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Could radiation replace the knife? new trial tests surgery-free breast cancer treatment

NCT ID NCT07217990

Not yet recruiting Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether some people with early-stage breast cancer can safely skip surgery after chemotherapy and instead use only radiation. It includes 84 adults with HER2-positive or triple-negative breast cancer who have responded well to initial chemo. The goal is to see if this non-surgical approach can keep the cancer from coming back, using MRI and mammograms to monitor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Neoadjuvant chemotherapy and radiation therapy
What this could lead to
If successful, this could offer a non-surgical option for some breast cancer patients, avoiding mastectomy or lumpectomy while still controlling the disease.
What could go wrong
This is an early-phase trial with only 84 participants, so results may not apply broadly. There is a risk that radiation alone may not control the cancer as well as surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER2-POSITIVE BREAST CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

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