks at whether mammograms and ultrasounds can accurately predict the molecular subtype of breast cancer (like Luminal A, HER2-enriched, or triple-negative) without needing a biopsy. Researchers will compare imaging features to standard tissue tests in 122 women with …

This study tests whether a new AI software, Kenko Breast AI+, helps doctors read breast MRI scans more accurately to diagnose breast cancer. About 200 adult women who may have breast cancer or are being monitored for it will participate. Researchers will compare MRI readings done…

This study tests a special scanner that lets surgeons check if all cancer has been removed during breast-conserving surgery, right in the operating room. The goal is to see if this real-time check reduces the need for a second surgery. About 228 women with certain types of breast…

This study tests a wearable ultrasound patch that sticks to the breast and takes images in under 15 minutes. Researchers want to see if it can find breast lumps as well as a standard handheld ultrasound. About 50 women will try the patch, and the team will check for any discomfor…

This study will check if two simple blood test ratios (AST/ALT and MPV/platelet count) are different in women with breast cancer compared to healthy women. Researchers will look at medical records of 110 people to see if these ratios can help diagnose breast cancer. The goal is t…

This study looks at whether a special mammogram risk score can help decide which women with dense breasts should get an MRI after a normal mammogram. About 78 women aged 25-55 with dense breasts and a higher risk score will be invited for MRI. The goal is to see if this approach …

This study tests a new blood test that uses artificial intelligence to analyze DNA fragments. The goal is to see if it can accurately determine the stage of breast cancer and whether it has spread to lymph nodes, potentially reducing the need for surgery. The study will enroll 26…

This study aims to make breast cancer diagnosis faster in Rwanda by training non-radiologist clinicians at rural district hospitals to perform breast ultrasound. Currently, only radiologists at urban hospitals offer this service, causing delays. The project will compare two suppo…

This study compares a new type of PET scan (FAPI) with the standard PET scan (FDG) in 15 people with metastatic invasive lobular breast cancer. The goal is to see if the new scan finds more cancer spots. Participants will get both scans within two weeks, and doctors will compare …

This study is testing a new type of MRI scanner to see if it can measure the size of a specific type of early breast cancer more accurately. Twelve patients scheduled for surgery will get both a standard MRI and the new scan. Researchers will compare the scan results to the actua…

This study tests a surgical technique to prevent arm swelling (lymphedema) in women at high risk after breast cancer surgery. The procedure uses a small flap of tissue from the side of the chest to help restore normal fluid drainage in the armpit. One hundred women will be follow…

This study tests whether rosuvastatin, a cholesterol-lowering drug, can prevent heart damage in women with breast cancer receiving anthracycline chemotherapy. 400 participants will take either rosuvastatin or a placebo daily for 12 months. The main goal is to see if the drug help…

This study tests a simple idea: wearing tight surgical gloves during chemotherapy sessions might prevent nerve damage in the hands. About 44 breast cancer patients will try it on one hand only, so doctors can compare. The goal is to see if this cheap, easy method can reduce numbn…

This study tests whether telmisartan, a drug used for high blood pressure, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 36 women who are newly diagnosed and have not had chemotherapy before. Participants w…

This study compares two ways to prevent long-term pain after breast cancer surgery: a nerve block (Pecs block) plus ketamine versus ketamine alone. About 120 women having mastectomy will be followed for 6 months to see which approach reduces chronic pain better. The goal is to fi…

This study compares two low-dose hormone drugs, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which drug better maintains quality of life while reducing cancer risk. Participants will take the assigned drug for 12 months,…

This study tests whether desloratadine, a common allergy medicine, can prevent or reduce nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 116 people will receive either desloratadine or a placebo during their 12-week chemo course…

This study tests whether two types of diabetes medications (SGLT2 inhibitors and DPP-4 inhibitors) can prevent heart damage caused by the chemotherapy drug doxorubicin in women with breast cancer. About 150 Egyptian women will be randomly assigned to receive one of these drugs or…

This study looks at whether breast cancer patients can safely stop taking premedication (drugs to prevent allergic reactions) after two well-tolerated doses of weekly paclitaxel chemotherapy. The goal is to see if stopping these extra drugs improves quality of life, since they ca…

