Magnetic seeds vs. radioactive tracers: which better guides breast tumor removal?
NCT ID NCT05942118
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two modern, wire-free methods for locating non-palpable breast lesions before surgery: radioguided occult lesion localization (ROLL) using a radioactive tracer, and magnetic seed localization. The goal is to see which technique more reliably achieves clear surgical margins (no cancer cells at the edge of removed tissue) while minimizing excess tissue removal. The trial enrolls women with non-palpable, borderline or malignant breast lesions who are scheduled for breast-conserving surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Magnetic markers and radioactive tracer (ROLL)
What this could lead to
If one method proves superior, it could become the preferred standard for guiding breast-conserving surgery, reducing repeat procedures and improving patient comfort.
What could go wrong
This is a single-center study with 262 participants, so results may not apply broadly. Both techniques are already in use, so dramatic differences are unlikely.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Istituti Clinici Scientifici Maugeri SpA
Pavia, Lombardy, 27100, Italy