New study tests if anesthesia can stop chronic pain after breast cancer surgery

NCT ID NCT05876390

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Niguarda Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether using loco-regional anesthesia (numbing a specific area) during breast cancer surgery can help prevent chronic pain that often lasts months or years after the operation. About 30% of women experience this long-term pain. Researchers will follow 1,500 patients across multiple hospitals to see how different anesthesia techniques affect pain outcomes. The study is observational, meaning it will observe real-world practices rather than assign treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: loco-regional anesthesia plus multimodal analgesia (NSAIDs, paracetamol)
What this could lead to: If successful, this could identify better ways to prevent long-term pain after breast cancer surgery.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not lead to a new standard of care.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

ASST GOM Niguarda

Milan, Lombardy, 20162, Italy

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