BREAST NEOPLASM

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 people with low-risk, early-stage breast cancer. The goal is to see if freezing is as safe and effective at controlling the disease, with fewer side effects and better quality of lif…

This study tests whether proton radiation therapy can effectively treat early-stage breast cancer while reducing side effects. About 132 women aged 50 and older with specific breast cancer types will receive radiation only to the tumor area. The goal is to keep cancer from coming…

This study tests whether giving personalized chemotherapy before surgery (neoadjuvant therapy) can improve outcomes for people with early-stage breast cancer. Researchers will use detailed tumor typing to match each participant with the most promising drug combination. The trial …

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. About 404 adults whose cancer has not responded to other treatments will participate. The…

This study compares a new breast biopsy marker (HydroMARK Plus) with the current marker (HydroMARK) to see which one surgeons can find and remove more successfully during surgery. About 150 adults with breast tumors who are scheduled for surgery will take part. The goal is to imp…

This study is testing a new blood test that uses laser technology and artificial intelligence to help doctors tell apart high-risk and low-risk breast cancer patients. The test looks at tiny particles in the blood called extracellular vesicles. About 330 people with breast cancer…

This study tests whether a special type of breast imaging called molecular breast imaging (MBI) can help doctors take tissue samples (biopsies) from breast abnormalities that are hard to see on standard ultrasound or mammogram. About 70 women with a known breast finding will unde…

This study tests a new breast ultrasound method to see if it can better find breast cancer and track how well treatment is working. About 550 adults with suspicious breast lumps or known breast cancer will take part. The goal is to improve detection and monitor response to therap…

This study tests whether a special exercise program, which includes gently restricting blood flow to the limbs, can prevent nerve damage caused by chemotherapy in breast cancer patients. About 25 adults with HER2+ breast cancer who are about to start chemotherapy will either do t…

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will drink either a high or low dose of the juice daily during their 12-week chemo t…

This study looks at whether a guided exercise program can improve quality of life and lower healthcare costs for women with breast cancer who are undergoing treatment like surgery, chemo, or radiation. About 866 women will be split into two groups: one gets the exercise program, …

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking skills in breast cancer survivors from diverse racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past diagnosis. Participants co…