Radioactive seeds aim to boost Chemo's punch against breast cancer

NCT ID NCT07269691

Not yet recruiting Disease control Sponsor: Pengfei Qiu Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether placing tiny radioactive seeds in breast tumors before chemotherapy can help eliminate cancer more completely. About 194 women with early or locally advanced breast cancer will either get standard chemo alone or chemo plus seed placement. The goal is to see if the seeds increase the rate of complete cancer disappearance and improve long-term survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Iodine-125 radioactive seed
What this could lead to: If it works, this could improve the chance of eliminating all cancer before surgery and lead to better long-term survival for women with early or locally advanced breast cancer.
What could go wrong: This is a relatively small phase 3 trial, and the benefit of radioactive seeds is unproven. There is a risk of seed migration or local side effects, and the approach may not improve outcomes compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER EARLY STAGE BREAST CANCER (STAGE 1-3)

Contacts and locations

Locations

Shandong Cancer Hospital affiliated to Shandong First Medical University

Jinan, Shandong, 250117, China

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