Chemo-Free hope for HER2+ breast cancer patients in new trial

NCT ID NCT06068985

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether certain women with early-stage HER2-positive breast cancer can be treated with a targeted drug combination (PHESGO™) without chemotherapy. Researchers use specific markers to select patients whose tumors are highly dependent on the HER2 pathway. The goal is to see if this approach can still eliminate the tumor while avoiding chemo side effects.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A.C. Camargo Cancer Center

    São Paulo, São Paulo, 01.509-001, Brazil

  • Centro Paulista de Oncologia (Oncoclínicas)

    São Paulo, São Paulo, 04.538-135, Brazil

  • Centro de Câncer de Brasília - CETTRO (Oncoclínicas)

    Brasília, Federal District, 70.710-904, Brazil

  • Centro de Pesquisa Vencer & Oncoclínica

    Teresina, Piauí, 60.449-200, Brazil

  • Centro de Pesquisa do Hospital Pérola Byington

    São Paulo, São Paulo, 01.317-000, Brazil

  • Centro de Pesquisa em Oncologia do Hospital São Lucas da PUCRS - CPO

    Porto Alegre, Rio Grande do Sul, 90.610-000, Brazil

  • Hospital da Fundação Oswaldo Aranha - HFOA

    Volta Redonda, Rio de Janeiro, 27.251-260, Brazil

  • Hospital de Amor de Barretos

    São Paulo, São Paulo, 14.784-400, Brazil

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, Rio de Janeiro, 20.230-130, Brazil

  • Instituto do Câncer do Estado de São Paulo - ICESP

    São Paulo, São Paulo, 01.246-000, Brazil

  • Núcleo de Oncologia da Bahia - NOB (Oncoclínicas)

    Salvador, Estado de Bahia, 40.170-110, Brazil

  • Oncocentro Belo Horizonte (Oncoclínicas)

    Belo Horizonte, Minas Gerais, 30.360-680, Brazil

  • Santa Casa de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90.050-170, Brazil

  • Universidade Estadual de Campinas - UNICAMP

    Campinas, São Paulo, 13.083-881, Brazil