Can a potato starch supplement ease cancer drug side effects?

NCT ID NCT07406594

Not yet recruiting Knowledge-focused Sponsor: University of Vermont Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will track gut microbiome changes in 12 women with hormone receptor-positive breast cancer starting Verzenio (abemaciclib) therapy. Participants will take either a resistant potato starch supplement or a placebo, and provide stool samples and symptom questionnaires remotely. The goal is to see if the supplement is feasible and whether microbiome changes relate to digestive side effects like diarrhea.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Resistant potato starch (dietary supplement)
What this could lead to: If successful, this study could point toward dietary strategies to reduce digestive side effects from Verzenio, improving quality of life for breast cancer patients.
What could go wrong: This is a very small, early feasibility study with only 12 participants. It is not designed to prove whether the supplement works, only whether the study procedures are practical. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER HER 2 POSITIVE BREAST CANCER

Contacts and locations

Locations

University of Vermont

Burlington, Vermont, 05401, United States

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