New drug combo aims to shrink breast tumors before surgery
NCT ID NCT07197697
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase II trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy before surgery can improve tumor response in 30 patients with HR+/HER2- breast cancer. The study uses a two-stage design to check if enough patients achieve a complete response (no cancer found after surgery). If successful, the drug combination may be studied further.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- iparomlimab and tuvonralimab (immunotherapy drugs) combined with chemotherapy (epirubicin, cyclophosphamide, paclitaxel)
- What this could lead to
- If successful, this could lead to a new treatment option that shrinks tumors before surgery in HR+/HER2- breast cancer, potentially improving outcomes.
- What could go wrong
- This is a small, early-phase study with only 30 participants, so results may not apply to everyone. The combination therapy may cause side effects like immune reactions or chemotherapy toxicity.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Chest-Injected drug drain Cancer's fluid trap?
- A dab of gel on the breathing tube might spare surgery patients a sore throat — a trial puts it to the test.
- Can a deeper nerve block ease pain after breast surgery?
- Does breast cancer radiation harm a key immune gland? a study investigates
- A web program may ease the emotional toll of chemotherapy hair loss
- Can 3D breast imaging spot more dangerous cancers than standard mammograms?