Creatine may shield breast cancer patients from 'Chemo Brain'

NCT ID NCT07372144

Not yet recruiting Symptom relief Sponsor: D'Or Institute for Research and Education Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether taking creatine supplements daily can prevent or reduce the memory and thinking problems that often come with chemotherapy. About 227 women with early-stage breast cancer will receive either creatine or a placebo, starting before chemo and continuing for a year after. Researchers will track cognitive function through tests and questionnaires, along with brain scans and blood samples.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: creatine monohydrate (5 g per day oral supplement)
What this could lead to: If it works, this could offer a simple, safe way to protect thinking and memory during chemotherapy for breast cancer patients.
What could go wrong: This is a large Phase 3 trial, but it is not yet recruiting. Creatine may not prevent cognitive decline, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Instituto D'Or de Pesquisa e Ensino de São Paulo

São Paulo, São Paulo, Brazil

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