Heart shield: statin may guard against chemo damage in breast cancer

NCT ID NCT07254221

Not yet recruiting Prevention Sponsor: Shiraz University of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking rosuvastatin, a cholesterol-lowering drug, can prevent heart damage caused by anthracycline chemotherapy in women with breast cancer. Four hundred participants will receive either rosuvastatin or a placebo daily for 12 months. The main goal is to see if the drug helps maintain heart pumping function and reduces signs of heart stress.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: rosuvastatin
What this could lead to: If it works, this could offer a simple way to protect the heart during breast cancer chemotherapy, reducing long-term heart risks.
What could go wrong: This is a Phase 4 trial, but it hasn't started yet. The benefit may be small or not apply to all patients, and statins can cause muscle pain or liver issues.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Cardiotoxicity cardiomyopathy due to anthracyclines prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTHRACYCLINE INDUCED CARDIOTOXICITY ANTHRACYCLINE RELATED CARDIOTOXICITY IN BREAST CANCER ANTHRACYCLINE-INDUCED CARDIAC TOXICITY BREAST CANCER

Contacts and locations

Locations

Kowsar Hospital, Fars Heart Foundation

Shiraz, Fars, Iran
Modarres Hospital, Shahid Beheshti University of Medical Sciences

Tehran, Tehran Province, Iran
Motahari Breast Cancer Clinic

Shiraz, Fars, 71344-1864, Iran
Rajaee Hospital, Iran University of Medical Sciences

Tehran, Tehran Province, Iran
Sina Hospital, Tehran University of Medical Sciences

Tehran, Tehran Province, Iran
Taleghani Hospital, Shahid Beheshti University of Medical Sciences

Tehran, Tehran Province, Iran
Toba Oncology Department, Mazandaran University of Medical Sciences

Sari, Mazandaran, Iran

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