Could a pill replace chemo for some breast cancer patients?

This study tests whether a chemotherapy-free treatment using the targeted drug Dalpiciclib (a CDK4/6 inhibitor) plus hormone therapy works as well as standard chemotherapy for women with small, high-risk, hormone-receptor-positive breast cancer. About 2,288 participants will be randomly assigned to either the new drug combo or standard chemo, both followed by hormone therapy. The goal is to see if the new approach can prevent cancer from coming back while avoiding chemotherapy's harsh side effects.