Low-Dose tamoxifen shows promise in cutting breast cancer risk for radiation survivors

NCT ID NCT01196936

First seen Jan 05, 2026 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tests whether a low dose of tamoxifen, a drug that blocks estrogen, can reduce the risk of breast cancer in people who have had radiation therapy for other cancers. About 84 participants are randomly assigned to receive either low-dose tamoxifen or a placebo. The main goal is to see if tamoxifen lowers breast density, a known risk factor for breast cancer.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • MD Anderson

    Houston, Texas, 77030, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109, United States

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • University Health Network, Toronto

    Toronto, Ontario, M5G 2M9, Canada

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Colorado, Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109-5718, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • Wake Forest University

    Winston-Salem, North Carolina, 27157, United States

Conditions

Explore the condition pages connected to this study.