Monthly vs. quarterly shots: can a simple switch boost ovarian suppression in young breast cancer?
NCT ID NCT07610733
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial will enroll 100 young women (ages 18-45) with hormone receptor-positive breast cancer who are already on a 3-month GnRH injection for ovarian suppression. Half will switch to a monthly injection, while the other half stays on the 3-month schedule. The study aims to see if the switch leads to better control of estrogen levels at 3 months, which is important for managing the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GnRH agonists (goserelin or leuprolide) plus endocrine therapy (aromatase inhibitor/tamoxifen ± CDK4/6 inhibitor)
- What this could lead to
- If successful, this could show that switching to a monthly GnRH injection provides better ovarian suppression, potentially improving treatment outcomes for young breast cancer patients.
- What could go wrong
- This is a small Phase 2 study (100 participants) and has not yet started recruiting. The primary endpoint is a hormone level, not a direct measure of cancer recurrence or survival, so benefits may not translate to better long-term outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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