New radiation technique aims to spare heart in breast cancer patients

NCT ID NCT01758445

Ongoing Disease control Sponsor: Proton Collaborative Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing a precise type of radiation called proton therapy for women with stage II or III breast cancer who need radiation to the whole breast or chest wall and lymph nodes. The goal is to see if this approach causes fewer side effects, especially to the heart, compared to standard radiation. About 220 participants will be followed for up to 15 years to track heart health and risk of new cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton radiotherapy
What this could lead to: If successful, this could offer a safer radiation option for advanced breast cancer, lowering the risk of heart problems and second cancers later in life.
What could go wrong: This is a mid-stage trial with 220 participants, so results are not yet proven. Long-term benefits and risks (like heart issues or new cancers) will take 10-15 years to fully assess.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST NEOPLASM BREAST TUMOR CANCER OF THE BREAST

Contacts and locations

Locations

Hampton University Proton Therapy Institute

Hampton, Virginia, 23666, United States
Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States
Northwestern Medicine Chicago Proton Center

Warrenville, Illinois, 60555, United States
Oklahoma Proton Center

Oklahoma City, Oklahoma, 73142, United States
Princeton ProCure Managment LLC

Somerset, New Jersey, 08873, United States

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