This study tests a non-invasive device that stimulates a nerve in the ear to reduce joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. About 60 women with hormone-positive breast cancer who experience joint pain will receive either the acti…

This study tests a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) to see if it helps reduce anxiety and depression and improve quality of life in 300 Mexican patients with advanced breast, prostate, colorectal, or thyroid cancer. Participants will be randomly a…

This study tests whether taking creatine daily can help prevent the memory and concentration problems often caused by chemotherapy in people with early-stage breast cancer. About 227 participants will receive either creatine or a placebo starting before chemo and continuing for a…

This study tests a six-month online program for women recently diagnosed with breast cancer. The program offers daily guidance on exercise, stress relief, and healthy habits through videos and group chats. Researchers want to see if it reduces psychological distress and improves …

This study looks at whether removing drainage tubes sooner after a special type of breast cancer surgery (nipple-sparing mastectomy with immediate implant reconstruction) is safe and improves patient satisfaction. About 379 women aged 18-70 will be randomly assigned to early or s…

This study looks at whether adding logotherapy—a type of counseling that helps people find meaning in their experiences—to standard psychological support can reduce anxiety and depression in women newly diagnosed with breast cancer. About 66 women will be randomly assigned to rec…

This study tests whether a traditional Chinese medicine hand and foot bath can reduce nerve pain and numbness caused by chemotherapy in breast cancer patients. About 78 adults with nerve symptoms will either receive the herbal bath or a standard vitamin treatment. The goal is to …

This study reviews the outcomes of a breast reconstruction technique done through the armpit, at least 6 months after mastectomy. Researchers will look at patient satisfaction and complication rates in 150 women. The goal is to see if this method offers good cosmetic results and …

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can help reduce pain and anxiety after breast surgery. About 126 adults having their first mastectomy will be randomly assigned to one of the breathing groups or to standard care. They wi…

This study compares two surgical methods for early-stage breast cancer: conventional and endoscopic nipple-sparing mastectomy with immediate reconstruction. The goal is to see which approach better preserves breast skin sensation after surgery. About 170 women will be randomly as…

This study tests a short, phone-based pain coping skills program for women aged 55 and older with breast cancer who have ongoing pain. Participants will learn techniques to manage pain and improve their quality of life through one main session and five follow-up calls. The goal i…

This study is testing a new web and mobile app called SHIELD, designed to help women with hormone-receptor-positive breast cancer who are on long-term endocrine therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women aged 18-49 wil…

This study looks at whether a supervised, moderate-intensity interval exercise program (like walking or cycling) can reduce inflammation, improve physical fitness, and boost quality of life in women with breast cancer who are undergoing radiotherapy. Forty women aged 20-65 with e…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked before and after…

This study compares two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—against standard care for reducing pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is …

This study tests whether doing physiotherapy and mechanical stimulation before breast reconstruction surgery can reduce shoulder pain and improve movement afterward. About 72 women scheduled for a latissimus dorsi flap reconstruction will take part. Half will receive the pre-surg…

This study tests whether acupuncture can safely reduce anxiety and depression in women with breast cancer. Researchers will enroll 360 women who have finished active cancer treatment and still have mild to moderate mood symptoms. Participants will receive acupuncture, and their m…

This study tests whether a 6-week home program combining exercise and a limited eating window (10 hours or less per day) is practical and helpful for breast cancer survivors who are on hormone therapy and feel fatigued. Twenty adults who have finished initial cancer treatment wil…

This study tests whether using nerve monitoring and a gentle electric tool during armpit lymph node removal can help surgeons find and protect small nerves that often cause long-term pain after breast cancer surgery. Six adults with breast cancer will take part. The goal is to se…

This study tests an Arabic-language AI mobile app designed to support women with breast cancer during chemotherapy. The app provides medication reminders, side-effect management tips, and alerts healthcare teams about serious symptoms. Researchers will compare 130 women who use t…

This study tests a bilingual online peer-support program for Korean-speaking breast cancer survivors and patients. The goal is to see if the program is easy to use and helps improve quality of life, reduce anxiety and depression, and increase social support. Participants will be …

This study tests a new way to do nipple-sparing mastectomy using a tiny camera and small cuts, aiming to reduce pain and scarring. Ten women with early breast cancer or high genetic risk will try it. Doctors will check if the procedure can be done without switching to standard op…

