New combo aims to boost breast cancer remission before surgery
NCT ID NCT07178730
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether a combination of sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda) works better than standard chemotherapy before surgery for stage II-III triple-negative breast cancer. About 765 participants will be enrolled. The study aims to improve event-free survival and complete response rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda)
What this could lead to
If successful, this could offer a more effective neoadjuvant treatment for triple-negative breast cancer, potentially increasing the chance of a complete response and reducing recurrence.
What could go wrong
This is a phase 3 trial, but it's not yet recruiting. The combination may cause more side effects, and it's unclear if it will outperform current standard care for all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brustzentrum Rhein-Ruhr Servicegesellschaft mbH
Mönchengladbach, North Rhine-Westphalia, 41061, Germany
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Caritas-Krankenhaus St. Josef, Frauenheilkunde und Geburtshilfe
Regensburg, Bavaria, 93053, Germany
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GRN Gesundheitszentren Rhein-Neckar gGmbH, Brustzentrum Weinheim
Weinheim, Baden-Wurttemberg, 69469, Germany
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Gemeinschaftspraxis Frauenärzte am Bahnhofsplatz
Hildesheim, Lower Saxony, 31134, Germany
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Gesundheitszentrum Wetterau gGmbH, Gynäkologische Ambulanz
Bad Nauheim, Hesse, 61231, Germany
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Haematologisch Onkologische Schwerpunktpraxis
Würzburg, Bavaria, 97080, Germany
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Klinikum Dortmund gGmbH, Frauenklinik Dortmund
Dortmund, North Rhine-Westphalia, 44137, Germany
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Klinikum Kassel GmbH, Klinik für Frauenheilkunde und Geburtshilfe
Kassel, Hesse, 34125, Germany
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Klinikum Obergoeltzsch Rodewisch Frauenklinik / Brustzentrum
Rodewisch, Saxony, 08228, Germany
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Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), Brustzentrum
München, Bavaria, 81675, Germany
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Klinikum der Universitaet Muenchen AöR, Frauenheilkunde und Geburtshilfe
München, Bavaria, 80336, Germany
Contact
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MKS St. Paulus GmbH, Märkisches Brustzentrum
Schwerte, North Rhine-Westphalia, 58239, Germany
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Marien-Hospital Witten, Brustzentrum
Witten, North Rhine-Westphalia, 58452, Germany
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Medical University Of Lausitz Carl Thiem, Frauenklinik
Cottbus, Brandenburg, 03048, Germany
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Onkodok GmbH Onkologische Gemeinschaftspraxis
Gütersloh, North Rhine-Westphalia, 33332, Germany
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Praxisnetz Hämatologie / internistische Onkologie
Troisdorf, North Rhine-Westphalia, 53840, Germany
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SLK-Kliniken Heilbronn GmbH, Klinik für Gynäkologie und Geburtshilfe
Heilbronn, Baden-Wurttemberg, 74078, Germany
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St. Barbara-Klinik Hamm GmbH, Brustzentrum
Hamm, North Rhine-Westphalia, 59073, Germany
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St. Franziskus-Hospital GmbH, MVZ MediaVita
Münster, North Rhine-Westphalia, 48145, Germany
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St.-Antonius-Hospital gGmbH, Klinik für Hämatologie und Onkologie
Eschweiler, North Rhine-Westphalia, 52249, Germany
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Universitaetsklinikum Aachen AöR, Gynäkologie und Geburtsmedizin
Aachen, North Rhine-Westphalia, 52074, Germany
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Universitaetsklinikum Augsburg, Klinik für Frauenheilkunde und Geburtsmedizin
Augsburg, Bavaria, 86156, Germany
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Universitaetsklinikum Bonn AöR, Senologie
Bonn, North Rhine-Westphalia, 53127, Germany
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Universitaetsklinikum Essen AöR Klinik für Frauenheilkunde und Geburtshilfe
Essen, North Rhine-Westphalia, 45147, Germany
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University Hospital Cologne AöR, Brustkrebszentrum
Cologne, North Rhine-Westphalia, 50937, Germany
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University Medical Center Hamburg-Eppendorf, Klinik und Poliklinik für Gynäkologie
Hamburg, 20246, Germany
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Contact
Contact