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New combo aims to boost breast cancer remission before surgery

NCT ID NCT07178730

Not yet recruiting Disease control Sponsor: Women's Cancer Study Group GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether a combination of sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda) works better than standard chemotherapy before surgery for stage II-III triple-negative breast cancer. About 765 participants will be enrolled. The study aims to improve event-free survival and complete response rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
sacituzumab govitecan (Trodelvy) and pembrolizumab (Keytruda)
What this could lead to
If successful, this could offer a more effective neoadjuvant treatment for triple-negative breast cancer, potentially increasing the chance of a complete response and reducing recurrence.
What could go wrong
This is a phase 3 trial, but it's not yet recruiting. The combination may cause more side effects, and it's unclear if it will outperform current standard care for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

    Mönchengladbach, North Rhine-Westphalia, 41061, Germany

  • Caritas-Krankenhaus St. Josef, Frauenheilkunde und Geburtshilfe

    Regensburg, Bavaria, 93053, Germany

  • GRN Gesundheitszentren Rhein-Neckar gGmbH, Brustzentrum Weinheim

    Weinheim, Baden-Wurttemberg, 69469, Germany

  • Gemeinschaftspraxis Frauenärzte am Bahnhofsplatz

    Hildesheim, Lower Saxony, 31134, Germany

  • Gesundheitszentrum Wetterau gGmbH, Gynäkologische Ambulanz

    Bad Nauheim, Hesse, 61231, Germany

  • Haematologisch Onkologische Schwerpunktpraxis

    Würzburg, Bavaria, 97080, Germany

  • Klinikum Dortmund gGmbH, Frauenklinik Dortmund

    Dortmund, North Rhine-Westphalia, 44137, Germany

  • Klinikum Kassel GmbH, Klinik für Frauenheilkunde und Geburtshilfe

    Kassel, Hesse, 34125, Germany

  • Klinikum Obergoeltzsch Rodewisch Frauenklinik / Brustzentrum

    Rodewisch, Saxony, 08228, Germany

  • Klinikum der Technischen Universitaet Muenchen (TUM Klinikum), Brustzentrum

    München, Bavaria, 81675, Germany

  • Klinikum der Universitaet Muenchen AöR, Frauenheilkunde und Geburtshilfe

    München, Bavaria, 80336, Germany

  • MKS St. Paulus GmbH, Märkisches Brustzentrum

    Schwerte, North Rhine-Westphalia, 58239, Germany

  • Marien-Hospital Witten, Brustzentrum

    Witten, North Rhine-Westphalia, 58452, Germany

  • Medical University Of Lausitz Carl Thiem, Frauenklinik

    Cottbus, Brandenburg, 03048, Germany

  • Onkodok GmbH Onkologische Gemeinschaftspraxis

    Gütersloh, North Rhine-Westphalia, 33332, Germany

  • Praxisnetz Hämatologie / internistische Onkologie

    Troisdorf, North Rhine-Westphalia, 53840, Germany

  • SLK-Kliniken Heilbronn GmbH, Klinik für Gynäkologie und Geburtshilfe

    Heilbronn, Baden-Wurttemberg, 74078, Germany

  • St. Barbara-Klinik Hamm GmbH, Brustzentrum

    Hamm, North Rhine-Westphalia, 59073, Germany

  • St. Franziskus-Hospital GmbH, MVZ MediaVita

    Münster, North Rhine-Westphalia, 48145, Germany

  • St.-Antonius-Hospital gGmbH, Klinik für Hämatologie und Onkologie

    Eschweiler, North Rhine-Westphalia, 52249, Germany

  • Universitaetsklinikum Aachen AöR, Gynäkologie und Geburtsmedizin

    Aachen, North Rhine-Westphalia, 52074, Germany

  • Universitaetsklinikum Augsburg, Klinik für Frauenheilkunde und Geburtsmedizin

    Augsburg, Bavaria, 86156, Germany

  • Universitaetsklinikum Bonn AöR, Senologie

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitaetsklinikum Essen AöR Klinik für Frauenheilkunde und Geburtshilfe

    Essen, North Rhine-Westphalia, 45147, Germany

  • University Hospital Cologne AöR, Brustkrebszentrum

    Cologne, North Rhine-Westphalia, 50937, Germany

  • University Medical Center Hamburg-Eppendorf, Klinik und Poliklinik für Gynäkologie

    Hamburg, 20246, Germany

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