This study tests whether doing breathing muscle exercises at home for at least two weeks before breast cancer surgery can prevent the respiratory weakness that often happens after surgery. Forty newly diagnosed adults will either do breathing training or guided imagery exercises.…

This study tests if a smartwatch-guided exercise program helps cancer survivors feel less tired after finishing chemotherapy. About 98 adults with certain cancers (breast, colorectal, ovarian, pancreatic, stomach) will either follow the exercise program or receive standard care. …

This study tests whether a short, daily mindfulness breathing video can improve quality of life and mental well-being in people with breast cancer. Fifty participants who have finished chemotherapy will either practice a 5-minute breathing exercise for 6 weeks or receive standard…

This study compares two types of nipple-sparing mastectomy: one using robotic technology through a small side incision, and the standard open surgery. Researchers want to see if the robotic approach leads to better satisfaction, body image, and recovery in women having breast rec…

This study tests whether giving atropine before chemotherapy can prevent severe diarrhea in people with advanced breast cancer. About 30 participants will receive atropine alongside the drug sacituzumab govitecan. The goal is to make treatment more tolerable by reducing a common …

This study will test SerenApp, a mobile app designed to provide psychological support to women who have finished breast cancer treatment. Many survivors face ongoing anxiety, sadness, or fear of recurrence that standard check-ups don't address. The app will be co-created with pat…

This study tests whether hyaluronic acid injections can improve facial appearance and quality of life in women who have completed breast cancer treatment. Many younger women experience premature skin aging due to chemotherapy or hormone therapy, which can affect self-esteem. The …

This study looks at whether using virtual reality (VR) during chemotherapy can help breast cancer patients feel less pain and anxiety. Fifty patients who are starting chemo for the first time will use VR while receiving treatment. Researchers will measure their pain and anxiety l…

This early study tests if a new device that uses short electric pulses is safe for treating cancer spots just under the skin in people with metastatic breast cancer. About 20 adults will receive the treatment, and researchers will watch for side effects and check quality of life.…

This study tests two different nerve blocks to see which one provides better pain relief after breast cancer surgery that also removes lymph nodes from the armpit. About 60 women having this surgery will be randomly assigned to receive one of the two blocks. The goal is to find w…

This study tests whether a breath-based group program (Breath-Body-Mind) can reduce psychological distress in 30 young breast cancer survivors (ages 18-50) who are on hormone therapy. Participants will be randomly assigned to either the breath program or a general survivorship ed…

This study looks at whether weekly acupuncture sessions for 8 weeks can lower stress in breast cancer patients who have recently finished their main treatments like surgery, chemo, or radiation. About 112 women will be randomly assigned to get acupuncture right away or wait for i…

This study tests if starting a personalized exercise program early can prevent or reduce the joint and muscle pain that many breast cancer patients get from hormone therapy (aromatase inhibitors). About 182 postmenopausal women will be assigned to either the exercise program or u…

This study tests whether a continuous nerve block (erector spinae plane block) with the numbing medicine ropivacaine can reduce pain after mastectomy in 40 women with breast cancer. Participants will be randomly assigned to receive the block or standard pain care. The study will …

This study tests a special nerve block (SPSIP block) to see if it can lower pain and the need for strong painkillers after mastectomy and lymph node removal. About 50 women with breast cancer will either get the block or a placebo before surgery. The goal is to make recovery more…

This study tests a drug called romiplostim N01 in 68 breast cancer patients whose platelet counts dropped too low due to chemotherapy. The goal is to see if a weekly shot can safely bring platelet levels back up within two weeks, allowing patients to continue their cancer treatme…

This study tests whether a traditional Chinese medicine formula called Qibei Jiedu can prevent or reduce skin burns caused by radiation therapy in breast cancer patients. Sixty women who are scheduled for radiation after breast cancer surgery will receive either the herbal formul…

This study tests whether a remote group stress management program (R-CBSM) can help women aged 50+ who have finished breast cancer treatment but still feel stressed. Participants learn relaxation and coping skills via video calls. The goal is to see if this reduces distress and s…

This study tests whether giving esketamine during breast cancer surgery can reduce severe depression and anxiety in 242 women. Participants have severe depressive symptoms before surgery and will receive either esketamine or a placebo during their operation. The goal is to see if…

