Could two weeks of radiation be enough for breast cancer?

NCT ID NCT04175210

Ongoing Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial compares a standard 3-week radiation course to an experimental 2-week course for women with early-stage breast cancer. About 400 participants who had lumpectomy will receive whole breast radiation plus an extra boost to the tumor site. The study checks if the shorter schedule causes similar side effects and controls cancer just as well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy
What this could lead to: If successful, this could offer a shorter, more convenient radiation schedule for early breast cancer patients without compromising outcomes.
What could go wrong: This is a non-inferiority trial, so it aims to show the shorter course is not worse, not better. Results may not apply to all breast cancer types or stages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm ductal breast carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Brooklyn Methodist Hospital - NewYork Presbyterian

New York, New York, 11215, United States
New York Presbyterian Hospital - Queens

New York, New York, 11355, United States
New York Presbyterian Hospital at Lower Manhattan Cancer Center

New York, New York, 10007, United States

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