Could thousands of breast cancer patients skip extra radiation?
NCT ID NCT07385365
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial will test if women with intermediate-risk breast cancer can safely skip radiation to the lymph nodes after surgery. About 3,142 participants will be randomly assigned to receive either standard radiation to the breast or chest wall plus lymph nodes, or radiation only to the breast or chest wall (or no radiation after mastectomy). The goal is to see if skipping lymph node radiation leads to similar cancer-free survival with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy
- What this could lead to
- If successful, this could show that many intermediate-risk breast cancer patients can safely avoid extra radiation to the lymph nodes, reducing side effects without harming survival.
- What could go wrong
- This is a large phase 3 trial, but it's not yet recruiting. The benefit of skipping radiation may be small, and there is a risk of higher cancer recurrence in the non-radiation group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cancer Hospital,Chinese Academy od Medical Sciences
Beijing, Beijing Municipality, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a radioactive tracer pinpoint Cancer's first stop?
- Can a personalized exercise program boost recovery in cancer survivors?
- Smartwatch could spot nerve damage before it starts
- Could ionized gas help fight breast cancer after surgery?
- Radiation may let breast cancer patients keep their nipple
- Can a smart digital program restore sleep for cancer survivors?