This study tests if wearing tight surgical gloves on the hands can prevent nerve damage caused by the chemotherapy drug paclitaxel in breast cancer patients. About 84 people with stage II-III breast cancer will be randomly assigned to either standard care or glove compression dur…

This study looks at whether a short form of talk therapy (Brief Acceptance and Commitment Therapy) can help women with locally advanced breast cancer get better results from chemotherapy before surgery. Researchers will measure tumor shrinkage, stress levels, and blood markers of…

This study looks at whether a simple writing exercise can improve quality of life for people recently diagnosed with breast cancer. Participants will write about their thoughts and feelings for 20 minutes, once a week for four weeks. The study will track changes in well-being thr…

This study is testing a new program to help young and middle-aged women with breast cancer who worry about raising their children. Twenty women will receive psychological counseling and parenting guidance. The goal is to see if the program is helpful and practical for reducing pa…

This study tests if using a machine to inject breast cancer medication at a steady speed causes less pain than a nurse injecting by hand. Forty women with HER2-positive breast cancer will receive both methods and rate their pain. The goal is to find a more comfortable way to give…

This study tests if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have completed chemo and developed peripheral neuropathy…

This study tests a program called FOCUS, delivered through a smartphone app and telemedicine, to help people with advanced cancer manage common symptoms like trouble sleeping, worry, sadness, and fatigue. The goal is to improve quality of life and make these skills accessible to …

This study compares two types of nerve blocks to manage pain after breast cancer surgery. 70 adults aged 18-65 will be randomly assigned to receive one of the two blocks. The goal is to see which method reduces the need for painkillers and improves recovery.

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This study tests whether a supervised exercise program, started before chemotherapy and continued during treatment, helps adults aged 35 to 65 with breast, lung, or colon cancer tolerate chemo better. The goal is to see if participants can receive more than 85% of the planned che…

This study compares a newer, less invasive breast cancer surgery (using small incisions and a camera) to the standard open surgery. About 1,366 women with early-stage breast cancer will take part. The goal is to see if the newer approach leads to better cosmetic results, similar …

This study tests a tool called BCT Aid that helps women newly diagnosed with breast cancer make informed decisions about their surgery. 160 women will be randomly assigned to use the tool or receive standard care. The goal is to see if the tool increases breast-conserving surgery…

This study observes 2,200 young women (up to age 40) with breast cancer who carry gene changes (like TP53, PALB2, CHEK2) other than BRCA1/2. Researchers will track pregnancies after diagnosis and see how they relate to cancer recurrence or survival. No treatments or interventions…

This study looks at whether an artificial intelligence (AI) tool can safely and accurately help breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI tool to ask questions and get answers. Doctors will check if the in…

This study looks at how the bacteria in your gut (microbiome) might influence diarrhea and other stomach issues caused by the breast cancer drug abemaciclib. It involves 20 adults with HR+/HER2- breast cancer. First, researchers will collect stool samples to study gut bacteria. T…

This study looks at how often taste changes happen in women with early-stage breast cancer who are getting chemotherapy. Researchers will use taste tests to measure changes in sweet, sour, salty, and bitter perception. They will also check how these changes affect eating habits, …

This study looks at whether tiny particles called exosomes, released by breast cancer cells, can help predict how well a tumor will respond to chemotherapy given before surgery. Researchers will collect blood and tumor tissue from 60 women with breast cancer and analyze their mic…

This study tests whether using more sensitive imaging methods based on a person's individual risk can detect breast cancer recurrences earlier than standard mammograms. It will include 2,300 women who had breast-conserving surgery and are at higher risk of recurrence. The goal is…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health and find the right follow-up care. The goal is to see if this program improves how confident and capable survi…

This study aims to find the best score on a simple, self-administered questionnaire to identify moderate to severe nerve damage caused by chemotherapy in breast cancer survivors. Researchers will enroll 26 women who have completed taxane-based chemotherapy and radiation. Particip…

This study explores why some breast cancer patients get severe diarrhea from the drug pyrotinib while others don't. Researchers will compare the gut bacteria of 60 patients who develop diarrhea with those who don't, using stool samples. No new treatments are tested—the goal is to…

This study looks at whether doing broad gene testing early, instead of later, can help find more effective treatments for people with advanced liver, breast, or pancreatic cancers. About 360 adults with poor-prognosis cancers will be randomly assigned to early or standard gene te…

