Could a gentler chemo cocktail beat breast cancer with fewer side effects?
NCT ID NCT07421141
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing a less intense chemotherapy regimen for people with early-stage HER2-positive breast cancer. The experimental treatment combines paclitaxel with two targeted drugs (trastuzumab and pertuzumab), skipping the harsher anthracycline drugs. Researchers want to see if this gentler approach can still eliminate all signs of cancer before surgery, while causing fewer side effects. The study includes 186 participants and compares results to a historical group that received standard chemo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Paclitaxel, trastuzumab, and pertuzumab (THP)
- What this could lead to
- If successful, this could offer a less toxic chemotherapy option for early HER2-positive breast cancer, reducing side effects while maintaining high cure rates.
- What could go wrong
- This is a phase II study with only 186 participants, so results are preliminary. The experimental regimen may prove less effective than standard treatment, and long-term outcomes are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
P.A. Hertsen Moscow Oncology Research Institute
Moscow, 125284, Russia
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