Can a risk score and MRI outsmart dense breasts?

NCT ID NCT07277738

Not yet recruiting Diagnosis Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study looks at whether adding an MRI to the yearly mammogram can help find breast cancer earlier in women with dense breasts. Participants will have a mammogram and a risk score calculated from it. Those with a high risk score will be offered an MRI. The goal is to see if this approach reduces cancers found between screenings or at a later stage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prognosia Breast (a mammogram-based risk algorithm) and MRI
What this could lead to: If successful, this could show that using a risk score to select women for supplemental MRI reduces late-stage or interval breast cancers.
What could go wrong: This is a small, early feasibility study (78 participants) and not yet recruiting. The risk score may not accurately predict who benefits from MRI, and MRI can lead to false alarms or unnecessary biopsies.

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm breast cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER CANCER OF THE BREAST

Contacts and locations

Locations

Washington University School of Medicine

St Louis, Missouri, 63110, United States

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