This study looks at 300 women aged 45-55 with hormone-positive breast cancer who are near menopause. Researchers will track a hormone called AMH over time to see if it can predict when menopause starts. The goal is to create a tool that helps doctors choose the best hormone thera…

This study explores whether special PET scans can help doctors tailor chemotherapy for early-stage HER2-positive breast cancer. About 156 participants will have their treatment adjusted based on how their tumor responds after two cycles, either intensifying or reducing therapy. T…

This study aims to adapt a community weight loss program called TOPS for breast cancer survivors. Researchers will first hold focus groups with survivors to review and improve program materials, then test the tailored program with 25 women. The goal is to see if the program helps…

This study will give a radioactive version of a breast cancer drug to 6 healthy postmenopausal women. The goal is to see how the drug moves through the body, how it breaks down, and how it leaves the body. This helps researchers understand the drug better before testing it in pat…

This study involves 50 adults with a certain type of advanced breast cancer (HR+HER2-) who are taking hormone therapy and CDK4/6 inhibitors. Researchers want to see if a simple questionnaire can accurately tell which patients truly need to come to the hospital for a check-up. If …

This study aims to understand why some breast cancers resist chemotherapy. Researchers will grow mini-tumors (organoids) from patient samples and test how they respond to drugs. The goal is to find ways to predict and overcome resistance, but this is an observational study with n…

This study looks at whether a blood test that counts and analyzes circulating tumor cells can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, pancreatic, or ovarian cancer. Researchers will collect blood samples from 300 adul…

This study looks at whether a color Doppler ultrasound feature called 'twinkling artifact' can make breast tissue marker clips easier to see. About 86 women with breast cancer who had these clips placed will have their past ultrasound images reviewed. The goal is to see if this t…

This study reviews medical records of 200 breast cancer patients to see if those who had COVID-19 are more likely to develop lung inflammation (radiation pneumonitis) after radiation therapy. Researchers will compare the rate, severity, and timing of lung problems between patient…

This study surveys 240 breast cancer patients (stages I–III) who have had chemotherapy or hormone therapy. Researchers want to learn which herbs and supplements people use, how ethnicity affects those choices, and whether these products interact with standard treatments. Particip…

This study checks if a newer, cheaper DNA sequencing machine (MGI) works as well as the current standard (Illumina) for finding gene changes linked to hereditary cancers like breast, ovarian, and Lynch syndrome. Researchers will compare results from 248 stored DNA samples using b…

This study looks at whether getting a brain MRI every 6 months can find cancer that has spread to the brain earlier in people with stage IV breast cancer who have no brain symptoms. About 156 participants will be randomly assigned to either regular scans or standard care (scans o…

This study looks at a molecule called PCGEM1 in blood and tissue samples from 90 people newly diagnosed with breast cancer. The goal is to learn more about how breast cancer develops and find possible targets for future treatments. No extra procedures are needed beyond standard c…

This study looks at whether women with a higher risk of breast cancer will come back for extra imaging. About 3,000 women in Norway who have very dense breasts or a false-positive result will be invited for an additional mammogram or tomosynthesis. The goal is to see how many att…

This study tests whether special PET/MRI tracers can predict how well breast cancer treatments work. About 300 women with breast cancer will get two types of PET/MRI scans before and after two treatment cycles. The goal is to find which tracers best match treatment outcomes, help…

This study will test whether a training program based on the Health Belief Model can increase how often women perform breast self-exams and improve their knowledge and awareness of breast cancer while reducing fear. About 76 women aged 20 to 69 who have not had breast cancer will…

This study looks at whether a blood test can find tiny bits of cancer DNA left after surgery for breast, lung, prostate, ovarian, or stomach cancer. About 840 adults who had their cancer removed will give blood samples over a year. The goal is to learn how often this DNA is found…

This study aims to see if MRI scans combined with artificial intelligence can predict how aggressive a breast cancer is and whether it has a protein called HER2. Currently, doctors need a needle biopsy to check for HER2, which can be uncomfortable and miss some cancer spots. The …

This study looks at whether using a blue dye alone to find and remove key lymph nodes after chemotherapy is safe and effective for women with breast cancer that had spread to the armpit. About 240 women will get the dye-guided biopsy plus standard lymph node removal. The goal is …

