BREAST NEOPLASM

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing offers similar disease control with fewer complications and better quality of life. Participants will b…

This study tests whether proton radiation, a precise type of radiation, can control early-stage breast cancer while causing fewer side effects than standard radiation. About 132 women aged 50 and older with certain types of breast cancer will receive proton therapy only to the ar…

This study tests a new breast biopsy marker (HydroMARK Plus) to see if surgeons can find and remove it more easily than the current marker. About 150 adults with breast cancer who need surgery will take part. The goal is to improve how well the marker is retrieved and how satisfi…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. It is for patients whose cancer has not responded to available treatments. About 404 adul…

This study tests a new breast ultrasound method to see if it can better detect breast cancer and measure how well treatment is working. Researchers at Mayo Clinic will enroll 550 adults with suspicious breast lumps or confirmed breast cancer. The goal is to improve diagnosis and …

This study tests a new blood-based device that uses laser technology and artificial intelligence to help doctors tell apart high-risk and low-risk breast cancer patients. About 330 people with breast cancer will give a blood sample before treatment. The goal is to see if the devi…

This study tests whether a special type of breast imaging called molecular breast imaging (MBI) can help doctors take tissue samples (biopsies) from breast abnormalities that are hard to see on standard ultrasound or mammography. About 70 women with a known breast finding will un…

This study tests whether drinking tart cherry juice can help prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice daily …

This study tests whether a special exercise program using blood flow restriction can prevent nerve damage (peripheral neuropathy) caused by chemotherapy in breast cancer patients. About 25 adults with HER2+ breast cancer awaiting taxane-based chemo will either do the exercises or…

This study looks at whether a guided exercise program can improve quality of life and lower healthcare costs for women with breast cancer who are still getting treatment. About 866 women will either follow a structured exercise plan or get standard advice to stay active. The goal…

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when not needed. About 402 participants will …

This study tests whether a 14-day mobile daily diary is a practical way to measure daily stress and thinking (cognitive) performance in breast cancer survivors from different racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past t…