This study looks at whether a hormone called GDF-15, measured in the blood, can predict which breast cancer patients will experience severe nausea and vomiting from the drug T-DXd. Researchers will track 150 patients starting T-DXd treatment and compare their GDF-15 levels with s…

This study looks at how a personalized strength training program affects people with different cancers (lung, colon, breast, lymphoma, and leukemia). 150 adults will either do supervised strength training plus home exercises, or just home exercises, for 12 weeks. Researchers will…

This study looks at whether training oncologists in shared decision-making and giving patients educational booklets and videos can improve how treatment choices are made for HER2-negative metastatic breast cancer. About 120 patients starting their first treatment will join, and t…

This study collects ultrasound images from 100 women who have had a breast biopsy marker placed. The goal is to train an AI software to automatically detect and show the marker's location during routine ultrasound exams. The study does not change or affect the patient's medical c…

This study looks at how the drug abemaciclib, used with hormone therapy for a certain type of breast cancer, causes severe diarrhea in some patients. Researchers will measure drug levels in the blood of 235 women to see if higher levels lead to more side effects. The goal is to c…

This study looks at why older breast cancer survivors often have faster declines in memory and thinking after chemotherapy. Researchers will track 152 women aged 60-85 who finished chemo at least a year ago, measuring their diet, exercise, stress, sleep, blood sugar, cholesterol,…

This study involves 30 women with breast cancer who will receive proton radiation after surgery. Researchers will use PET/CT scans to check how accurately the proton beams hit their targets. They will also see if any beam errors are linked to side effects like lung inflammation o…

This study looks at how well the DPD enzyme works in people with cancer and/or kidney failure. The DPD enzyme breaks down common chemotherapy drugs, and low activity can cause severe side effects. Doctors currently use a blood test to check DPD function, but kidney problems may m…

This study tests a virtual reality (VR) program called SurviVRSE that teaches breast cancer survivors about heart health. About 30 women currently receiving certain cancer treatments will try the VR program. Researchers will check if the program is easy to use, acceptable, and if…

This study looks at whether it's safe for people with early-stage breast cancer to skip a common surgery that removes lymph nodes from the armpit. Researchers will track 827 patients over three years to see if the cancer comes back in the armpit and how their quality of life is a…

This study tests a special scanner that helps doctors check if all cancer has been removed during breast cancer surgery. About 20 women will take part. The scanner uses light to look at the removed tissue right away, without damaging it. The goal is to see if this method can redu…

This study looks at how the bacteria in your gut change when you take Verzenio (abemaciclib) for breast cancer. Verzenio often causes diarrhea and other stomach problems, and researchers want to see if these changes in gut bacteria are linked to those side effects. About 12 adult…

This study aims to see if a simple finger-prick blood sample can accurately measure levels of certain breast cancer drugs (CDK4/6 inhibitors) compared to standard blood draws from a vein. About 90 breast cancer patients currently taking these drugs will provide both types of samp…

This study tracks 81 patients with early-stage, hormone-positive breast cancer who are prescribed a two- to three-year course of CDK4/6 inhibitor pills (abemaciclib or ribociclib) after surgery. The goal is to see how many stop taking the pills early and why. Researchers hope to …

This study tests a new PET camera designed specifically for breast imaging, with very high detail. The main goal is to see how well the camera works in a real clinic and whether it produces clear images. About 20 people with breast cancer will take part. This is an early-stage st…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …

This study tests a culturally tailored program to help Black women keep their mammogram appointments. Researchers will compare no-show rates between women who get the program and those who don't. The goal is to find better ways to reduce racial disparities in breast cancer screen…

This study looks at bacteria living inside breast tumors and nearby healthy tissue, as well as in the gut and urine, of 240 women with breast cancer. Researchers want to see if these bacteria differ by cancer subtype and if they relate to how the tumor behaves. The goal is to gat…

This study looks at whether common chemicals called endocrine disruptors (found in plastics and personal care products) are linked to breast cancer. Researchers will measure these chemicals in urine, hair, and breast tissue from 42 women scheduled for breast lesion surgery. The g…

This study follows 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will test participants before treatment and one year after using questionnaires and exams. The goal is to better understand these…